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9034378 Biodegradable polyurethane and polyurethane ureas  
This invention relates to biocompatible, biodegradable thermoplastic polyurethane or polyurethane/ureas comprising isocyanate, polyol and a conventional chain extender and/or a chain extender...
9023393 Pharmaceutical compositions of adsorbates of amorphous drugs and lipophilic microphase-forming materials  
A pharmaceutical composition comprises a solid adsorbate comprising a drug adsorbed onto a substrate and a lipophilic microphase-forming material. The solid adsorbate may also be co-administered...
9023394 Formulations and methods for the controlled release of active drug substances  
Controlled release formulations and methods for preparing controlled release formulations for delivery of active drug substances are described herein. The formulations described herein may be...
9018008 Three-dimensional scaffold and method of manufacturing the same  
A scaffold having a reinforced tissue regeneration ability and a method of manufacturing the same are provided. The scaffold is formed in a lattice form by alternately stacking biodegradable...
9011919 Compositions for targeted delivery of siRNA  
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with...
9012594 Catalyst and byproduct-free native chemical ligation using cyclic thioester precursors  
A method of synthesizing a biocompatible hydrogel by covalently cross-linking an effective amount of a first macromonomer including a cyclic thioester group with an effective amount of a second...
9011899 Methods and devices for cellular transplantation  
Devices and methods for transplanting cells in a host body are described. The cell comprises a porous scaffold that allows ingrowth of vascular and connective tissues, a plug or plug system...
9012424 Nanogels  
The present invention relates to a polymer according to Formulas (1) or (2): The present invention further relates to nanogels and nanoparticles made of a polymer according to general Formulas (1)...
9011918 Biocompatible and biodegradable elastomeric polymers  
Disclosed herein are biocompatible and biodegradable polymers which are useful in tissue engineering, wound healing, coatings, and drug delivery, the polymers comprising one or more ECM-mimetic...
9011411 Methods for treatment of bladder cancer  
Apparatus and methods for treatment of an internal cavity are provided. The internal cavity is coated with a treatment solution. The treatment solution can include a solidifiable matrix with or...
9005597 Formulation for treatment of vaginal dryness  
The present invention is directed to a composition for treating vaginal dryness and lack of lubrication comprising: a poloxamer component; a phospholipid component; an optional oil component; and...
8999945 Methods, compositions and systems for local delivery of drugs  
Implantable medical device eluting drug locally and in a prolonged fashion are provided.
8999390 Sustained release formulation comprising octreotide and three linear polylactide-co-glycolide polymers  
The present invention relates to sustained release formulations comprising as active ingredient octreotide or a pharmaceutically-acceptable salt thereof and three different linear...
8992979 Sustained-release drug carrier composition  
The present invention provides compositions for extended release of one or more active ingredients, comprising a lipid-saturated matrix formed from a non-biodegradable polymer or a...
8992899 Clean volume mascara compositions comprising at least one film former and at least one silicone elastomer  
Disclosed herein are cosmetic compositions comprising at least one film-forming polymer, at least one silicone elastomer blend, and at least one wax. Also disclosed herein are methods for making...
8986734 Material with bacteriostatic properties  
The invention relates to a method for making a composite material including a porous polymer matrix containing HEMA monomers and in which silver nanoparticles are dispersed, and to the use thereof...
8986735 Solid dosage form containing a taste masked active agent  
A solid dosage form containing a taste masked active agent is provided. The solid dosage form may be provided as a water soluble film that is disintegrable in the oral cavity to deliver and...
8980278 Bio-functionalized stimulus-responsive dissolvable PEG-hydrogels  
The present invention is directed to a bio-functionalized stimulus-responsive dissolvable PEG-hydrogel. This inventive stimulus-responsive dissolvable PEG-hydrogel comprises a matrix of...
8974827 Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer  
A pharmaceutical composition comprises nanoparticles comprising a poorly water-soluble drug, a poorly aqueous soluble non-ionizable cellulosic polymer, and a poorly aqueous soluble polymeric...
8974774 Compositions and methods for topical diagnostic and therapeutic transport  
Compositions and methods are provided that are useful for the delivery, including transdermal delivery, of biologically active agents, such as non-protein non-nucleotide therapeutics and...
8968782 Combination degradable and non-degradable matrices for active agent delivery  
The present invention relates to relates to combination degradable and non-degradable matrices and related methods. In an embodiment, the invention includes an active agent delivery matrix...
8968715 Drug delivery systems for photodynamic therapy  
The invention is generally related to the field of photodynamic therapy by use of photosensitizers and stabilized formulations of the photosensitizers. These formulations may be used to deliver a...
8968783 Hydrogel implants with varying degrees of crosslinking  
The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as...
8962024 Method for treating primary insomnia  
The invention relates to a medicament, for treating and improving the restorative quality of sleep, in a patient suffering from primary insomnia, which comprises at least one compound selected...
8961936 Ultrasonography using time- and temperature-sensitive variable adhesion coupling gels  
One aspect of the present invention relates to a method of ultrasonography, utilizing a gel comprising a reverse phase polymer which facilitates the transmission of high-frequency sound waves....
8962023 UV cured gel and method of making  
A method of UV curing and corresponding resulting non-polymeric cross-linked gel are provided. The cross-linked gel can be combined with a medical device structure. The cross-linked gel can...
8962025 Rapidly acting dry sealant and methods for use and manufacture  
Compositions, methods, and kits are provided for sealing applications. Compositions are prepared by combining a first cross-linkable component with a second cross-linkable component to form a...
8962548 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Multi-component biological transport systems
 
Compositions and methods are provided that are useful for the delivery, including transdermal delivery, of biologically active agents, including nucleic acids and therapeutic proteins including...
8956655 Biodegradable drug delivery system  
A drug delivery system (DDS) comprised of segmented biodegradable implants sized and suitable for implantation in an ocular region or site and methods for treating ocular conditions. The segmented...
8951595 Coatings with tunable molecular architecture for drug-coated balloon  
A drug delivery balloon is provided, the a balloon having an outer surface, and a tunable coating disposed on at least a length of the balloon surface. The tunable coating includes a first...
8951557 Sustained release solid formulations and methods of manufacturing the same  
Disclosed are a sustained release solid formulation comprising a drug, for example, oxycodone or its pharmaceutically acceptable salt, in a water-insoluble matrix, which comprises a wax type...
8951545 Insertable medical devices having microparticulate-associated elastic substrates and methods for drug delivery  
The present invention provides insertable medical devices having elastic surfaces associated with bioactive agent-containing microparticulates and a coating material. Upon expansion of the elastic...
8945619 Shell-and-core dosage form approaching zero-order drug release  
Drugs are formulated as oral dosage forms for controlled release in which the release rate limiting portion is a shell surrounding the drug-containing core. The shell releases drug from the core...
8945927 Polymers for delivering molecules of interest  
The present invention relates to a new class of cationic polymers that self-assemble with a pH-sensitive dissolution switch, and their uses to deliver molecules of interest to a cell. The present...
8945598 Low temperature drying methods for forming drug-containing polymeric compositions  
The present invention relates to a process for reducing solvent contents in drug-containing polymeric compositions. Specifically, the solvent contents in the drug-containing polymeric compositions...
8945624 Photoinitiated tissue filler  
Visible light-activated polymer cosmetic filler preparations useful in a variety of applications are provided. In some embodiments, the photo-activated polymer composition comprises a conventional...
8945623 Compositions comprising biomembrane sealing agent for treatment of neuronal injury, and methods of use  
The invention provides compositions, kits, and methods for treatment of neuronal injury. In one embodiment, the composition comprises a biomembrane sealing agent, such as PEG, and a bioactive...
8940332 High-molecular weight conjugate of podophyllotoxins  
A novel podophyllotoxin derivative, which is capable of releasing a drug without depending on biological enzymes and can be expected to have an effective therapeutic effect and is soluble in water...
8940336 Polymer particles prepared from polymerisable alkylene glycol (meth) acrylate monomers  
The invention provides polymer particles that are obtainable by a method selected from emulsion methods, diffusion methods and evaporation methods carried out in the presence of...
8936805 Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same  
A structure of, and a method of producing, a biocompatible structure for bone and tissue regeneration are disclosed. The method includes dissolving a polyurethane polymer in methanol, adding...
8936825 Method and system for forming a pharmaceutical product directly onto a packaging surface  
The present invention relates to a method for forming a pharmaceutical product, such as a dissolvable film dosage form, onto a surface. Particularly, the present invention relates to a method of...
8932564 Compositions comprising solid particles encapsulated in a cross-linked silicone matrix, and methods of making the same  
The present invention relates to topical compositions containing solid particles that are stabilized via encapsulation into a cross-linked silicone matrix. The solid particles are preferably...
8932590 Method of adsorbing transforming growth factor β  
An adsorbent for immunosuppressive substance, which can adsorb an excessive immunosuppressive substance directly from a body fluid, can carry out extracorporeal perfusion safely and can be...
8932618 Biodegradable osmotic pump implant for drug delivery  
The present disclosure relates to a drug delivery device including a biodegradable housing and a hydrogel within the biodegradable housing. The housing, the hydrogel, or both, may include a...
8927023 Biocompatible, non-biodegradable, non-toxic polymer useful for nanoparticle pharmaceutical compositions  
The invention relates to a biocompatible, non-biodegradable, and non-toxic polymer of formula (I), comprising of three monomeric units, selected from 1-Vinylpyrrolidne (VP), N-Isopropylactylamide...
8920841 Biodegradable polymer system  
A polymer system useful for in vivo delivery of a therapeutic agent is provided. The polymer system comprises a biocompatible biodegradable polymeric backbone that is capable of a reversible...
8920788 High-molecular weight conjugate of physiologically active substances  
Disclosed is a water-soluble high-molecular weight conjugate of physiologically active substances which enable medicament to release without depending on the enzymes in a living body and which is...
8916143 Polymer compositions of dihydroxyacetone and uses thereof  
The present disclosure provides injectable synthetic and biodegradable polymeric biomaterials that effectively prevent seroma, a common postoperative complication following ablative and...
8916683 Nanostructured physically-associating hydrogels for injectable, responsive, and tough biomaterials  
Described herein are block copolymer conjugates that form double-network hydrogels under appropriate conditions. The conjugates comprise a block of polymer end-group, a block of self-associating...
8911492 Coating for a medical device having an anti-thrombotic conjugate  
An implantable device having a coating comprising a comb-type anti-thrombotic conjugate to prevent or reduce the formation of thrombosis on the surface of the device. The device includes a frame...