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7619007 |
Method and composition for administering an NMDA receptor antagonist to a subject
The invention provides methods and compositions for administering an NMDA receptor antagonist (e.g., memantine) to a subject.
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7618650 |
Combination of a hypnotic agent and substituted bis aryl and heteroaryl compound and therapeutic application thereof
The invention concerns the combination of a short-acting hypnotic agent and a compound of formula (I):
Wherein X, Y, Z, A, B, D, Ar, R 1 and R 2 are as defined herein. The combination of this...
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7618649 |
Extended release oral dosage composition
A bilayer solid composition comprising (a) an immediate release first layer comprising an anti-allergic effective amount of desloratadine and at least one pharmaceutically acceptable excipient and...
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7611730 |
Tramadol-based medicament
The invention relates to a medicament containing the racemate of tramadol in a retarded form and the (+)-enantiomer of tramadol in a non-retarded form.
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7611729 |
Dosage forms having prolonged active ingredient release
The present invention relates to prolonged-release oral dosage forms of 4-phenylbutyric acid salts, such as sodium 4-phenylbutyrate. The prolonged release oral dosage forms are preferably tablets....
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7605138 |
Nucleic acid compositions for stimulating immune responses
The invention provides an immunostimulatory nucleic acid comprising CpG motifs, and methods of use thereof in stimulating immunity.
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7604820 |
Solid preparation containing chitosan powder and process for producing the same
A colonic delivery solid preparation containing chitosan powder, which can control the dissolution of a medicament therefrom in the large intestine and release the medicament contained therein...
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7585527 |
Composition and method for treating iron deficiency anemia
A composition comprising heme iron and/or heme iron polypeptide in combination with ionic iron(s) and/or chelated iron(s). Administration of effective dosages of the present composition provides a...
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7585520 |
Compositions containing both sedative and non-sedative antihistamines and sleep aids
Compositions containing both a sedative compound and a non-sedative antihistamine are provided. More particularly, compositions for administration at bedtime containing a sedating antihistamine or...
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7579020 |
Controlled release arginine α-ketoglutarate
An oral formulation of arginine α-ketoglutarate is disclosed which formulation is comprised of arginine α-ketoglutarate and one or more excipient materials. A wide range of different controlled...
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7576067 |
Pulsatile release compositions and methods for enhanced intestinal oligonucleotide drug absorption
Delayed release oral pharmaceutical formulations and methods for enhanced intestinal drug absorption. The formulation comprises a first population of carrier particles comprising a drug and a...
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7575762 |
Composition comprises sustained-release fine particles and manufacturing method thereof
The present invention relates to a composition comprising sustained-release fine particles, characterized in that it contains sustained-release fine particles that can be used in...
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7572463 |
Oral dosage forms
A controlled-release oral dosage formulation of a salt-forming active ingredient, wherein the active ingredient is present as at least two different salts in a solid aggregation state, wherein the...
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7553500 |
Pharmaceutical composition having uniform drug distribution and potency
Pharmaceutical compositions having uniform drug distribution and potency utilizing laxofoxifene as an active ingredient and containing a silicon dioxide to reduce loss of the active ingredient...
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7553499 |
Sustained release tablet containing indapamide
The present invention relates to a sustained release tablet containing indapamide and the process of manufacturing sustained release tablet containing indapamide. The tablet contains indapamide in...
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7550158 |
Controlled release by extrusion of solid amorphous dispersions of drugs
Controlled release dosage forms for low solubility drugs are disclosed wherein an amorphous solid dispersion of the drug is coated with a non-dissolving and non-eroding coating that controls the...
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7537784 |
Modified release tablet of bupropion hydrochloride
A modified-release tablet of bupropion hydrochloride comprising (i) a core comprising an effective amount of bupropion hydrochloride, a binder, a lubricant; and (ii) a control releasing coat...
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7524515 |
Pharmaceutical safety dosage forms
Pharmaceutical safety dosage forms are provided which include a pharmaceutical and an antagonist to the pharmaceutical. The safety dosage forms are such that the antagonist has no significant...
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7514100 |
Controlled release hydrocodone formulations
A solid oral controlled-release dosage form of hydrocodone is disclosed, the dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof,...
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7510727 |
Melt-extrusion multiparticulates
A unit dose sustained-release oral dosage form containing a plurality of melt-extruded particles, each consisting essentially of a therapeutically active agent, one or more retardants, and an...
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7488498 |
Antidiabetic preparation for oral administration
There is provided a single preparation which directly decreases both of the post prandial blood glucose level and the fasting blood glucose level close to normal levels, by release-sustaining a...
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7476403 |
Oral extended-release composition
The invention is directed to controlled release formulations containing drugs which are preferably considered sparingly soluble to insoluble and which are suitable for administration to a patient...
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7470435 |
Extended release venlafaxine formulation
A controlled release dosage form of venlafaxine that comprises an immediate release pellet and an extended release pellet.
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7465462 |
Multiparticulate controlled release selective serotonin reuptake inhibitor formulations
A multiparticulate controlled release selective serotonin reuptate inhibitor (SSRI) formulation for oral administration is provided. The formulation includes particles of an SSRI or a...
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7442387 |
Pharmaceutical composition for controlled release of active substances and manufacturing method thereof
The present invention pertains to a sized product, which contains a drug, polyethylene oxide with a molecular weight of 2,000,000 or higher, and a specific size controlling agent for polyethylene...
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7431944 |
Delivery of multiple doses of medications
Dosage forms for oral administration of a methylphenidate drug are provided. The dosage forms provide a substantially immediate dose of methylphenidate upon ingestion, followed by one or more...
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7431943 |
Controlled release and taste masking oral pharmaceutical compositions
Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic,...
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7419686 |
Opioid agonist/antagonist combinations
The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid...
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7419684 |
System and method for manufacturing oral osmotic drug delivery devices, and methods of administering same
A system and method for manufacturing oral osmotic drug delivery devices including the use of a mathematical model in deriving relationships between parameters used in manufacturing the devices for...
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7413751 |
Methods of treatment using a gastric retained losartan dosage
A method of treatment for hypertension and other disease states is described, which comprises the delivery of losartan in a gastric retained dosage form.
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7413749 |
Titration dosing regimen for controlled release tramadol
A titration dosing regimen for the administration of controlled release tramadol analgesic to patients. The titration dosing regimen provides a significant reduction in the occurrence of adverse...
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7402321 |
Oral administration form for pyridin-2-ylmethylsulfinyl-1H-benzimidazoles
The invention relates to an oral administration form for pyridin-2-ylmethylsulfinyl-1H-benzimidazoles and their salts, which comprises the active compound together with tablet disintegrants and is...
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7399486 |
Method of preparing mixed formulation of sustained release microspheres by continuous one-step process
Disclosed is a method for preparing a mixed formulation of sustained release microspheres with various compositions by a continuous one-step process. The present method is characterized by...
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7387792 |
Pharmaceutical composition for compressed annular tablet with molded triturate tablet for both intraoral and oral administration
New pharmaceutical compositions in unit dosage form are disclosed for both intraoral and oral administration to a patient, said unit dosage form configured to be placed intraorally of said patient,...
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7384653 |
Oral dosage form comprising a therapeutic agent and an adverse-effect agent
The present invention provides an oral dosage form comprising a first composition and a second composition. The first composition comprises an effective amount of a therapeutic agent and the second...
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7378394 |
Sustained-release microparticle preparation of human growth hormone and process for producing thereof
Provided is a sustained-release microparticle preparation of a human growth hormone which combines biodegradability with sustained-release performance while avoiding the use of an organic solvent...
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7348028 |
Chronotherapeutic diltiazem formulations and the administration thereof
A method of treating or preventing myocardial ischemia in a patient in need thereof comprising administration of a controlled-release Galenical preparation of pharmaceutically acceptable Diltiazem...
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7342048 |
Bioabsorbable pharmaceutical formulation
A bioabsorbable release-sustaining pharmaceutical formulation using a biodegradable release-sustaining base material which can prevent an effective component drug from being released too rapidly...
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7338942 |
Composition and method for maintaining healthy mobile joints and cartilage
Compositions and methods for maintaining healthy mobile joints and cartilage in humans and animals are disclosed. The composition comprises glucosamine and chondroitin dispersed in a...
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7338667 |
Pharmaceutical formulation
The present invention concerns an extended release formulation having an accelerating erosion and/or dissolution rate of the surface of the formulation. The formulation comprises a drug having low...
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7335380 |
Amlodipine free base
Amlodipine free base can be formulated into a convenient oral dosage form, especially a tablet, without excessive stickiness or tablet punch residue. The amlodipine free base can be crystalline...
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7329418 |
Pharmaceutical tablets having height greater than width
An immediate release compressed pharmaceutical tablet that has two or more segments and a top and a bottom and has a height that exceeds the width of the tablet. The height is measured vertically...
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7318935 |
Pharmaceutical tablets with active and inactive segments
An immediate release compressed pharmaceutical tablet that has two or more segments and a top and a bottom and has a height that exceeds the width of the tablet. The height is measured vertically...
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7316818 |
Liposome drug delivery of polycyclic, aromatic, antioxidant or anti-inflammatory compounds
This invention comprises pharmaceutical compositions for administering a polycyclic, aromatic, antioxidant or anti-inflammatory compound to an animal. Particularly provided are proliposomal...
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7314640 |
Formulation and process for drug loaded cores
The present invention relates to a controlled release pellet of metoprolol and its pharmaceutically acceptable salts that uses a water soluble or a water swellable inert starting seed or core.
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7314638 |
Preparing method for controlled released type tablet tamsulosin HCL and the tablet thereof
The present invention relates to a simple and effective method for preparing a tamsulosin HCl sustained-release tablet and a tamsulosin HCl sustained-release tablet produced thereby. The method...
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7304043 |
β-L-2′-deoxy-nucleosides for the treatment of hepatitis B
This invention is directed to a method for treating a host infected with hepatitis B comprising administering an effective amount of an anti-HBV biologically active...
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7300668 |
System for manufacturing controlled release dosage forms, such as a zero-order release profile dosage form manufactured by three-dimensional printing
The present invention includes controlled release dosage forms and methods of designing and manufacturing dosage forms to obtain specific release profiles, for example, zero-order release profiles,...
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7282216 |
Biocompatible polymer blends and uses thereof
The present invention relates to a novel series of polymers which have been prepared by blending hydrophobic biocompatible, biodegradable polymers or copolymers, such as poly(lactide-co-glycolide),...
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7276252 |
Method and form of a drug delivery device, such as encapsulating a toxic core within a non-toxic region in an oral dosage form
A drug delivery device such as an oral dosage form (ODF) with a toxic or potent core encapsulated by a non-toxic region. The non-toxic region may be a region including multiple layers, coatings,...
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