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5198228 |
Direct dry compressible acetaminophen tablet
This invention relates to an analgesic composition and more particularly, to a directly dry compressible composition comprising at least about 70% by dry weight of the composition of acetaminophen...
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5196203 |
Theophylline dosage form
A pH-dependent sustained release pharmaceutical pellet composition and a method of administering the same to a patient at a predetermined dosage and interval, said pellet composition comprising: a...
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5192551 |
Neutral glycolipid as an adsorbent for enteric viral pathogens
The binding of neutral glycolipid GA1 (asialo-GM1) to a broad spectrum of enteric viruses is taught. The glycolipid can be used to pass through the gastrointestinal tract of adults and children to...
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5190766 |
Method of controlling drug release by resonant sound wave
A drug carrier carrying a drug is introduced to a diseased region of the living body while it is observed in the B mode echograms. The drug carrier is irradiated with an ultrasonic wave for...
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5186937 |
Composition for feeding ruminants
A composition which is stable in a medium in which the pH is greater than or equal to 5.5 and which permits the release of an active substance in a medium in which the pH is less than or equal to...
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5183690 |
Starch encapsulation of biologically active agents by a continuous process
Biologically active agents to be encapsulated are continuously blended with a starchy material and water, subjected to high-shear mechanical action at a temperature above the gelatinization...
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5178882 |
Viral decoy vaccine
A biologically active composition made up of core particles having diameters of less than about 1000 nanometers which are coated with a layer which is designed to allow attachment of biologically...
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5158779 |
Particles of hydrophobic or sparingly soluble substance
The surface of micronized and hydrophilized powder particles of a hydrophobic or sparingly soluble substance is covered with a cohesive layer of not more than 0.1 part by weight of surfactant in...
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5156845 |
Dry mouth lozenge
A dry mouth lozenge comprising a base, a pharmaceutically acceptable acedulate, such as a natural sweetener, betaine hydrochloride and a phramaceutically acceptable fluoride.
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5151264 |
Particulate vector useful in particular for the transport of molecules with biological activity and process for its preparation
A particulate carrier, including a hydrophilic, non-liquid core, a first layer or ring of lipid nature bonded to the core by covalent bonds and a second layer or outer shell of amphiphilic...
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5149541 |
Psyllium-containing produces with a distribution of particle size
Psyllium husk comprising particle sizes distributed such that: less than about 15% is larger than about 80 mesh, at least about 45% is within the range of from about 80 mesh to about 200 mesh, and...
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5149542 |
Coating membrane and compositions prepared therefrom
Controlled release pellets consisting of an inert material, a medicament layer and a coating membrane of a mixture or stearic acid and ethyl cellulose or of parrafin and methacrylic acid copolymer.
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5132117 |
Aqueous core microcapsules and method for their preparation
A microcapsule comprising an aqueous core, and capsular membrane formed from the interfacial reaction product of a hydrophilic polymeric Lewis acid or salt thereof with a lipophilic Lewis base or...
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5130140 |
Method of making direct dry compressible acetaminophen composition
This invention relates to an analgesic composition and more particularly, to a directly dry compressible composition comprising at least about 70% by dry weight of the composition of acetaminophen...
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5108758 |
Delayed release formulations
Delayed release compositions comprising an active compound and glassy amylose. A variety of different types of active compound may be employed in the compositions. The compositions are particularly...
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5108759 |
Endothelial envelopment drug carriers
This application describes the preparation and in vivo testing of surface coatings and matrix materials, which when applied to or caused to comprise the carriers for drugs and diagnostic agents,...
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5104648 |
High ibuprofen content granulations
A granular pharmaceutical composition containing 85 to 99 percent ibuprofen, 0.9 to 15.0 percent binder, and 0.1 to 5.0 percent polyvinylpyrrolidone, wherein the polyvinylpyrrolidone forms a film...
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5093198 |
Adjuvant-enhanced sustained release composition and method for making
Improved sustained-release delivery forms comprising Lewis acid-Lewis base salt microparticulate material modified by the addition of at least one additional constituent known as an "adjuvant"...
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5091175 |
Pharmaceutical composition containing bile acid sequestrant enclosed in a size-exclusion membrane
A pharmaceutical composition useful for treating hypercholesterolemia comprising a bile acid sequestrant resin such as cholestyramine and cholestipol maintained in a semipermeable water-insoluble...
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5089272 |
Process for producing capsules having a permeability-controllable membrane
The present invention relates to a process for producing a microcapsule comprising a permeability-controllable membrane. This process comprises adjusting the ionic strength of a solution of a...
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5087438 |
Method for affecting intracellular and extracellular electric and magnetic dipoles
A treatment of infectious diseases and enhancement of genetic engineering processes is described comprising the use of external electromagnetic energy to alter electric and magnetic dipoles...
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5077052 |
Chitosan derivatives useful in compositions for coating feedstuff additives intended for ruminants
Novel organosoluble derivatives of chitosan, useful in coating biologically active feedstuff additives intended for ruminants, to provide coatings which are stable at a pH greater than 5 and which...
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5073377 |
Method of preparing oral dosage forms with a granulating composition
The invention involves a granulating composition composed of an aqueous solution of magnesium sulfate heptahydrate and sodium hexametaphosphate. This composition can be used to prepare granules of...
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5059416 |
Zinc compound delivery system with improved taste and texture
A new delivery system for zinc compounds and the process for its preparation is disclosed, which has use in a variety of products including comestibles such as chewing gum compositions,...
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5055307 |
Slow release drug delivery granules and process for production thereof
Slow release drug delviery granules comprising porous granules of a calcium phosphate compound having an atomic ratio of Ca to P of 1.3 to 1.8, a porosity of 0.1 to 70%, a specific surface area of...
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5051304 |
Microcapsules based on gelatin and polysaccharides and process for obtaining same
This invention relates to microcapsules based on gelatin and anionic polysaccharides of low molecular weight which may contain solid or liquid matters, prepared by coacervation. The aqueous...
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5049394 |
Pharmaceutical composition containing high drug load and method for preparing same
A pharmaceutical composition in the form of beads prepared by an extrusion-spheronization technique and containing more than 80% by weight drug, less than 15% by weight non-lipophilic...
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5047247 |
Dispersible tablets of dihydroergotoxine methanesulfonate and of acid addition salts thereof
There are described novel dispersible tablets of dihydroergotoxine or of acid addition salts thereof, containing 0.1 to 4% by weight of dihydroergotoxine or its acid addition salts, 4 to 60% by...
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5037658 |
Direct dry compressible acetaminophen composition
This invention relates to analgesic composition and more particularly, to a directly dry compressible composition comprising at least about 70% by dry weight of the composition of acetaminophen and...
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5037657 |
Effervescent acetysalicylic acid
The rate of disintegration and/or dissolution of effervescent acetylsalicylic acid tablets obtained by direct compression of a dry powder mixture is surprisingly increased by incorporating in said...
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5019399 |
Granular product (IV)
The present invention relates to a granular product, whereby it consists of a solid product, which has been provided with a coating of a water-soluble material, which has been provided as a melt,...
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5017383 |
Method of producing fine coated pharmaceutical preparation
A method of producing a fine coated pharmaceutical preparation, which includes cooling fine liquid droplets composed of a liquid medium, a drug dissolved or suspended in the liquid medium, and as...
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5015480 |
Film coating formulations
Aqueous diffusion coating formulations suitable for use on pharmaceutical dosage forms comprising an admixture of an insoluble polymer component of a copolymer of ethylacrylate and...
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5013557 |
Taste masking compositions comprising spray dried microcapsules containing sucralfate and methods for preparing same
The present invention pertains to spray dried spheroidal microcapsules under about 150 microns in diameter which comprise in percentages by weight of the microcapsule composition (a) sucralfate...
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5010065 |
Cyclodextrin clathrates of 5-cyanoprostacyclin derivatives and their use as pharmaceutical agents
The invention relates to cyclodextrin clathrates of 5-cyanoprostacyclin analogs.
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5010181 |
Partially treated shellfish waste for removal of heavy metals from aqueous solution
A particle which is capable of removing heavy metal ions from aqueous solution, which comprises chitin having formed thereon a layer of chitosan, wherein the particle has a size of from 0.2 to 1.5...
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5008117 |
Formulation for preparing extemporaneous homogeneous microcapsule suspension
The invention relates to a method by which it is possible to prepare a formulation consisting of thickening or suspending agents and other excipients, having the property of dispersing and...
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5006341 |
Protection
A composition useful in oral immunisation of animals such as poultry comprises dry free-flowing particles each consisting of a solid beadlet of lipid-continuous emulsion containing from about 25%...
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4994279 |
Multi-layer granule
A multi-layered granule comprises an inner, slow-releasing layer, an outer, rapid-releasing layer and an intermediate layer provided between said slow-releasing layer and said rapid-releasing layer...
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4975270 |
Elastomer encased active ingredients
Active ingredients useful in chewable articles of commerce are physically encased in non-porous, chewable, particles of elastomer and such particles are then incorporated in the articles of...
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4968505 |
Long-acting diclofenac sodium preparation
A long-acting diclofenac sodium preparation is disclosed. The preparation comprises a sustained-release diclofenac sodium component which is prepared by coating a sustained-release coat onto a...
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4966770 |
Prednisone microencapsulated granules
The invention disclosed is prednisone microencapsulated granules with activity densities greater than about 0.030 g/ml. These granules are unusually small, having diameters less than about 1000...
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4965072 |
Granulating composition and method
The invention involves a granulating composition composed of an aqueous solution of magnesium sulfate heptahydrate and sodium hexametaphosphate. This composition can be used to prepare granules of...
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4963365 |
Controlled release dosage form
A controlled release dosage form which consists essentially of a core containing a medicament; an inner coating layer composed of ethylcellulose and a hydrophobic substance; and an outer coating...
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4954298 |
Method for producing microcapsule
Microcapsules are advantageously produced with high take-up of a water-soluble drug by preparing a W/O emulsion composed of a water-soluble drug-containing solution as the inner aqueous phase and a...
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4937080 |
Granular product (I)
The present invention relates to a granular product comprised of a solid product which has been provided with a coating of a melt of itself, as well as a process for the preparation of the granular...
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4923645 |
Sustained release of encapsulated molecules
A method for sustained release of molecules from gels or microcapsules has been developed. The method is based on controlling the gel state using chelating agents or ion transfer. The method is...
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4919939 |
Periodontal disease treatment system
A controlled release drug delivery system for placement in the periodontal pocket, gingival sulcus, tooth socket, wound or other cavity within the mouth. The system incorporates drug-containing...
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4917899 |
Controlled absorption diltiazem formulation
A diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid and a lubricant, and a...
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4917900 |
Controlled release formulations containing zidovudine
The invention relates to pharmaceutical formulations comprising discrete units of zidovudine provided with a controlled release coating in which the said units are preferably in the form of spheroids.
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