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6521431 |
Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments
Biodegradable cross-linkers are provided having a polyacid core with at least two acidic groups covalently connected to reactive groups usable to cross-link polymer filaments. Between at least one...
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6521258 |
Polymer matrices prepared by supercritical fluid processing techniques
Polymer matrices for use in orthopedic, pharmaceutical, and similar mixtures are prepared by mixing two or more polymers and a process medium in a reactor to form a supercritical fluid slurry. The...
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6517869 |
Positively charged poly(alpha-(omega-aminoalkyl)lycolic acid) for the delivery of a bioactive agent via tissue and cellular uptake
A biodegradable, positively-charged aminoalkyl polyester polymer for the delivery of bioactive agents, such as DNA, RNA, oligonucleotides is disclosed. Biologically active moieties, such as drugs,...
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6518313 |
Solid sanitizers and cleaner disinfectants
Solid sanitizing compositions have advantages over corresponding liquids and powders. A solid sanitizing product can be contained within a plastic bottle with a label indicating that the contents...
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6517825 |
Polyether-based bile acid sequestrants
The present invention relates to a method for sequestering bile acids in a patient and to particular polymers for use in the method. The invention further relates to a method for reducing blood...
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6517858 |
Bioactive prostheses with immunosuppressive, antistenotic and antithrombotic properties
The invention relates to a bioactive implant comprising a substrate coated with a polymer layer with reactive functions, and a bioactive substance fixed on the implant by means of said reactive...
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6514492 |
Taste masking of oral quinolone liquid preparations using ion exchange resins
This invention relates to the formulation of oral liquid products of quinolones or derivatives thereof using ion exchange resins, such as methacrylic acid polymer crosslinked with divinylbenzene,...
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6514533 |
Device for the sustained release of aggregation-stabilized, biologically active agent
A device for the sustained release in vivo of a water soluble, biologically active agent wherein the agent is susceptible to aggregation comprising a drug delivery device and...
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6514481 |
Magnetic nanoparticles for selective therapy
The present invention provides novel nanosized particles termed as “nanoclinics” for therapeutic and/or diagnostic use. The particles have a core made of a therapeutic or diagnostic material...
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6514535 |
Bioadhesive hydrogels with functionalized degradable crosslinks
This invention relates to A bioadhesive composition comprising two or more essentially excretable, essentially non-degradable polymer backbones, wherein the polymer backbones are crosslinked, said...
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6511657 |
Two-phase roll-on cosmetic product
A two-phase roll-on antiperspirant and/or deodorant is described which comprises: (a) a clear, translucent or opaque non-polar phase having a viscosity in the range of 20 cps-9,000 made by...
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6509031 |
System for polymerizing collagen and collagen composites in situ for a tissue compatible wound sealant, delivery vehicle, binding agent and/or chemically modifiable matrix
This invention relates to materials and methods for crosslinking, in situ, proteins, including collagen, with peroxidase, including horseradish peroxidase, to from biocompatible semi-solid gels...
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6509028 |
Methods and compositions for treating pain of the mucous membrane
Compositions useful for long-lasting pain relief from mucosal damage, such as mucosal inflamation, abrasions, ulcerations, lesions, trauma and incisions, without significant systemic absorption....
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6509040 |
Fast dispersing dosage forms essentially free of mammalian gelatin
The present invention relates to fast dispersing solid dosage forms that preferably dissolve in the oral cavity within sixty (60), more preferably within thirty (30), most preferably within ten...
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6509037 |
Sustained release pharmaceutical matrix tablet of pharmaceutically acceptable salts of diclofenac and process for preparation thereof
The present invention provides a novel sustained release composition and method for making such a composition of diclofenac and its pharmaceutically acceptable salts. The composition of the present...
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6503955 |
Pourable liquid vehicles
The present invention covers pourable liquid vehicles that can be combined with compositions, materials and substances. Among the benefits of such pourable liquid vehicles is the compositions are...
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6503954 |
Biocompatible carrier containing actinomycin D and a method of forming the same
A biocompatible carrier and a composition for forming the carrier are disclosed. The carrier is made from an ethylene vinyl alcohol copolymer which can serve as a reservoir, allowing for the local...
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6495127 |
Compositions and systems for forming high strength medical sealants, and associated methods of preparation and use
The present invention relates generally to synthetic polymer compositions that form interpenetrating polymer networks. In a preferred embodiment, the compositions comprise two multifunctionally...
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6491904 |
Topical composition containing human epidermal growth factor
The present invention relates to a topical composition containing human epidermal growth factor (hEGF) and polyoxyethylene-polyoxypropylene copolymer having a viscosity of 4-10 cps at 37° C, 60...
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6488965 |
Synergistic antimicrobial preparations containing chlorite and hydrogen peroxide
Antimicrobial/pharmaceutical preparations (e.g., solutions, gels, ointments, creams, sustained release preparations, etc.) which comprise chlorite (e.g., a metal salt of a chlorite) in combination...
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6488963 |
Hot-melt extrudable pharmaceutical formulation
The present invention relates to pharmaceutical formulations comprising a hot-melt extrudable mixture of a therapeutic compound and a high molecular weight poly(ethylene oxide) in an essentially...
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6485749 |
Absorbable &egr -Caprolactone polymers and medical devices
Crystalline, low melting ε-Caprolactone polymers which undergo accelerated hydrolysis, and their use as lubricant coatings and/or as coatings containing bioactive agents, as carriers of viable...
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6482446 |
Astringent composition and method of use
The invention provides for astringent compositions comprising from about 0.1% to about 20% by weight of an astringent and between about 0.1% to 10% by weight of alcohol. The compositions have...
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6482435 |
Temperature sensitive gel for sustained delivery of protein drugs
Pharmaceutical compositions for the delivery of pharmacologically active proteins are provided by the present invention. The compositions of the present invention comprise a polymeric matrix having...
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6479065 |
Process for the preparation of polymer-based sustained release compositions
The invention relates to a sustained release composition and methods of forming and using said composition for the sustained release of biologically active agent. The sustained release compositions...
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6475500 |
Anhydrous cosmetic compositions
An anhydrous skin treatment composition is provided which includes a crosslinked siloxane elastomer gel of specific yield point, a skin conditioning agent and a volatile siloxane. Inclusions of the...
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6475779 |
Polymeric gene delivery
A means for obtaining efficient introduction of exogenous genes into a patient, with long term expression of the gene, is disclosed. The gene, under control of an appropriate promoter for...
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6475513 |
Skin-care pouch
A skin-care pouch includes a sealed enclosure storing therein a number of carbide aggregations including carbides in the form of small pieces, granules or particles, water-absorbent shape-keeping...
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6475522 |
Synthetic polymer compositions containing antibiotics as antidegradants
Synthetic polymer compositions contain antibiotics as antidegradants. Antibiotics from classes of glycopeptides and β-lactams have been found to prevent or inhibit synthetic polymer degradation.
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6475516 |
Drug delivery via therapeutic hydrogels
The present invention is directed to a vehicle for effecting drug delivery from a solid substrate. Hydrogels loaded with liposomal therapeutic agents such as antibiotics are covalently bonded to...
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6475496 |
Gelled cosmetic remover composition
An organic solvent based cosmetic remover composition gelled to a viscosity of 25 to 500,000 centipoise with a synthetic metal silicate gelling agent.
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6475521 |
Biphasic controlled release delivery system for high solubility pharmaceuticals and method
A biphasic controlled release delivery system for pharmaceuticals which have high water solubility, such as the antidiabetic metformin HCl salt, is provided which provides a dosage form that has...
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6475994 |
Method and articles for transfection of genetic material
A gene transfection particle includes a polymer, a support particle conjugated with the dendritic polymer, and genetic material conjugated with the dendritic polymer. The gene transfection...
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6476079 |
Devices for the delivery of drugs having antiprogestinic properties
A device for the controlled release over a prolonged period of time of a drug having antiprogestinic properties, the device including a core containing the drug, optionally a membrane encasing the...
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6471992 |
Dosage form exhibiting rapid disperse properties, methods of use and process for the manufacture of same
A rapidly dispersing dosage form is described, which releases its active ingredients within a period of less than about ninety seconds. These dosage forms exhibit a three-dimensional shape that is...
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6471993 |
Three-dimensional polymer matrices
Matrices that include a macrostructure having a semi-solid network and voids, and a microstructure having voids, in which the microstructure is located within the semi-solid network are disclosed....
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6471987 |
Drug releasing elastic band and method
A ligating band according to the present invention comprises an elastomeric layer and an inner drug releasing layer. The inner drug releasing layer includes a therapeutic agent, for example a...
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6468522 |
Controlled release of thioamide moiety-containing therapeutic agents
This invention pertains to disulfide-linked conjugates of therapeutic agents containing at least one thioamide group with polymer comprising at least one thiol group, so as to provide a controlled...
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6465001 |
Treating medical conditions by polymerizing macromers to form polymeric materials
Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions...
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6465014 |
pH-dependent sustained release, drug-delivery composition
A pH-dependent sustained release, drug delivery composition capable of being formed into tablets or pellets, wherein the release is controlled by a diffusion barrier formed by the interaction of a...
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6464961 |
Polymeric delivery and release systems for oral care actives
A polymer useful in oral care compositions which has a reactive group covalently bonded to a bactericide, flavorant and/or essential oil compound, said bond being hydrolyzable in aqueous solution...
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6465016 |
Cyclosporiine particles
Pharmaceutical compositions containing solid cyclic oligopeptide cyclosporine microparticles are prepared by applying energy input to solid cyclic oligopeptide cyclosporine in the presence of...
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6464999 |
Bioadhesive medical devices
Disclosed herein are bioadhesive medical devices formed in whole or in part of a cohesive bioadhesive copolymer of a carboxyl functional monomer and a hydrophobic functional monomer.
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6462093 |
Method for converting sparingly water-soluble medical substance to amorphous state
A process for producing a solid dispersion of a sparingly water-soluble medical substance which comprises subjecting the sparingly water-soluble medical substance, an amorphous state-inducing agent...
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6461597 |
Method of treating hair or skin
A cosmetic consists of a cosmetic raw material in the form of an emulsion of silicone or organic oil containing crosslinked particles mixed with other cosmetic raw materials. Its touch on fingers...
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6461640 |
Local delivery of fibrinolysis enhancing agents
A method of preventing adhesions by topical administration of fibrinolysis enhancing agents is described. The method uses a topically applied polymeric matrix for delivery of a fibrinolytic agent,...
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6458385 |
Hydrogels containing absorbable polyoxaamides
The present invention describes a crosslinked aliphatic polyoxaamide polymer and blends thereof that may be used to produce hydrogels, surgical devices such as catheters, molded devices, and the...
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6458763 |
Bone sialoprotein-based compositions for enhancing connective tissue repair
The present invention is directed to bioactive compositions that induce the repair of damaged or diseased connective tissues upon contact of the damaged or diseased tissues with the composition in...
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6455071 |
Branched dendrimeric structures
The present invention provides new reagents and methods which allow the assembly of large, branched structures from simple but versatile building blocks. The invention discloses dendrimers...
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6455067 |
Transdermal patch for nonsteroidal antiinflammatory drug(s)
This invention relates to an external patch for an antiinflammatory drug containing nonsteroidal antiinflammatory drug which is excellent in the dermal absorption and the skin adhesion, has hardly...
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