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7083808 |
Controlled/modified release oral methylphenidate formulations
The invention is directed to oral modified/controlled release methylphenidate formulations which provide a rapid initial onset of effect and a prolonged duration of effect. Preferably, the peak...
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7070803 |
Controlled release pharmaceutical composition for oral use containing midodrine and/or active metabolite, desglymidodrine
Novel controlled release pharmaceutical compositions for oral use containing midodrine and/or its active metabolite desglymidodrine. The novel compositions are designed to release midodrine and/or...
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7048945 |
Timed pulsatile drug delivery systems
A pharmaceutical dosage form such as a capsule capable of delivering therapeutic agents into the body in a time-controlled or position-controlled pulsatile release fashion, is composed of a...
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7037529 |
Fenofibrate pharmaceutical composition having high bioavailability and method for preparing it
The invention provides an immediate-release fenofibrate composition comprising (a) an inert hydrosoluble carrier covered with at least one layer containing fenofibrate in a micronized form having a...
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6994873 |
Multiparticulate formulations of lithium salts for oral administration suitable for once-a-day administration
This invention refers to:
multiparticulate formulations of Lithium salts for oral administration constituted by either modified release granules or mixtures of modified and conventional...
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6994871 |
Once a day antihistamine and decongestant formulation
A controlled release pharmaceutical formulation for the administration of an antihistamine and decongestant to a patient wherein the formulation employs a compressed matrix core for the controlled...
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6991807 |
Antibiotic composition
Disclosed are antibiotic products for delivering at least two different antibiotics, wherein the products are comprised of at least three or four dosage forms with different release profiles and...
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6984449 |
Pellets and process for production thereof
The invention relates to pellets and a production process therefor. Pellets comprise at least one oily component, which is either an active component alone or comprises such an active component....
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6976981 |
Osmotic delivery system with membrane plug retention mechanism
An osmotic delivery system has a membrane plug retention mechanism which can also be used to control the delivery rate of a beneficial agent from the osmotic delivery system. The osmotic delivery...
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6964780 |
Controlled-release pharmaceutical formulations
The invention provides controlled-release formulations for oral administration containing a cGMP PDE-5 inhibitor. The formulations are useful, inter alia, in the treatment or prevention of sexual...
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6960356 |
Orally administered drug delivery system providing temporal and spatial control
A pharmaceutical composition in the form of tablets or capsules provides a combination of temporal and spatial control of drug delivery to a patient for effective therapeutic results. The...
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6958161 |
Modified release coated drug preparation
A modified release preparation having one or more coated core elements, each core element including an active ingredient and having a modified release coating, wherein a stabilising coat is...
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6955821 |
Sustained release formulations of guaifenesin and additional drug ingredients
The invention relates to a novel pharmaceutical sustained release formulation of guaifenesin and at least one additional drug ingredient. The formulation may comprise a hydrophilic polymer,...
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6946145 |
Block copolymers based on poly(ortho esters) containing amine groups
Block copolymers based on poly(ortho esters) containing amine groups. These block copolymers have both hydrophilic and hydrophobic blocks. They form micelles in aqueous solution, making them...
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6913767 |
Compositions for microencapsulation of antigens for use as vaccines
Methods and compositions are provided for the encapsulation of antigens in PLGA microspheres for use as vaccines. Such microspheres can also contain adjuvants. Mixtures of microspheres are provided...
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6902742 |
Multiparticulate modified release composition
The invention relates to a multiparticulate modified release composition that in operation delivers an active ingredient in a pulsed or bimodal manner. The multiparticulate modified release...
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6893661 |
Controlled release formulations using intelligent polymers
An extended release dosage composition of pharmaceutically active substances that have a water contact angle (θ) such that cos θ is between +0.9848 and −0.9848 presented as a matrix tablet...
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6890561 |
Microencapsulated and controlled-release formulations of isoflavone from enriched fractions of soy and other plants
There is provided an orally-administrable formulation for the controlled release or stable storage of a granulated isoflavone-enriched fraction or mixture of such fractions, comprising at least one...
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6878387 |
Coated medicament forms with controlled active substance release
The invention relates to a pharmaceutical preparation consisting of: (a) a core containing an active substance, optionally an excipient and common pharmaceutical additives in addition to the salt...
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6869615 |
Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor
An oral solid dosage form includes a therapeutically effective amount of an NSAID and a proton pump inhibitor in an amount effective to inhibit or prevent gastrointestinal side effects normally...
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6863902 |
Immediate release eplerenone compositions
The invention relates to oral pharmaceutical compositions useful as aldosterone receptor blockers comprising the active agent micronized eplerenone in an amount of about 10 mg to about 1000 mg and...
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6861069 |
Production of a directly compressible tabletting aid
The invention relates to directly compressible tabletting aids with a xylitol content of more than 90% by weight and a content of at least one other polyol of less than 10% by weight, which are...
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6861072 |
Pharmaceutical composition with gastric residence and controlled release
The invention concerns a pharmaceutical composition with gastric residence and controlled release, characterized in that it comprises two or three layers and contains (a) an active principle...
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6835397 |
Controlled release encapsulated bioactive substances
The present invention is an encapsulated yeast composite comprising a core comprising yeast and a coating containing an emulsifiable lipid. The yeast includes Saccharomyces cerevisiae . The...
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6821530 |
Polymer composite compositions
The invention relates to methods of treating mixtures containing polymeric materials, e.g., collagen, to form a polymer that intercalates into the polymeric material. The treatment provides greater...
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RE38629 |
Solid oral dosage form comprising a combination of metformin and glibenclamide
The present invention relates to a solid oral dosage form comprising a combination of metformin and glibenclamide in which the size of glibenclamide is such that the glibenclamide bioavailability...
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6797283 |
Gastric retention dosage form having multiple layers
The present invention is directed to a multilayered dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of an active agent to a fluid environment of use....
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6793935 |
Mineral supplement
The present invention is directed to a novel flavored extended release composition which forms a non-effervescent suspension when dropped into a liquid, and the methods of using said supplement,...
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6790459 |
Methods for treating diabetes via administration of controlled release metformin
A method for treating patients having non-insulin-dependent diabetes mellitus (NIDDM) by administering a controlled release oral solid dosage form containing preferably a biguanide drug such as...
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6783772 |
Pharmaceutical preparations containing alendronate sodium
An oral composition in tablet form containing therapeutic amounts of alendronate sodium for release of the alendronate sodium in the stomach and by passing the oesophagus, comprising a compacted...
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6773720 |
Mesalazine controlled release oral pharmaceutical compositions
Controlled-release oral pharmaceutical compositions containing as active ingredient 5-amino-salicylic acid, comprising: a) an inner lipophilic matrix consisting of substances with a melting point...
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6773721 |
Osmotic caplet
An osmotic caplet is disclosed comprising an osmotic caplet exit for delivering a preselected dose of drug to a patient in need of therapy.
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6762267 |
Controlled release polyacrylic acid granules and a process for preparing the same
The present invention pertains to a method for forming polyacrylic acid granules and granules formed therefrom wherein the granules are flowable, have an increased bulk density relative to the as...
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6733782 |
Core tablet for controlled release of gliclazide after oral administration
The invention relates to a matrix tablet for the prolonged release of gliclazide which ensures continuous and consistent release of the active ingredient after administration by the oral route, the...
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6713509 |
Controlled release formulation for treating COPD
This invention relates to a controlled or sustained release formulation designed to deliver a PDE4 inhibitor for treating an inflammatory disease such as asthma or COPD and the like.
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6706284 |
Bitterness-reduced oral pharmaceutical composition
The invention relates to an oral pharmaceutical composition which has excellent drug release-controlling ability in the mouth even 5 to 10 minutes after its administration and also has excellent...
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6696084 |
Spray drying process and compositions of fenofibrate
The present invention relates to a novel spray drying process for the preparation of pharmaceutical compositions containing small particles of phospholipid-stabilized fenofibrate. This invention...
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6692764 |
Wet granulation formulation for bisphosphonic acids
Pharmaceutical compositions of bisphosphonic acids, and salts thereof, are prepared by wet granulation tablet formulation. These pharmaceutical compositions are useful in the treatment of...
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6692768 |
Preparation method of drug-containing spherical fine particles
The present invention discloses an efficient preparation method of spherical fine particles containing a drug for an easily-swallowed, controlled-release preparation comprising the production of...
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6689386 |
Sustained release matrix for high-dose insoluble drugs
Sustained release dosage forms of high dose insoluble drugs such as ibuprofen and methods for their manufacture are disclosed.
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6682759 |
Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs
A method is disclosed for manufacturing a pharmaceutical tablet for oral administration, the tablet combining both immediate-release and prolonged-release modes of drug delivery and using an...
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6676966 |
Extended release metformin hydrochloride formulations
An extended release formulation of metformin hydrochloride is disclosed. The metformin hydrochloride is encased within polymeric film layers providing for gradual release of the metformin...
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6670407 |
Biofunctional polymers prepared in supercritical fluid
Process for the preparation of a composition comprising a biofunctional polymer substrate and biofunctional material substrate adapted for use in or in association with the human or animal body,...
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6663889 |
Ambroxol-containing lozenge
The present invention relates to a new tablet for sucking containing the active substance ambroxol and having improved properties.
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6660300 |
Method of use of a biphasic controlled release delivery system for high solubility pharmaceuticals and method
A biphasic controlled release delivery system for pharmaceuticals which have high water solubility, such as the antidiabetic metformin HCl salt, is provided which provides a dosage form that has...
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6638532 |
Tetracycline—doxycycline antibiotic composition
An antibiotic product for delivering at least Tetracycline or Doxycycline that is comprised of three dosage forms with different release profiles with each of Tetracycline and Doxycycline being...
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6635276 |
Oral or mucosal preparation containing an active ingredient, with controlled active ingredient release, and its use
The invention relates to the use of a preparation containing a first group of particles and at least one other group of particles which is not identical to the first group of particles for...
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6635280 |
Extending the duration of drug release within the stomach during the fed mode
Drugs are formulated as unit oral dosage forms by incorporating them into polymeric matrices comprised of hydrophilic polymers that swell upon imbibition of water to a size that is large enough to...
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6635281 |
Gastric retaining oral liquid dosage form
The present invention is directed to an active agent dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of a liquid, active agent formulation to a fluid...
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6632453 |
Ciprofoxacin-metronidazole antibiotic composition
An antibiotic product for delivering at least Ciprofoxacin or Metronidazole that is comprised of three dosage forms with different release profiles with each of Ciprofoxacin and Metronidazole being...
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