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8440227 |
Biodegradable, non-toxic biological adhesive and methods for use in abdominal surgery
A biological adhesive formulation comprising dextrin, at least one adhesiveness modifier agent, and at least one antibiotic is suitable for promoting healing of tissue in a patient, for example, to...
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8435552 |
Collagen/hydroxyapatite composite scaffold, and process for the production thereof
A process for producing a collagen/hydroxyapatite (HA) composite scaffold comprises the steps of forming a homogenous suspension of collagen and HA in an acidic solution, lyophilizing the...
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8435565 |
Bioresorbable polymer matrices and methods of making and using the same
A bioerodible composition for delivery of a bioactive agent is the reaction product of a reaction mixture which includes an oxidized dextran solution, and a mixture of solids containing a...
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8435566 |
Demineralized bone matrix compositions and methods
Bone matrix compositions and, more specifically, demineralized bone matrix (DBM) having increased osteoinductive capacity and methods for its production are provided. Specifically, DBM derived from...
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8431143 |
Therapeutic method of administering pharmaceutical titanium dioxide composite and light irradiation
A titanium dioxide composite is provided that can be stably dispersed in an aqueous solvent and easily administered into a living body, such as human, and allows elimination of the drug efficacy of...
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8431147 |
Malleable implants containing demineralized bone matrix
Described are malleable medical compositions such as pastes or putties that include solids combined with a liquid carrier. The solids include particulate collagen and particulate demineralized bone...
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8426492 |
Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use
A tissue adhesive formed by reacting an oxidized cationic polysaccharide containing aldehyde groups and amine groups with a multi-arm amine is described. The oxidized cationic polysaccharide-based...
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8415325 |
Cell-mediated delivery and targeted erosion of noncovalently crosslinked hydrogels
A method for targeted delivery of therapeutic compounds from hydrogels is presented. The method involves administering to a cell a hydrogel in which a therapeutic compound is noncovalently bound to...
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8414925 |
Processing of acylchitosan hydrogels
An article containing N-acylchitosan is manufactured by a process comprising the steps of providing a mixture containing chitosan and/or N-acylchitosan, and extruding the mixture to form an...
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8404266 |
Method for stabilization of S-nitrosoglutathione and composition prepared by the same
The invention relates to pharmaceutical compositions having alkaline pH comprising S-nitrosoglutathione (GSNO) as active ingredient together with usual additives, optionally with one or more...
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8404276 |
Pulmonary delivery for levodopa
In one aspect, the invention is related to a method of treating a patient with Parkinson's disease, the method including administering to the respiratory tract of the patient particles that include...
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8404281 |
Formulations
Nanoparticles comprising T3 and their use in treating, e.g., cardiac conditions, for example cardiac arrest, are provided. Such nanoparticles provide improved delivery of T3 and allow for acute...
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8399019 |
Oral delivery vehicle and material
Compositions for an oral delivery vehicle are described as well as methods for their manufacture and administration. The oral delivery vehicles can be made in any size or shape and can further...
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8398998 |
Therapeutic composition comprising a botulinum neurotoxin
A pharmaceutical preparation comprising one of the botulinum neurotoxins from Clostridium botulinum of types A, B, C, D, E, F or G or a mixture of two or more of these neurotoxins, wherein the...
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8388984 |
Site-specific intestinal delivery of adsorbents, alone or in combination with degrading molecules
Compositions which deliver adsorbents, alone or in combination with active drug “degrading molecules,” in a site-specific manner to the intestine, and which eliminate or at least lower the con...
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8389011 |
Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors
A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.
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8388994 |
Fibrous non-woven polymeric material
The present invention relates to biocompatible non-woven fibrous materials having a nano-micro topography and methods for producing such materials. The materials may be used to cover implantable...
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8383157 |
Preparation of chitin and derivatives thereof for cosmetic and therapeutic use
The invention relates to novel chitin derivatives and their use in medical treatments of plastic surgery, dermocosmesis and therapy, in particular it relates to natural chitin derivatives, like...
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8383415 |
Hydrogel composition to enhance fluorescence
A composition comprising a hydrogel particle and a fluorophore; wherein said composition produces an enhanced fluorescent signal when excited by an energy source capable of exciting the fluorophore.
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8377432 |
Method and composition for neochondrogenesis
A method of neochondrogenesis, where following microfracture surgery or subchondral drilling, includes administering injections of an effective amount of a composition to the damaged, affected...
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8372933 |
Hyperbranched polymers based on cyclodextrins and poly (amidoamines) for the controlled release of insoluble drugs
Hyperbranched, water-soluble polymers, obtainable by Michael polyaddition of α-, β-, or γ-cyclodextrins and amines to bisacrylamides.
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8372805 |
Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with...
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8372394 |
Compositions and methods for treating cartilage disease
The present invention provides a composition for regenerating cartilage or treating a cartilage disease containing a monovalent metal salt of alginic acid for which the endotoxin level thereof has...
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8367639 |
Hydrogels with covalent and noncovalent crosslinks
A method for targeted delivery of therapeutic compounds from hydrogels is presented. The method involves administering to a cell a hydrogel in which a therapeutic compound is noncovalently bound to...
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8367118 |
Solid pharmaceutical dispersions with enhanced bioavailability
Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or biavailability in a use...
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8357795 |
Hyaluronic acid-based gels including lidocaine
Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and pharmaceutically acceptable salts thereof. In one aspect, hyaluronic...
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8357645 |
Semi-rigid gel cleansing article and uses thereof
The present invention relates to semi-rigid gels, methods of manufacture and uses thereof.
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8357400 |
Stimuli-responsive systems for controlled drug delivery
A method of delivering a therapeutic agent by providing a cross-linked polymer encapsulating the therapeutic agent to a site in a patient. The degradation rate of the cross-linked polymer is...
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8354376 |
Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with...
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8337823 |
Modified macromolecule
The present invention relates to a macromolecule having a controlled terminal group stoichiometry, the macromolecule including a surface layer, at least one subsurface layer and at least two...
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8337894 |
Process of manufacturing a solid cosmetic product
A process of manufacturing a solid cosmetic product, includes the steps of applying to a composition based on powder and fluid binder, introduced into a mould, a sheet of porous material having an...
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8338151 |
Method for creating intracellular artificial nanostructures in situ
A method of creating intracellular artificial nanostructures in situ, which employees a chemical precursor. The precursor does not self-assemble due to the presence of a cleavable motif linked to...
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8338390 |
Multifunctional and biologically active matrices from multicomponent polymeric solutions
A functionalized electrospun matrix for the controlled-release of biologically active agents, such as growth factors, is presented. The functionalized matrix comprises a matrix polymer, a...
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8329220 |
Controlled release formulations
The present invention provides stable, self-assembling, biocompatible and biodegradable hydrogel formulations, into which one or more compounds may be incorporated allowing for delayed release or...
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8324184 |
Anti-adhesion composites and methods of use thereof
Described herein are composites that inhibit or reduce adhesion between two or more tissues. Also described herein are methods of using the composites.
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8303989 |
Compositions and methods for increasing the oral absorption of antimicrobials
The present invention provides compositions and methods for increasing absorption of antibacterial agents, particularly third generation cephalosporin antibacterial agents, in oral dosage solid...
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8298582 |
Polysaccharide-based impregnated solid material with improved stability, processes for the preparation thereof and impregnating solutions used
A polysaccharide-based solid material including, in its mass, at least one active agent having bactericidal, fungal, insecticidal and/or flame-retardant properties, and at least one complexing...
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8298581 |
Matrix compositions for controlled delivery of drug substances
A controlled release pharmaceutical composition for oral use is provided in the form of a coated matrix composition, the matrix composition comprising i) a mixture of a first and a second polymer...
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8293267 |
Method for preparing an antimicrobial cotton of cellulose matrix having chemically and/or physically bonded silver and antimicrobial cotton prepared therefrom
There is provided a method for preparing a natural cellulose-OAg matrix having antimicrobial activity without leaching silver from the cellulose-OAg matrix. The method comprises: introducing silver...
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8287659 |
Poly phosphate functionalized alkyl polyglucosides for enhanced food soil removal
A cleaning composition including a primarily C12 poly phosphate functionalized alkyl polyglucoside, a water conditioning agent, an acid source, a solvent, and water. In one embodiment, the cleaning...
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8282953 |
Malleable implants containing demineralized bone matrix
Described are malleable medical compositions such as pastes or putties that include solids combined with a liquid carrier. The solids include particulate collagen and particulate demineralized bone...
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8282959 |
Branched end reactants and polymeric hydrogel tissue adhesives therefrom
Branched end reactants having two or three functional groups at the ends are disclosed. The branched end reactants are used to prepare crosslinked hydrogel tissue adhesives, which have a good...
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RE43711 |
Pulmonary delivery for levodopa
In one aspect, the invention is related to a method of treating a patient with Parkinson's disease, the method including administering to the respiratory tract of the patient particles that include...
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8277845 |
Formulations and methods for lyophilization and lyophilates provided thereby
The present invention provides compositions, methods for lyophilizing compounds and making pharmaceutical compositions, and kits providing solutions and lyophilized formulations of compounds. The...
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8273324 |
Embolization
A particle includes a ferromagnetic material, a radiopaque material, and/or an MRI-visible material.
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8268351 |
Matrix film tablet with controlled release of a natural mixture of conjugated estrogens
A pharmaceutical matrix film tablet with controlled release of natural mixtures of conjugated estrogens which have been obtained from the urine of pregnant mares.
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8268240 |
Ciclesonide-containing sterile aqueous suspension
The present invention provides methods of manufacturing a sterile ciclesonide-containing aqueous suspension comprising the step of sterilization by autoclaving a ciclesonide-containing aqueous...
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8262805 |
Poly sulfonate functionalized alkyl polyglucosides for enhanced food soil removal
A cleaning composition including a primarily C12 poly sulfonate functionalized alkyl polyglucoside, a water conditioning agent, an acid source, a solvent, and water. In one embodiment, the cleaning...
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8257741 |
Solid pharmaceutical dispersions with enhanced bioavailability
Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or biavailability in a use...
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8257740 |
Pharmaceutical composition of nanoparticles
The invention discloses a composition of chitosan-shelled nanoparticles and methods of manufacturing. The chitosan-shelled nanoparticles are characterized with a positive surface charge and...
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