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6656487 |
Composition containing fibers and a dispersing copolymer
The invention relates to a composition containing fibers and a copolymer comprising carboxylate groups and polydimethylsiloxane groups. The composition according to the invention may especially...
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6656508 |
Sustained-release alginate gels
The present invention relates to sustained-release formulations using alginate gel beads and methods thereof.
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6652883 |
Tissue bulking and coating compositions
Compositions comprising macromers having a backbone comprising units having a 1,2-diol and/or 1,3-diol structure for tissue bulking and coating. Such polymers include poly(vinyl alcohol) (PVA) and...
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6652876 |
Active substance patch, kind to the skin, for transdermal administration of nonsteroidal antirheumatics
An active substance matrix patch for controlled delivery of nonsteroidal antirheumatics to the skin, comprising a flexible cover layer and a water insoluble, pressure sensitively adhesive active...
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6652882 |
Controlled release formulation containing bupropion
The present invention relates to a controlled release pharmaceutical formulation comprising an effective amount of an active ingredient and from about 1% to about 70% by weight of an uncrosslinked...
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6649702 |
Stabilization and acoustic activation of polymeric micelles for drug delivery
Methods are disclosed in which a micelle is stabilized against degradation upon dilution. The micelle comprises molecules of a block polymer having a hydrophobic block and a hydrophilic block. The...
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6649189 |
Methods for use of delivery composition for expanding, activating, committing or mobilizing one or more pluripotent, self-renewing and committed stem cells
A hematopoietic growth factor delivery composition includes a hematopoietic growth factor, a liquid vehicle, a first biocompatible polymer and a second biocompatible polymer. The composition...
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6646014 |
Organic compounds
The present invention concerns a method for the control of various diseases in bee-hives by applying to the bee-hives an effective amount of an essential oil in a slow-release formulation whereby...
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6641832 |
Increasing blood flow to tissue with angiogenic material containing polymer and vascularizing compound
An angiogenic material is prepared which promotes extensive vascularization when implanted in animal tissue. The angiogenic material is preferably used in microcapsule coatings and microspheres for...
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6641842 |
Thermoplastic articles exhibiting high surface-available silver
Improvements in increasing the amount of surface-available silver in thermoplastic articles comprising certain silver-containing antimicrobial agents. Such an invention requires the incorporation...
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6641831 |
Medical products with sustained pharmacological activity and process for producing them
A non-degradable medical product comprising at least two substances or groups of substances, of which a first substance is referred to as substance A and a second is referred to as substance B,...
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6641833 |
Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same
Biodegradable polymer compositions suitable for intraperitoneal administration to treat a mammalian subject having ovarian cancer are described, wherein the polymer compositions provide extended...
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6638537 |
Microemulsion and micelle systems for solubilizing drugs
A microemulsion delivery system for water insoluble or sparingly water soluble drugs that comprises a long polymer chain surfactant component and a short fatty acid surfactant component, with the...
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6635280 |
Extending the duration of drug release within the stomach during the fed mode
Drugs are formulated as unit oral dosage forms by incorporating them into polymeric matrices comprised of hydrophilic polymers that swell upon imbibition of water to a size that is large enough to...
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6635236 |
Method for treating podotrochlosis
A method for treating podotrochlosis (navicular disease/navicular syndrome) in the foot of a horse is disclosed. The method comprises identifying the specific area(s) of the horse's foot affected...
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6632455 |
Molecular dispersion composition with enhanced bioavailability
A molecular dispersion composition is disclosed. The molecular dispersion comprises a compound of the formula: molecularly dispersed in a polymer matrix. Also disclosed are solid dosage forms,...
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6632446 |
Coating substrates by polymerizing macromers having free radical-polymerizable substituents
Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions...
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6630171 |
Particles based on polyamino-acid(s) and methods for preparing same
The invention concerns delivery particles (DP's) for active principles (AP's) based on linear amphiphilic polyamino-acids (PAA's), with α-peptide chains, capable of being spontaneously formed by...
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6623729 |
Process for preparing sustained release micelle employing conjugate of anticancer drug and biodegradable polymer
The present invention relates to a process of preparing a sustained release micelle by copolymerizing a biodegradable polyester hydrophobic polymer and a hydrophilic polyethylene glycol (PEG) to...
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6623749 |
Medical device containing polyhydroxyalkanoate treated with oxidizing agent to remove endotoxin
Polyhydroxyalkanoate (PHA) that contains a pyrogen such as an endotoxin due to a process of producing the PHA is treated to remove the pyrogen by a process that does not affect the inherent...
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6620432 |
Phenytoin sodium pharmaceutical compositions
A pharmaceutical composition is provided containing an admixture of phenytoin sodium and an erodible matrix which extends the release of the phenytoin sodium over about a two hour period. The...
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6620617 |
Polymeric gene delivery system
A means for obtaining efficient introduction of exogenous genes into a patient, with long term expression of the gene, is disclosed. The gene, under control of an appropriate promoter for...
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6620422 |
Compositions containing a peptide and polylactic-glycolic acid suitable for preparing subcutaneous implants with an extended release period
Compositions comprising a peptide and polylactic-glycolic acid (PLGA) wherein the distribution of the size of the particles of the peptide in the PLGA results highly heterogeneous, suitable to the...
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6616941 |
Polymeric composition for solubilizing poorly water soluble drugs and process for the preparation thereof
A composition capable of forming a micelle in body fluids or in an aqueous medium and that can be injected into the body undiluted or as a diluted solution in an aqueous medium and method of...
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6613355 |
Semi-solid delivery vehicle and pharmaceutical compositions
A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical...
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6610282 |
Polymeric controlled release compositions
Disclosed are compositions containing biologically active compounds that slowly release the biologically active compound. These compositions may be directly incorporated into the locus to be...
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6610281 |
Water soluble activated polymers containing an active ethyl sulfone moiety for modification of surfaces and molecules
Water soluble activated polymers are provided containing an active ethyl sulfone moiety having a reactive site located at the second carbon from the sulfone group. In an embodiment, a poly(ethylene...
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6607752 |
Method for the anhydrous loading of nicotine onto ion exchange resins
An environmentally friendly method of loading nicotine onto cation exchange resins under anhydrous conditions is described. The method eliminates many of the processing problems that are associated...
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6605294 |
Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
Pharmaceutically acceptable hydrogel polymers of natural, recombinant or synthetic origin, or hybrids thereof, are introduced in a dry, less hydrated, or substantially deswollen state and rehydrate...
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6605069 |
Aromatic copolyester containing active ingredients
The invention relates to aromatic copolyesters comprising antimicrobially active substances in homogeneous distribution, processes for their preparation and their use in medical articles.
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6599519 |
Biodegradable poly(alkylene oxide)-poly(p-dioxanone) block copolymer soluble in organic solvents, and drug delivery composition comprising same
The present invention relates to a biocompatible and biodegradable block copolymer of poly(alkylene oxide) and poly(p-dioxanone), which is soluble in organic solvents, and a drug delivery...
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6599931 |
Test system for characterizing the compatibility of bioactive substances and polyvinylpyrrolidone
A test system for characterizing the compatibility of bioactive substances with polyvinylpyrrolidones in a solid dispersion consisting of one or more bioactive substances and...
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6596540 |
Method for introduction of an exogenous genetic substance or a physiologically active compound
A novel method for introduction of an exogenous substance or a physiologically active compound into cells is provided according to this invention. This method can realize introduction of an...
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6596309 |
Stable pharmaceutical dosage form for paroxetin anhydrate
Medicaments in the form of soft gelatin capsules contain paroxetin anhydrate or pharmaceutically acceptable salts thereof together with lipophilic carriers, namely silicone oils.
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6596293 |
Polyurethane-biopolymer composite
A method is provided for preparing a drug delivery material and device comprising cross-linking a biological polymer with a cross-linking agent and loading the cross-linked biopolymer with a...
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6596308 |
Controlled release pharmaceutical composition
A sustained/prolonged release pharmaceutical dosage form is disclosed. The form comprises a hard shell capsule and a formulation comprising (a) a water insoluble medicant, (b) a high melting fatty...
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6592898 |
Bioadhesive compositions comprising hydrophobic polymers
Bioadhesive compositions which comprise a hydrophobic polymer wherein the concentration of the polymer at the surface of the adhesive is greater than its concentration in the bulk of the adhesive...
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6592899 |
PLA/PLGA oligomers combined with block copolymers for enhancing solubility of a drug in water
Polymeric compositions having improved capability of solubilizing a drug in a hydrophilic environment to form a solution, comprising: a biodegradable polyester oligomer; and biodegradable AB-type,...
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6592900 |
Stabilized polyvinylpyrrolidone formulation
Preparations in powder form comprising or consisting of soluble or insoluble polyvinylpyrrolidone and/or polyvinylpyrrolidone copolymers and suitable as aid for pharmaceutical formulations comprise...
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6590059 |
Bioerodible polyorthoesters from dioxolane-based diketene acetals
Bioerodible polyorthoesters useful as orthopedic implants or vehicles for the sustained delivery of pharmaceutical, cosmetic and agricultural agents contain hydrogen bonding groups and α-hydroxy...
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6589998 |
Gel composition for filling a breast milk duct prior to surgical excision of the duct or other breast tissue
The invention is a gel composition for delivery to a breast milk duct prior to surgical excision of breast tissue including cancerous lesions. The invention also provides methods of mapping all or...
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6589546 |
Polymeric coatings for controlled delivery of active agents
Implantable medical device having a structure adapted for introduction into a patient wherein the structure is composed of a base material positioned over the structure. The implantable medical...
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6589550 |
Methods of producing intraocular lenses and materials suitable for their production
A method for producing an intraocular lens, comprising the steps of injecting a high-refractive index, low viscosity composition of crosslinkable units into an enclosure and initiating...
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6589549 |
Bioactive agent delivering system comprised of microparticles within a biodegradable to improve release profiles
A composition and method for releasing a bio-active agent or a drug within a biological environment in a controlled manner is disclosed. The composition is a dual phase polymeric agent—delivery...
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6589511 |
Composition for forming solid particles
The composition for forming solid particles of the present invention comprises a biodegradable polymer, a solvent, a polyhydric alcohol, a viscosity-increasing agent, and an active drug, wherein...
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6589562 |
Multicomponent biodegradable bioadhesive controlled release system for oral care products
The present invention relates to a controlled release system useful for site'specific delivery of biologically active ingredients or sensory markers, over an extended period of time, targeting...
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6585966 |
Solid for lubrication and a process for manufacturing the same
The present invention relates to a water-soluble solid composition that produces a lubricating liquid when dissolved in water. The composition is preferably prepared by kneading particles of a...
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6586007 |
Polyolefin additive composition comprising 3,4-dimethyl dibenzylidene sorbitol and rho-methyl dibenzylidene
A specific combination of two different polyolefin clarifying and nucleating agents, namely 3,4-dimethyldibenzylidene sorbitol and p-methyldibenzylidene sorbitol is provided. Such a combination...
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6585993 |
Controlled release neurotoxin system
A biocompatible implant for continuous in vivo release of a neurotoxin over a treatment period extending from one month to five years. The implant can be made of casting a solution of a polymer,...
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6586011 |
Microencapsulated plasminogen activators
A drug delivery system which includes a plurality of microcapsules, each microcapsule containing a plasminogen activator entrapped in a biocompatible, biodegradable, substantially water-soluble...
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