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5405616 |
Means for containing active substances, having a shell of hydrophilic macromolecules, active substances and process for preparation thereof
The invention is directed to exactly dosable molded particles, for example granulates or pellets comprising hydrophilic macromolecules, active materials and additionally further pharmaceutically...
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5405617 |
Aliphatic or fatty acid esters as a solventless carrier for pharmaceuticals
A physicochemically stable pharmaceutical matrix composition is provided comprising: a pharmaceutical active and a water insoluble aliphatic or fatty acid ester, preferably stearyl stearate; a...
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5401502 |
Pellets containing plant extracts, process of making same and their pharmaceutical peroral or cosmetic use
Plant extract containing pellets are formed by a dispersion of plant extract or extracts in a matrix, principally comprising a skeleton builder namely collagen, gelatin, fractionated gelatin, a...
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5399359 |
Controlled release oxybutynin formulations
A solid oral sustained release oxybutynin formulation includes a sustained release matrix including a gelling agent, an inert pharmaceutical diluent, and a cationic cross-linking agent.
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5399358 |
Sustained release formulations for 24 hour release of metroprolol
A sustained release oral solid dosage form of metoprolol pharmaceutical formulation includes a sustained release excipient including a gelling agent, an inert pharmaceutical diluent, a cationic...
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5399362 |
Once-a-day metoprolol oral dosage form
A sustained release oral solid dosage form of metoprolol pharmaceutical formulation includes a sustained release excipient including a gelling agent, an inert pharmaceutical diluent, a cationic...
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5391375 |
Transdermal therapeutical system with physostigmine as active component and process for the production thereof
The present invention relates to a transdermal therapeutical system for the administration of physostigmine to the skin via a backing layer which is impermeable to active substances, an active...
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5387415 |
Aloe vera juice containing pellets process for production thereof and the use thereof as pharmaceutical, cosmetic and peroral agents
Aloe vera juice containing pellets are formed by a dispersion of aloe vera juice in a matrix, principally comprising a skeleton builder namely collagen, gelatin, fractionated gelatin, a collagen...
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5384129 |
Pellets containing dihydropyridine derivatives process for the production thereof and use as rapid action dosage in heart and circulatory diseases
The present invention is directed to dihydropyridine derivative containing pellets comprising a dispersion of the dihydropyridine derivatives in a matrix which is substantially formed of a skeleton...
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5380535 |
Chewable drug-delivery compositions and methods for preparing the same
A non-aqueous, chewable composition for oral delivery of unpalatable drugs is provided along with preparative methods therefor. The composition contains the drug intimately dispersed or dissolved...
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5362497 |
Transdermal therapeutic composition
When a transdermal therapeutic composition which contains a pharmaceutically effective ingredient, a water-soluble absorption enhancer, a fat-soluble absorption enhancer and a super water-absorbent...
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5354561 |
Process for producing solid active substance forms and products thereof
A process is described for the production of solid forms of active substances, which forms have good redispersibility in aqueous systems, which comprises mixing PEG and dextran with water and--if...
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5342628 |
Drug diffusion polymer system and method
A drug diffusion polymer system for the sustained release of drugs includes a composition comprising a polymeric matrix containing a uniform dispersion of a matrix expander and a drug. The matrix...
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5340586 |
Methods and formulations for use in treating oophorectomized women
Compositions and methods which are effective to prevent symptoms of loss of ovarian function (e.g., in oophorectomized women) over a period of time are described, consisting essentially of an...
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5340584 |
Methods and formulations for use in inhibiting conception and in treating benign gynecological disorders
Compositions and methods which are effective to inhibit conception and to treat benign gynecological disorders for extended periods of time are described, wherein an effective amount of a...
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5336501 |
Cross-linked hydrogels and their use as wound dressings
The invention relates to a wound secretion absorbing hydrogel of the following composition: TBL ______________________________________ a) 20 to 70%-wt of at least one multivalent alcohol b) 10...
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5330764 |
Methods of preparing bulk delivery matrices by solid-state dissolution
A method is disclosed for preparing pharmaceutical and other matrix systems that comprises solidifying a matrix composition dissolved or dispersed in a first solvent and subsequently contacting the...
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5330763 |
Delivery matrices prepared by solid-state dissolution
A method is disclosed for preparing pharmaceutical and other matrix systems that comprises solidifying a matrix composition dissolved or dispersed in a first solvent and subsequently contacting the...
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5326572 |
Freeze-dried polymer dispersions and the use thereof in preparing sustained-release pharmaceutical compositions
Freeze-dried polymer latices, which can be reconstituted in water to give aqueous polymer dispersions having high polymer solids content, are described. The reconstituted polymer dispersions are...
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5320837 |
Controlled release preparations of active materials
A controlled release preparation of an active material comprising a reaction product obtained by reacting (a) a copolymer consisting essentially of maleic anhydride and at least one polyalkylene...
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5298261 |
Rapidly distintegrating tablet
A tablet that rapidly disintegrates in aqueous solution includes a partially collapsed matrix network that has been vacuum-dried above the collapse temperature of the matrix. The matrix is...
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5298257 |
Method for the treatment of withdrawal symptoms associated with smoking cessation and preparations for use in said method
A preparation for the once-daily, percutaneous administration of nicotine comprises nicotine uniformly distributed in a solid, semi-solid or mucilaginous medium which can be placed in intimate...
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5296512 |
Water-soluble pressure-sensitive skin adhesive, its use, and agents provided with it
A salt of an uncrosslinked copolymer of a monoethylenically unsaturated mono- or dicarboxylic acid and an alkyl ester of acrylic or methacrylic acid is suitable as a pressure-sensitive skin...
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5296227 |
Attractant decoy for controlling bont ticks
A decoy which includes the attraction, aggregation and attachment components of bont tick pheromones is used to attract hungry male, female, and nymph bont ticks to a location where an acaricide...
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5294439 |
Stabilized benzimidazole derivative and composition
A stabilized physiologically active benzimidazole derivative having the formula (I): ##STR1## wherein R 1 is hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a fluoroalkyl group having 1...
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5294446 |
Composition and method of promoting hard tissue healing
Osteoprogenitor cells encapsulated in alginate and alternatively, additionally encapsulated in poly-L-lysine and/or agarose promote regeneration of bone at the site of implantation. The present...
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5292518 |
Prolonged-release drug tablet formulations
A prolonged-release unit dosage formulation or pharmaceutical composition, preferably in tablet form, is described. The composition consists essentially of a gel-forming dietary fiber, a...
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5284659 |
Encapsulated flavor with bioadhesive character in pressed mints and confections
A confectionery compressed tablet designed to dissolve in the oral cavity and containing a flavor ingredient intimately bound with a bioadhesive is disclosed. The flavor and bioadhesive composition...
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5277915 |
Gel-in-matrix containing a fractured hydrogel
A three dimensional porous matrix, such as a reticulated open-cell foam, having within its matrix structure a mechanically-fractured hydrogel containing a network of fracture channels. The...
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5271943 |
Wound gel compositions containing sodium chloride and method of using them
Therapeutic gels are provided which promote the healing of wounds and which have a minimum yield point of about 800 poise and a maximum apparent viscosity of about 100,000 cps, which gels comprise...
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5262171 |
Pharmaceutical tablet with PVP having enhanced drug dissolution rate
A pharmaceutical tablet is provided herein having an effective dissolution rate. The tablet contains a pharmaceutically-active ingredient and a substantially linear, i.e. non-crosslinked K-30 to...
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5256418 |
Collagen constructs
The present invention provides collagen constructs and methods of making and using such constructs. The present invention also provides tissue equivalents having improved characteristics and...
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5240712 |
Therapeutic agents
A high content of 2-(4-isobutylphenyl)propionic acid is achieved in a pharmaceutical composition by solidifying molten 2-(4-isobutylphenyl)propionic acid to provide a unit dose composition. The...
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5238681 |
Insect bait station
An insect bait station comprising a first compartment with a hydrated macel containing at least one species of entomopathogen and a second compartment containing a hydrated water retentive compound...
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5236703 |
Polymeric substrates containing povidone-iodine as a control release biologically active agent
A polymeric substrate such as rubber or latex incorporates povidone-iodine as a control release biologically active agent.
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5215756 |
Preparation of pharmaceutical and other matrix systems by solid-state dissolution
A method is disclosed for preparing pharmaceutical and other matrix systems that comprises solidifying a matrix composition dissolved or dispersed in a first solvent and subsequently contacting the...
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5213808 |
Controlled release article with pulsatile release
An article for controlled delivery of an active substance into an aqueous phase has a first layer containing an active substance, and a second layer of a crystalline polymer matrix and a non-ionic...
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5212154 |
Preparation for treating complications in diabetes
Preparation for preventing or combating complications in diabetes, characterized in that it comprises: (a) insulin or a salt or complex thereof, and (b) a peptide of the general formula I: ...
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5211952 |
Contraceptive methods and formulations for use therein
Contraceptive devices which are effective for extended periods of time are described, in the form of means for releasing an effective amount of a gonadotropin hormone releasing hormone composition...
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5194253 |
Aqueous gel, usable in cosmetics, based on hyaluronic acid and deoxyribonucleic acid, and a preparation process
An aqueous gel based on hyaluronic acid and on deoxyribonucleic acid usable in cosmetics, and a method of preparation. The invention relates to an aqueous gel formed by a homogeneous mix of: a)...
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5169633 |
Continuous release phenylethanolamine derivative compositions
The invention relates to compositions for the parenteral administration of an essentialy uniform and continuous amount of a phenylethanolamine derivative over an extended period of time. The...
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5169639 |
Controlled release verapamil tablets
Controlled release verapamil tablets are disclosed. The tablets include an excipient having a hydrophilic material, preferably containing a mixture of xanthan gum/locust bean gum, and an inert...
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5154927 |
Gum composition containing dispersed porous beads containing active chewing gum ingredients and method
A chewing gum that contains porous polymeric beads impregnated with active gum ingredients together with a method of making such a chewing gum.
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5147651 |
Hoof pack of polyolefin fiber and pine tar
There is disclosed a composition useful for medicated treatment of hooves of live animals. The composition comprises a major portion of a carrier and hoof penetrant, a minor amount of a filler...
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5141744 |
Insecticide delivery system and attractant
An insecticidal composition in the form of a hydrated macrogel containing at least one species of entomopathogen and a hydrated water retentive compound which acts as a water-reservoir for the...
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5124151 |
Drug delivery by injection with thermo-irreversible gels
Balanced pH, thermo-irreversible gels are ideal vehicles for drug injection into the body of a mammal.
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5118511 |
Aqueous or pulverulent, water-dispersible preparation of a sparingly water-soluble pharmaceutical active compound and its preparation
An aqueous or pulverulent, water-dispersible pharmaceutical preparation which contains an emulsifier, a protective colloid and, in microdisperse form, an edible oil or fat, a sparingly...
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5118528 |
Process for the preparation of dispersible colloidal systems of a substance in the form of nanoparticles
The process according to the invention comprises: (1) the preparation of a liquid phase consisting essentially of a solution of the substance in a solvent or in a mixture of solvents to which may...
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5100674 |
Process for preparing an effervescent aqueous solution having an emollient action on the cuticle of the nails, composition for carrying out the said process and corresponding cosmetic treatment
Preparation of an effervescent aqueous solution which has an emollient action on the cuticles of the nails, by dissolving the following anhydrous solid compounds substantially simultaneously in...
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5100668 |
Controlled release systems containing heparin and growth factors
A system for stabilizing fibroblast-derived growth factors, maintaining their bioactivity over a prolonged period of time and controllably releasing them for use is disclosed. The system uses...
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