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6641836 |
Process for enhancing immune response in canines using a dietary composition including garlic
A composition and method for enhancing immune response and improving the overall health of canines is provided which includes feeding the canines a dietary composition containing an effective...
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6641831 |
Medical products with sustained pharmacological activity and process for producing them
A non-degradable medical product comprising at least two substances or groups of substances, of which a first substance is referred to as substance A and a second is referred to as substance B,...
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6638537 |
Microemulsion and micelle systems for solubilizing drugs
A microemulsion delivery system for water insoluble or sparingly water soluble drugs that comprises a long polymer chain surfactant component and a short fatty acid surfactant component, with the...
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6635267 |
Hyaluronic acid gel, process for the preparation thereof and medical materials containing the same
A gel made of hyaluronic acid alone which is hardly soluble in a neutral aqueous solution and has fluidity enough to be easily ejectable from an injector.
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6635236 |
Method for treating podotrochlosis
A method for treating podotrochlosis (navicular disease/navicular syndrome) in the foot of a horse is disclosed. The method comprises identifying the specific area(s) of the horse's foot affected...
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6632452 |
Medicinal compositions retarded in the discoloration of phenolic hydroxyl compounds
Coloring change of a pharmaceutical composition containing a compound having a phenolic hydroxyl group, such as an anti-inflammatory agent or an antioxidant having a phenolic hydroxyl group or the...
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6632451 |
Delayed total release two pulse gastrointestinal drug delivery system
A two pulse gastrointestinal delivery system is provided. The system comprises a desired agent in combination with a swellable core material, the core being surrounded by an inner coat of a...
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6632446 |
Coating substrates by polymerizing macromers having free radical-polymerizable substituents
Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions...
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6630171 |
Particles based on polyamino-acid(s) and methods for preparing same
The invention concerns delivery particles (DP's) for active principles (AP's) based on linear amphiphilic polyamino-acids (PAA's), with α-peptide chains, capable of being spontaneously formed by...
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6630157 |
Therapeutic and dietary compositions containing essential fatty acids and bioactive disulphides
Compostions of GLA and/or other EFAs with TA or related compounds, and their use in therapy or nutrition or in preparation of composition for therapy or nutrition, especially to improve cell...
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6630153 |
Manufacture of bone graft substitutes
The present invention is directed to methods and compositions for manufacturing a bone graft substitute. A powder compaction process is utilized to generate a shaped product comprised of a...
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6630167 |
Hyaluronic acid anti-adhesion barrier
Methods of forming crosslinked hyaluronic acid anti-adhesion barriers, crosslinked hyaluronic acid anti-adhesions barriers, methods for preventing or inhibiting adhesions, and methods of promoting...
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6627631 |
Pharmaceutical composition containing desoxypeganine for the treatment of alcoholism
Desoxypeganine and its pharmaceutically acceptable acid addition salts can be used in the treatment of alcoholism. Said substances are administered preferably in a continuos and controlled manner....
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6627215 |
Devices for improved wound management
The present invention provides devices and compositions for the management of infection of topical lesions, each of the devices and compositions containing protonated/acidified nucleic acids either...
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6623748 |
Reverse phase connective tissue repair composition
A biocompatible connective tissue repair composition which comprises a therapeutic material and a carrier comprising a means for achieving reverse phase characteristics, and methods for using said...
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6620429 |
Use of basic alkali metal salts for manufacturing transdermal therapeutic system
A process for manufacturing transdermal systems comprising free active substance bases is characterized in that the free active substance base is liberated, during the manufacture of the system,...
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6620435 |
Compositions for topical application of therapeutic agents
The present invention generally relates to pharmaceutical compositions that enable control of drug, delivery properties and the development of optimal drug delivery strategies customized for...
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6620432 |
Phenytoin sodium pharmaceutical compositions
A pharmaceutical composition is provided containing an admixture of phenytoin sodium and an erodible matrix which extends the release of the phenytoin sodium over about a two hour period. The...
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6620422 |
Compositions containing a peptide and polylactic-glycolic acid suitable for preparing subcutaneous implants with an extended release period
Compositions comprising a peptide and polylactic-glycolic acid (PLGA) wherein the distribution of the size of the particles of the peptide in the PLGA results highly heterogeneous, suitable to the...
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6616944 |
Self-assembling colloidal carriers for protein delivery
The invention is directed to self-assembling, polymer-based delivery systems for proteins. The delivery systems comprises an active agent and a polyol ester of the invention, having a linear polyol...
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6607752 |
Method for the anhydrous loading of nicotine onto ion exchange resins
An environmentally friendly method of loading nicotine onto cation exchange resins under anhydrous conditions is described. The method eliminates many of the processing problems that are associated...
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6605303 |
Oral pharmaceutical extended release dosage form
An enteric coated pharmaceutical extended release dosage form of a H + , K + -ATPase inhibitor giving an extended plasma concentration profile of a H + , K + -ATPase inhibitor. The extended plasma...
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6602963 |
Polyesters containing (meth)acrylate end groups
The invention describes polyesters containing (meth)acrylate end groups, of the general formula (I) CH 2 ═CRCOO—PE—OCOCR═CH 2 where R=CH 3 or H, where PE=[—A—OCO—B—COO—] m...
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6599519 |
Biodegradable poly(alkylene oxide)-poly(p-dioxanone) block copolymer soluble in organic solvents, and drug delivery composition comprising same
The present invention relates to a biocompatible and biodegradable block copolymer of poly(alkylene oxide) and poly(p-dioxanone), which is soluble in organic solvents, and a drug delivery...
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6599534 |
Masking agent in powder form for pharmaceutical tastes
A masking agent for pharmaceutical tastes comprises a mixture of a sapid agent and an enhancer, in the form of an intimate mixture. The sapid agent/enhancer distribution is substantially...
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6599529 |
Modified release multiple-units compositions of non-steroid anti-inflammatory drug substances (NSAIDs)
An oral pharmaceutical modified release multiple-units composition for the administration of a therapeutically and/or prophylactically effective amount of a non-steroid anti-inflammatory drug...
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6599931 |
Test system for characterizing the compatibility of bioactive substances and polyvinylpyrrolidone
A test system for characterizing the compatibility of bioactive substances with polyvinylpyrrolidones in a solid dispersion consisting of one or more bioactive substances and...
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6596540 |
Method for introduction of an exogenous genetic substance or a physiologically active compound
A novel method for introduction of an exogenous substance or a physiologically active compound into cells is provided according to this invention. This method can realize introduction of an...
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6596293 |
Polyurethane-biopolymer composite
A method is provided for preparing a drug delivery material and device comprising cross-linking a biological polymer with a cross-linking agent and loading the cross-linked biopolymer with a...
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6596308 |
Controlled release pharmaceutical composition
A sustained/prolonged release pharmaceutical dosage form is disclosed. The form comprises a hard shell capsule and a formulation comprising (a) a water insoluble medicant, (b) a high melting fatty...
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6592885 |
Method for making infection-resistant fabricated textile articles for biomedical applications
The present invention provides a method for making an infection-resistant fabricated textile article which is suitable for any in-vivo usage either as a topical bandage, on an implantable...
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6592898 |
Bioadhesive compositions comprising hydrophobic polymers
Bioadhesive compositions which comprise a hydrophobic polymer wherein the concentration of the polymer at the surface of the adhesive is greater than its concentration in the bulk of the adhesive...
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6592860 |
Composition and applicator for topical substance delivery
A polymerized hydrogel composition and applicator for hydrating or dehydrating a surface, particularly a dermatological surface, to which it is applied and a method for forming the composition. The...
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6592899 |
PLA/PLGA oligomers combined with block copolymers for enhancing solubility of a drug in water
Polymeric compositions having improved capability of solubilizing a drug in a hydrophilic environment to form a solution, comprising: a biodegradable polyester oligomer; and biodegradable AB-type,...
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6592900 |
Stabilized polyvinylpyrrolidone formulation
Preparations in powder form comprising or consisting of soluble or insoluble polyvinylpyrrolidone and/or polyvinylpyrrolidone copolymers and suitable as aid for pharmaceutical formulations comprise...
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6592902 |
Controlled release eplerenone compositions
The invention relates to oral pharmaceutical compositions useful as aldosterone receptor blockers comprising the active agent micronized eplerenone in an amount of about 10 mg to about 1000 mg and...
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6592893 |
Transdermal patch and topical compositions comprising propylnorapomorphine
A pharmaceutical composition is characterized by: an active principle selected from one or more components of the group consisting of R(−)-propylnorapomorphine hydrochloride,...
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6589558 |
Photoablatable lenticular modulator
Photoablatable modulator for use in Laser ablation processes on the cornea consisting of a mixture of collagen and vegetable gelatins which is formed in situ on the corneal surface to be treated. A...
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6589557 |
Porous celecoxib matrices and methods of manufacture thereof
Celecoxib is provided in a porous matrix form wherein the dissolution rate of the drug is enhanced when the matrix is contacted with an aqueous medium. The porous matrix yields upon contact with an...
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6589998 |
Gel composition for filling a breast milk duct prior to surgical excision of the duct or other breast tissue
The invention is a gel composition for delivery to a breast milk duct prior to surgical excision of breast tissue including cancerous lesions. The invention also provides methods of mapping all or...
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6589556 |
Rapid-melt semi-solid compositions, methods of making same and methods of using same
A novel rapid-melt, semi-solid molded composition, including methods of making the same, and methods of using the same for the delivery of prophylactic and therapeutic active materials to a mammal...
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6589590 |
Composite material and methods of making the same
A method of making artificial bone comprises providing a membrane of collagen with solutions of calcium ions and of phosphate ions on opposite sides of the membrane. The calcium ions and phosphate...
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6589546 |
Polymeric coatings for controlled delivery of active agents
Implantable medical device having a structure adapted for introduction into a patient wherein the structure is composed of a base material positioned over the structure. The implantable medical...
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6589550 |
Methods of producing intraocular lenses and materials suitable for their production
A method for producing an intraocular lens, comprising the steps of injecting a high-refractive index, low viscosity composition of crosslinkable units into an enclosure and initiating...
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6589562 |
Multicomponent biodegradable bioadhesive controlled release system for oral care products
The present invention relates to a controlled release system useful for site'specific delivery of biologically active ingredients or sensory markers, over an extended period of time, targeting...
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6585960 |
Abrasive silica compositions and dentifrice compositions prepared therefrom
Silica compositions for abrasive systems in dentifrice formulations are disclosed. The silica abrasive system comprises (a) silica gels having a median particle size below 7 microns, a pH of from...
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6586007 |
Polyolefin additive composition comprising 3,4-dimethyl dibenzylidene sorbitol and rho-methyl dibenzylidene
A specific combination of two different polyolefin clarifying and nucleating agents, namely 3,4-dimethyldibenzylidene sorbitol and p-methyldibenzylidene sorbitol is provided. Such a combination...
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6586006 |
Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
The present invention encompasses solid dose delivery systems for administration of guest substances. Preferred delivery systems are suitable for delivery of bioactive materials to subcutaneous and...
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6585993 |
Controlled release neurotoxin system
A biocompatible implant for continuous in vivo release of a neurotoxin over a treatment period extending from one month to five years. The implant can be made of casting a solution of a polymer,...
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6586011 |
Microencapsulated plasminogen activators
A drug delivery system which includes a plurality of microcapsules, each microcapsule containing a plasminogen activator entrapped in a biocompatible, biodegradable, substantially water-soluble...
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