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7160553 |
Matrix for oxygen delivery to compromised tissues
The present invention comprises methods and compositions for delivery devices. More particularly, the present invention comprises methods and compositions for devices comprising a matrix comprising...
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7153519 |
Implantable substrate coated with a macromer having free radical polymerizable substituents
Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions...
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7153497 |
Controlled dissolution of active ingredients
A dosage form comprising a resin/resinate combination is described. Said dosage form allows optimization of the release rate profile of active ingredients.
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7153524 |
Method for improving adsorption of a drug from ethylene oxide derivative
The present invention relates to a method for improving adsorption on the gastrointestinal mucous layers of one or more selected from polyethylene glycol, polyethylene oxide, and polyoxyethylene...
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7153522 |
Sorbefacients and preparations for percutaneous absorption containing the same
Percutaneous sorbefacients comprising hexylene glycol and 1-menthol, more particularly, percutaneous sorbefacients for female hormones or derivatives thereof; and preparations for percutaneous...
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7138132 |
Hydrogel entrapping therapeutic agent and stent with coating comprising this
A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide containing hydroxy groups which are...
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7135190 |
Mixtures of various triblock polyester polyethylene glycol copolymers having improved gel properties
A water soluble, biodegradable reverse thermal gelation system comprising a mixture of at least two types of tri-block copolymer components is disclosed. The tri-block copolymer components are made...
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7135180 |
Preservation of bioactive materials by freeze dried foam
This invention provides methods and compositions to preserve bioactive materials in a dried foam matrix. Methods provide non-boiling foam generation and penetration of preservative agents at...
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7128927 |
Emulsions for in-situ delivery systems
The invention is provides a composition for sustained delivery of a biologically active agent comprising a biologically active mixture and a controlled release formulation. The composition protects...
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7129293 |
Crosslinked polymers, fine polymer particle, and process for producing these
A crosslinked polymer or polymer fine particles which can be obtained through copolymerization of at least a macromonomer having a polyethylene glycol segment, a comonomer having tertiary amine...
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7125570 |
Antibacterial composition
An antibacterial composition is provided which comprises a base, an antibacterial agent consisting of a silver-supporting inorganic compound and a water-soluble salt of a nitrogen atom-containing...
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7122205 |
Bioerodable polymeric adhesives for tissue repair
Methods for tissue repair are provided employing a matrix comprising a biocompatible, bioerodable polymer, said polymer comprising a thermoplastic lactide-containing terpolymer of monomer units...
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7122615 |
Polyanhydrides with therapeutically useful degradation products
An aromatic polyanhydride having a repeating unit with structure (I) wherein Ar is a substituted or unsubstituted aromatic ring and R is a difunctional organic moiety substituted on each Ar ortho...
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7118761 |
Method for producing a silver-containing wound care device
Wound care devices having a topically applied silver-based antimicrobial finish are provided. The finish comprises at least one silver ion-containing compound and at least one binder compound. The...
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7112417 |
Foam composite for the repair or regeneration of tissue
The present patent describes a biocompatible composite made of a first fibrous layer attached to a three-dimensional inter-connected open cell porous foams that have a gradient in composition...
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7109166 |
Sustained release formulation of a peptide
This invention is directed to a sustained release composition comprised of Compound (A) having the formula
or a pharmaceutically acceptable salt thereof, and a copolymer comprised of...
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7101840 |
Polymeric drug formulations
A method of forming a polymeric drug formulation in which a water-soluble drug is blended with a water-insoluble tissue-compatible polymer that is miscible in the solid phase with the drug, and...
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7101572 |
Taste masked aqueous liquid pharmaceutical composition
A substantially taste masked liquid pharmaceutical composition containing a pharmaceutically effective amount of an unpleasant tasting drug dissolved or dispersed in an aqueous excipient base, said...
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7097855 |
Transdermal thermal polymerization
An invention for polymerizing or crosslinking a prepolymer using a water soluble, thermal polymerization initiator is disclosed. The prepolymer mixed with the initiator is injected or placed into...
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7097856 |
Dendrimeric support or carrier macromolecule
The present invention provides a family of dendrimers that are useful as supports, vectors, carriers or delivery vehicles for a variety of compounds in biomedical and technological applications. In...
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7094418 |
Crosslinkable macromers
A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue...
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7094421 |
Plaster containing 4-biphenylacetic acid
It is provided the plaster of anti-inflammatory and analgesic, improving the sustained releasing of 4-biphenylacetic acid from the base adhesive material and low skin irritation, by using more than...
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7090869 |
Method for producing preparation containing bioactive substance
A method for producing a preparation containing a bioactive substance, characterized in that it comprises forming a solid material containing the bioactive substance and a polymer, and contacting...
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7090866 |
Opioid agonist in a fast dispersing dosage form
This invention relates to a pharmaceutical composition for oral administration comprising a carrier and, as active ingredient, an opioid (μ receptor) agonist, such as fentanyl, or a salt thereof,...
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7087240 |
Device and method for the treatment of erectile dysfunction
Devices and methods for treatment of erectile dysfunction and methods of manufacture and of use are provided. The devices include filmogenic material, a therapeutic agent, a permeation enhancer,...
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7087244 |
Thermogelling oligopeptide polymers
Disclosed is a thermogelling biodegradable aqueous polymer solution useful in providing a bioactive agent delivery system. A thermogelling biodegradable aqueous polymer solution may comprise a...
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7083781 |
Film forming polymers, methods of use, and devices and applications thereof
Compositions and methods for delivering active agents to the skin of a subject, including a polymer, an active ingredient and a solvent are disclosed, the compositions being capable of delivery by...
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7083806 |
Wound gels
The present invention relates to hydrogels, in particular gels for use on wounds. The invention provides a gel which is better able to maintain viscosity and gel integrity when exposed to wound...
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7078055 |
Method of attenuating swelling or inflammation
The present invention provides a method of attenuating swelling or inflammation in the tissue of a patient via applying a composition comprising a hydrophilic foam substrate and a polymeric...
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7078056 |
Method of attenuating bruise formation
The present invention provides a method of attenuating the formation or reducing the severity of a bruise in the tissue of a patient via applying a composition comprising a hydrophilic foam...
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7074431 |
Process for preparing a pharmaceutical composition
A method for the preparation of compositions, preferably pharmaceutical compositions, in form of expanded, mechanically stable, lamellar, porous, sponge-like or foam structures out of solutions and...
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7074432 |
Method of modifying the release profile of sustained release compositions
The present invention relates to a method for the sustained release in vivo of a biologically active agent comprising administering to a subject in need of treatment an effective amount of a...
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7070807 |
Branched histidine copolymers and methods for using same
The invention provides a branched transport polymer characterized as having at least 10 amino acids and a ratio of histidine to non-histidine amino acids greater than 1.5, said branched transport...
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7070808 |
Adhesive mixture for transdermal delivery of highly plasticizing drugs
Transdermal drug delivery patches and methods of their production are described. The patches can be made such that the accommodate highly plasticizing drugs such as selegiline and/or the use of...
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7070798 |
Coatings for implantable medical devices incorporating chemically-bound polymers and oligomers of L-arginine
A coating for an implantable medical device is disclosed. The coating comprises a polymer and an amino acid chemically bonded, attached or conjugated to the polymer. In one embodiment, the coating...
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7060296 |
Hydrolysable hydrogels for controlled release
The present invention relates to a biodegradable hydrogel comprising bonds which are hydrolyzable under physiological conditions. More particularly, the hydrogel consists of two interpenetrating...
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7060299 |
Biodegradable microparticles that stabilize and control the release of proteins
Disclosed herein are biodegradable microparticle compositions, and methods for the generation of biodegradable and biocompatible microparticles that stabilize proteins and also control the kinetics...
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7060295 |
Formulations for the prevention and treatment of insulin resistance and type 2 diabetes mellitus
The compositions and dosage forms of the invention are clinically useful as methods for increasing the effectiveness, efficiency and safety of biguanides (metformin) and/or sulfonylureas in the...
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7056533 |
Medicament incorporation matrix
A coating composition, in both its uncrosslinked and crosslinked forms, for use in delivering a medicament from the surface of a medical device positioned in vivo. Once crosslinked, the coating...
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7056901 |
Microgel particles for the delivery of bioactive materials
Novel microgels, microparticles and related polymeric materials capable of delivering bioactive materials to cells for use as vaccines or therapeutic agents. The materials are made using a...
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7056532 |
Compositions for delivery of biological agents and methods for the preparation thereof
A composition for facilitating delivery of biological agents, comprising a supramolecular complex including as constituents a block copolymer, having at least one nonionic, water soluble segment...
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7056527 |
Patches containing buprenorphine hydrochloride
A patch comprising an adhesive layer formed on one surface of a flexible support, wherein said adhesive layer containing a drug, an absorption enhancer and an adhesive comprising;
(i) said drug is...
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7052719 |
Matrices formed of polymer and hydrophobic compounds for use in drug delivery
A lipid or other hydrophobic or amphiphilic compound (collectively referred to herein as “hydrophobic compounds”) is integrated into a polymeric matrix for drug delivery to alter drug release...
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7052713 |
Carrier with solid fibrinogen and solid thrombin
The present invention relates to a solid composition useful for tissue gluing, tissue sealing and hemostasis consisting essentially of a) a carrier which has at least one of the following physical...
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7048946 |
Formulation for controlled release of drugs by combining hyrophilic and hydrophobic agents
Combinations of hydrophilic and hydrophobic entities in a biodegradable sustained release implant are shown to modulate each other's rate of release. Formulations of a therapeutically active agent...
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7045184 |
Polyvinyl alcohol compositions
The invention concerns polyvinyl alcohol (PVA) compositions for the use in pharmaceutical, veterinary, food, cosmetic or other products like films for wrapping food, aspics or jellies, preferably...
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7037527 |
Bifunctionalized polyester material for surface treatment and biomodification
The invention features a method of treating polyester material to generate functional carboxylic acid and amine groups. These functional groups can be used as sites for covalent bond formation to...
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7033606 |
Pharmaceutical composition intended in particular for the prevention and the treatment of radiomucositis and chemomucositis
The invention concerns a pharmaceutical composition designed to adhere to a mucous membrane for preventing or treating radiotherapy-related and chemotherapy-related mucositis, induced by...
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7034037 |
Compositions and medical devices utilizing bioabsorbable polymeric waxes and rapamycin
The present invention is directed to medical devices and pharmaceutical or agricultural compositions, and seeds, each containing a synthetic, bioabsorbable, biocompatible polymeric wax that is the...
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7029609 |
Composition which can be foamed from a pressurized container for producing insulating foams
The invention relates to a composition which can be foamed from pressurized containers. Said composition is based on an aqueous plastic dispersion containing an aqueous dispersion of at least one...
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