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7615539 |
Nucleic acid-lipophilic conjugates
The invention relates to a nucleic acid-lipophilic conjugates and methods for modulating an immune response using the conjugates. The lipophilic moiety associated with an immunostimulatory nucleic...
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7597908 |
Use of microparticles with adsorbed antigen to stimulate immune responses
The use of poly(lactide) or poly(lactide-co-glycolide) microparticles with adsorbed antigen is disclosed. The microparticles are useful for enhancing CTL responses to a selected antigen.
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7597905 |
Hollow protein nano-particles and method of introducing substances into cells
As a versatile means for specifically and safely transporting and transferring substances (genes, proteins, compounds, etc.) into target cells and tissues, hollow nano particles comprising a...
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7563457 |
Nanoparticle assembled hollow spheres
A design strategy for constructing hierarchically structured materials using nanoparticles and synthetic biopolymers has been developed. Block copolypeptides or homopolymer polyelectrolytes are...
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7547446 |
Dry hemostatic compositions and methods for their preparation
Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross-linked in the presence of certain...
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7534854 |
Apparatus and method for oxidation and stabilization of polymeric materials
An apparatus for treating polymeric materials comprises a treatment chamber adapted to maintain a selected atmosphere; a means for supporting the polymeric material within the chamber; and, a...
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7531334 |
Polymeric microcarriers for cell culture functions
Polymeric microcarriers suitable for use in cell culture processes and the methods of making such polymeric microcarriers by emulsion/aggregation polymerization processes.
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7521068 |
Dry powder aerosols of nanoparticulate drugs
There invention discloses aqueous dispersions of nanoparticulate aerosol formulations, dry powder nanoparticulate aerosol formulation, propellant-based aerosol formulations, methods of using the...
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7510729 |
Combination of polyvinyl acetate with water-insoluble, acid-insoluble, or alkali-insoluble polymers used for the production of film coatings with highly controlled release and high stability
The invention relates to the combination of polyvinyl acetate and water-insoluble, acid-insoluble, or alkali-insoluble polymers used for producing film coatings for forms of administration in which...
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7501134 |
Microparticles with adsorbed polypeptide-containing molecules
Microparticles with absorbed polypeptide-containing molecules formed without the use of surfactant, methods of making such microparticle compositions, and uses thereof, are disclosed. The...
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7498045 |
Biodegradable polymeric nanocapsules and uses thereof
The present invention relates to a biodegradable polymeric nanocapsule composition, adaptable for encapsulation of an agent of therapeutic interest for enhancing the in vivo circulation time of...
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7465463 |
Compositions comprising microspheres with anti-inflammatory properties for healing of ocular tissues
The present invention relates to compositions of microspheres suitable for application to ocular injuries and inflammation, and to methods of use of the compositions alone or in combination with...
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7425543 |
Microencapsulated materials and method of making same
A method of forming microspheres of a bioactive material, such as a protein polymer or drug by nebulizing a solubilized form of a material to be encapsulated and an encapsulating material, such as...
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7413781 |
Gels for encapsulation of biological materials
This invention provides novel methods for the formation of biocompatible membranes around biological materials using photopolymerization of water soluble molecules. The membranes can be used as a...
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7378110 |
High pressure spray-dry of bioactive materials
This invention provides compositions and methods providing, e.g., stable powder particles containing bioactive materials. The methods include, e.g., high pressure spraying of the bioactive...
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7375077 |
In vivo synthesis of connective tissues
The in vivo synthesis of connective tissue by fibroblast or fibroblast precursor cells ensconced within a biocompatible scaffold is disclosed. The cells are preferably present in a biocompatible...
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7348026 |
Nanoparticles for targeting hepatoma cells
The invention discloses the nanoparticles composed of γ-PGA-PLA block copolymers conjugated with galactosamine as a potential drug delivery system for treating liver cancers.
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7332586 |
Nanoparticle delivery vehicle
A nanoparticle delivery vehicle, comprising a nanoparticle, an active agent and a nuclear localization signal and methods of modulating gene expression and protein expression employing the...
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RE40059 |
Sensitive substance encapsulation
A process for stabilizing a sensitive substance; (a) plating a sensitive substance onto a solid carrier under a controlled atmosphere to reduce loss of the sensitive substance; (b) encapsulating...
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7316819 |
Oral peptide pharmaceutical dosage form and method of production
A pharmaceutical composition for oral delivery of a peptide is in the form of a lamination having at least two layers. The first layer of the lamination includes at least one pharmaceutically...
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7314640 |
Formulation and process for drug loaded cores
The present invention relates to a controlled release pellet of metoprolol and its pharmaceutically acceptable salts that uses a water soluble or a water swellable inert starting seed or core.
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7311926 |
Biocomposite materials and methods for making the same
A particle (and a composition that includes a plurality of the particles) that includes at least one polypeptide molecule and at least one polymer covalently bound to the polypeptide molecule so as...
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7309500 |
Microparticles
A method of forming particles, comprises accelerating a first stream comprising a first liquid, applying a charging voltage of at most 1.5 kV to the first stream, and vibrating the first stream, to...
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7304035 |
Stimulation of bone growth with thrombin peptide derivatives
Disclosed is a method of stimulating bone growth at a site in a subject in need of osteoinduction. The method comprises the step of administering a therapeutically effective amount of an agonist of...
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7303756 |
Multiphase system
The invention relates to a preparation comprising a carrier phase and at least one further phase which cannot be mixed with the carrier phase or only partially mixed therewith, wherein the change...
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7288267 |
Bioadhesive nanoparticulate compositions having cationic surface stabilizers
Bioadhesive nanoparticulate compositions, comprising active agent particles and one or more cationic surface stabilizers, are described. The cationic surface stabilizers prevent aggregation of the...
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7258873 |
Preservation of bioactive materials by spray drying
This invention provides methods and compositions to preserve bioactive materials in a matrix of powder particles. Methods provide high-pressure gas spraying and/or near supercritical spraying of...
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7238371 |
Triggered release from proteinoid microspheres
The invention provides proteinoid microsphere made up of a mixture of thermally condensed amino acids that are crosslinked with a bis dithiol crosslinker reagent. The proteinoid microspheres of the...
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7226618 |
Colloidal suspension of submicronic particles as vectors for active principles and method for preparing same
A suspension of vector particles (PV) based on polyamino acids and have a mean hydrodynamic diameter between 30 and 120 nm, and an insulin load factor of from 5 to 25% of associated insulin volume...
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7186796 |
Method for drying water-borne materials
Provided is a method of isolating a bio-molecule from a water-borne mixture, the method comprising: contacting the water-borne mixture with dimethyl ether to form solid particles of the bio-molecule.
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7166296 |
Pharmaceutical formulations and ligands for use therein; mimetics for UEA-1
UEA-1 Mimetics, pharmaceutical formulations comprising them, and their uses as targeting agents for therapeutic and diagnostic purposes.
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7166295 |
Methods of treatment and diagnostic visualization, particularly in cancer
Methods and reagents for improved treatment and diagnostic imaging, particularly of cancer. The methods and reagents utilize specific targeting of treatment and imaging ligands to the targeted...
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7163701 |
Controlled release microencapsulated NGF formulation
NGF microencapsulation compositions having controlled release characteristics, preferably with increased stability, for the NGF component, particularly human recombinant NGF (“rhNGF”) are...
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7163700 |
Amorphous drug beads
The present inventive subject matter relates to amorphous drug beads comprising an amorphous active drug and an organic surfactant having improved solubility, absorption and wettability...
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7141236 |
Methods and compositions for delivering macromolecules to or via the respiratory tract
Methods and compositions for delivering macromolecules to or via the respiratory tract, such that the macromolecules exhibit improved local and/or systemic bioavailability are provided. Such...
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7125567 |
Process for producing an oral sustained-release preparation of fasudil hydrochloride
Disclosed is an oral sustained-release preparation which contains at least one active ingredient selected from the group consisting of fasudil hydrochloride and a hydrate thereof, the preparation...
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7122503 |
Uniform microcapsules
The present invention teaches an improved process for preparing a population of microcapsules having a substantially uniform size distribution, especially useful for manufacture of carbonless...
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7118888 |
Gene expression vaccine
An effective prophylactic mucosal gene expression vaccine (GXV), made up of a cocktail of at least 4 different plasmid DNAs encoding corresponding RSV antigens, coacervated with chitosan to...
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7115282 |
Multi component controlled release system for anhydrous cosmetic compositions
The present invention relates to an improved controlled release system that can be incorporated into anhydrous cosmetic formulations and can encapsulate different types of fragrances, flavors,...
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7108867 |
Process for preparing particles
A process for preparing particles of a substance, such as a protein or polypeptide, comprising: (a) preparing a first liquid comprising water, the substance and a modulator, wherein the modulator...
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7105158 |
Methods of administering microencapsulated materials for immune modulated diseases
Compositions useful in treating immune modulated disease comprising an anticytokine antibody or immune active drug capable of modifying cytokine activity or modulating the immune system...
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7101576 |
Nanoparticulate megestrol formulations
The present invention is directed to nanoparticulate compositions comprising megestrol. The megestrol particles of the composition have an effective average particle size of less than about 2000 nm.
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7101566 |
Polymer coated microparticles for sustained release
The present invention is directed to sustained release microparticle formulation for parenteral administration of biologically active substances, especially drugs. More specifically it relates to...
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7097857 |
Methods and compositions for the targeted delivery of biologically active agents
The present invention relates to a sustained release composition for the targeted delivery of biologically active agents to specific tissues and cells. The composition comprises microparticles...
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7074427 |
Medicine, carrier for medicine, method of producing medicine, and method of tumor treatment
A medicinal preparation capable of lowering the threshold of cavitation and generating active oxygen species via acoustic cavitation caused by an ultrasound is provided. The preparation, which is...
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7070812 |
Process for producing dry powders of one or more carotenoids
The invention relates to a process for producing dry powders of one or more carotenoids by a) dispersing one or more carotenoids in an aqueous molecular or colloidal solution of a mixture of...
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7067152 |
Multi component moisture triggered controlled release system that imparts long lasting cooling sensation on the target site and/or provides high impact fragrance or flavor burst
The present invention relates to cosmetic formulations comprising a multi component controlled release system that imparts long lasting cooling sensation and/or provides high odor or flavor...
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7060299 |
Biodegradable microparticles that stabilize and control the release of proteins
Disclosed herein are biodegradable microparticle compositions, and methods for the generation of biodegradable and biocompatible microparticles that stabilize proteins and also control the kinetics...
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7056535 |
Triggered release from proteinoid microspheres
The invention provides proteinoid microsphere made up of a mixture of thermally condensed amino acids that are crosslinked with a bis dithiol crosslinker reagent. The proteinoid microspheres of the...
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7033608 |
“Burst-free” sustained release poly-(lactide/glycolide) microspheres
Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1–100 days in an aqueous...
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