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5654003 |
Process and apparatus for making tablets and tablets made therefrom
The present invention is a process for making edible units from compression and the products resulting therefrom. The method of the present invention includes compression of shearform matrix mass...
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5637320 |
Controlled absorption naproxen formulation for once-daily administration
A once-daily naproxen formulation for oral administration having a first portion of the naproxen as a multi-particulate pellet form, each pellet having a core of naproxen or a pharmaceutically...
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5637313 |
Chewable dosage forms
Disclosed is a soft, chewable dosage form, including a matrix of hydrogenated starch hydrolysate, a water soluble bulking agent, and a water insoluble bulking agent. The present invention also...
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5629018 |
Composition for controlled release of an active substance and method for the preparation of such a composition
In a composition for delayed release of an active substance, the active substance is incorporated in a polysaccharide matrix which consists of an essentially crystalline straight-chain glucan and...
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5626877 |
Polymer-based drug delivery system
Described herein is a drug delivery system useful to deliver drugs at low dosage levels to patients in a sustained fashion and at a controlled rate. The system comprises a wettable polymeric matrix...
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5621005 |
Aqueous pharmaceutical suspension for substantially water insoluble pharmaceutical actives
The present invention relates to an aqueous pharmaceutical suspension composition comprising: from about 0.2% to 20% of a substantially water insoluble pharmaceutical active, e.g. ibuprofen; a...
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5614219 |
Oral administration form for peptide pharmaceutical substances, in particular insulin
A peroral administration form for peptidic medicaments contains the peptidic medicament, in particular insulin, distributed in a gelatine or gelatine derivate matrix, besides usual pharmaceutical...
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5601846 |
Proteinoid microspheres and methods for preparation and use thereof
Improved proteinoid micropheres and methods for their preparation and use as oral delivery systems for pharmaceutical agents are described. The proteinoid microspheres are soluble within selected...
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5601842 |
Sustained release drug formulation containing a tramadol salt
A drug formulation of tramadol or a tramadol salt in orally administrable tablet form containing at least one pharmaceutically acceptable matrixing agent is disclosed from which a non-moisture...
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5594030 |
Controlled release pharmaceutical compositions based on one or more pharmaceutically acceptable salts of gamma hydroxy-butyric acid
Controlled release pharmaceutical compositions administrable by oral route, containing as the active principle at least one salt of the gamma hydroxy butyric acid with a pharmaceutically acceptable...
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5585115 |
Pharmaceutical excipient having improved compressability
A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is...
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5571533 |
Controlled-release mucoadhesive pharmaceutical composition for the oral administration of furosemide
Disclosed are controlled-release mucoadhesive pharmaceutical compositions for the oral administration of furosemide. This composition comprises a multiplicity of microgranules of lipophilic...
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5567693 |
Method for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
The invention relates to a method for inhibiting angiogenesis and proliferation of endothelial cells by administering an inhibitory amount of a 7-(hydrogen or di (C 1 -C 4...
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5560928 |
Nutritional and/or dietary composition and method of using the same
A composition and method of using the same which provides in as little as a single dose covering a 24 hour period a nutritional and/or dietary supplement which provides administration of water...
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5554388 |
Systemic drug delivery compositions comprising a polycationi substance
A composition for administration to the mucosa comprises a pharmacologically active compound and a polycationic substance. The polycationic substance is preferably DEAE-dextran or chitosan and the...
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5549911 |
Galenic form of 5-nitromidazole derivatives which is effective for the treatment of parasitoses and infections of the entire gastrointestinal tract
The present invention relates to a galenic form of 5-nitroimidazole derivatives which is characterized in that it comprises a combination of microgranules of 5-nitroimidazole derivatives...
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5549891 |
Method for disinfecting contact lens with catalase compositions
Compositions and methods for destroying hydrogen peroxide in hydrogen peroxide-containing liquid aqueous media, for example, employed to disinfect contact lenses, are disclosed. In one embodiment,...
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5529790 |
Delayed, sustained-release diltiazem pharmaceutical preparation
A delayed, sustained-release pharmaceutical preparation is provided in which a water-soluble drug core is surrounded by a hydratable diffusion barrier which delays drug release for about 2-10...
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5525354 |
Pharmaceutical preparation and process for its manufacture
In a pharmaceutical preparation for oral use containing a pharmacologically acceptable salt of a bisphosphonic acid, the improvement comprising: a drug delivery form of the preparation which is...
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5518737 |
Peroral drug delivery system
This invention describes a device for peroral administration of a therapeutic agent which is capable of existing in an unionized therapeutically active form. The device comprises a reservoir...
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5512299 |
Method of treating oral inflammatory disease
A method of treating inflammatory disease of the mouth by locally delivering beclomethasone dipropionate and related compounds to the oral cavity of a patient over an extended period of time is...
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5510108 |
Sanitizer for swimming pools, spas, and hot tubs
A sanitizer composition comprising a bactericidal effective amount of the combination of (a) chlorinated isocyanuric acids such as trichloroisocyanuric acid or sodium dichloroisocyanurate and...
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5508042 |
Controlled release oxycodone compositions
A method for substantially reducing the range in daily dosages required to control pain in approximately 90% of patients is disclosed whereby an oral solid controlled release dosage formulation...
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5505967 |
Microparticulate pharmaceutical delivery system
A pharmaceutical composition comprising a shaped enteric material having distributed therethrough preferably substantially uniformly, pharmaceutical loaded particles, said particles having a size...
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5484608 |
Sustained-release drug delivery system
A sustained-release pharmaceutical composition comprising a highly soluble pharmaceutical agent, such as selegiline, in a pharmaceutical carrier comprising a hydrophilic polymer dispersed in a...
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5478572 |
Gepirone dosage form
Gepirone compositions having extended release properties contain a gepirone salt, a cellulosic polymer matrix and suitable quantities of pharmaceutical excipients. Dosage forms based thereon...
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5478571 |
Process for the preparation of substantially alcohol free pharmaceutical compositions
A novel process for the preparation of pharmaceutical compositions involving the stabilization of the active drug(s) through the reduction of residual alcohol present in a drug/carrier blend. The...
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5472710 |
Pharmaceutical preparation to be administered orally with controlled release of active substance and method for its manufacture
Pharmaceutical preparation to be administered orally with controlled release of active substance and method for its manufacture. Pharmaceutical preparation to be administered orally with controlled...
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5462747 |
Pharmaceutical sustained release matrix
A pharmaceutical sustained release homogeneous tablet or homogeneous tablet layer is formed by making a wet granulation using povidone (PVP) in alcohol as the granulating fluid which is mixed with...
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5458888 |
Controlled release tablet formulation
The present invention provides a controlled release dosage form which may be made using a blend having an internal drug containing phase and an external phase which comprises a polyethylene glycol...
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5451409 |
Sustained release matrix system using hydroxyethyl cellulose and hydroxypropyl cellulose polymer blends
The present invention is directed to a novel sustained release matrix and oral dosage form comprising a homogeneous matrix formed from a wet granulation containing an effective amount of a...
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5447729 |
Multilamellar drug delivery systems
A pharmaceutical preparation including a pharmaceutical agent incorporated into particles comprising (i) a core formed from a hydrophilic material, a hydrophobic material or a hydrophobic emulsion...
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5443843 |
Gastric retention system for controlled drug release
An oral drug delivery system having delayed gastrointestinal transit comprising a non-continuous compressible element and an attached controlled release device and which in the expanded form...
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5437872 |
Pharmaceutical compositions and a device for administering the same
A pharmaceutical tablet or lozenge is described, which comprises a non-absorbable pharmaceutically active agent, in combination with a tablet matrix, arranged for providing controlled and sustained...
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RE34990 |
Oral therapeutic system having systemic action
The invention relates to a therapeutic system for peroral administration and having systemic action, which system is in the form of a coated and/or laminated mono-compartment system for...
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5427799 |
Sustained release composition and method utilizing xanthan gum and an active ingredient
A compacted sustained release composition for delivering a drug as an active ingredient to the gastro-intestinal tract comprises an effective amount of the active ingredient in mixture with xanthan...
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5419917 |
Controlled release hydrogel formulation
The invention is directed to a method for the modification of the rate of release of a drug from a hydrogel which is based on the use of an effective amount of a pharmaceutically acceptable...
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5415871 |
Therapeutic agents
A sustained release pharmaceutical formulation comprising xanthan gum, a pharmaceutically active ingredient for example, ibuprofen or flurbiprofen, and other optional excipients.
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5399359 |
Controlled release oxybutynin formulations
A solid oral sustained release oxybutynin formulation includes a sustained release matrix including a gelling agent, an inert pharmaceutical diluent, and a cationic cross-linking agent.
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5399360 |
Pharmaceutical compositions
A ketotifen pharmaceutical composition adapted for once-a-day oral administration e.g. based on a fat matrix.
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5399358 |
Sustained release formulations for 24 hour release of metroprolol
A sustained release oral solid dosage form of metoprolol pharmaceutical formulation includes a sustained release excipient including a gelling agent, an inert pharmaceutical diluent, a cationic...
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5399362 |
Once-a-day metoprolol oral dosage form
A sustained release oral solid dosage form of metoprolol pharmaceutical formulation includes a sustained release excipient including a gelling agent, an inert pharmaceutical diluent, a cationic...
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5393533 |
Pharmaceuticals microencapsulated by vapor deposited polymers and method
A microencapsulated pharmaceutical is formed by vapor depositing a polymeric film about an active pharmaceutical agent. The film thickness of the vapor deposited film is controlled to provide...
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5382601 |
Memantine-containing solid pharmaceutical dosage forms having an extended two-stage release profile and production thereof
The present invention provides solid pharmaceutical compositions in dosage form containing an active ingredient or principle, preferably memantine, which exhibit an extended two-phase release...
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5378474 |
Sustained release pharmaceutical composition
The present invention relates to a pharmaceutical pellet composition having a core element including at least one highly soluble active ingredient and a core coating which is partially soluble at a...
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5376382 |
Tablets, granulates and pellets with a high active substance content for highly concentrated, solid dosage forms of thioctic acid
A solid medicinal form having an active substance content of over 45 weight % and processes for its preparation by granulating with large amounts of water, drying and optionally conventional...
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5374430 |
Pharmaceutical formulation
The residence time in the human stomach of a pharmaceutical, gastric controlled release unit can be increased significantly if the units has a density that is much higher than normal. A preferred...
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5370878 |
Method for preparing a direct compression granulated acetaminophen composition
A direct compression granulated acetaminophen tableting composition is prepared by blending acetaminophen with a binder, disintegrant, lubricant and a small amount of water or alcohol, compacting...
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5348747 |
Pharmaceutical coating sugars
A finely divided solid pharmaceutical dosage form for oral administration dissolved or suspended in a pharmaceutically acceptable liquid is described which pharmaceutical dosage form consists of a...
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5342627 |
Controlled release device
The invention relates to a device for the release of at least one active substance (e.g. ranitidine) into a fluid medium by dissolution comprising a covering, which is impermeable to the active...
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