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7618784 |
Assay for phospholipid transfer protein (PLTP) activity
Improved methods for assaying the activity of phospholipid transfer protein (PLTP) enhance the signal-to-noise ratio by providing the substrate in donor particles with an aqueous core in the...
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7615547 |
Granulates containing liposoluble substances and a process for the preparation thereof
A process is described for the preparation of granulates that contain liposoluble and hydrophobic substances, preferably steroidal substances, and that exhibit rapid and excellent...
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7612176 |
Polymer-based sustained release device
This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically...
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7611731 |
Mesostructured silica/block copolymer monoliths as a controlled release device and methods of manufacture
The invention comprises the design, synthesis, and characterization of mesostructured silica/block copolymer composite monoliths as controlled release systems. The controlled release function is...
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7611709 |
1,4 O-linked saccharose derivatives for stabilization of antibodies or antibody derivatives
Disclosed are applications of oligosaccharides/oligosaccharide mixtures for the production and stabilization of pharmaceutical compositions, chiefly powders, that contain antibodies or antibody...
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7604819 |
Clay-based hemostatic agents and devices for the delivery thereof
A hemostatic device for promoting the clotting of blood includes a gauze substrate, a clay material disposed on the gauze substrate, and also a polyol such as glycerol or the like disposed on the...
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7601363 |
Sustained-release drug formulations
The present invention relates to a formulation for implantation having a novel constitution, which accomplishes controlled releases of active ingredients. The formulation comprises one of...
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7601337 |
Delivery of antipsychotics through an inhalation route
The present invention relates to the delivery of antipsychotics through an inhalation route. Specifically, it relates to aerosols containing antipsychotics that are used in inhalation therapy. In a...
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7597897 |
Medicinal compositions and method for the preparation thereof
Methods for the manufacture of medicinal compositions are described. A method for the manufacture of a medicinal composition according to the invention comprises: (a) Providing a biocompatible...
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7595348 |
Butyl lactate emulsions for the precipitation of water-insoluble drug nanoparticles
Emulsions for use in precipitating water-insoluble drug nanoparticles. The continuous phase of the emulsions include water and an external surfactant. The discontinuous phase of the emulsions...
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7591999 |
Powdery preparation for nasal administration
According to the present invention, a powdery preparation for nasal administration comprising a physiologically active substance, a non-water-absorbing and hardly water-soluble powder(s) and one or...
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7591993 |
Polyvinyl alcohol microspheres, and injectable solutions of the same
The present invention relates to microspheres useful for embolization which comprises polyvinylalcohol. The present invention also relates to an injectable suspension suitable for embolization...
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7588782 |
Rare earth metal compositions for treating hyperphosphatemia and related methods
Rare earth metal compounds, particularly lanthanum, cerium, and yttrium, are formed as porous particles and are effective in binding metals, metal ions, and phosphate. A method of making the...
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7588780 |
Embolization
Embolic polymer particles are described. For example, the particles include pores such that the predominant size of pores near the center of the particles is greater than the predominant size of...
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7588777 |
Surface cross-linked superabsorbent polymer particles and methods of making them
The present invention relates to superabsorbent polymer particles with improved surface cross-linking and their use in absorbent articles. The superabsorbent polymer particles of the present...
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7585521 |
Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use
Controlled release ceramic particles, processes for their preparation, controlled release ceramic particles prepared by such processes, compositions comprising such controlled release ceramic...
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7585520 |
Compositions containing both sedative and non-sedative antihistamines and sleep aids
Compositions containing both a sedative compound and a non-sedative antihistamine are provided. More particularly, compositions for administration at bedtime containing a sedating antihistamine or...
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7585493 |
Thin-film drug delivery article and method of use
An article for use in an aerosol device, for producing an aerosol of a drug composition is disclosed. The article includes a heat-conductive substrate having a surface with a selected surface area,...
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7582312 |
Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
Methods of producing lung surfactant formulations through solvent dissolution and lyophilization are described as well as surfactant formulations derived therefrom. Methods of treating respiratory...
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7582311 |
Injection vehicle for polymer-based formulations
The invention provides injection vehicles suitable for administering particulate suspensions, such as polymer-based formulations, as well as associated pharmaceutical formulations, articles of...
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7582284 |
Particulate materials
The present invention relates to active substances in particulate form, to methods for preparing them, to formulations containing them and to uses of such substances and formulations. A preferred...
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7579020 |
Controlled release arginine α-ketoglutarate
An oral formulation of arginine α-ketoglutarate is disclosed which formulation is comprised of arginine α-ketoglutarate and one or more excipient materials. A wide range of different controlled...
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7579014 |
Mesoporous compositions for use in drug delivery
The present invention encompasses novel mesoporous compositions comprising vitamin E and alumina, and methods for their synthesis. The mesoporous compositions of the present invention have...
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7575761 |
Spray drying process control of drying kinetics
The present invention provides exemplary systems and methods for producing dry powder formulations. In one embodiment, a system ( 10 ) includes at least one conditioning zone ( 12 ) having an inlet...
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7569236 |
Sustained-release microgranules containing gingko biloba extract and the process for manufacturing these
The subject of the present invention is a new stable herbal drug formulation in the form of sustained-release microgranules containing Gingko Biloba extract as well as the process for preparing it.
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7569025 |
Methods and devices for treating severe peripheral bacterial infections
The present invention relates to novel methods and devices for treating severe bacterial infections, such as septicemia, using an extracorporeal adsorption container. The device has a solid support...
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7563871 |
Polymer-based sustained release device
This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically...
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7563818 |
Photosensitizer functionalised nanoparticles
The present invention relates to self-assembly of a photosensitizer on a nanoparticle. The invention also provides methods for production of functionalized (eg. stabilized) nanoparticles. The...
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7563613 |
Detoxification and decontamination using nanotechnology therapy
A method of removing a toxic compound comprising contacting the toxic compound with a particle having two regions, the first region containing a detoxifying enzyme and the second region containing...
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7563457 |
Nanoparticle assembled hollow spheres
A design strategy for constructing hierarchically structured materials using nanoparticles and synthetic biopolymers has been developed. Block copolypeptides or homopolymer polyelectrolytes are...
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7563456 |
Process for preparation of programmed liberation composition with venlafaxine and the resulting product
Process for the preparation of programmed liberation compositions with venlafaxine and the resulting product, from which the resulting product allows a better absorption of the active principle and...
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7556798 |
Highly efficient delivery of a large therapeutic mass aerosol
A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a...
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7553844 |
Methods for treatment of HIV or malaria using combinations of chloroquine and protease inhibitors
The present invention relates to a drug combination capable of conferring therapeutic benefits in the treatment of both AIDS and malaria. In particular, it relates to a drug combination including...
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7550441 |
Controlled release polymer nanoparticle containing bound nucleic acid ligand for targeting
The present invention relates to a conjugate that includes a nucleic acid ligand bound to a controlled release polymer system, a pharmaceutical composition that contains the conjugate, and methods...
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7550158 |
Controlled release by extrusion of solid amorphous dispersions of drugs
Controlled release dosage forms for low solubility drugs are disclosed wherein an amorphous solid dispersion of the drug is coated with a non-dissolving and non-eroding coating that controls the...
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7550157 |
Method for the preparation of polymeric micelle via phase separation of block copolymer
A method for preparing a biodegradable polymeric micellar composition using liquid polyethylene glycol as a phase separation medium. The present invention also provides an efficient method to...
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7550156 |
Optimised pellet formulations
The invention concerns chemical compositions in the form of pellets which disintegrate quickly and efficiently in aqueous media. Such pellets comprise a) at least one constituent with...
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7547446 |
Dry hemostatic compositions and methods for their preparation
Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross-linked in the presence of certain...
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7544374 |
Lipidated glycosaminoglycan particles and their use in drug and gene delivery for diagnosis and therapy
Lipidated glycosaminoglycan particles are prepared by reacting a glycosaminoglycan with at least one lipid to cross-link the carboxylic acid groups in the glycosaiminoglycan with a primary amine in...
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7544367 |
Chemical method of making a suspension, emulsion or dispersion of pyrithione particles
A method for producing a suspension, emulsion or dispersion of de-agglomerated particles (advantageously submicron-sized particles) of pyrithione salts comprising contacting agglomerated pyrithione...
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7541347 |
Minocycline oral dosage forms for the treatment of acne
Minocycline oral dosage forms containing a controlled release carrier are useful for the treatment of acne.
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7541050 |
Two-layered olefin-based resin pellets for insecticidal resin composition
A two-layered olefin-based resin pellet comprising a core layer formed of an olefin-based resin composition (A) and a sheath layer formed of an olefin-based resin composition (B) and laminated on...
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7541022 |
Pharmaceutical formulations for dry powder inhalers
A powder for use in a dry powder inhaler comprises: i) a fraction n of fine particle size constituted by a mixture of physiologically acceptable excipient and an additive; ii) a fraction of coarse...
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7537787 |
Method for modulating glutamate and/or aspartate release in a central nervous system locus
Methods and compositions are disclosed for providing prolonged-release of therapeutic agents by way of in situ stereotaxic implantation in specific loci, including pathways, to treat know...
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7537786 |
Complex of drug-carbon nanohorn and a process for producing the complex
The present invention provides a carbon nanohorn complex that is excellent in characteristics of adsorption or inclusion of drugs and release, in particular, a sustained release of drugs as a novel...
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7537785 |
Composition for treating vascular diseases characterized by nitric oxide insufficiency
The present invention provides a composition comprising an antioxidant, and at least one of isosorbide dinitrate and isosorbide mononitrate in therapeutically effective dosage of each of the...
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7531500 |
Preventing airway mucus production by administration of EGF-R antagonists
Hypersecretion of mucus in the lungs is inhibited by the administration of an epidermal growth factor receptor (EGF-R) antagonist. The EGF-R antagonist may be in the form of a small organic...
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7531191 |
Stimuli-responsive systems for controlled drug delivery
A method of delivering a therapeutic agent by providing a cross-linked polymer encapsulating the therapeutic agent to a site in a patient. The degradation rate of the cross-linked polymer is...
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7531184 |
Composite powders and cosmetics containing the same
A composite powder containing a powdery base and aluminum hydroxide adhered to at least a portion of the surface of the base, wherein said adhered aluminum hydroxide in the form of a spherical and...
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7527809 |
Polyhydroxyalkanoate-containing magnetic structure, and manufacturing method and use thereof
A structure containing polyhydroxyalkanoate and a magnetic substance includes an external phase part containing polyhydroxyalkanoate and an internal phase part contained in the external phase part,...
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