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RE38071 |
Method for treating infectious respiratory diseases
A method of treating pneumonia caused by a microorganism by administering directly into the lower respiratory tract of a host an amount of an anti-inflammatory agent effective to reduce...
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6537524 |
Combinations of formoterol and a tiotropium salt
A medicament containing, separately or together, (A) formoterol or a pharmaceutically acceptable salt thereof or a solvate of formoterol or said salt and (B) a tiotropium salt of a pharmaceutically...
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6534078 |
Micro-encapsulated pepper-mustard composition and methods of using the same
A micro-encapsulated pepper-mustard composition which comprises positioning pepper and mustard mixtures within a cluster of surfactant molecules, i.e. micelles, dispersed in water. This...
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6531112 |
Formulations for administering calcitonin and processes for preparing the same
The present invention provides a non-invasive method for administering polypeptides across epithelial membranes. The formulations in the present invention comprise solid polypeptide particles mixed...
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6528096 |
Carrier mixed with additives having lubricant properties for preparing powdery pharmaceutical compositions for inhalation
Powdery pharmaceutical compositions including an active ingredient and carrier particles containing only a small amount of lubricant, 0.1-0.5% by weight, are used to prepare dry powder inhalers in...
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6524557 |
Aerosol formulations of peptides and proteins
A pharmaceutical aerosol formulation comprising (a) a HFA propellant; (b) a pharmaceutically active polypeptide dispersible in the propellant; and (c) a surfactant which is a C 8 -C 16 fatty acid...
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6524555 |
Metered dose inhaler for salmeterol
A metered dose inhaler having part or all of its internal metallic surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for...
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6521212 |
Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation
A method of delivering benzindene prostaglandins to a patient by inhalation is discussed. A benzindene prostaglandin known as UT-15 has unexpectedly superior results when administered by inhalation...
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6511652 |
Metered dose inhaler for beclomethasone dipropionate
A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for...
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6511653 |
Metered dose inhaler for beclomethasone dipropionate
A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for...
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6509006 |
Devices compositions and methods for the pulmonary delivery of aerosolized medicaments
According to the subject invention, dispersible dry powder pharmaceutical-based compositions are provided, including methods for their manufacture and dry powder dispersion devices. A dispersible...
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6503482 |
Non-chlorofluorocarbon aerosol formulations
Aerosol formulations substantially free of chlorofluorocarbons, for oral and/or nasal administration, are described. The formulations comprise 1,1,1,2-tetrafluoroethane, a medicament, optionally an...
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6495154 |
On demand administration of clomipramine and salts thereof to treat premature ejaculation
A method is provided for delaying the onset of ejaculation in an individual. The method involves systemic and on demand administration to an individual of a pharmaceutical formulation containing an...
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6491897 |
Stable pharmaceutical budesonide preparation for producing propellant-free aerosols
A stable ethanolic solution of budesonide is disclosed, which solution is suitable for use in nebulizers, together with a process for making such stable solution.
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6485706 |
Formulations comprising dehydrated particles of pharma-ceutical agents and process for preparing the same
A formulation for non-invasive delivery of pharmaceutical agents, particularly proteins and peptides, by absorption through a membrane at a targeted site is provided, along with a process of making...
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6482390 |
Aerosol formulations and method
A hand held apparatus and method for creating an aerosolized mist of particles is described. The apparatus comprises a high pressure vessel containing a solution or suspension of the substance to...
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6479049 |
Methods and compositions for the dry powder formulation of interferons
According to the present invention, methods and compositions are provided for spray-dried, interferon-based dry powder compositions, particularly interferon-beta. The compositions are useful for...
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6475524 |
Composition of matter
The invention provides a process for crystallization of amorphous and/or meta-stable crystalline regions of preformed particles by treating the particles with a supercritical or subcritical fluid...
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6475523 |
Powders comprising anti-adherant materials for use in dry powder inhalers
A powder for use in a dry powder inhaler comprises active material and additive material. The additive material comprises an anti-adherent material and the powder includes at least 60% by weight of...
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6471944 |
Aerosol powder with improved skin adhesion
Powdery aerosol preparations, which are characterized in that 50 to 90% by weight of a propellant having a vapor pressure at 20° C. of 4.5 kg/cm 2 or less, 5 to 30% by weight of an aliphatic...
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6464886 |
Device and method for creating spherical particles of uniform size
Spherical particles having a size on the order of 0.1 to 100 microns in size are created by systems and devices of several types. The device includes a source of a stream of gas which is forced...
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6461592 |
Method for transferring one or more active ingredients between different phase carriers
The present invention relates to a method for transferring one or more active ingredients between different phase carriers, which includes: (a) providing a solid, semi-solid, or nonaqueous liquid...
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6458338 |
Amino acid stabilized medicinal aerosol formulations
This invention relates to a medicinal aerosol formulation and more particularly, to a medicinal aerosol formulation containing a particulate drug, a propellant and a stabilizing agent selected from...
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6455028 |
Ipratropium formulation for pulmonary inhalation
Pharmaceutical aerosol formulations are provided comprising substantially nonacicular particles of a bronchodilator selected from the group consisting of ipratropium and pharmacologically...
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6451288 |
Method of treating lung diseases with uridine 5′-diphosphate and analogs thereof
Compounds of Formula I: wherein: X 1 , and X 2 are each independently either O − or S − ; X 3 and X 4 are each independently either —H or —OH, with the proviso that X 3 and X 4 are...
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6451286 |
Pharmaceutical compositions for buccal and pulmonary administration comprising an alkali metal alkyl sulfate and at least three micelle-forming compounds
Pharmaceutical compositions comprising a macromolecular pharmaceutical agent in mixed micellar form are disclosed. The mixed micelles are formed from an alkali metal alkyl sulfate, and at least...
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6451285 |
Suspension aerosol formulations containing formoterol fumarate and a fluoroalkane propellant
Provided are pressurized metered dose inhalers containing stable formulations of a β-agonist drug in suspension or solution. Also provided are aerosol formulations suitable for inhalation therapy...
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6447751 |
Method and device for facilitating combined aerosol and oral treatments for diabetes mellitus
A dispensing container which incorporates an aerosolizable topical insulin preparation, at least one oral hypoglycemic agent, and indicia and instructions for their coordinated use as a single...
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6447752 |
Amorphous porous particles for deep lung delivery
Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a...
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6447753 |
Porous particles for deep lung delivery
Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a...
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6436368 |
Process for preparing beclomethasone dipropionate freon® clathrate
Described is a process for preparing beclomethsaone dipropionate Freon® clathrate comprising the use of an agent which selectively binds methanol to selectively remove methanol from a mixture of...
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6432440 |
Pectin compositions and methods of use for improved delivery of drugs to mucosal surfaces
Liquid pharmaceutical compositions for administration to a mucosal surface, comprising a therapeutic agent and a pectin with a low degree of esterification are described. Such compositions gel, or...
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6432383 |
Method for administering insulin
A mixed micellar pharmaceutical formulation includes a micellar proteinic pharmaceutical agent, an alkali metal lauryl sulphate, alkali metal salicylate, a pharmaceutically acceptable edetate and...
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6433040 |
Stabilized bioactive preparations and methods of use
Stabilized dispersions are provided for the delivery of a bioactive agent. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that...
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6428771 |
Method for drug delivery to the pulmonary system
Drug delivery to the pulmonary system has been achieved by encapsulation of the drug to be delivered in microparticles having a size range between 0.5 and ten microns, preferably in the range of...
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6428769 |
Acute testosterone administration
The libido of adult human female patients is increased by the intrapulmonary delivery of testosterone. A formulation of testosterone is aerosolized and inhaled into a patient's lungs where...
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6423299 |
Composition for treatment of a bacterial infection of an upper respiratory tract
An aerosol composition for treating bacterial infections of the respiratory tract by delivering said aerosol to the mouth, throat or nasal passage, wherein the bacteria to be treated is selected...
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6423298 |
Pharmaceutical formulations for aerosols with two or more active substances
The present invention relates to new pharmaceutical formulations for aerosols with at least two or more active substances for administration by inhalation or by nasal route. Specifically, the...
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6419901 |
Method for treating neoplasms by inhalation
A formulation, method, and apparatus for treating neoplasms such as cancer by administering a pharmaceutically effective amount of highly toxic composition by inhalation, wherein the composition is...
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6416743 |
Aerosol formulations of albuterol and 1,1,1,2-tetrafluoroethane
Aerosol formulations substantially free of chlorofluorocarbons, for oral and/or nasal administration are described. The formulations comprise 1,1,1,2 tetrafluoroethane, a medicament, optionally an...
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6416742 |
Medicinal aerosol solution formulation with biocompatible polymer
Methods, compounds, and medicinal formulations utilizing biocompatible polymers for delivery of a drug, particularly for solubilizing, stabilizing and/or providing sustained release of drug from...
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6416739 |
Microparticles and their therapeutic or diagnostic use
Microcapsules having a wall thickness of no more than 500 nm, and a bulk density of no more than 0.2 g.cm −3 , are suitable for therapeutic or diagnostic use. They are aerodynamically light, and...
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6413497 |
Pharmaceutical composition using a mixture of propellant gases for a metered dose inhaler
New advantageous propellent gas mixtures contain two or more components, at least one of which is a partially fluorinated lower alkane, and may be used in pharmaceutical preparations.
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6413496 |
Pharmaceutical compositions and devices for their administration
A device for providing pharmaceutical doses comprising a container, filled with a pharmaceutical composition including a pharmaceutically active agent in a solution of liquified...
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6413547 |
Liquid crystal forms of cyclosporin
This invention relates to novel, liquid crystal forms of the cyclic peptide cyclosporin and to novel powder formulations of cyclosporin prepared using this novel liquid crystal form of the drug....
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6403058 |
Pesticidal aerosol formulation
A pesticidal aerosol formulation which comprises (a) the compound shown by the general formula (1), (2) or (3) defined in the specification, (b) a powder carrier, (c) a propellant and (d) a solvent...
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6383471 |
Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
The present invention is directed to a pharmaceutical composition including a hydrophobic therapeutic agent having at least one ionizable functional group, and a carrier. The carrier includes an...
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6375984 |
Aqueous-based pharmaceutical composition
An aqueous pharmaceutical composition which is capable of being sprayed into the nasal cavity of an individual and which comprises: (A) a pharmaceutically effective amount of solid particles of...
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6372258 |
Methods of spray-drying a drug and a hydrophobic amino acid
According to the subject invention, dispersible dry powder pharmaceutical-based compositions are provided, including methods for their manufacture and dry powder dispersion devices. A dispersible...
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6372196 |
Hemostatically active aerosol composition of polyanhydroglucoronic acids and its salts
Wounds involving minor lesions such as cuts, excoriations, burns, scalds and various kinds of open efflorescence require rapid covering to arrest bleeding, to disinfect the wound area and to...
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