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5641513 |
Tablet coating method
A method for coating pharmaceutical tablets is disclosed in which polymeric coating ingredients are combined with saccharides in a melt spinning operation to form composite particulates. The...
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5641511 |
Granular drug delivery system
A novel granular drug delivery system having a gel-forming dietary fiber that can be made into a an orally-ingestible dispersion by admixture with a liquid that can deliver an effective dose of a...
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5641515 |
Controlled release biodegradable nanoparticles containing insulin
A controlled release pharmaceutical formulation comprises nanoparticles formed of a biodegradable polycyanoacrylate polymer in which insulin is entrapped, the insulin being complexed to the...
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5635609 |
Particles prepared by transacylation reaction between an esterified polysaccharide and a polyamine, methods of preparation therefor and compositions containing same
Particles, preparation methods therefor, and compositions containing same. The particles include at least one esterified polysaccharide and at least one polyamine, as well as at least one gellable...
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5633015 |
Beads having a core coated with an antifungal and a polymer
The present invention is concerned with beads comprising a 25-30 mesh core, a coating of a hydrophilic polymer and an antifungal agent, and a seal outer coating layer; pharmaceutical dosage forms...
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5631013 |
Cosmetic deodorant products containing encapsulated co-micronized bicarbonate ingredient
This invention provides cosmetic stick, roll-on and cream deodorant and deodorant-antiperspirant products. The cosmetic products consisting of an organic matrix having a dispersed phase of...
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5629090 |
Starch hydrolysates as sequesterers
A starch hydrolysate composition is particularly suited for use as a sequesterer, i.e., it readily interacts noncovalently with other molecules to form stable inclusion complexes which are useful...
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5626870 |
Method of forming hydrogel particles having a controlled size using liposomes
A method of fabricating hydrogel particles within liposomes, which entails: a) encapsulating an effective amount of each of one or more hydrogel substances and one or more release agents in...
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5626879 |
Terfenadine oral granules
The present invention contemplates a dry, granular terfenadine composition. That composition comprises (i) particulate terfenadine and (ii) a polyethylene oxide-polypropylene oxide-polyethylene...
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5622723 |
Procedure for encapsulating chlorpheniramine
An improvement in the process of coacervation of chlorpheniramine maleate is provided whereby a predetermined amount of chlorpheniramine maleate charged to the process is maintained in the...
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5622938 |
Sugar base surfactant for nanocrystals
Dispersible particles consisting essentially of a crystalline drug substance having a surface modifier having the formula: ##STR1## wherein R is phenyl-(CH 2 ) 10 CO or C 12 H 25 NHCO adsorbed...
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5622716 |
Process for preparing a retard product containing diltiazem for a single daily administration
This invention is directed towards pellets and a process for manufacturing pellets of diltiazem HCl having a dissolution kinetic independent from pH.
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5616343 |
Cross-linked amylose as a binder/disintegrant in tablets
The present invention is concerned with the manufacture of solid dosage units (pharmaceutical and others). More specifically, the invention is related to powders of cross-linked amylose, having a...
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5599555 |
Encapsulated cometic compositions
This invention relates to polymeric liquid crystals prepared from a polysaccharide and a solvent, preferably water, which are used to deliver nutrients, perfumes, flavors, drugs and other...
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5591456 |
Milled naproxen with hydroxypropyl cellulose as a dispersion stabilizer
Dispersible particles consisting essentially of crystalline NSAID having hydroxypropyl cellulose adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle...
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5585093 |
Cosmetic deodorant compositions containing encapsulated bicarbonate and liquid fragrance ingredients
This invention provides deodorant and antiperspirant-deodorant cosmetic stick and roll-on products with an organic matrix having a dispersed particle phase of an encapsulated bicarbonate salt...
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5571534 |
Drug formulations for parenteral use
This invention relates to parenteral preparations of antiestrogens such as toremifene, desmethyl toremifene, tamoxifen or desmethyltamoxifen. The preparations can be emulsions, liposomes or aqueous...
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5571532 |
Pharmaceutical preparation for supplying fluoride ions
Pharmaceutical preparation in tablet form for supplying fluoride ions for the treatment and prevention of losses of bone substance, including osteoporosis and alveolar bond damage, with a content...
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5569468 |
Vaccine delivery system for immunization, using biodegradable polymer microspheres
A controlled release oral formulation, for human vaccines, are formed in microspherical form. The vaccine is suspended in a polymer matrix. The polymer matrix is formed from at least two highly...
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5565407 |
Biologically active agent encapsulated in biodegradable starch/polymer matrices
Improved release-extending compositions are provided for encapsulation of bioactive agents which exhibit reduced release rates of the bioactive agent from the composition matrix when compared with...
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5550226 |
Saccharide in the form of powder, and its preparation and use
A novel panose-rich saccharide powder which contains 48-93 w/w % panose, d.s.b., together with other oligo-saccharides, and has a crystallinity of 19% or higher on x-ray powder diffraction...
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5545410 |
Method of controlling the release of carbohydrates by encapsulation and composition therefor
A composition of carbohydrates having an edible coating is disclosed, whereby the coated carbohydrate, when orally ingested, causes a time delay release of the carbohydrate into the digestive...
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5545414 |
Cholesterol lowering food product
A nutritional product having a solid matrix containing protein, fat and carbohydrate has disposed therein particles of dietary fiber encapsulated in zein. The preferred dietary fiber is guar. Such...
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5540945 |
Pharmaceutical preparations for oral administration that are adapted to release the drug at appropriate sites in the intestines
The improved pharmaceutical preparation for oral administration which is adapted to release the drug at appropriate sites in the intestines comprises: a core that comprises an active ingredient and...
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5536507 |
Colonic drug delivery system
A three component pharmaceutical formulation of one or more pharmacologically active substances such that greater than 80% of the pharmacologically active substance will be released in the large...
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5534501 |
Particle for use as a milk fat globule substitute, composition containing same and process for the preparation of said particle
Particle for use especially as a fat substitute, characterized in that it includes an insoluble hydrophile matrix, surrounded by a hydrophobic layer of fatty acids bound to the matrix by covalent...
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5527542 |
Process for sugarless coating and products obtained according to the process
The present invention relates to a process for coating with maltitol making it possible easily and rapidly to create a coating on the surface of a product. This process consists, on the one hand,...
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5527540 |
Effervescent system having an alkali-sensitive and/or metal-sensitive, pharmaceutical active substance, and process for its preparation
In the pharmaceutical formulation of at least one alkali-sensitive active substance with an effervescent system, the carbonate component is embedded in at least one edible, organic acid and is...
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5525354 |
Pharmaceutical preparation and process for its manufacture
In a pharmaceutical preparation for oral use containing a pharmacologically acceptable salt of a bisphosphonic acid, the improvement comprising: a drug delivery form of the preparation which is...
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5523099 |
Non-reducing oligosaccharaide with neotrehalose structure, and its production and uses
Disclosed is a novel non-reducing oligosaccharide with neotrehalose structure represented by the general formula as shown by: ##STR1## The oligosaccharide is obtainable by exposing an aqueous...
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5518738 |
Nanoparticulate nsaid compositions
A composition comprising a crystalline NSAID having polyvinylpyrrolidone adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about...
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5516520 |
Controlled-release pesticides and methods for preparation and use thereof
A particulate controlled-release pesticide composition having a pesticide encapsulated in a polymer matrix of starch-borax-urea and method of preparation and use thereof is provided. The release...
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5510117 |
Entrapment vehicle and method
This invention concerns delivery vehicles entrapping active materials suspended in a water immiscible carrier. Methods of making these materials, preferably using a carboxymethylcellulose support...
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5510119 |
Controlled release therapeutic system for liquid pharmaceutical formulations
Disclosed is a controlled release pharmaceutical dosage form, including: (a) microgranules of a pharmaceutical and an excipient; (b) a plurality of polymeric lipidic and wax-like coatings applied...
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5508044 |
Diltiazem pharmaceutical spheroid formulation
A solid oral dosage form comprising diltiazem (or a pharmaceutically acceptable salt thereof) in controlled release form and hydrochlorothiazide in immediate release form. Preferably, the...
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5505967 |
Microparticulate pharmaceutical delivery system
A pharmaceutical composition comprising a shaped enteric material having distributed therethrough preferably substantially uniformly, pharmaceutical loaded particles, said particles having a size...
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5505966 |
Therapeutical composition and process for its preparation
A colon selective pharmaceutical composition for oral delivery of one or more therapeutically active substances, comprises (i) a matrix core having the active substance or substances dispersed...
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5503852 |
Method for making self-assembling diketopiperazine drug delivery system
Drug delivery systems have been developed based on the formation of diketopiperazine (or analogs) microparticles. In the preferred embodiment the microparticle is stable at low pH and disintegrates...
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5489401 |
Method for entrapment of active materials in chitosan
Encapsulation of active materials in chitosan beads of uniform size and improved mechanical and chemical stability. The active material is suspended in an acidic aqueous solution of a chitosan...
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5484608 |
Sustained-release drug delivery system
A sustained-release pharmaceutical composition comprising a highly soluble pharmaceutical agent, such as selegiline, in a pharmaceutical carrier comprising a hydrophilic polymer dispersed in a...
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5482720 |
Encapsulated co-micronized bicarbonate salt compositions
This invention provides an encapsulated co-micronized bicarbonate salt powder composition which is a blend of crystalline ingredients having a particle size between about 0.1-30 microns. The...
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5470583 |
Method of preparing nanoparticle compositions containing charged phospholipids to reduce aggregation
This invention discloses a composition comprised of nanoparticles having a non-ionic surfactant as a surface modifier adsorbed on the surface thereof and a charged phospholipid as a cloud point...
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5470581 |
Aqueous maltodextrin and cellulosic polymer film coatings
A method of coating substrates such as pharmaceutical tablets, food and confectionery forms, agricultural seeds and the like, with a protective film comprises the steps of mixing a cellulosic...
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5470582 |
Controlled delivery of pharmaceuticals from preformed porous polymeric microparticles
A controlled release pharmaceutical composition comprising a physiologically active agent dispersed in preformed porous polymeric microparticles is provided. The active agent concentration may be...
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5464634 |
Red blood cell surrogate
A red blood cell surrogate which is composed of a nanocrystalline core particle to which an oxygen carrier such as hemoglobin is bound. An oxygen carrier anchor coating is provided between the...
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5462750 |
Biologically active compositions having a nanocrystalline core
A biologically active composition made up of core particles having diameters of less than about 1000 nanometers which are coated with a layer which is designed to allow attachment of biologically...
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5462751 |
Biological and pharmaceutical agents having a nanomeric biodegradable core
A biologically active composition made up of biodegradable core particles which are coated with a layer that is designed to allow attachment of biologically active agents without denaturing them....
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5460831 |
Targeted transfection nanoparticles
A biologically active composition for use in gene therapy and other transfection procedures. The composition is composed of nanocrystalline core particles which are coated with a layer that is...
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5460830 |
Biochemically active agents for chemical catalysis and cell receptor activation
A biologically active composition made up of core particles or surfaces which are coated with a layer which is designed to allow attachment of biochemically reactive pairs (BRP's) without...
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5456985 |
Microcapsules of oily liquid
The present invention relates to micro-capsules constituted by a solid envelope consisting of a layer of coating materials including at least one gastro-resistant polymer, said solid envelope...
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