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6899896 |
Hydrogel-driven layered drug dosage form
A controlled release dosage form for sertraline has a core comprising a sertraline-containing composition and a water-swellable composition wherein the water-swellable composition is in a separate...
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6893661 |
Controlled release formulations using intelligent polymers
An extended release dosage composition of pharmaceutically active substances that have a water contact angle (θ) such that cos θ is between +0.9848 and −0.9848 presented as a matrix tablet...
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6893662 |
Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures
The present invention relates to a pharmaceutical composition in a solid unit dosage form for oral administration in a human or lower animal comprising: a. a safe and effective amount of a...
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6890561 |
Microencapsulated and controlled-release formulations of isoflavone from enriched fractions of soy and other plants
There is provided an orally-administrable formulation for the controlled release or stable storage of a granulated isoflavone-enriched fraction or mixture of such fractions, comprising at least one...
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6869615 |
Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor
An oral solid dosage form includes a therapeutically effective amount of an NSAID and a proton pump inhibitor in an amount effective to inhibit or prevent gastrointestinal side effects normally...
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6861069 |
Production of a directly compressible tabletting aid
The invention relates to directly compressible tabletting aids with a xylitol content of more than 90% by weight and a content of at least one other polyol of less than 10% by weight, which are...
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6844172 |
Amylose products as matrix former for programmed release systems, process for preparing these amylose products, and process for making programmed release systems
The invention relates to matrix-forming amylose products for programmed release systems and a process for the preparation thereof. These amylose products have a dextrose equivalent (DE) of 5 to 10,...
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RE38629 |
Solid oral dosage form comprising a combination of metformin and glibenclamide
The present invention relates to a solid oral dosage form comprising a combination of metformin and glibenclamide in which the size of glibenclamide is such that the glibenclamide bioavailability...
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6790459 |
Methods for treating diabetes via administration of controlled release metformin
A method for treating patients having non-insulin-dependent diabetes mellitus (NIDDM) by administering a controlled release oral solid dosage form containing preferably a biguanide drug such as...
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6783773 |
Composition comprising amoxicillin and potassium clavulanate
Bacterial infections may be treated using a high dosage regimen of amoxicillin and potassium clavulanate. Preferably, the dosage is provided by a bilayer tablet.
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6756056 |
Treatment of Parkinson's disease and related disorders by novel formulations of the combination carbidopa-levodopa
An oral antiparkinson drug delivery system consisting of carbidopa and levodopa in immediate and sustained release compartments provides a significant clinical advantage over currently available...
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6746874 |
Reagent preparation containing magnetic particles in tablet form
Subject matter of the invention is a reagent preparation for binding components of a sample in the form of a tablet comprising a multitude of magnetic particles which are held together with the aid...
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6746692 |
Modified release pharmaceutical formulation comprising amoxycillin
Bacterial infections may be treated using a high dosage regimen of amoxycillin and potassium clavulanate. Preferably, the dosage is provided by a bilayer tablet.
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6733782 |
Core tablet for controlled release of gliclazide after oral administration
The invention relates to a matrix tablet for the prolonged release of gliclazide which ensures continuous and consistent release of the active ingredient after administration by the oral route, the...
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6723346 |
Process for preparing spray granules containing riboflavin
The invention is concerned with a novel process for the manufacture of flowable, non-dusty, binder-free riboflavin granulates by subjecting an aqueous suspension of riboflavin crystals of crystal...
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6720004 |
Controlled release formulation of divalproex sodium
A new oral polymeric controlled release formulation suitable for the once-a-day administration of valproate compounds, such as divalproex sodium, has been discovered. This formulation exhibits...
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6716453 |
Method for increasing the active loading of compressible composition forms
A process for increasing the percentage of active ingredient relative to non-active excipient in a compressible formulation, and also for reducing tablet size, by excluding an amount of the...
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6713509 |
Controlled release formulation for treating COPD
This invention relates to a controlled or sustained release formulation designed to deliver a PDE4 inhibitor for treating an inflammatory disease such as asthma or COPD and the like.
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6706284 |
Bitterness-reduced oral pharmaceutical composition
The invention relates to an oral pharmaceutical composition which has excellent drug release-controlling ability in the mouth even 5 to 10 minutes after its administration and also has excellent...
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6696084 |
Spray drying process and compositions of fenofibrate
The present invention relates to a novel spray drying process for the preparation of pharmaceutical compositions containing small particles of phospholipid-stabilized fenofibrate. This invention...
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6692764 |
Wet granulation formulation for bisphosphonic acids
Pharmaceutical compositions of bisphosphonic acids, and salts thereof, are prepared by wet granulation tablet formulation. These pharmaceutical compositions are useful in the treatment of...
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6692768 |
Preparation method of drug-containing spherical fine particles
The present invention discloses an efficient preparation method of spherical fine particles containing a drug for an easily-swallowed, controlled-release preparation comprising the production of...
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6689386 |
Sustained release matrix for high-dose insoluble drugs
Sustained release dosage forms of high dose insoluble drugs such as ibuprofen and methods for their manufacture are disclosed.
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6682759 |
Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs
A method is disclosed for manufacturing a pharmaceutical tablet for oral administration, the tablet combining both immediate-release and prolonged-release modes of drug delivery and using an...
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6680070 |
Particulate blends and compacted products formed therefrom, and the preparation thereof
The dry blends comprise a powdery or finely-divided active ingredient such as a pharmaceutical, dietary supplement, agricultural chemical, water-treating agent or biocidal agent, and a micronized...
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6676967 |
Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia
Methods for reducing flushing in individuals being treated for hyperlipidemia with nicotinic acid are disclosed. According to the methods of the present invention, flushing can be reduced in...
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6669954 |
Controlled release of drugs
A device for controlled release of pharmaceutical agents and a method for use of the device. The drug delivery device comprises a covered container with an aperture and an aperture cover,...
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6663896 |
Delayed release aspirin for vascular obstruction prophylaxis
A method and controlled release oral unit dosage form of acetylsalicylic acid (aspirin) delays the release of the drug until a predetermined time interval after ingestion. This enables the drug to...
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6660300 |
Method of use of a biphasic controlled release delivery system for high solubility pharmaceuticals and method
A biphasic controlled release delivery system for pharmaceuticals which have high water solubility, such as the antidiabetic metformin HCl salt, is provided which provides a dosage form that has...
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6638533 |
Pulse dosage formulations of methylphenidate and method to prepare same
Dosage forms comprising pulse release formulations for oral administration of a Methylphenidate drug are provided. The dosage forms provide a substantially immediate dose of methylphenidate upon...
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6635279 |
Active ingredient-containing floating forms comprising polyvinyl acetate and polyvinylpyrrolidone, their use and production
The present invention relates to oral dosage forms comprising a) one or more active ingredients b) a formulated mixture of polyvinyl acetate and polyvinylpyrrolidone c) where appropriate other...
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6623756 |
Directly compressed solid dosage articles
Solid dosage articles such as pharmaceutical tablets for the controlled release of a desired compound such as an active ingredient are directly compressed from a flowable, compressible mixture of...
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6620433 |
Dispersible and soluble galenic paracetamol formulation, method for its preparation and its applications
The new galenic formulation of paracetamol is comprised of a base mixture of paracetamol and citric acid in a proportion of 85:15 to 90:10 w/w among other pharmaceutically acceptable components, in...
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6605300 |
Oral pulsed dose drug delivery system
A multiple pulsed dose drug delivery system for pharmaceutically active amphetamine salts, comprising an immediate-release component and an enteric delayed-release component wherein (1) the enteric...
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6605303 |
Oral pharmaceutical extended release dosage form
An enteric coated pharmaceutical extended release dosage form of a H + , K + -ATPase inhibitor giving an extended plasma concentration profile of a H + , K + -ATPase inhibitor. The extended plasma...
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6599531 |
Method of making ibuprofen and narcotic analgesic compositions
Provided herein are compositions and methods of making compositions of ibuprofen in combination with a narcotic analgesic. Specifically provided is a pharmaceutical tablet composition comprising...
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6599529 |
Modified release multiple-units compositions of non-steroid anti-inflammatory drug substances (NSAIDs)
An oral pharmaceutical modified release multiple-units composition for the administration of a therapeutically and/or prophylactically effective amount of a non-steroid anti-inflammatory drug...
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6599931 |
Test system for characterizing the compatibility of bioactive substances and polyvinylpyrrolidone
A test system for characterizing the compatibility of bioactive substances with polyvinylpyrrolidones in a solid dispersion consisting of one or more bioactive substances and...
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6596311 |
Fast disintegrating tablets
This invention provides a formulation for preparing a fast disintegrating tablet comprising a drug in multiparticulate form, one or more water insoluble inorganic excipients, one or more...
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6576260 |
Sustained-release form of administration containing tramadol saccharinate
Disclosed herein is sustained-release formulations of tramadol comprising tramadol saccharinate coated with at least one sustained-release coating. The sustained release formulations may also...
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6569463 |
Solid carriers for improved delivery of hydrophobic active ingredients in pharmaceutical compositions
The present invention provides solid pharmaceutical compositions for improved delivery of a wide variety of pharmaceutical active ingredients contained therein or separately administered. In one...
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6558703 |
Porous hydroxyapatite particles as carriers for drug substances
A drug delivery system for oral administration in solid dry form of a greasy/oily/sticky substance and a pharmaceutically active substance or a pharmaceutically active substance which itself is...
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6558699 |
High drug load immediate and modified release oral dosage formulations and processes for their manufacture
This invention relates to high drug load granulation of (E)-α-[2-n-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-
yl]methylene-2-thiophenepropionic acid in the anhydrous form, a process for its...
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6558700 |
Multiple-unit sustained release tablets
A multiple-unit sustained release tablet characterized by consisiting of a granular part and a powdery part, each granule comprising a matrix composed of a water-insoluble polymer and an active...
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6555137 |
Sucralfate-containing composition and process for the preparation thereof
A coated antacid comprising sucralfate and an antacid inhibits decline in the adhesion characteristics of sucralfate whereby the drug ingested can reliably show its effect in the stomach. This...
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6548084 |
Controlled release compositions
A controlled release or delayed release formulation contains a selective serotonin reuptake inhibitor (SSRI) such as paroxetine.
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6548083 |
Prolonged release active agent dosage form adapted for gastric retention
The present invention is directed to an active agent dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of an active agent formulation to a fluid...
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6544556 |
Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor
An oral solid dosage form includes a therapeutically effective amount of an NSAID and a proton pump inhibitor in an amount effective to inhibit or prevent gastrointestinal side effects normally...
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6544553 |
Dosage forms and methods for oral delivery of progesterone
Provided is an oral dosage form suitable to deliver a combined dosage of progesterone and which upon delivery through the gastrointestinal tract provides a blood concentration of from about 0.1...
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6534089 |
Uniform drug delivery therapy
The invention disclosed pertains to a novel delivery system comprising an agent formulation and means for dispensing the agent formulation from the delivery system.
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