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6960357 Chemical delivery device  
The invention provides a controlled release dissolution and diffusion devices which can deliver an active ingredient at a constant or controlled-variable rate comprising an active ingredient and...
6958161 Modified release coated drug preparation  
A modified release preparation having one or more coated core elements, each core element including an active ingredient and having a modified release coating, wherein a stabilising coat is...
6955821 Sustained release formulations of guaifenesin and additional drug ingredients  
The invention relates to a novel pharmaceutical sustained release formulation of guaifenesin and at least one additional drug ingredient. The formulation may comprise a hydrophilic polymer,...
6953588 Multi-vitamin and mineral supplement  
This invention is directed to a multi-vitamin and mineral supplement tailored to men and post-menopausal women, pre-menopausal women, and athletes which supplies the right amount of the right...
6953586 Growth promoting pharmaceutical implant  
A combination growth promoting pharmaceutical pellet system which delivers doses of both a growth stimulating pharmaceutical agent and a supplemental agent that enhances the growth produced by the...
6933380 Excipients containing low residual solvent and method for producing the same  
The present invention provides low-residual-solvent containing excipients with residual solvent less than <3000 ppm. Most of the excipients are required to first be modified to become more water...
6932981 Rapidly disintegrating sustained release cefuroxime axetil composition  
A fast disintegrating controlled release oral composition comprising a core material containing cefuroxime axetil present as controlled release form, the cefuroxime axetil being provided with an...
6929804 Anti-fungal composition  
An anti-fungal product for delivering at least two different anti-fungals that is comprised of three dosage forms with different release profiles with each anti-fungal being present in at least one...
6926907 Pharmaceutical compositions for the coordinated delivery of NSAIDs  
The present invention is directed to drug dosage forms that release an agent that raises the pH of a patient's gastrointestinal tract, followed by a non-steroidal anti-inflammatory drug. The dosage...
6923988 Solid carriers for improved delivery of active ingredients in pharmaceutical compositions  
The present invention provides solid pharmaceutical compositions for improved delivery of a wide variety of pharmaceutical active ingredients contained therein or separately administered. In one...
6919092 Method for the management of incontinence  
A composition and a dosage form are disclosed comprising oxybutynin alone/or accompanied by another drug indicated for therapy. A method is disclosed for administering oxybutynin alone/or...
6914141 Clopidogrel bisulfate tablet formulation  
Pharmaceutical tablets comprising clopidogrel bisulfate and a lubricant selected from zinc stearate, stearic acid, and sodium stearyl fumarate.
6913767 Compositions for microencapsulation of antigens for use as vaccines  
Methods and compositions are provided for the encapsulation of antigens in PLGA microspheres for use as vaccines. Such microspheres can also contain adjuvants. Mixtures of microspheres are provided...
6913768 Sustained release delivery of amphetamine salts  
A pharmaceutical composition comprises a once-a-day sustained release formulation of at least one amphetamine salt which provides mean plasma concentration profile aspects in human ADHD patients...
6911217 Controlled release bead, a method of producing the same and multiple unit formulation comprising it  
A controlled release bead comprises: (i) a core unit of a substantially water-soluble or water-swellable inert material; (ii) a first layer on the core unit of a substantially water-insoluble...
6905707 Controlled release arginine alpha ketoglutarate  
An oral formulation of arginine α-ketoglutarate is disclosed which formulation is comprised of arginine α-ketoglutarate and one or more excipient materials. A wide range of different controlled r...
6902746 Oral pharmaceutical compositions containing non-steroidal anti-inflammatory drugs and method for preparing the same  
The present invention provides oral pharmaceutical compositions for acetic acid class of non-steroidal anti-inflammatory drug (NSAID), particularly ketorolac. The pharmaceutical composition...
6902742 Multiparticulate modified release composition  
The invention relates to a multiparticulate modified release composition that in operation delivers an active ingredient in a pulsed or bimodal manner. The multiparticulate modified release...
6899896 Hydrogel-driven layered drug dosage form  
A controlled release dosage form for sertraline has a core comprising a sertraline-containing composition and a water-swellable composition wherein the water-swellable composition is in a separate...
6893661 Controlled release formulations using intelligent polymers  
An extended release dosage composition of pharmaceutically active substances that have a water contact angle (θ) such that cos θ is between +0.9848 and −0.9848 presented as a matrix tablet con...
6890561 Microencapsulated and controlled-release formulations of isoflavone from enriched fractions of soy and other plants  
There is provided an orally-administrable formulation for the controlled release or stable storage of a granulated isoflavone-enriched fraction or mixture of such fractions, comprising at least one...
6887857 Microparticle protection of therapeutic agents  
The present invention is directed to the use of microparticles to protect the pharmaceutical effectiveness of a pharmaceutically active agent. According to one embodiment, a pharmaceutically...
6887492 Magnesium plus interactive agent delivery  
The present invention is an orally administered pharmaceutical composition that provides for the controlled release of magnesium. The composition has an interactive agent component and a magnesium...
6884433 Sustained release formulation containing tacrolimus  
Sustained release formulation containing tacrolimus or its hydrate is provided. The time (T63.2%) required for 63.2% of the maximum amount of tacrolimus or its hydrate to be dissolved is 0.7 to 15...
6875448 Method of intracellular sustained-release of drug and preparations  
A substance of interest is contained in nanospheres which are then encapsulated in fusogenic liposomes to prepare transport carriers that allow physiologically active substances, especially those...
6875446 Method for prophylaxis and/or treatment of thromboembolism  
A new oral IR formulation in solid form for a low molecular weight thrombin inhibitor having pH dependant dissolution, characterized in that the formulation comprises a filler or a combination of...
6872407 Extended release formulations of erythromycin derivatives  
Disclosed is a pharmaceutical composition for extended release of an erythromycin derivative in the gastrointestinal environment. The composition comprises an erythromycin derivative and a...
6869615 Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor  
An oral solid dosage form includes a therapeutically effective amount of an NSAID and a proton pump inhibitor in an amount effective to inhibit or prevent gastrointestinal side effects normally...
6869976 Inorganic-polymer complexes for the controlled release of compounds including medicinals  
This invention relates generally to the production and use of inorganic-polymer complexes for the controlled release of compounds including medicinals. Advantageously, the inorganic used is calcium...
6866867 Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose  
The present invention provides an improved process for the preparation of a agglomerated solid dosage form, comprising: (1) preparing an aqueous slurry of (a) microcrystalline cellulose; (b) a...
6866866 Controlled release metformin compositions  
A composition for treating patients having non-insulin-dependent diabetes mellitus (NIDDM) by administering a controlled release oral solid dosage form containing preferably a biguanide drug such...
6863902 Immediate release eplerenone compositions  
The invention relates to oral pharmaceutical compositions useful as aldosterone receptor blockers comprising the active agent micronized eplerenone in an amount of about 10 mg to about 1000 mg and...
6861072 Pharmaceutical composition with gastric residence and controlled release  
The invention concerns a pharmaceutical composition with gastric residence and controlled release, characterized in that it comprises two or three layers and contains (a) an active principle...
6855331 Sustained release hydrophobic bioactive PLGA microspheres  
A controlled release microcapsulate pharmaceutical formulation for burst-free, sustained, programmable release of hydrophobic bioactive agent over a duration from 24 hours to 100 days comprising:...
6855334 Controlled delivery of active agents  
Controlled release of active agents from sustained release push delivery devices having high drug loading are described wherein residual drug content in the device is minimized by the utilization...
6844172 Amylose products as matrix former for programmed release systems, process for preparing these amylose products, and process for making programmed release systems  
The invention relates to matrix-forming amylose products for programmed release systems and a process for the preparation thereof. These amylose products have a dextrose equivalent (DE) of 5 to 10,...
6838093 System for osmotic delivery of pharmaceutically active agents  
An osmotic system for delivering a pharmaceutically active agent which comprises a core portion, a layer portion enclosing the core portion, and a semipermeable wall portion enclosing the core...
6835398 Method of administering high-dose, oral magnesium for treatment of chronic pain syndrome of erythromelalgia  
A method of treating patients, particularly for pain and/or symptoms of erythromelalgia, and other neurovascular or neuropathic disorders, etc. involves administering high doses of magnesium. The...
6833140 Orally administered dosage forms of GABA analog prodrugs having reduced toxicity  
The present invention provides an extended release oral dosage form of prodrugs of gabapentin and other GABA analogs, which dosage forms exhibit reduced toxicity. The dosage forms are particularly...
6827946 Compositions containing both sedative and non-sedative antihistamines  
Compositions comprising both a sedative and a non-sedative antihistamine are disclosed as well as methods of inhibiting the release of histamines by administration of the compositions to a...
6821532 Methods and compositions for the treatment of benign prostatic hypertrophy  
This invention relates to a composition for use in treating benign prostatic hyperplasia including a saw palmetto extract provided in an oral controlled release formulation which allows release of...
6811794 Sustained release pharmaceutical dosage forms with minimized pH dependent dissolution profiles  
A pharmaceutical composition comprising at least one pharmaceutically active agent that is pH dependent, at least one non-pH dependent sustained release agent, and at least one pH dependent agent...
RE38629 Solid oral dosage form comprising a combination of metformin and glibenclamide  
The present invention relates to a solid oral dosage form comprising a combination of metformin and glibenclamide in which the size of glibenclamide is such that the glibenclamide bioavailability...
6806294 Opioid analgesic  
The invention is relative to a pharmaceutical preparation, especially for oral administration, with at least one active substance and with formulation components influencing the release of active...
6805880 Pharmaceutical delivery system for vitamin C and vitamin E and use of a combination of vitamin C and E for preventing or treating conditions involving oxidative stress  
A pharmaceutical delivery system comprising a slow-release formulation of vitamin C (ascorbic acid) and a plain-release formulation of vitamin E (tocopherol) has been found to raise and maintain...
6805881 Multiple unit controlled food effect-independent release pharmaceutical preparations and method for preparing the same  
The present invention relates to orally administrable multiple-unit sustained-release dose forms having controlled agitation-independent release of active compound and processes for their...
6797704 Systemic delivery of compounds through non-invasive bladder administration  
The present invention features methods of administering a therapeutic agent to a patient's lymph nodes by instillation of microparticles or nanoparticles comprising a biocompatible polymer and the...
6797283 Gastric retention dosage form having multiple layers  
The present invention is directed to a multilayered dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of an active agent to a fluid environment of use....
6794464 Membrane or matrix for controlling the permeation rate of drugs  
A membrane or matrix for controlling the permeation rate of a drug, where the membrane or matrix includes a siloxane-based elastomer composition which contains at least one elastomer and optionally...
6790459 Methods for treating diabetes via administration of controlled release metformin  
A method for treating patients having non-insulin-dependent diabetes mellitus (NIDDM) by administering a controlled release oral solid dosage form containing preferably a biguanide drug such as...