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5213811 |
Oral sustained-release drug compositions
Sugar or sugar/starch beads coated with a first coating of a drug, for example 1,2-dihydro-6-(lower alkyl)-2-oxo-5-(4-pyridinyl)-nicotinonitrile (milrinone), hydroxypropyl methylcellulose or...
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5187150 |
Polyester-based composition for the controlled release of polypeptide medicinal substances
The pharmaceutical composition is intended in particular for the sustained and controlled release of an effective dose of a medicinal substance. It comprises, as a carrier for the medicinal...
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5122384 |
Oral once-per-day organic nitrate formulation which does not induce tolerance
A controlled-release organic nitrate formulation for once-per-day oral administration is provided by spheres having a core which includes an organic nitrate, and a membrane surrounding the core...
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5114720 |
Gelatin coated tablets and method for producing same
Pharmaceutical tablets having increased slipperiness and swallowability are provided. The enhanced swallowability is imparted by an overcoat of a low bloom gelatin, which overcoat has a lower...
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5102668 |
Sustained release pharmaceutical preparation using diffusion barriers whose permeabilities change in response to changing pH
A sustained-release pH independent pharmaceutical preparation having multi-units of microparticles comprising a granular drug which is less soluble at low pH and more soluble at high pH. The...
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5096717 |
Double-coated granules of disodium pamidronate
The invention relates to an advantageous oral administration from the disodium pamidronate in capsules. These capsules are filled with double-coated granules. The inner coating is hydrophilic and...
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5091189 |
Controlled release dosage forms having a defined water content
A controlled release, solid, oral dosage form containing a 3-alkylxanthine, preferably theophylline, at least one hydrophilic or hydrophobic polymer, at least one wax having a melting point between...
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5075109 |
Method of potentiating an immune response
A method of delivering a bioactive agent to an animal entailing the steps of encapsulating effective amounts of the agent in a biocompatible excipient to form microcapsules having a size ranging...
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5043167 |
Galenic formulations with programmed release
New galenic formulations with programmed release, to be administered by the oral route, containing as the active ingredient a drug selected from the non steroidal antiinflammatory, bronchodilator,...
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5023083 |
Azarbine composition
A method for treating azaribine-responsive diseases in patient's who exhibit severe pyridoxal phosphate depletion following the oral administration of azaribine comprises first encapsulating...
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4971805 |
Slow-releasing granules and long acting mixed granules comprising the same
Slow-releasing granules which are characterized by coating the quick-releasing granules which comprise an active ingredient, polyvinyl pyrrolidone polymer and a disintegrator where the polymer...
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4942040 |
Pharmaceutical preparation and a process for its preparation
Preparation giving a controlled and extended release of both a dihydropyridine, e.g. felodipine and a β-adrenoreceptor antagonist, namely metoprolol as well as a method for the manufacture of the...
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4925672 |
Products containing a calcium antagonist and a lipid-lowering agent
Combinations of calcium antagonists and lipid-lowering agents are suitable for controlling diseases.
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4919929 |
Mammal immunization
Mammals are brought to a specific state of immunization by administering an amount of an antigenic substance sufficient to elicit an immunization response to said mammal, said antigenic substance...
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4917899 |
Controlled absorption diltiazem formulation
A diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid and a lubricant, and a...
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4898737 |
Controlled absorption pharmaceutical composition
A sustained absorption propranolol-containing pellet for oral administration comprises a core of propranolol or a pharmaceutically acceptable salt thereof and an organic acid embedded in a...
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4891230 |
Diltiazem formulation
A diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid, and a multi-layer membrane...
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4874613 |
Taste concealing pharmaceutical dosage unit
A pharmaceutical dosage unit suitable for masking the unpleasant taste of orally administered pharmaceutical agents and which facilitates swallowing comprises a plurality of subdosage units...
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4867985 |
Spheroids
A controlled release pharmaceutical composition contains a number of spheroids, the spheroids containing a water-insoluble drug dispersed in a controlled release matrix. The matrix contains between...
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4859469 |
Novel galenic forms of verapamil, their preparation and medicines containing said novel galenic forms
The invention relates to a novel galenic form of verapamil which show an excellent bioavailability. The novel galenic form comprises microgranules containing a verapamil addition salt with an acid,...
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4814175 |
Nifedipine combination preparation
The invention relates to nifedipine combination preparations, containing nifedipine with delayed release of active agent and a β-blocker in each case in granulated form, and their pharmaceutical...
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4810500 |
Medication and method for treating heartworms in dogs
A medication and method for treating heartworms in dogs, which medication includes a time release capsule or tablet dosage structure which is characterized either by discrete elements (capsule) or...
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4794000 |
Coacervate-based oral delivery system for medically useful compositions
The present invention provides for an oral drug delivery system based on a two phase liquid coacervate system prepared from water and one or more surfactants selected from anionic, cationic,...
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4773907 |
Primary delivery system comprising secondary dosage form
A delivery system is disclosed comprising a wall surrounding a lumen containing a plurality of dosage delivery devices. The wall is formed of an environment sensitive material that releases the...
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4721619 |
Controlled absorption diltiazen pharmaceutical formulation
A controlled absorption diltiazem formulation for oral administration comprises a pellet having a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid...
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4716040 |
Controlled absorption methyldopa pharmaceutical formulation
A controlled absorption methyldopa formulation for oral administration comprises a pellet having a core of methyldopa or a pharmaceutically acceptable salt thereof in association with an organic...
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4587118 |
Dry sustained release theophylline oral formulation
A dry sustained release oral dosage formulation of theophylline and a method of orally administering theophylline is disclosed. The oral formulation is comprised of a capsule which includes upper...
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4525339 |
Enteric coated oral dosage form
There is presented a method, in the form of a dosage formulation, for transforming substantially orally inactive β-lactam antibiotics or their pharmaceutically acceptable salts or the esters,...
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4524060 |
Slow release pharmaceutical composition
The invention provides a sustained release pharmaceutical composition comprising a mixture of micronized indoramin or a pharmaceutically acceptable salt thereof, a water-channelling agent, a...
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4507276 |
Analgesic capsule
An analgesic capsule containing asprin and APAP. The aspirin is in the form of an enteric coated granule, and the APAP is present in powder form.
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4427648 |
Dipyridamole-containing pharmaceutical form
This invention relates to vehicles for the administration of dipyridamole. More specifically, this invention relates to a method of treating cardiovascular disorders in a host in need of such...
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4421736 |
Sustained release diethylpropion compositions
Sustained release formulations for the anorectic agent, diethylpropion hydrochloride, are disclosed which are suitable for use in capsules.
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4367217 |
Dipyricamole sustained release forms comprising lacquer-coated particles and the preparation thereof
This invention relates to a composition for the sustained release of dipyridamole which comprises (i) spheroid particles comprised of dipyridamole or crystallized salts thereof and...
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4365060 |
Enterosoluble capsules
The invention provides a novel enterosoluble capsule for containing a medicament, which is shaped with a hitherto not used novel cellulose derivative. The cellulose derivative is a mixed ester of...
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4292298 |
Pharmaceutical compositions containing paracetamol
The acute liver toxicity effects of paracetamol are reduced by co-formulating with sustained release ascorbic acid which produces high liver concentrations of ascorbate anion after oral...
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4287221 |
Method for providing enteric coating on solid dosage forms
The invention provides a novel method for providing entric coating on solid dosage forms using an aqueous coating liquid so that the problems inherent to the use of a coating liquid in an organic...
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4259315 |
Controlled release potassium dosage form
Pharmaceutical compositions for treating potassium deficiency in monogastric animals comprising gelatin capsules containing mixture comprised of controlled release form of microencapsulated...
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4199560 |
Solid oral pharmaceutical product with increased efficacy and predetermined steady state of solubility
The present invention relates to a solid oral pharmaceutical preparation with protracted release of the active ingredient consisting of discrete solid granules containing the active ingredient...
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4198390 |
Simethicone antacid tablet
A tablet containing at least two separate and discrete volume portions one of which contains simethicone and the other of which contains antacid. A barrier separates the two volume portions to...
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4193985 |
Multiple-units drug dose
A controlled release multiple-units drug dose is described, which comprises a tablet or a capsule enclosing a plurality of subunits, each containing a therapeutically active agent and being...
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4154636 |
Method of film-coating medicines
A method of film-coating medicines which comprises either putting a prescribed dose of a medicine between two sheets capable of releasing the medicine wrapped therein within the digestive organs or...
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4138475 |
Sustained release pharmaceutical composition
Sustained release pharmaceutical composition consisting of a hard gelatine capsule containing film coated spheroids, the spheroids comprising propranolol, or a pharmaceutically-acceptable salt...
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4126502 |
Manufacture of pharmaceutical dosage forms
Pharmaceutical dosage forms comprising an edible web having deposited thereon or at least partially thereon a particulate medicament, the webs being thereafter fabricated and finished to...
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4126503 |
Manufacture of pharmaceutical dosage forms
Pharmaceutical dosage forms comprising an edible web having deposited thereon or at least partially thereon a particulate medicament, the webs being thereafter fabricated and finished to...
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4083949 |
New oral form of medicament and a method for producing it
An oral form of medicament releases active substance in the gastrointestinal tract at a constant rate.
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4064230 |
Polyenic macrolide compositions
A method of increasing the overall effectiveness, including stability and gastrointestinal tolerability, of a polyenic macrolide selected from the class consisting of candicidin, fungimycin,...
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4031200 |
Manufacture of pharmaceutical unit dosage forms
Pharmaceutical dosage forms comprising an edible web having deposited thereon or at least partially thereon a particulate medicament, the webs being thereafter fabricated and finished to...
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4020005 |
Gelled reagent materials
Reagents can be provided in more convenient and readily-utilizable forms by converting the basic desired reagent material into a shapeable solid using gelation techniques (i.e., a non-crystalizing...
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4013784 |
Delayed release pharmaceutical preparations
A novel delayed release pharmaceutical preparation which is free of added enzymes and thus is stable on storage is provided. The preparation comprises particles of the therapeutically effective...
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4001211 |
Pharmaceutical capsules from improved thermogelling methyl cellulose ethers
Improved thermogelling methyl cellulose ether compositions for use in preparing pharmaceutical capsules by the pin dip coating process are prepared by blending the properties of water soluble...
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