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7364752 |
Solid dispersion pharamaceutical formulations
A pharmaceutical composition is disclosed which comprises a solid dispersion of an HIV protease inhibitor in a water soluble carrier, such as PEG, having enhanced bioavailability and improved...
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7357943 |
Pharmaceutical preparation in the form of a suspension comprising an acid-labile active ingredient
The present invention relates to the field of pharmaceutical technology and describes a novel pharmaceutical preparation in the form of a suspension comprising an acid-labile active ingredient, in...
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7354600 |
Muco-adhesive polymers, use thereof and method for producing the same
Mucoadhesive polymers, the use thereof and a production method therefor. Mucoadhesive polymers assembled of not more than 10 different monomers and comprising at least one non-terminal thiol group,...
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7347988 |
Synthesis, uses and compositions of crystal hydrogels
A method is disclosed for creating hydrogels with ordered crystalline structures that exhibit a characteristic colored opalescence. In addition to the unique optical properties, these materials...
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7341999 |
Povidone-containing carriers for polypeptide growth factors
A liquid carrier medium is provided which is suitable for solubilizing growth factors, such as mixtures of bone morphogenetic proteins, that are found to induce an angiogenic response in ischemic...
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7338664 |
Color changing matrix as wear indicator
A sustained-release matrix for dental application includes either an anti-microbial agent or a colorant that is released from the matrix when the matrix contacts water. The preferred matrices...
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7332566 |
Biocompatible crosslinked polymers with visualization agents
Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having...
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7326426 |
Compositions and medical devices utilizing bioabsorbable liquid polymers
The present invention is directed to medical devices and pharmaceutical compositions containing a synthetic, bioabsorbable, biocompatible liquid polymer that is the reaction product of a polybasic...
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7316816 |
Temperature and pH sensitive copolymers
The invention is directed to a copolymer comprising at least three types of monomeric units, said three types of monomeric units comprising:
a temperature-sensitive unit, a hydrophilic unit,...
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7314612 |
Cosmetic compositions containing at least one heteropolymer and at least one gelling agent and methods of using the same
The invention relates to a physiologically acceptable composition, in particular a cosmetic composition, containing at least one liquid fatty phase comprising at least one structuring polymer...
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7304035 |
Stimulation of bone growth with thrombin peptide derivatives
Disclosed is a method of stimulating bone growth at a site in a subject in need of osteoinduction. The method comprises the step of administering a therapeutically effective amount of an agonist of...
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7300669 |
Fluticasone lotion having improved vasoconstrictor activity
A fluticasone lotion having improved vasoconstrictor and anti-inflammatory activity and higher than expected potency. The fluticasone lotion contains 0.05 weight percent fluticasone propionate and...
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7297348 |
Biodegradable triblock copolymers, synthesis methods therefore, and hydrogels and biomaterials made there from
A drug delivery system that includes a hydrogel formed from cyclodextrin and an amphiphilic copolymer that includes an A polymer block comprising a poly(alkylene oxide) and a B polymer block...
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7297673 |
Thickener for high-pH aqueous systems
An aqueous composition having a pH of at least 10, and comprising from 0.1% to 5% of at least one crosslinked copolymer comprising from 2.5% to 65% (meth)acrylic acid residues, from 10% to 80% C 2...
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7297347 |
Polyanhydrides
The invention provides polyanhydrides with aliphatic hydrocarbon terminals having ester or amide bonds.
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7294348 |
Polyfunctional biocompatible hydrogel and method for the production thereof
The inventive polyfunctional biocompatible hydrogel comprises 1.3–15 mass % of acrylamide, 0.004–0.975 mass % of cross-linking agents—N,N′-methylen-bis-acrylamide, 0.004–5.1 mass % of...
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7279176 |
Nitric oxide-producing hydrogel materials
Hydrogels releasing or producing NO, most preferably photopolymerizable biodegradable hydrogels capable of releasing physiological amounts of NO for prolonged periods of time, are applied to sites...
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7276256 |
Cosmetic or healing gel for application to the human skin
A gel formed from an intimate mixture of polyvinyl alcohol, an alkaline or alkaline earth metal borate, water and an alginate and/or a carrageenan, having cryogenic characteristics, substances with...
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7270834 |
Pharmaceutical composition comprising dimethylsulfoxide and ozone
A pharmaceutical composition to be externally applied as a topical preparation for treating several diseases, the composition comprising dimethylsulfoxide (DMSO) and ozone. A method for obtaining...
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7267828 |
Light stabilized antimicrobial materials
Methods of enhancing the photostabilizing of silver in medical materials are described. More particularly, the methods increase the photostabilization of silver in certain materials comprising...
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7252838 |
Drug releasing elastic band and method
A ligating band according to the present invention comprises an elastomeric layer and an inner drug releasing layer. The inner drug releasing layer includes a therapeutic agent, for example a...
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7250177 |
Multiblock biodegradable hydrogels for drug delivery and tissue treatment
Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The...
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7247314 |
Biocompatible material composition adaptable to diverse therapeutic indications
A biocompatible material genus serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication.
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7244442 |
Method for making devices using polyhydroxyalkanoate having pyrogen removed
Polyhydroxyalkanoates (PHAs) from which pyrogen has been removed are provided for use in numerous biomedical applications. PHAs which have been chemically modified to enhance physical and/or...
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7241813 |
End-capped polymers and compositions containing such compounds
End-capped polymers, methods for making those end-capped polymers and compositions containing those end-capped polymers are disclosed. One of the disclosed end-capped copolymers has the formula:
...
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7241458 |
Antiviral compositions
The present invention is concerned with pharmaceutical compositions of antiviral compounds which can be administered to a mammal, in particular a human, suffering from a viral infection. These...
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7229973 |
pH-sensitive polymeric micelles for drug delivery
Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug...
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7229642 |
Amino acid modulated extended release dosage form
Disclosed herein is a oral extended release dosage form comprising a plurality of granules of an effective amount of a pharmaceutically active compound, at least one amino acid, and an...
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7226617 |
Thermosensitive and biodegradable microgel and a method for the preparation thereof
The present invention provides a thermosensitive and biodegradable microgel and a method of synthesizing such microgels. The thermosensitive and biodegradable microgel is synthesized from a...
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7226616 |
Positively charged amphiphilic block copolymer as drug carrier and complex thereof with negatively charged drug
The present invention provides a cationic group-containing amphiphilic block copolymer that is biocompatible and biodegradable, and when used as a drug carrier for an anionic drug, provides several...
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7214366 |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
Water soluble activated polymers are provided containing an active ethyl sulfone moiety having a reactive site located at the second carbon from the sulfone group. In an embodiment, a poly(ethylene...
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7208460 |
Multi component controlled delivery system for soap bars
The present invention relates to an improved controlled delivery system that can be incorporated in soap bars to enhance deposition of active ingredients and sensory markers onto skin. The carrier...
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7204997 |
Responsive microgel and methods related thereto
A responsive microgel is provided which responds volumetrically and reversibly to a change in one or more aqueous conditions selected from the group consisting of (temperature, pH, and ionic...
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7202230 |
Use of hyaluronic acid derivatives in the preparation of biomaterials with a physical haemostatic and plugging activity
The present invention describes the use of polysaccharide derivatives for the preparation of biocompatible and biodegradable biomaterials with absorbent properties for body fluids and physical...
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7192607 |
Formulations for the prevention or the treatment of diseases affecting mucosae or skin, or for pregnancy prevention, and an applicator for the delivery of topical formulations into mucosal cavities
This invention relates to formulations for the prevention of infection and/or abnormal conditions of mucosae and/or skin caused by any pathogen and/or any disease, and more particularly for the...
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7193007 |
Environment responsive gelling copolymer
The invention relates to a gelable copolymer composition comprising a copolymer in a solvent. The copolymer has the structure A(B)n, wherein the core (A) is soluble in the solvent, the arms (B) are...
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7189413 |
Drug delivery of proteins from polymeric blends
Degradable blend of polycaprolactone and crystallization modifier especially suitable for use in the controlled release of biologically active proteins
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7182957 |
Polymer blends that swell in an acidic environment and deswell in a basic environment
A polymer blend is prepared by dissolving chitosan and a second polymer in an acidic aqueous solution to form an aqueous polymer blend, dehydrating said aqueous polymer blend, and recovering said...
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RE39497 |
Storage of materials
A material or mixture of materials which is not itself storage stable is rendered storage stable by incorporation into a water-soluble or swellable glassy or rubbery composition which can then be...
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7179487 |
Hydrogels of water soluble polymers crosslinked by protein domains
A stimuli-responsive, hybrid hydrogel wherein the bulk of the polymer is made up of relatively inexpensive water soluble polymer strands crosslinked by protein domains. The responsiveness of the...
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7176256 |
Biocompatible crosslinked composition
Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups....
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7169318 |
Imbibed organic liquids, especially halogenated organics
Solid composition has an organic spill absorbing material in which is absorbed certain of a liquid organic compound or composition. The organic spill absorbing material can be water insoluble,...
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7169411 |
Composition for delivery of biological agents and methods for the preparation thereof
A composition for facilitating delivery of biological agents, comprising a therapeutic or diagnostic agent and a supramolecular complex, the latter comprising (i) a block copolymer, having at least...
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7166302 |
Complexing agents for compositions containing inclusion complexes
The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the...
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7166303 |
Anesthetic formulations
Propofol solubilised in aqueous micellar preparations of poloxamers is stable at low concentrations and that such preparations are effective administration forms for Propofol.
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7163694 |
Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them
Bioerodible poly(ortho esters) useful as orthopedic implants or vehicles for the sustained delivery of pharmaceutical, cosmetic and agricultural agents from dioxane-based di(ketene acetals). Block...
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7163695 |
Histidine copolymer and methods for using same
The invention provides a pharmaceutical agent delivery composition comprising: (i) a transport polymer comprising a linear or branched peptide having from about 10 to about 300 amino acid residues,...
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7163926 |
Adjuvant-containing vaccines
This invention provides a DNA vaccine which comprises a naked DNA incorporating and expressing in vivo a nucleotide sequence encoding an antigenic polypeptide, preferably a gene of a pathogenic...
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7163696 |
Pharmaceutical formulations
The invention provides a controlled-release pharmaceutical formulation for oral administration comprising...
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7160557 |
Matrices formed of polymer and hydrophobic compounds for use in drug delivery
A lipid or other hydrophobic or amphiphilic compound (collectively referred to herein as “hydrophobic compounds”) is integrated into a polymeric matrix for drug delivery to alter drug release...
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