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9000046 Gastric retentive dosage forms for extended release of acamprosate into the upper gastrointestinal tract  
Gastric retentive dosage forms for sustained release of acamprosate are described which may allow once- or twice-daily dosing for both acute and long-term treatment of a disorder including alcohol...
8999386 Methylphenidate extended release chewable tablet  
An oral methylphenidate extended release tablet is described, which can be scored and still retain its extended release profile. The tablet contains a combination of an uncoated...
8968776 Composition comprising a benzimidazole and process for its manufacture  
The invention provides new benzimidazole compositions, comprising: (a) a core containing said benzimidazole active ingredient; (b) an intermediate layer; and (c) an enteric layer; said core being...
8962022 Pharmaceutical compositions comprising an active substance from the substituted benzhydrylpiperazine family  
The present invention is directed to compositions of taste-masked microparticles comprising a substituted benzhydrylpiperazine coated and a taste-masking layer comprising a water-insoluble polymer...
8962019 Sustained drug release composition  
The invention relates to a sustained release formulation for delivering one or more pharmaceutically active agents. The formulation comprises cross-linked high amylose starch and at least one...
8927014 Misuse preventative, controlled release formulation  
Disclosed is a misuse preventative, controlled release composition in the form of a multilayered oral dosage form. A first layer contains a plurality of controlled release microparticles having a...
8927016 Producing a sustained-release preparation  
This invention provides a production method for a solid sustained-release preparation, characterized in that a sustained-release preparation (a sustained-release preparation suspension) is...
8927013 Misuse preventative, controlled release formulation  
Disclosed is a misuse preventative, controlled release composition in the form of a multilayered oral dosage form. A first layer contains a plurality of controlled release microparticles having a...
8920834 Misuse preventative, controlled release formulation  
Disclosed is a misuse preventative, controlled release formulation comprising a core comprising a first layer and a second layer. The core comprises a superabsorbent material (for example,...
8920833 Misuse preventative, controlled release formulation  
Disclosed is a misuse preventative, controlled release formulation comprising a core comprising a superabsorbent material (for example, polycarbophil), a controlled release coat surrounding the...
8911780 Multiparticulate L-menthol formulations and related methods  
An L-menthol-containing multiparticulate formulation includes a plurality of individual enteric coated cores containing L-menthol from an at least 80% pure L-menthol source. The enteric coated...
8895064 Controlled release and taste masking oral pharmaceutical composition  
Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic,...
8877238 Film-coated tablet or granules containing as active ingredient a pyridylpyrimidine compound or a pharmaceutically acceptable salt of this compound  
Film-coated tablet, consisting of a tablet core with a film coating, or granules containing as active ingredient a pyridylpyrimidine compound or a pharmaceutically acceptable salt of this...
8871269 Method for the preparation of controlled release formulations  
The methods disclosed herein are of use for the production of controlled release compositions. In particular, the methods provide the contacting of an organic phase containing a bioactive agent...
8865213 Modified release pharmaceutical compositions  
Disclosed herein are multiparticulate modified release pharmaceutical compositions comprising: (a) a first portion comprising an active ingredient, at least one surfactant and at least one release...
8865219 Orodispersible tablets of bitter active principles  
The invention concerns coated granules including (A) at least one amine-containing pharmacological active principle, preferably as an acid addition salt, the pharmacological active principle being...
8865214 Bioactive gypsum starch composition  
Bioactive formulations and methods of use comprising a gypsum biopolymer matrix and soil beneficial microorganisms are described herein.
8858995 Methods and compositions for controlled delivery of phytochemical agents  
Compositions are provided that comprises a biocompatible polymeric matrix incorporating an effective amount of a phytochemical agent, a combination of phytochemical agents, or a phytochemical...
8852626 Controlled-release CNS modulating compositions and methods for the treatment of otic disorders  
Disclosed herein are compositions and methods for the treatment of otic disorders with CNS modulating agent compositions and compositions administered locally to an individual afflicted with an...
8846085 Method for production of directly compressible ibuprofen formulations  
A directly tabletable ibuprofen formulation comprising a) 50-99% by weight of crystalline ibuprofen, b) 1-15% by weight of a finely divided excipient with a surface area of at least 100 m2/g, and...
8840925 Orally disintegrating tablet compositions of lamotrigine  
The compositions of the present invention composition comprise a therapeutically effective amount of particles comprising lamotrigine, in combination with granules comprising a disintegrant, and a...
8840923 Slow-release pharmaceutical formulation and process for its preparation  
Slow-release excipients which comprise an association of at least one glycogen and at least one alginate with an alkaline-earth metal salt are useful for the preparation of slow-release...
8840924 Compositions and methods of making rapidly dissolving ionically masked formulations  
The present invention includes compositions and methods for reduce the taste of the drug in the drug resin complex. The composition may include one or more drug-resin complexes and a highly...
8828431 Solid oral dosage form containing an enhancer  
The invention relates to a solid oral dosage form comprising a pharmaceutically active ingredient in combination with an enhancer which enhances the bioavailability and/or the absorption of the...
8828432 Embedding and encapsulation of sensitive components into a matrix to obtain discrete controlled release particles  
Controlled release, discrete, solid particles which contain an encapsulated and/or embedded component such as a heat sensitive or readily oxidizable pharmaceutically, biologically, or...
8815287 Opiod agonist formulations with releasable and sequestered antagonist  
Disclosed are oral dosage forms, comprising (i) a therapeutically effective amount of an opioid agonist; (ii) an opioid antagonist in releasable form; and (iii) a sequestered opioid antagonist...
8815293 Organic compounds  
A depot formulation comprising iloperidone and a biodegradable, biocompatible polymer. Preferably, the polymer is a star polymer.
8808740 Encased tamper resistant controlled release dosage forms  
In certain embodiments, the present invention is directed to a solid controlled release dosage form comprising: a core comprising a first portion of an opioid analgesic dispersed in a first matrix...
8795723 Sustained drug release compositions  
The invention relates to a sustained release formulation for delivering one or more pharmaceutically active agents. The formulation comprises cross-linked high amylose starch and at least one...
8795726 Sustained-release nucleic acid matrix compositions  
The present invention provides compositions for extended release of a nucleic acid agent, a biodegradable polymer. The present invention also provides methods of producing the matrix compositions...
8784870 Controlled release compositions for modulating free-radical induced damage and methods of use thereof  
Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with free-radical modulating agent compositions and formulations administered locally to an...
8784888 Controlled release and taste masking oral pharmaceutical composition  
Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic,...
8778395 Diltiazem controlled release formulation and method of manufacture  
A controlled release diltiazem dosage formulation comprising a plurality of diltiazem pellets and a gel-forming material where the time of maximum diltiazem blood plasma levels occurs more than 8...
8778396 Multi-unit gastroretentive pharmaceutical dosage form comprising microparticles  
This invention relates to an orally administrable, gastroretentive pharmaceutical dosage form which contains at least one pharmaceutically active ingredient and at least one polymeric adjuvant....
8747895 Orally disintegrating tablets of atomoxetine  
A coated multi-particulate pharmaceutical dosage form such as an orally disintegrating tablet (ODT) presentation for delivering atomoxetine or a pharmaceutically acceptable salt thereof, a...
8722090 Granulate comprising an oily substance, corresponding production method and tablet  
The invention relates to a process for the preparation of granules comprising an oily substance. It relates also to granules for a pharmaceutical formulation and to a tablet as a product of...
8703189 Medicinal composition  
The present invention provides a medicinal composition that exhibits excellent storage stability and, even over long-term storage, little change in the release rate of the pharmacologically active...
8703191 Controlled-release pharmaceutical tablets  
Controlled-release tablets exhibiting excellent storage stability are achieved by granulating a pharmaceutically active agent with a hydroxyalkylcelluose, blending the resulting granules with an...
8691270 Misuse preventative, controlled release formulation  
Disclosed is a misuse preventative, controlled release formulation comprising a core comprising a superabsorbent material (for example, polycarbophil), a controlled release coat surrounding the...
8685443 Sequestering subunit and related compositions and methods  
A sequestering subunit comprising an aversive agent and a blocking agent, wherein the blocking agent substantially prevents release of the aversive agent from the sequestering subunit in the...
8685447 Misuse preventative, controlled release formulation  
Disclosed is a misuse preventative, controlled release composition in the form of a multilayered oral dosage form. A first layer contains a plurality of controlled release microparticles having a...
8679535 Sustained release matrix systems for highly soluble drugs  
Disclosed are sustained release oral solid dosage forms comprising a therapeutically effective amount of a medicament having a solubility of more than about 10 g/l; a pH modifying agent; and a...
8673344 Solid dosage form with a film containing an active substance, as well as its method of production  
The present invention relates to a solid dosage form with at least one film, which contains an active substance at least in sections, and the concentration of the active substance in the film or...
8668934 Pharmaceutical formulation comprising a water-insoluble active agent  
A method of preparing a pharmaceutical formulation comprises providing a solution comprising a first solvent, a second solvent, an active agent, and an excipient. The second solvent is less polar...
8668929 Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic  
Compositions and methods for the treatment of pain in a mammal are described. More specifically, a dosage form designed for release of acetaminophen and an opioid is described, wherein the dosage...
8668932 Extended release venlafaxine formulation  
A controlled release dosage form of venlafaxine that comprises an immediate release pellet and an extended release pellet.
8647656 Orally disintegrating tablet compositions of lamotrigine  
The compositions of the present invention composition comprise a therapeutically effective amount of particles comprising lamotrigine, in combination with granules comprising a disintegrant, and a...
8642082 Pharmaceutical compositions for the oral administration of heparin or derivatives thereof  
Pharmaceutical compositions suitable for the oral administration of heparin or derivatives thereof, particularly controlled-release oral pharmaceutical compositions containing heparin with...
8637079 Solid preparation comprising alogliptin and pioglitazone  
A solid preparation containing compound (I), wherein the definition of compound (I) is as defined in the description, and pioglitazone, which is useful as a therapeutic drug for diabetes and the...
8632805 Controlled-release formulations, method of manufacture, and use thereof  
The present invention includes a controlled-release composition having a matrix. The matrix contains a pharmaceutically effective amount of an active agent or a pharmaceutically acceptable salt,...