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5654005 Controlled release formulation having a preformed passageway  
A controlled release pharmaceutical tablet having at least one passageway, said tablet having: (a) a compressed core which comprises: (i) a medicament; (ii) an amount of a water soluble...
5651983 Bisacodyl dosage form for colonic delivery  
The present invention relates to a pharmaceutical composition in a unit dosage form for peroral administration in a human or lower animal, having a gastrointestinal tract comprising a small...
5650168 Tablet with improved bioavailability containing dichloromethylenediphosphonic acid as the active substance  
The invention concerns tablets with improved bioavailability of the active substance dichloromethylenediphosphonic acid or of a physiologically tolerated salt thereof and with a content of...
5650170 Dosage form for delivering drug at a controlled rate to the intestine and to the colon  
A drug delivery device is disclosed for delivering a drug to the intestine and the colon. The device comprises external means for delaying the delivery of drug in the stomach, and hydrophobic means...
5641513 Tablet coating method  
A method for coating pharmaceutical tablets is disclosed in which polymeric coating ingredients are combined with saccharides in a melt spinning operation to form composite particulates. The...
5637320 Controlled absorption naproxen formulation for once-daily administration  
A once-daily naproxen formulation for oral administration having a first portion of the naproxen as a multi-particulate pellet form, each pellet having a core of naproxen or a pharmaceutically...
5637309 Physiologically active substance-prolonged releasing-type pharmaceutical preparation  
A prolonged releasing pharmaceutical preparation is provided carrying a physiologically active substance, particularly, calcitonin gene-related peptide (CGRP) or a maxadilan (MAX). This...
5633000 Subcutaneous implant  
A non-abusable, non-inflammatory, biocompatible, non-biodegradable, subcutaneous, polymeric implant for the prolonged, controlled release of hydromorphone with near zero-order kinetics is...
5629018 Composition for controlled release of an active substance and method for the preparation of such a composition  
In a composition for delayed release of an active substance, the active substance is incorporated in a polysaccharide matrix which consists of an essentially crystalline straight-chain glucan and...
5628993 Sustained releasable parenteral pharmaceutical preparations and method of producing the same  
A parenteral pharmaceutical preparation comprises a matrix containing a physiologically active peptide or protein and a polyglycerol diester of a saturated fatty acid, and the matrix is in a solid...
5626876 Floating system for oral therapy  
The invention relates to a floatable, oral, therapeutic system, in which a lengthening of the gastrointestinal residence time of medicaments and a controlled delivery thereof are achieved by...
5624683 Sustained-release multi-granule tablet  
A sustained-release multi-granule tablet is obtained by compressing sustained-release granules, which contains a basis, and a formulation adjuvant. Each of the granules has been coated in advance...
5618559 Method of making modified-release metronidazole compositions  
Pharmaceutical compositions having a modified release profile for once daily dosing of metronidazole, methods for making the pharmaceutical compositions, and methods for treating a microbial...
5618803 Targeted drug delivery via phosphonate derivatives  
The invention provides compounds of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein [D] is the residue of a drug having a reactive functional group, said functional...
5616345 Controlled absorption diltiazen formulation for once-daily administration  
A diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid, and a multi-layer membrane...
5614219 Oral administration form for peptide pharmaceutical substances, in particular insulin  
A peroral administration form for peptidic medicaments contains the peptidic medicament, in particular insulin, distributed in a gelatine or gelatine derivate matrix, besides usual pharmaceutical...
5609590 PH-triggered osmotic bursting delivery devices  
An osmotic bursting device for dispensing a beneficial agent to an aqueous environment. The device comprises a beneficial agent and osmagent surrounded at least in part by a semipermeable membrane....
5607695 Process for the manufacture of porous cellulose matrices  
A process for the manufacture of porous cellulose particles, which have regular shape, and a capacity of sorbing 1.5-9 times of their own weight of water, a tap bulk density of less than 0.85 g/ml...
5603957 Microcapsules for the controlled release of acetylsalicyclic acid in the gastrointestinal environment  
The present invention relates to controlled-release microcapsules of acetylsalicylic acid which comprise particles of acetylsalicylic acid with a size of between 100 and 1000 μm, coated with a...
5603953 Supported liquid membrane delivery devices  
Supported liquid membrane delivery devices that release a beneficial agent to an aqueous environment following exposure to an environmental trigger. A microporous hydrophobic support membrane at...
5593694 Sustained release tablet  
A sustained release tablet comprising a base tablet comprising a water-swellable gelling agent and a pharmaceutically active ingredient dispersed homogeneously in said gelling agent, said base...
5594013 Pharmaceutical compositions containing nifedipine and process for the preparation thereof  
This invention relates to a slow release nifedipine-containing pharmaceutical compositions and methods of making such compositions. The compositions of the inventions comprise a soluble carrier...
5582837 Alkyl-substituted cellulose-based sustained-release oral drug dosage forms  
Sustained release oral drug dosage forms that comprise a tablet or capsule containing a plurality of particles of a solid-state drug dispersed in alkyl cellulose such as hydroxyethylcellulose or...
5573776 Oral osmotic device with hydrogel driving member  
An osmotic device (10) for delivering an ergot alkaloid into the mouth of a human patient is disclosed. The device (10) has a size and shape adapting it to be comfortably retained in the mouth for...
5569469 Poorly soluble medicaments supported on polymer substances in a form suitable for increasing their dissolving rate  
A poorly soluble medicament is incorporated into particles of a crosslinked polymer which is swellable in water but insoluble in water, and the product obtained is brought into contact with a...
5567439 Delivery of controlled-release systems(s)  
The present invention is a method and a dosage unit for delivery of a controlled-release system. The dosage unit is a quick dissolve unit which can be prepared by mixing uncured shearform matrix...
5562919 Dried animal plasma as a pharmaceutical excipient for compressed tablet formulation  
This invention relates to the use of purified spray dried animal plasma as a binder for tablet pharmaceutical compositions. Spray dried plasma demonstrates good tablet formation as a direct...
5560930 Method for preparing aqueous emulsion for coating solid pharmaceutical preparations  
A method permits the easy preparation of an aqueous emulsion for coating solid pharmaceutical preparations through emulsification in water without addition of additives such as emulsifying agents,...
5560928 Nutritional and/or dietary composition and method of using the same  
A composition and method of using the same which provides in as little as a single dose covering a 24 hour period a nutritional and/or dietary supplement which provides administration of water...
5560921 Chewable decongestant compositions  
The present invention relates to immediate release compositions comprising a pre-complex comprising a polymeric polycarboxylate and an aminophenylalkanol vasoconstrictor in a solid chewable matrix...
5558879 Controlled release formulation for water soluble drugs in which a passageway is formed in situ  
A controlled release pharmaceutical tablet is disclosed which is based on: (a) a compressed core which contains: (i) a medicament; (ii) from 5 to 20% by weight of a water soluble osmotic...
5556638 Flurbiprofen-containing immediate-effect medicament and its use  
A medicament for immediately treating painful, inflammatory and/or febrile acute diseases contains flurbiprofen as a racemate, a mixture of a racemate with its enantiomers, a pseudoracemate...
5552152 Taste masking of ibuprofen by fluid bed coating  
A chewable taste-masked ibuprofen tablet having controlled release characteristics.
5549911 Galenic form of 5-nitromidazole derivatives which is effective for the treatment of parasitoses and infections of the entire gastrointestinal tract  
The present invention relates to a galenic form of 5-nitroimidazole derivatives which is characterized in that it comprises a combination of microgranules of 5-nitroimidazole derivatives...
5549891 Method for disinfecting contact lens with catalase compositions  
Compositions and methods for destroying hydrogen peroxide in hydrogen peroxide-containing liquid aqueous media, for example, employed to disinfect contact lenses, are disclosed. In one embodiment,...
5543156 Bioerodible devices and compositions for diffusional release of agents  
The present invention is directed to erodible delivery devices and to the compositions comprising the devices. The devices comprise (a) a body formed of a bioerodible polymer or polymers together...
5543155 Diffusion-osmotic controlled drug-release pharmaceutical composition and process for preparing same  
The invention relates to a novel diffusion-osmotic controlled drug-release pharmaceutical composition containing a one-layer tablet core including a polymeric film-coat, a therapeutically active...
5538734 5-methyltetrahydrofolic acid, 5-formyl-tetrahydrofolic acid and their pharmaceutically acceptable salts for use in the therapy of depressive disturbances  
The present invention refers to the use of 5-methyltetrahydrofolic acid, of 5-formyltetrahydrofolic acid and of their pharmaceutically acceptable salts for the preparation of controlled release...
5536505 Controlled release matrix system using cellulose acetate/poly-2-ethyl-2-oxazoline blends  
This invention relates to a controlled release matrix system comprising a homogenous mixture of poly-2-ethyl-2-oxazoline, cellulose acetate having a degree of substitution for acetyl of from about...
5529777 Hydrogel microencapsulated vaccines  
Water soluble polymers or polymeric hydrogels are used to encapsulate antigen to form vaccines. The antigen is mixed with a polymer solution, microparticles are formed of the polymer and antigen,...
5525354 Pharmaceutical preparation and process for its manufacture  
In a pharmaceutical preparation for oral use containing a pharmacologically acceptable salt of a bisphosphonic acid, the improvement comprising: a drug delivery form of the preparation which is...
5520931 Controlled release morphine preparation  
The present invention concerns an oral morphine preparation having essentially complete bioavailability and, for the major part of the dissolution, an essentially zero order and essentially pH...
5521091 Compositions and method for destroying hydrogen peroxide on contact lens  
Compositions and methods for destroying hydrogen peroxide, for example, contact lens disinfecting amounts of hydrogen peroxide, are disclosed. The present invention utilizes non-mammalian-derived...
5512290 Compositions containing 2-acetyl-1-pyrroline  
A powder-form composition of 2-acetyl-1-pyrroline incorporated with a support of maltodextrin and/or cyclodextrin. The composition is prepared by hydrolyzing a 2-(1-alkoxyethenyl)-1-pyrroline with...
5510114 Slow release pharmaceutical composition containing a bile acid as an active ingredient  
A slow-release pharmaceutical composition containing a bile acid as active ingredient and comprising at least one bioadhesive substance and at least one high specific gravity substance, an aliquot...
5508042 Controlled release oxycodone compositions  
A method for substantially reducing the range in daily dosages required to control pain in approximately 90% of patients is disclosed whereby an oral solid controlled release dosage formulation...
5505963 Slow release pharmaceutical preparation  
A method of preparing pharmaceutical preparations for oral administration, free of organic solvents. The method employs solidified melt granulates of an active ingredient in admixture with a...
RE35162 Rumen and other stomach chamber bypass nutrients and methods of fabrication  
A stomach chamber bypass nutrient comprises a beadlet fabricated in two steps having two regions, a first region having the desired nutrient and a second region including fats and calcium based...
5487900 Stabilized vitamin D preparation  
Heat-labile vitamin D is dispersed in a basic polymer and an excipient readily soluble in an organic solvent to provide a pharmaceutical composition. The composition exhibits reduced isomerization,...
5486364 Readily available konjac glucomannan as a sustained release excipient  
A solid dosage form, such as a pharmaceutical tablet, containing a rapidly hydratable konjac glucomannan sustained release excipient such as clarified konjac, cryogenically ground konjac and...