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5654003 Process and apparatus for making tablets and tablets made therefrom  
The present invention is a process for making edible units from compression and the products resulting therefrom. The method of the present invention includes compression of shearform matrix mass...
5637320 Controlled absorption naproxen formulation for once-daily administration  
A once-daily naproxen formulation for oral administration having a first portion of the naproxen as a multi-particulate pellet form, each pellet having a core of naproxen or a pharmaceutically...
5637313 Chewable dosage forms  
Disclosed is a soft, chewable dosage form, including a matrix of hydrogenated starch hydrolysate, a water soluble bulking agent, and a water insoluble bulking agent. The present invention also...
5629018 Composition for controlled release of an active substance and method for the preparation of such a composition  
In a composition for delayed release of an active substance, the active substance is incorporated in a polysaccharide matrix which consists of an essentially crystalline straight-chain glucan and...
5626877 Polymer-based drug delivery system  
Described herein is a drug delivery system useful to deliver drugs at low dosage levels to patients in a sustained fashion and at a controlled rate. The system comprises a wettable polymeric matrix...
5621005 Aqueous pharmaceutical suspension for substantially water insoluble pharmaceutical actives  
The present invention relates to an aqueous pharmaceutical suspension composition comprising: from about 0.2% to 20% of a substantially water insoluble pharmaceutical active, e.g. ibuprofen; a...
5614219 Oral administration form for peptide pharmaceutical substances, in particular insulin  
A peroral administration form for peptidic medicaments contains the peptidic medicament, in particular insulin, distributed in a gelatine or gelatine derivate matrix, besides usual pharmaceutical...
5601846 Proteinoid microspheres and methods for preparation and use thereof  
Improved proteinoid micropheres and methods for their preparation and use as oral delivery systems for pharmaceutical agents are described. The proteinoid microspheres are soluble within selected...
5601842 Sustained release drug formulation containing a tramadol salt  
A drug formulation of tramadol or a tramadol salt in orally administrable tablet form containing at least one pharmaceutically acceptable matrixing agent is disclosed from which a non-moisture...
5594030 Controlled release pharmaceutical compositions based on one or more pharmaceutically acceptable salts of gamma hydroxy-butyric acid  
Controlled release pharmaceutical compositions administrable by oral route, containing as the active principle at least one salt of the gamma hydroxy butyric acid with a pharmaceutically acceptable...
5585115 Pharmaceutical excipient having improved compressability  
A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is...
5571533 Controlled-release mucoadhesive pharmaceutical composition for the oral administration of furosemide  
Disclosed are controlled-release mucoadhesive pharmaceutical compositions for the oral administration of furosemide. This composition comprises a multiplicity of microgranules of lipophilic...
5567693 Method for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth  
The invention relates to a method for inhibiting angiogenesis and proliferation of endothelial cells by administering an inhibitory amount of a 7-(hydrogen or di (C 1 -C 4...
5560928 Nutritional and/or dietary composition and method of using the same  
A composition and method of using the same which provides in as little as a single dose covering a 24 hour period a nutritional and/or dietary supplement which provides administration of water...
5554388 Systemic drug delivery compositions comprising a polycationi substance  
A composition for administration to the mucosa comprises a pharmacologically active compound and a polycationic substance. The polycationic substance is preferably DEAE-dextran or chitosan and the...
5549911 Galenic form of 5-nitromidazole derivatives which is effective for the treatment of parasitoses and infections of the entire gastrointestinal tract  
The present invention relates to a galenic form of 5-nitroimidazole derivatives which is characterized in that it comprises a combination of microgranules of 5-nitroimidazole derivatives...
5549891 Method for disinfecting contact lens with catalase compositions  
Compositions and methods for destroying hydrogen peroxide in hydrogen peroxide-containing liquid aqueous media, for example, employed to disinfect contact lenses, are disclosed. In one embodiment,...
5529790 Delayed, sustained-release diltiazem pharmaceutical preparation  
A delayed, sustained-release pharmaceutical preparation is provided in which a water-soluble drug core is surrounded by a hydratable diffusion barrier which delays drug release for about 2-10...
5525354 Pharmaceutical preparation and process for its manufacture  
In a pharmaceutical preparation for oral use containing a pharmacologically acceptable salt of a bisphosphonic acid, the improvement comprising: a drug delivery form of the preparation which is...
5518737 Peroral drug delivery system  
This invention describes a device for peroral administration of a therapeutic agent which is capable of existing in an unionized therapeutically active form. The device comprises a reservoir...
5512299 Method of treating oral inflammatory disease  
A method of treating inflammatory disease of the mouth by locally delivering beclomethasone dipropionate and related compounds to the oral cavity of a patient over an extended period of time is...
5510108 Sanitizer for swimming pools, spas, and hot tubs  
A sanitizer composition comprising a bactericidal effective amount of the combination of (a) chlorinated isocyanuric acids such as trichloroisocyanuric acid or sodium dichloroisocyanurate and...
5508042 Controlled release oxycodone compositions  
A method for substantially reducing the range in daily dosages required to control pain in approximately 90% of patients is disclosed whereby an oral solid controlled release dosage formulation...
5505967 Microparticulate pharmaceutical delivery system  
A pharmaceutical composition comprising a shaped enteric material having distributed therethrough preferably substantially uniformly, pharmaceutical loaded particles, said particles having a size...
5484608 Sustained-release drug delivery system  
A sustained-release pharmaceutical composition comprising a highly soluble pharmaceutical agent, such as selegiline, in a pharmaceutical carrier comprising a hydrophilic polymer dispersed in a...
5478572 Gepirone dosage form  
Gepirone compositions having extended release properties contain a gepirone salt, a cellulosic polymer matrix and suitable quantities of pharmaceutical excipients. Dosage forms based thereon...
5478571 Process for the preparation of substantially alcohol free pharmaceutical compositions  
A novel process for the preparation of pharmaceutical compositions involving the stabilization of the active drug(s) through the reduction of residual alcohol present in a drug/carrier blend. The...
5472710 Pharmaceutical preparation to be administered orally with controlled release of active substance and method for its manufacture  
Pharmaceutical preparation to be administered orally with controlled release of active substance and method for its manufacture. Pharmaceutical preparation to be administered orally with controlled...
5462747 Pharmaceutical sustained release matrix  
A pharmaceutical sustained release homogeneous tablet or homogeneous tablet layer is formed by making a wet granulation using povidone (PVP) in alcohol as the granulating fluid which is mixed with...
5458888 Controlled release tablet formulation  
The present invention provides a controlled release dosage form which may be made using a blend having an internal drug containing phase and an external phase which comprises a polyethylene glycol...
5451409 Sustained release matrix system using hydroxyethyl cellulose and hydroxypropyl cellulose polymer blends  
The present invention is directed to a novel sustained release matrix and oral dosage form comprising a homogeneous matrix formed from a wet granulation containing an effective amount of a...
5447729 Multilamellar drug delivery systems  
A pharmaceutical preparation including a pharmaceutical agent incorporated into particles comprising (i) a core formed from a hydrophilic material, a hydrophobic material or a hydrophobic emulsion...
5443843 Gastric retention system for controlled drug release  
An oral drug delivery system having delayed gastrointestinal transit comprising a non-continuous compressible element and an attached controlled release device and which in the expanded form...
5437872 Pharmaceutical compositions and a device for administering the same  
A pharmaceutical tablet or lozenge is described, which comprises a non-absorbable pharmaceutically active agent, in combination with a tablet matrix, arranged for providing controlled and sustained...
RE34990 Oral therapeutic system having systemic action  
The invention relates to a therapeutic system for peroral administration and having systemic action, which system is in the form of a coated and/or laminated mono-compartment system for...
5427799 Sustained release composition and method utilizing xanthan gum and an active ingredient  
A compacted sustained release composition for delivering a drug as an active ingredient to the gastro-intestinal tract comprises an effective amount of the active ingredient in mixture with xanthan...
5419917 Controlled release hydrogel formulation  
The invention is directed to a method for the modification of the rate of release of a drug from a hydrogel which is based on the use of an effective amount of a pharmaceutically acceptable...
5415871 Therapeutic agents  
A sustained release pharmaceutical formulation comprising xanthan gum, a pharmaceutically active ingredient for example, ibuprofen or flurbiprofen, and other optional excipients.
5399359 Controlled release oxybutynin formulations  
A solid oral sustained release oxybutynin formulation includes a sustained release matrix including a gelling agent, an inert pharmaceutical diluent, and a cationic cross-linking agent.
5399360 Pharmaceutical compositions  
A ketotifen pharmaceutical composition adapted for once-a-day oral administration e.g. based on a fat matrix.
5399358 Sustained release formulations for 24 hour release of metroprolol  
A sustained release oral solid dosage form of metoprolol pharmaceutical formulation includes a sustained release excipient including a gelling agent, an inert pharmaceutical diluent, a cationic...
5399362 Once-a-day metoprolol oral dosage form  
A sustained release oral solid dosage form of metoprolol pharmaceutical formulation includes a sustained release excipient including a gelling agent, an inert pharmaceutical diluent, a cationic...
5393533 Pharmaceuticals microencapsulated by vapor deposited polymers and method  
A microencapsulated pharmaceutical is formed by vapor depositing a polymeric film about an active pharmaceutical agent. The film thickness of the vapor deposited film is controlled to provide...
5382601 Memantine-containing solid pharmaceutical dosage forms having an extended two-stage release profile and production thereof  
The present invention provides solid pharmaceutical compositions in dosage form containing an active ingredient or principle, preferably memantine, which exhibit an extended two-phase release...
5378474 Sustained release pharmaceutical composition  
The present invention relates to a pharmaceutical pellet composition having a core element including at least one highly soluble active ingredient and a core coating which is partially soluble at a...
5376382 Tablets, granulates and pellets with a high active substance content for highly concentrated, solid dosage forms of thioctic acid  
A solid medicinal form having an active substance content of over 45 weight % and processes for its preparation by granulating with large amounts of water, drying and optionally conventional...
5374430 Pharmaceutical formulation  
The residence time in the human stomach of a pharmaceutical, gastric controlled release unit can be increased significantly if the units has a density that is much higher than normal. A preferred...
5370878 Method for preparing a direct compression granulated acetaminophen composition  
A direct compression granulated acetaminophen tableting composition is prepared by blending acetaminophen with a binder, disintegrant, lubricant and a small amount of water or alcohol, compacting...
5348747 Pharmaceutical coating sugars  
A finely divided solid pharmaceutical dosage form for oral administration dissolved or suspended in a pharmaceutically acceptable liquid is described which pharmaceutical dosage form consists of a...
5342627 Controlled release device  
The invention relates to a device for the release of at least one active substance (e.g. ranitidine) into a fluid medium by dissolution comprising a covering, which is impermeable to the active...