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6528089 |
Method for producing solid dosing forms
Solid dosage forms are obtained by mixing at least one polymeric binder, at least one active ingredient, and, where appropriate, conventional additives to form a plastic mixture, and shaping, using...
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6524607 |
Formulations and methods for providing prolonged local anesthesia
A formulation and methods for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible,...
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6524611 |
Compositions containing creatine and creatinine
A composition for human consumption, comprising creatine and creatinine, the latter being in sufficient quantity to render creatine in an aqueous medium substantially stable, and a method of making...
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6521265 |
Method for applying a blood clotting agent
A method of arresting the flow of blood and other protein containing body fluids flowing from an open wound and for promoting wound healing. In the method, a substantially anhydrous compound of a...
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6521244 |
Body filling material
A body filling agent is formed of a collagen in the form of powder, fiber or gel, and at least one kind of implantable particles selected from a group consisting of implantable polymer and...
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6521431 |
Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments
Biodegradable cross-linkers are provided having a polyacid core with at least two acidic groups covalently connected to reactive groups usable to cross-link polymer filaments. Between at least one...
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6521258 |
Polymer matrices prepared by supercritical fluid processing techniques
Polymer matrices for use in orthopedic, pharmaceutical, and similar mixtures are prepared by mixing two or more polymers and a process medium in a reactor to form a supercritical fluid slurry. The...
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6521257 |
Gelled compositions
A gelled composition was provided by adding a gelling component to a carrier for adsorption. Not only was the taste of the carrier for adsorption significantly reduced in this composition, but the...
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6521253 |
Immediate release tablet
A new oral IR formulation in solid form for a low molecular weight thrombin inhibitor having pH dependant dissolution, characterized in that the formulation comprises a filler or a combination of...
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6517869 |
Positively charged poly(alpha-(omega-aminoalkyl)lycolic acid) for the delivery of a bioactive agent via tissue and cellular uptake
A biodegradable, positively-charged aminoalkyl polyester polymer for the delivery of bioactive agents, such as DNA, RNA, oligonucleotides is disclosed. Biologically active moieties, such as drugs,...
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6517825 |
Polyether-based bile acid sequestrants
The present invention relates to a method for sequestering bile acids in a patient and to particular polymers for use in the method. The invention further relates to a method for reducing blood...
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6517866 |
Sertraline salts and sustained-release dosage forms of sertraline
Sustained release dosage forms of sertraline which release sertraline at a rate between 1 mgA/hr and 40 mgA/hr. The dosage forms may exhibit an initial delay period during which sertraline is...
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6517858 |
Bioactive prostheses with immunosuppressive, antistenotic and antithrombotic properties
The invention relates to a bioactive implant comprising a substrate coated with a polymer layer with reactive functions, and a bioactive substance fixed on the implant by means of said reactive...
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6514518 |
Dosage forms exhibiting multi-phasic release kinetics and methods of manufacture thereof
Dosage forms prepared by solid free form fabrication (SFF) provide release of medicament in multiple phases.
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6514514 |
Device and method for regeneration and repair of cartilage lesions
Disclosed is a cartilage repair product that induces both cell ingrowth into a bioresorbable material and cell differentiation into cartilage tissue. Such a product is useful for regenerating...
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6514535 |
Bioadhesive hydrogels with functionalized degradable crosslinks
This invention relates to A bioadhesive composition comprising two or more essentially excretable, essentially non-degradable polymer backbones, wherein the polymer backbones are crosslinked, said...
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6511958 |
Compositions for regeneration and repair of cartilage lesions
Disclosed is a cartilage repair product that induces both cell ingrowth into a bioresorbable material and cell differentiation into cartilage tissue. Such a product is useful for regenerating...
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6509039 |
Crosslinked products of biopolymers containing amino groups
The invention relates to cross linked products of chitosan or gelatin and of a carboxylic acid di- or polyanhydride. These products form hydrogels with a wide variety of applications, preferably in...
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6503536 |
Granulates of hexahydropyrazine derivatives which can be administered orally
The present invention relates to the preparation of orally administrable granules of hexahydropyrazine derivatives by mixing the active compound in the presence of suitable solvents with...
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6503534 |
Pharmaceutical compositions for prolonged peptide release and preparation method
Solid or semisolid pharmaceutical composition comprising a gellable and water-soluble peptide salt optionally combined with an appropriate excipient, said pharmaceutical composition being...
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6503761 |
Selective removal of contaminants from a surface using articles having magnets
A system and method for removing contaminants from a surface. The system is designed to use particles having means thereon which are capable of selectively binding to a contaminant or contaminants...
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6503954 |
Biocompatible carrier containing actinomycin D and a method of forming the same
A biocompatible carrier and a composition for forming the carrier are disclosed. The carrier is made from an ethylene vinyl alcohol copolymer which can serve as a reservoir, allowing for the local...
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6504079 |
Terminally sterilized osteogenic devices and preparation thereof
Disclosed are terminally sterilized osteogenic devices for implantation into a mammal. The devices contain a combination of a biologically active osteogenic protein and an insoluble carrier which...
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6503553 |
Processed dairy products
A range of products and methods are based on a creamy base of cream, artificial cream, thickened cream, cream cheese, mixtures thereof and mixtures with compatible incidental ingredients, the...
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6500452 |
Energy-enhancing supplement
A composition for a dietary supplement supplies components to increase the cellular formation of ATP, and thus provide energy for cellular activity. Active ingredients include 4-aminobenzoic acid,...
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6500456 |
Compressed nitroglycerin tablet and its method of manufacture
The present invention is directed to a stable nitroglycerin containing pharmaceutical composition, preferably a tablet which is prepared by direct compression technology. The formulation closely...
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6497902 |
Ionically crosslinked hydrogels with adjustable gelation time
Biocompatible hydrogels, for: scaffoldings for tissue engineering; cell encapsulation matrices; injectable bulking materials for cosmetic and functional restorations; controlled release matrices;...
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6497890 |
Anti-wrinkle preparation and method of reducing wrinkles in facial skin and neck
A method for the prevention or minimization of wrinkles in the face and neck areas of a patient by topically applying to the face and neck areas of a patient finely divided safflower seeds or...
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6497899 |
Rapidly disintegrating and fast-dissolving solid dosage form
Described are non-friable, rapidly disintegrating, fast-dissolving solid dosage forms that are produced from pharmaceutically acceptable steam extruded polymers. The solid dosage forms dissolve in...
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6497891 |
Make-up compositions
Cosmetic compositions comprising, in a cosmetically acceptable medium, at least one film-forming polymer and at least one water-superabsorbent polymer in the form of water-swelled particles, the...
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6491904 |
Topical composition containing human epidermal growth factor
The present invention relates to a topical composition containing human epidermal growth factor (hEGF) and polyoxyethylene-polyoxypropylene copolymer having a viscosity of 4-10 cps at 37° C, 60...
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6491948 |
Composition comprising isoquercetin and ascorbic acid in a sustained release form
The present invention relates to novel, orally administered compositions comprising two redox systems: reduced ascorbic acid in a sustained release form and oxidized isoquercetin with an increased...
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6491952 |
Cholesterol lowering composition
The present invention concerns a composition containing a cholesterol lowering component such as β-sitosterol and/or β-sitostanol in a monomolecular, low associated or “cluster” form, where a...
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6488965 |
Synergistic antimicrobial preparations containing chlorite and hydrogen peroxide
Antimicrobial/pharmaceutical preparations (e.g., solutions, gels, ointments, creams, sustained release preparations, etc.) which comprise chlorite (e.g., a metal salt of a chlorite) in combination...
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6488962 |
Tablet shapes to enhance gastric retention of swellable controlled-release oral dosage forms
The retention of oral drug dosage forms in the stomach is improved by using swellable dosage forms that are shaped in a manner that will prevent them from inadvertently passing through the pylorus...
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6485749 |
Absorbable &egr -Caprolactone polymers and medical devices
Crystalline, low melting ε-Caprolactone polymers which undergo accelerated hydrolysis, and their use as lubricant coatings and/or as coatings containing bioactive agents, as carriers of viable...
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6485735 |
Multilayer thermoset polymer matrix and structures made therefrom
A composite thermoset polymer matrix structure having a plurality of homogeneously bonded thermoset polymer layers and a method of forming the same is disclosed. Each of the layers is formed from...
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6482433 |
Encapsulation of active ingredients
A process for preparing free-flowing and, during handling, dust-free microparticles. The particles are at least 90% by weight, have a diameter of 100-400 μm, and contain one or more active...
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6482864 |
Sustained-release preparation of physiologically active polypeptide and production thereof
A method for producing a sustained-release preparation, which comprises dispersing a physiologically active polypeptide into an organic solvent solution of a biodegradable polymer and removing the...
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6479076 |
Nicotine delivery compositions
A composition containing nicotine and an uncrosslinked, water-insoluble vinylpyrrolidone copolymer is applied on the skin of patients in the form of a gel, ointment, solution, suspension or film...
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6479073 |
Pressure sensitive adhesive articles and methods for preparing same
An article that includes a substrate having a surface, at least a portion of which is provided with a pressure sensitive adhesive composition that includes a blend of discrete, crosslinked polymer...
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6479545 |
Formulation for menopausal women
The present disclosure relates to novel compositions which provide improved nutritional support for premenopausal and menopausal women and/or relief from symptoms associated with menopause, as well...
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6475500 |
Anhydrous cosmetic compositions
An anhydrous skin treatment composition is provided which includes a crosslinked siloxane elastomer gel of specific yield point, a skin conditioning agent and a volatile siloxane. Inclusions of the...
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6475779 |
Polymeric gene delivery
A means for obtaining efficient introduction of exogenous genes into a patient, with long term expression of the gene, is disclosed. The gene, under control of an appropriate promoter for...
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6475516 |
Drug delivery via therapeutic hydrogels
The present invention is directed to a vehicle for effecting drug delivery from a solid substrate. Hydrogels loaded with liposomal therapeutic agents such as antibiotics are covalently bonded to...
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6475521 |
Biphasic controlled release delivery system for high solubility pharmaceuticals and method
A biphasic controlled release delivery system for pharmaceuticals which have high water solubility, such as the antidiabetic metformin HCl salt, is provided which provides a dosage form that has...
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6471970 |
Use of pharmaceutical compositions capable of being gelled in periodontology
A method is described for preparing a fluid pharmaceutical composition which allows the controlled release of at least one active substance. The method involves mixing a therapeutically effective...
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6471992 |
Dosage form exhibiting rapid disperse properties, methods of use and process for the manufacture of same
A rapidly dispersing dosage form is described, which releases its active ingredients within a period of less than about ninety seconds. These dosage forms exhibit a three-dimensional shape that is...
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6471993 |
Three-dimensional polymer matrices
Matrices that include a macrostructure having a semi-solid network and voids, and a microstructure having voids, in which the microstructure is located within the semi-solid network are disclosed....
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6471983 |
Skin application agents
The present invention relates to a skin application agent containing a polyisoprene latex.
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