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8697746 Solid dispersion of alpha-ketoamide derivatives  
A solid dispersion comprising ((1S)-1-((((1S)-1-benzyl-2,3-dioxo-3-(cyclopropylamino)propy l)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester made amorphous in the presence...
8697643 Method for controllably releasing a drug conjugate within subcutaneous tissue in response to the local concentration of an indicator  
A conjugate that includes a drug covalently linked to a polymer. Upon administration, the conjugate is digested by an enzyme that is present at the site of administration thereby releasing a...
8697105 Injectable drug delivery formulation  
The invention provides an injectable formulation that includes an active agent; a biocompatible solvent system, crosslinkable polymers such as polysaccharides; and crosslinking agents; wherein the...
8697125 Tablet preparation without causing a tableting trouble  
The present invention provides a tablet without causing a tableting trouble, which is superior in the tablet formability, dissolution property of pharmaceutically active ingredient, and the like.
8691279 Polysaccharide and protein-polysaccharide cross-linked hydrogels for soft tissue augmentation  
Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and optionally including proteins. In one aspect, hyaluronic acid-based...
8691973 Method of producing chitosan scaffold having high tensile strength and chitosan scaffold produced using the method  
Provided are a method of producing a porous chitosan scaffold, the method including: providing an aqueous acidic solution having chitosan and a solvent which does not dissolve the chitosan; and...
8685454 Lubricating composition  
A lubricating composition prepared primarily from organic materials (primarily plants and micro-organisms). The unique process and mixture of organic materials comprising this lotion provide with...
8679536 Aldol-crosslinked polymeric hydrogel adhesives  
Adhesives formed by reacting an oxidized polysaccharide with a poly(hydroxylic) compound derivatized with acetoacetate groups in the presence of a base catalyst are disclosed. The use of the...
8679540 Pharmaceutical formulations for the prolonged release of active principle(s), and their applications, especially therapeutic applications  
The present invention relates to novel pharmaceutical formulations based on aqueous colloidal suspensions for the prolonged release of one or more active principles, and to the applications,...
8679537 Methods for sealing an orifice in tissue using an aldol-crosslinked polymeric hydrogel adhesive  
Methods for sealing an orifice in tissue in the body of a living animal using an adhesive formed by reacting an oxidized polysaccharide with a poly(hydroxylic) compound derivatized with...
8679535 Sustained release matrix systems for highly soluble drugs  
Disclosed are sustained release oral solid dosage forms comprising a therapeutically effective amount of a medicament having a solubility of more than about 10 g/l; a pH modifying agent; and a...
8679523 Oxygen-delivery closed cell foam matrix for wound treatment  
The present invention comprises methods and compositions for delivery devices. More particularly, the present invention comprises methods and compositions for devices comprising a matrix comprising...
8673294 Immunoisolation patch system for cellular transplantation  
An immunoisolation patch system, and particularly a patch system comprising multiple immunoisolation microcapsules, each encapsulating biological material such as cells for transplantation, which...
8663686 Biodegradable chitosan-PEG compositions and methods of use  
The present invention provides compositions comprising an interpolymer of chitosan and polyethylene glycol, wherein the interpolymer is a liquid below 25° C. and a gel above 35° C. The present i...
8663690 Method for nanoencapsulation  
Methods of nanoencapsulation are described herein. Embodiments of the method utilize the coacervation of a cationic polyelectrolyte with an anionic polyelectrolyte to form a novel capsular matrix....
8663691 Gel composition for shower filter, method for manufacturing shower gel filter and shower filter  
Provided are a gel composition for a shower filter with viscosity restorability, a method for manufacturing a shower gel filter and a shower filter. More particularly, the gel composition for a...
8658207 Extended release tablet formulations of flibanserin and method for manufacturing the same  
The present invention provides pharmaceutical release systems comprising an therapeutically effective amount of flibanserin and at least one pharmaceutically acceptable excipient, characterized in...
8653029 Flowable paste and putty bone void filler  
The present invention provides a composition that may be used as an implant or a bone graft substitute or extender for filling voids and/or promoting fusion of osseous tissues. The implant may...
8652522 Pharmaceutical composition of an iontophoresis  
It is an object of the present inventions to produce a pharmaceutical composition for the iontophoresis wherein a drug stability is excellent, and it is easy to blend and fill up when manufactured...
8642088 Tannin-chitosan composites  
The invention provides a composition comprising a matrix of chitosan and a tannin wherein the chitosan is electrostatically bonded to the tannin to form a chitosan-tannin composite material. The...
8632805 Controlled-release formulations, method of manufacture, and use thereof  
The present invention includes a controlled-release composition having a matrix. The matrix contains a pharmaceutically effective amount of an active agent or a pharmaceutically acceptable salt,...
8632813 Prostaglandin compositions and methods for the treatment of vasospasm  
Compositions and methods for the treatment of vasospasm are provided comprising applying an amount of a semi-solid vasoactive prostaglandin composition to the affected tissue. Also provided are...
8617604 Pharmaceutical compositions with enhanced performance  
Pharmaceutical compositions of a low-solubility drug and lower alkanoate-, phthalate- and trimellitate esters of hydroxypropyl methyl cellulose and lower alkanoate- and succinate esters of...
8617317 All-purpose cleaners with natural, non-volatile solvent  
Renewable, non-volatile cleaning compositions incorporating ethyl ester solvents are disclosed. Preferred compositions employ non-volatile C8-16 ethyl ester solvents. All-purpose cleaning...
8586078 Emulsion-containing medical articles  
Oil-in-water emulsion gels and medical articles containing an omega-3 oil are disclosed. Also disclosed are methods of preparing and using such emulsion gels and medical articles.
8586089 Enhanced carriers for the delivery of microparticles to bodily tissues and fluids  
Improved compositions for tissue augmentation are provided. These compositions comprise an amount of crosslinked material sufficient to provide a melt temperature (Tm) greater than 37C, wherein...
8580830 Non-mucoadhesive film dosage forms  
Orally disintegrating film dosage forms for delivering active pharmaceutical agents, methods of formulating the dosage forms to retard absorption through the oral mucosa, and methods of using the...
8568778 Multiparticulate form of administration, comprising nucleic acid-containing mucoadhesive active ingredients, and method for producing said form of administration  
The invention relates to an oral, multiparticulate form of administration, comprising pellets in the size ranging from 50 to 2500 $g(m)m which are substantially constituted of a) an inner matrix...
8563039 Biomaterials consisting of sulphated hyaluronic acid and gellan to be used in the prevention of spinal adhesions  
New biomaterials consisting of a combination of sulphated hyaluronic acid and gellan (as well as gellan that has not been associated with other polymers), to be used as a highly effective barrier...
8563040 Compositions and methods for forming and strengthening bone  
Compositions are provided which stimulate bone growth. Also provided are methods for utilizing the compositions for filling in bone defects, promoting rapid fusion of bone fractures, grafts, and...
8557275 Composition and method to alleviate joint pain using a mixture of fish oil and fish oil derived, choline based, phospholipid bound fatty acid mixture including polyunsaturated EPA and DHA  
Beneficial and synergistic effects for alleviating joint pain and symptoms of osteoarthritis and/or rheumatoid arthritis have been found using a mixture of fish oil and fish oil derived, choline...
8557286 Method for producing a water-insoluble amorphous or partially amorphous controlled release matrix  
The invention relates to a method for producing pharmaceutical forms or preliminary stages thereof by means of extrusion. The pharmaceutical form has a matrix which the active agent is contained...
8551502 Process for producing poly(vinyl alcohol)-bacterial cellulose nanocomposite  
Hydrogel-bacterial cellulose nano-composite materials are created using a hydrogel and never dried bacterial cellulose fibers. Such materials are suitable for a broad range of soft tissue...
8545861 Lotioned fibrous web having a short water absorption time  
A fibrous web, in particular tissue web treated with a lotion composition based on an O/W emulsion comprising: (A) at least one oil; (B) an (O/W) emulsifier or (O/W) emulsifier combination; and (C)...
8545886 Extended release tablet formulations of flibanserin and method for manufacturing the same  
The invention is directed to a Pharmaceutical extended release system, particularly for oral administration, of a pH-dependent water-soluble active substance, comprising or essentially consisting...
8536231 Methods for treating diabetic foot ulcers  
The present invention provides methods and pharmaceutical formulations for treating diabetic foot ulcers.
8529951 Elastogenic cues and methods for using same  
Disclosed are elastogenic cues that can be utilized to encourage growth and development of elastin-containing cellular constructs. The elastogenic cues include hyaluronan fragments and oligomers,...
8524271 Skin wound dressing and preparing method thereof  
A skin wound dressing is disclosed. The skin wound dressing comprises Tremella polysaccharide and alginate and is used to cover on a skin wound to accelerate wound healing. The Tremella...
8524759 Phenylbutazone carrier formulation showing increased bioactivity in animals  
An improved phenylbutazone carrier composition provides increased palatability to horses. Additionally, the composition improves the bioavailability of the phenylbutazone and thus increases the...
RE44459 Method for lowering blood glucose  
The invention disclosed comprises a method for administering the antidiabetic drug glipizide to a patient in need of glipizide in need of antidiabetic therapy.
8518394 Seakem gold agarose beads comprising islets and coated with agarose  
The invention describes the manufacture and use of secretory cell containing bead structures that are coated with agarose. The beads, which are preferably 4 mm-12 mm in diameter, and which...
8512751 Pharmaceutical compositions for sleep disorders  
Pharmaceutical compositions are provided for the pharmacological treatment of breathing disorders and, more specifically, to compositions containing agents having serotonin receptor modulating...
8512752 Hyaluronic acid derivatives obtained via “click chemistry” crosslinking  
Crosslinked derivatives of polycarboxylated polysaccharides are described, wherein at least one of the polysaccharide chains consists of hyaluronic acid or a derivative thereof, crosslinked by...
8506983 Bone filler material  
Described are bone generation matrixes having an admixture of demineralized bone matrix (DBM) particles and/or bone chips in combination with at least one binding agent selected from the group...
8507629 Organic polymer containing two or more organic ring structures and a chain structure threading through the organic ring structures, and production method thereof  
A production method of the present invention is a production method of an organic polymer containing two or more organic ring structures and a chain structure threading through the organic ring...
8481072 Composition and method to alleviate joint pain  
Beneficial and synergistic effects for alleviating joint pain and symptoms of osteoarthritis and/or rheumatoid arthritis have been found with krill oil and/or marine oil in combination with other...
8481071 Hydrogel compositions with an erodible backing member  
A composition is provided, wherein the composition comprises a water-swellable, water-insoluble polymer, a blend of a hydrophilic polymer with a complementary oligomer capable of hydrogen or...
8481081 Pharmaceutical solid dispersions  
A composition comprises a solid dispersion comprising a low-solubility drug and at least one polymer. At least a major portion of the drug in the dispersion is amorphous. The polymer has a glass...
8470369 Bone paste composition  
Bone paste compositions are described, which promote bone healing and remodeling by stimulating bone marrow elements using a combination of hemopoietic agents, angiogenic agents and a bone...
8470370 Controlled release formulations  
The present invention provides stable, self-assembling, biocompatible and biodegradable hydrogel formulations, into which one or more compounds may be incorporated allowing for delayed release or...