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5186937 |
Composition for feeding ruminants
A composition which is stable in a medium in which the pH is greater than or equal to 5.5 and which permits the release of an active substance in a medium in which the pH is less than or equal to...
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5186930 |
Sustained release oral suspensions
Stable sustained release wax- and polymer-coated drug-ion exchange resin complexes especially useful in preparing oral suspensions are disclosed.
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5185159 |
Pharmaceutical composition based on valproic acid and a process for preparing it
New pharmaceutical composition based on valproic acid and one of the pharmaceutically acceptable salts thereof, obtained by a new galenic preparation process which makes it possible to improve and...
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5178882 |
Viral decoy vaccine
A biologically active composition made up of core particles having diameters of less than about 1000 nanometers which are coated with a layer which is designed to allow attachment of biologically...
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5167965 |
Palatable cholestyramine granules, tablets and methods for preparation thereof
Palatable cholestyramine granules, tablets and method for preparation thereof are disclosed.
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5167964 |
Semi-enteric drug delivery systems and methods for preparing same
The present invention pertains to semi-enteric drug delivery systems which comprise (a) an inert core, (b) a first coating layer over the core comprising a medicament, and (c) a second coating...
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5164195 |
Method of oral delivery with an adherent controlled-release salt sensitive capsule
A salt sensitive capsule has been developed which dissolves in the mouth and releases the encapsulated internal ingredient(s). The outer salt sensitive shell maintains its integrity when kept at a...
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5158777 |
Captopril formulation providing increased duration of activity
A formulation comprising captopril within an enteric or delayed release coated pH stable core combined with additional captopril that is available for immediate release following administration.
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5154925 |
Treatment of tibial dyschondroplasia
A method and compositions to treat and prevent tibial dyschondroplasia in animals, particularly fowl, which includes administering to animals an effective amount of the vitamin D 3 derivatives...
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5152995 |
Stable antibiotic ester feed compositions
Acid-sensitive antibiotic esters for oral administration to livestock are stabilized by incorporation in premix formulations comprising a carrier, a base, a protective coating, and optionally a...
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5151264 |
Particulate vector useful in particular for the transport of molecules with biological activity and process for its preparation
A particulate carrier, including a hydrophilic, non-liquid core, a first layer or ring of lipid nature bonded to the core by covalent bonds and a second layer or outer shell of amphiphilic...
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5137733 |
Controlled release pharmaceutical preparation
A controlled release pharmaceutical preparation comprising a core containing a medicinal compound and a coating layer containing a water-repellent salt and a water-insoluble and slightly...
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5130140 |
Method of making direct dry compressible acetaminophen composition
This invention relates to an analgesic composition and more particularly, to a directly dry compressible composition comprising at least about 70% by dry weight of the composition of acetaminophen...
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5112604 |
Oral suspension formulation
An aqueous suspension for oral administration of a drug, which suspension is storage stable for a prolonged period and maintains the drug in suspension during such period.
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5104648 |
High ibuprofen content granulations
A granular pharmaceutical composition containing 85 to 99 percent ibuprofen, 0.9 to 15.0 percent binder, and 0.1 to 5.0 percent polyvinylpyrrolidone, wherein the polyvinylpyrrolidone forms a film...
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5102668 |
Sustained release pharmaceutical preparation using diffusion barriers whose permeabilities change in response to changing pH
A sustained-release pH independent pharmaceutical preparation having multi-units of microparticles comprising a granular drug which is less soluble at low pH and more soluble at high pH. The...
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5096717 |
Double-coated granules of disodium pamidronate
The invention relates to an advantageous oral administration from the disodium pamidronate in capsules. These capsules are filled with double-coated granules. The inner coating is hydrophilic and...
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5093200 |
Multilayer sustained release granule
A multilayer granule of the invention comprises a core, a slow-release layer, a rapid-release layer to be provided outer of said slow-release layer and a film layer containing a metal stearate and...
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5091192 |
Bile salts permanently bound to insoluble cellulose as a dietary supplement
In accordance with practice of the process of this invention, a composition is provided which is useful as a dietary supplement. The composition, which comprises bile salts permanently complexed...
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5091175 |
Pharmaceutical composition containing bile acid sequestrant enclosed in a size-exclusion membrane
A pharmaceutical composition useful for treating hypercholesterolemia comprising a bile acid sequestrant resin such as cholestyramine and cholestipol maintained in a semipermeable water-insoluble...
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5089271 |
Stabilized antibiotic compositions for animal feeding
Stabilized antibiotic composition for animal feeds which provide for improved recovery of the antibiotic from the animal feed. The compositions contain the antibiotic in a coated form. In a...
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5089272 |
Process for producing capsules having a permeability-controllable membrane
The present invention relates to a process for producing a microcapsule comprising a permeability-controllable membrane. This process comprises adjusting the ionic strength of a solution of a...
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5085868 |
Liquid dosage form for all oral administration of a pharmaceutically active substance
A dosage form for oral administration of a pharmaceutically active substance characterized in that it includes a encapsulated or embedded pharmaceutically active substance in a pharmaceutically...
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5085869 |
Pharmaceutical granulate
A wet granulate is provided for therapeutically useful substances having a water solubility 10 wt % or less and microcrystalline or microfine cellulose or a mixture of both, where substantial...
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5084287 |
Pharmaceutically useful micropellets with a drug-coated core and controlled-release polymeric coat
A pharmaceutical preparation comprising drug micropellets containing a drug coated on a core material wherein each pellet ranges in size from about 70 microns to 750 microns and wherein each...
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5084278 |
Taste-masked pharmaceutical compositions
In accordance with the present invention, these and other objects are achieved by a pharmaceutical composition comprised of 1) a pharmaceutical core which is further comprised of a pharmaceutically...
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5082669 |
Rapid-releasing oral particle pharmaceutical preparation with unpleasant taste masked
A rapid-releasing oral particle pharmaceutical preparation with its unpleasant taste masked comprising a core and a film layer coating the core, the core at least containing a drug having an...
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5073377 |
Method of preparing oral dosage forms with a granulating composition
The invention involves a granulating composition composed of an aqueous solution of magnesium sulfate heptahydrate and sodium hexametaphosphate. This composition can be used to prepare granules of...
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5049394 |
Pharmaceutical composition containing high drug load and method for preparing same
A pharmaceutical composition in the form of beads prepared by an extrusion-spheronization technique and containing more than 80% by weight drug, less than 15% by weight non-lipophilic...
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5049395 |
Controlled release vehicle
A new controlled release vehicle which acts by breakdown of the entrapping material upon hydration has been developed. The preferred release vehicle is made of a carboxylated cellulose, e.g.,...
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5043167 |
Galenic formulations with programmed release
New galenic formulations with programmed release, to be administered by the oral route, containing as the active ingredient a drug selected from the non steroidal antiinflammatory, bronchodilator,...
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5037658 |
Direct dry compressible acetaminophen composition
This invention relates to analgesic composition and more particularly, to a directly dry compressible composition comprising at least about 70% by dry weight of the composition of acetaminophen and...
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5032405 |
Oral pharmaceutical composition for acid sensitive proteinaceous agents
An orally administrable formulation of a biologically active, acid sensitive, proteinaceous agent comprises a composition of a lyophilized mixture of the proteinaceous agent and maltose, optionally...
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5028433 |
Readily absorbable drug formulation of NB-818
A readily absorbable drug formulation obtained by incorporating to a water-soluble or enteric polymer, both a nonionic surfactant and (±)-2-carbamoyloxymethyl-4-...
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5019399 |
Granular product (IV)
The present invention relates to a granular product, whereby it consists of a solid product, which has been provided with a coating of a water-soluble material, which has been provided as a melt,...
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5017383 |
Method of producing fine coated pharmaceutical preparation
A method of producing a fine coated pharmaceutical preparation, which includes cooling fine liquid droplets composed of a liquid medium, a drug dissolved or suspended in the liquid medium, and as...
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5015481 |
Stabilized pharmaceutical admixture composition
A stabilized pharmaceutical composition which is an admixture of an NSAID selected from diclofenac and piroxicam, a prostaglandin and hydroxypropyl methylcellulose for maintaining the prostaglandin...
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5013728 |
Composition for treating osteoporosis and hormonal imbalance
A medication for providing fluoride ion for the prevention and treatment of bone loss disease, together with an estrogen-containing substance for not only treating hormonal imbalance but to obtain...
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5009895 |
Sustained release with high and low viscosity HPMC
Sustained release formulations are disclosed which contain a therapeutically active medicament and a high and low viscosity HPMC and which exhibit a zero order release profile.
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5009897 |
Pharmaceutical granules and tablets made therefrom
A pharmaceutical granule comprising a core of active pharmaceutical agent and a coating of a polymer/microcrystalline cellulose is provided. These granules permit superior tableting of...
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5008117 |
Formulation for preparing extemporaneous homogeneous microcapsule suspension
The invention relates to a method by which it is possible to prepare a formulation consisting of thickening or suspending agents and other excipients, having the property of dispersing and...
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5008118 |
Method for producing organic agent coated with powders of coating agent
A method for producing a coated organic agent is provided. The method comprises contacting a coating agent with core powders of an organic substance so that the coating agent collides against the...
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5006344 |
Fosinopril tablet formulations
Shelf stable tablets containing fosinopril sodium are prepared by employing either sodium stearyl fumarate or hydrogenated vegetable oil as the lubricant. The tablets can contain conventional...
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5002776 |
Controlled absorption diltiazem formulations
A controlled absorption diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid, and a...
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4996047 |
Sustained release drug-resin complexes
Disclosed are oral pharmaceutical preparations which comprise a pharmacologically active drug bound to small particles of an ion-exchange resin to provide a drug-resin complex having a drug content...
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4994260 |
Pharmaceutical mixture
A pharmaceutical mixture with controlled release of actice substance which includes masking of bad taste and stability increasing of active substance characterized in that an encapsulated active...
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4994279 |
Multi-layer granule
A multi-layered granule comprises an inner, slow-releasing layer, an outer, rapid-releasing layer and an intermediate layer provided between said slow-releasing layer and said rapid-releasing layer...
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4983401 |
Sustained release pharmaceutical preparations having pH controlled membrane coatings
A sustained-release pharmaceutical preparation utilizing a pH controlled diffusion membrane composed of a pH sensitive film-forming polymer. The film forming polymer may be an enteric polymer...
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4981695 |
Composition comprising L-dopa
The present invention relates to a multiple-unit-dose comprising L-dopa as pharmaceutically active compound, whereby the composition provides a release of L-dopa in accordance with a test in...
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4975284 |
Controlled release means
A controlled release means comprisng a core of at least one water-soluble ingredient of which at least one ingredient is to be released in a controlled manner, said core being surrounded by a...
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