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7615539 |
Nucleic acid-lipophilic conjugates
The invention relates to a nucleic acid-lipophilic conjugates and methods for modulating an immune response using the conjugates. The lipophilic moiety associated with an immunostimulatory nucleic...
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7611731 |
Mesostructured silica/block copolymer monoliths as a controlled release device and methods of manufacture
The invention comprises the design, synthesis, and characterization of mesostructured silica/block copolymer composite monoliths as controlled release systems. The controlled release function is...
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7608205 |
Decentralized solution of microscopic particles and circuit formation device
Microscopic particle decentralized solution having microscopic particles with different diameters are decentralized, wherein: the microscopic particle decentralized solution has two peaks in a...
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7605138 |
Nucleic acid compositions for stimulating immune responses
The invention provides an immunostimulatory nucleic acid comprising CpG motifs, and methods of use thereof in stimulating immunity.
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7604838 |
Method of making stably preserved microspheres in lower alcohol solvent
Active carboxylic acid ester groups are coupled on the surfaces of microspheres so as to reduce protocols for microsphere processing, control side reactions, and stably preserve beads containing...
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7604820 |
Solid preparation containing chitosan powder and process for producing the same
A colonic delivery solid preparation containing chitosan powder, which can control the dissolution of a medicament therefrom in the large intestine and release the medicament contained therein...
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7601363 |
Sustained-release drug formulations
The present invention relates to a formulation for implantation having a novel constitution, which accomplishes controlled releases of active ingredients. The formulation comprises one of...
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7597907 |
Antioxidant polymer nanocarriers for use in preventing oxidative injury
The present invention is a method for encapsulating active protein in a polymeric nanocarrier. The instant method employs homogenization at subzero temperatures so that enzyme activity is retained....
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7585520 |
Compositions containing both sedative and non-sedative antihistamines and sleep aids
Compositions containing both a sedative compound and a non-sedative antihistamine are provided. More particularly, compositions for administration at bedtime containing a sedating antihistamine or...
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7585499 |
Method for encapsulation of cellular material using a charged initiator polymer
Positively-charged initiator polymers having a polymerization initiator group and a cationic portion are provided. The initiator polymers can be used with a polymerizable material for the formation...
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7582311 |
Injection vehicle for polymer-based formulations
The invention provides injection vehicles suitable for administering particulate suspensions, such as polymer-based formulations, as well as associated pharmaceutical formulations, articles of...
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7575762 |
Composition comprises sustained-release fine particles and manufacturing method thereof
The present invention relates to a composition comprising sustained-release fine particles, characterized in that it contains sustained-release fine particles that can be used in...
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7569236 |
Sustained-release microgranules containing gingko biloba extract and the process for manufacturing these
The subject of the present invention is a new stable herbal drug formulation in the form of sustained-release microgranules containing Gingko Biloba extract as well as the process for preparing it.
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7569025 |
Methods and devices for treating severe peripheral bacterial infections
The present invention relates to novel methods and devices for treating severe bacterial infections, such as septicemia, using an extracorporeal adsorption container. The device has a solid support...
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7563456 |
Process for preparation of programmed liberation composition with venlafaxine and the resulting product
Process for the preparation of programmed liberation compositions with venlafaxine and the resulting product, from which the resulting product allows a better absorption of the active principle and...
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7553844 |
Methods for treatment of HIV or malaria using combinations of chloroquine and protease inhibitors
The present invention relates to a drug combination capable of conferring therapeutic benefits in the treatment of both AIDS and malaria. In particular, it relates to a drug combination including...
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7550158 |
Controlled release by extrusion of solid amorphous dispersions of drugs
Controlled release dosage forms for low solubility drugs are disclosed wherein an amorphous solid dispersion of the drug is coated with a non-dissolving and non-eroding coating that controls the...
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7550157 |
Method for the preparation of polymeric micelle via phase separation of block copolymer
A method for preparing a biodegradable polymeric micellar composition using liquid polyethylene glycol as a phase separation medium. The present invention also provides an efficient method to...
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7541347 |
Minocycline oral dosage forms for the treatment of acne
Minocycline oral dosage forms containing a controlled release carrier are useful for the treatment of acne.
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7541022 |
Pharmaceutical formulations for dry powder inhalers
A powder for use in a dry powder inhaler comprises: i) a fraction n of fine particle size constituted by a mixture of physiologically acceptable excipient and an additive; ii) a fraction of coarse...
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7531184 |
Composite powders and cosmetics containing the same
A composite powder containing a powdery base and aluminum hydroxide adhered to at least a portion of the surface of the base, wherein said adhered aluminum hydroxide in the form of a spherical and...
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7524828 |
Immunostimulatory nucleic acid molecules
Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity,...
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7524515 |
Pharmaceutical safety dosage forms
Pharmaceutical safety dosage forms are provided which include a pharmaceutical and an antagonist to the pharmaceutical. The safety dosage forms are such that the antagonist has no significant...
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7521068 |
Dry powder aerosols of nanoparticulate drugs
There invention discloses aqueous dispersions of nanoparticulate aerosol formulations, dry powder nanoparticulate aerosol formulation, propellant-based aerosol formulations, methods of using the...
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7510730 |
Apparatus and method for preparing microparticles using in-line solvent extraction
Apparatus and method for preparing microparticles using in-line solvent extraction. An emulsion is formed by combining two phases in a static mixer. The emulsion is combined with an extraction...
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7510729 |
Combination of polyvinyl acetate with water-insoluble, acid-insoluble, or alkali-insoluble polymers used for the production of film coatings with highly controlled release and high stability
The invention relates to the combination of polyvinyl acetate and water-insoluble, acid-insoluble, or alkali-insoluble polymers used for producing film coatings for forms of administration in which...
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7501134 |
Microparticles with adsorbed polypeptide-containing molecules
Microparticles with absorbed polypeptide-containing molecules formed without the use of surfactant, methods of making such microparticle compositions, and uses thereof, are disclosed. The...
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7498045 |
Biodegradable polymeric nanocapsules and uses thereof
The present invention relates to a biodegradable polymeric nanocapsule composition, adaptable for encapsulation of an agent of therapeutic interest for enhancing the in vivo circulation time of...
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7498044 |
Dosage form and method for producing the same
The invention relates to a process for producing a coated drug form or a drug form in the form of an active ingredient matrix, by processing a copolymer, an active pharmaceutical ingredient, a core...
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7470435 |
Extended release venlafaxine formulation
A controlled release dosage form of venlafaxine that comprises an immediate release pellet and an extended release pellet.
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7465462 |
Multiparticulate controlled release selective serotonin reuptake inhibitor formulations
A multiparticulate controlled release selective serotonin reuptate inhibitor (SSRI) formulation for oral administration is provided. The formulation includes particles of an SSRI or a...
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7459146 |
Stabilized aerosol dispersions
The invention relates to stabilized dispersions containing nanoparticles of use for the administration of medicaments. The dispersions comprise excipient nanoparticles, a dispersed phase comprising...
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7452547 |
Product for treating the skin comprising a polyamine microcapsule wall and a skin lightening agent
The present invention features a product including a water-insoluble substrate and a plurality of microcapsules comprising a microcapsule wall surrounding a liquid core, and the use thereof.
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7445797 |
Enhanced boron nitride composition and polymer-based compositions made therewith
A boron nitride composition having its surface treated with a coating layer comprising a zirconate coupling agent. The boron nitride composition can be used as fillers in polymeric compounds at...
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7445796 |
Pharmaceutically active particles of a monomodal particle size distribution and method
A method of obtaining improved reproducibility of dissolution profiles of dosage forms containing pharmaceutically active particles includes steps of screening raw pharmaceutically active particles...
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7442439 |
Microencapsulated heat delivery vehicles
Microencapsulated delivery vehicles comprising an active agent are disclosed. In one embodiment, the microencapsulated delivery vehicles are heat delivery vehicles capable of generating heat upon...
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7438930 |
Controlled release formulations having rapid onset and rapid decline of effective plasma drug concentrations
The invention is directed to oral modified/controlled release drug formulations which provide a rapid initial onset of effect and a prolonged duration of effect. Preferably, the peak concentration...
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7438929 |
Multi-particulate form of medicament, comprising at least two differently coated forms of pellet
The invention relates to a multiparticulate drug form suitable for uniform release of an active pharmaceutical ingredient in the small intestine and in the large intestine, comprising at least two...
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7435715 |
Microcapsules
Microcapsules for use in liquid detergents having a core and a polyelectrolyte complex shell in the form of a semipermeable membrane capable of withstanding a force before bursting of from about 20...
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7431944 |
Delivery of multiple doses of medications
Dosage forms for oral administration of a methylphenidate drug are provided. The dosage forms provide a substantially immediate dose of methylphenidate upon ingestion, followed by one or more...
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7431943 |
Controlled release and taste masking oral pharmaceutical compositions
Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic,...
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7429394 |
Ion binding compositions
The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides core-shell compositions and pharmaceutical compositions thereof....
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7427415 |
Implantation of encapsulated biological materials for treating diseases
The present invention relates to compositions and methods of treating a disease, such as diabetes, by implanting encapsulated biological material into a patient in need of treatment. This invention...
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7422758 |
Sustained release vitamin composition
A therapeutic formulation in the form of a beadlet, suitable for oral administration and adapted to provide immediate and sustained release of therapeutic material. Each beadlet comprises an...
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7422757 |
Tabletting process
The invention refers to a process for the preparation of a self-dispersing or self-emulsifying tablet, wherein a heated granulation mixture containing an active lipophilic substance and a...
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7408018 |
Elastomeric functional biodegradable copolyester amides and copolyester urethanes
The invention provides elastomeric copolyester amides, elastomeric copolyester urethanes, and methods for making the same. The polymers are based on α-amino acids and possess physical, chemical...
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7402321 |
Oral administration form for pyridin-2-ylmethylsulfinyl-1H-benzimidazoles
The invention relates to an oral administration form for pyridin-2-ylmethylsulfinyl-1H-benzimidazoles and their salts, which comprises the active compound together with tablet disintegrants and is...
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7399487 |
High-concentration aqueous dispersions comprising hydrophilic microfine metal oxide particles and dispersion auxiliaries
Aqueous dispersions comprising microfine metal oxide particles and dispersion auxiliaries, wherein, as dispersion auxiliaries, at least one of the compounds of the general formula (I)
in which
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7393544 |
Dispersion for pulmonary delivery of a bioactive agent
Stabilized dispersions are provided for the delivery of a bioactive agent. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that...
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7387795 |
Cosmetic compositions organophosphonic acid coated particulates and methods for producing the same
The invention provides cosmetic compositions containing powders that are surface treated with organophosphonic acid compounds, where the surface treated particulates are simultaneously hydrophobic...
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