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5023081 |
Controlled release hydroxybutyrate polymer microspheres
Controlled release microspheres of hydroxybutyrate polymer comprise active ingredient and hydroxybutyrate/hydrovalerate copolymer. The microspheres comprise a skin which is distinct from the...
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5019400 |
Very low temperature casting of controlled release microspheres
A process for preparing microspheres using very cold temperatures to freeze polymer-biologically active agent mixtures into polymeric microspheres with very high retention of biological activity...
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5019372 |
Magnetically modulated polymeric drug release system
A magnetically responsive composition for the modulated, sustained administration of a biologically active substance, the composition being in the form of a body sized and shaped for placement in...
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5019379 |
Unsaturated polyanhydrides
A class of unsaturated polyanhydrides having double bonds available for secondary polymerization is disclosed. A crosslinked material having improved or different physical and mechanical properties...
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5017383 |
Method of producing fine coated pharmaceutical preparation
A method of producing a fine coated pharmaceutical preparation, which includes cooling fine liquid droplets composed of a liquid medium, a drug dissolved or suspended in the liquid medium, and as...
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5015480 |
Film coating formulations
Aqueous diffusion coating formulations suitable for use on pharmaceutical dosage forms comprising an admixture of an insoluble polymer component of a copolymer of ethylacrylate and...
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5007790 |
Sustained-release oral drug dosage form
Sustained-release oral drug-dosage forms that release drug in solution at a rate controlled by the solubility of the drug are described. The dosage form comprises a tablet or capsule which...
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5008117 |
Formulation for preparing extemporaneous homogeneous microcapsule suspension
The invention relates to a method by which it is possible to prepare a formulation consisting of thickening or suspending agents and other excipients, having the property of dispersing and...
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5008118 |
Method for producing organic agent coated with powders of coating agent
A method for producing a coated organic agent is provided. The method comprises contacting a coating agent with core powders of an organic substance so that the coating agent collides against the...
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5002776 |
Controlled absorption diltiazem formulations
A controlled absorption diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid, and a...
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5000955 |
Thermally reversible polyurethane hydrogels and cosmetic, biological and medical uses
Thermally reversible polyurethane hydrogels are formed by adding water to a gel forming hydrophilic polyurethane polymer produced by reacting under anhydrous conditions a non-aromatic organic...
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4999190 |
Preparation of I.sub.5 - polyiodide disinfectant resins
A method is provided for strong base anion exchange resins containing high concentrations of pentaiodide (I 5 - ). The resins are prepared from highly concentrated solutions of I 5 - and I 3 - ...
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4994281 |
Polylactic acid microspheres and process for producing the same
Polylactic acid microspheres having an average particle diameter of about 0.1 to 10 μm which are produced from solution containing a physiologically active substance by the solvent-evaporation...
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4994260 |
Pharmaceutical mixture
A pharmaceutical mixture with controlled release of actice substance which includes masking of bad taste and stability increasing of active substance characterized in that an encapsulated active...
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4990341 |
Controlled release hydromorphone composition
A solid controlled release, oral dosage form, the dosage form comprising a therapeutically effective amount of hydromorphone or a salt thereof in a matrix wherein the dissolution rate in vitro of...
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4983401 |
Sustained release pharmaceutical preparations having pH controlled membrane coatings
A sustained-release pharmaceutical preparation utilizing a pH controlled diffusion membrane composed of a pH sensitive film-forming polymer. The film forming polymer may be an enteric polymer...
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4976949 |
Controlled release dosage form
A dosage system for administering drugs and conducting gastric flow studies is configured in the form of a multiplicity of substantially spherical subunits which have advantageously preselected...
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4975284 |
Controlled release means
A controlled release means comprisng a core of at least one water-soluble ingredient of which at least one ingredient is to be released in a controlled manner, said core being surrounded by a...
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4971804 |
Water dispersible gemfibrozil compositions
A water-dispersible formulation of gemfibrozil comprising finely divided particles of pure gemfibrozil uniformly coated with a mixture of a wax and at least one hydrophilic material, the coated...
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4971805 |
Slow-releasing granules and long acting mixed granules comprising the same
Slow-releasing granules which are characterized by coating the quick-releasing granules which comprise an active ingredient, polyvinyl pyrrolidone polymer and a disintegrator where the polymer...
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4970081 |
Controlled-release, low-dose aspirin formulation and method of treating vascular occlusive disease therewith
An aqueous-based formulation for coating aspirin granules to provide granules that may be compressed into tablets and that show approximately zero-order release kinetics for release rates of 5 to...
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4970031 |
Process for preparing microcapsules with controlled-release
Microcapsules with controlled-release are prepared by subjecting microcapsules encasing an aqueous solution of a substance to be released from the microcapsules under control to a heat treatment in...
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4968506 |
Pharmaceutical dosage with core of N-acetyl cystein
The present invention relates to a novel pharmaceutical composition comprising N-acetyl cysteine, wherein the composition releases N-acetyl cysteine in accordance with the United States Pharmacopea...
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4968505 |
Long-acting diclofenac sodium preparation
A long-acting diclofenac sodium preparation is disclosed. The preparation comprises a sustained-release diclofenac sodium component which is prepared by coating a sustained-release coat onto a...
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4966770 |
Prednisone microencapsulated granules
The invention disclosed is prednisone microencapsulated granules with activity densities greater than about 0.030 g/ml. These granules are unusually small, having diameters less than about 1000...
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4966872 |
Bacteriostatic activated carbon filter
Polymerized salts of polymerizable anionic monomers with cationic germicides are chemically grafted onto activated carbon in a manner to form a permanent, covalent bond thereon. The grafting of...
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4965072 |
Granulating composition and method
The invention involves a granulating composition composed of an aqueous solution of magnesium sulfate heptahydrate and sodium hexametaphosphate. This composition can be used to prepare granules of...
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4963365 |
Controlled release dosage form
A controlled release dosage form which consists essentially of a core containing a medicament; an inner coating layer composed of ethylcellulose and a hydrophobic substance; and an outer coating...
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4959220 |
Antiseptic-containing alginate impression material
An antiseptic-containing alginate impression material contains 0.01 to 7 parts by weight of an antiseptic such as glutaraldehyde and chlorohexydine gluconate per 100 parts by weight of a cured...
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4957746 |
Process for preparing etofibrate or similar compounds containing sustained release microgranules and products thus obtained
The present invention relates to the pharmaceutical field and particularly to the manufacturing of a pharmaceutical product named etofibrate in the form of sustained release microgranules, wherein...
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4956129 |
Microencapsulation process
A process is disclosed for the microencapsulation of a substantially water-insoluble liquid material within a porous shell to effect a slow rate of release of said material through said shell which...
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4954298 |
Method for producing microcapsule
Microcapsules are advantageously produced with high take-up of a water-soluble drug by preparing a W/O emulsion composed of a water-soluble drug-containing solution as the inner aqueous phase and a...
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4952403 |
Implants for the promotion of healing of meniscal tissue
Healing of injured avascular tissue is promoted by applying angiogenic factor in proximity to the injured tissue.
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4952404 |
Promotion of healing of meniscal tissue
Healing of injured avascular tissue is promoted by applying angiogenic factor in proximity to the injured tissue.
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4948581 |
Long acting diclofenac sodium preparation
A diclofenac sodium preparation comprising a rapidly soluble component including an active ingredient consisting essentially of diclofenac sodium, and an enteric component including an active...
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4938968 |
Controlled release indomethacin
In accordance with the present invention, the controlled release formulation contains coated pellets of indomethacin of only one type. The pellet releases indomethacin in both immediate and...
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4938966 |
Controlled release flecainide acetate formulation
Controlled release pharmaceutical formulations containing flecainide acetate and methods of suppressing arrhythmia using the formulations are described.
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4937254 |
Method for inhibiting post-surgical adhesion formation by the topical administration of non-steroidal anti-inflammatory drug
Postsurgical adhesion formation is inhibited by the topical administration to the site of surgical trauma of a non-steroidal anti-inflammatory drug, preferably ibuprofen, suprofen, or tolmetin.
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4935247 |
Composition for the oral administration of pharmaceuticals
The invention relates to a new composition for use on a pharmaceutical granule. The composition is three-layered, comprising as the innermost layer a substantially pure fat, as the middle layer a...
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4933105 |
Process for preparation of microspheres
Microspheres, prepared by solvent removal from an oil-in-water emulsion using carboxylic acid salt surfactant, e.g., sodium oleate as the emulsifier.
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4933167 |
Pesticide compositions
Toxicant, especially pesticide compositions, having lowered dermal toxicity are provided. The compositions include a microencapsulated lipophilicpesticide, a hydrophilic surfactant and water....
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4933187 |
Chemical pellets for aquatic attack protection belt
A belt including a pair of opposite layers of sheet material and subdivided into a series of pockets for receiving pellets of shark-repulsive chemical. One of the pellets is untreated so as to...
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4927639 |
Modified release gemfibrozil composition
A disintegratable formulation of gemfibrozil providing both immediate and sustained release and comprises a tablet compressed from a mixture of a first and second granulation, and a disintegration...
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4927640 |
Controlled release beads having glass or silicon dioxide core
Controlled release preparation containing a number of insoluble beads applied with one or more pharmaceutically active compounds, a method for the production thereof and the use in a treatment...
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4925674 |
Amoxicillin microencapsulated granules
The invention disclosed is amoxicillin microencapsulated granules with activity densities greater than about 0.200 g/ml. These granules are unusually small having diameters less than about 1000...
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4925676 |
Extended release gemfibrozil composition
A disintegratable gemfibrozil tablet providing both immediate and enteric release is compressed from a mixture of a first granulation of gemfibrozil with at least one acid-disintegratable binder...
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4925675 |
Erythromycin microencapsulated granules
The invention disclosed is erythromycin microencapsulated granules activity densities greater than about 0.300 g/ml. These granules are unusually small having diameters less than about 1000...
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4923645 |
Sustained release of encapsulated molecules
A method for sustained release of molecules from gels or microcapsules has been developed. The method is based on controlling the gel state using chelating agents or ion transfer. The method is...
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4919939 |
Periodontal disease treatment system
A controlled release drug delivery system for placement in the periodontal pocket, gingival sulcus, tooth socket, wound or other cavity within the mouth. The system incorporates drug-containing...
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4919929 |
Mammal immunization
Mammals are brought to a specific state of immunization by administering an amount of an antigenic substance sufficient to elicit an immunization response to said mammal, said antigenic substance...
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