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6117450 |
Method of making a perorally administered solid drug with controlled effective ingredient delivery
The method of making a solid drug with controlled effective ingredient delivery for oral administration includes selecting a predetermined number of at least three of four compressed compositions...
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6110494 |
Cisapride mini-tablet formulations
A sustained release cisapride oral dosage formulation suitable for once-daily administration comprises a plurality of mini-tablets containing cisapride or a salt thereof with an organic acid and...
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6103261 |
Opioid formulations having extended controlled release
Solid controlled-release oral dosage forms comprising a therapeutically effective amount of an opioid analgesic or a salt thereof which provide an extended duration of pain relief of about 24...
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6086918 |
Oral peptide pharmaceutical products
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6080430 |
Powder coated with sparingly soluble ultraviolet absorber
Powder coated with a sparingly soluble ultraviolet light absorber which is prepared by a method in which the melted sparingly soluble ultraviolet light absorber and an inorganic or organic powder...
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6030641 |
Sustained release capsule and method for preparing the same
A sustained release capsule in which an outer surface of a hard capsule mainly composed of gelatin and containing a physiologically active substance is uniformly covered with a film material...
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6025391 |
Enteric-coated pharmaceutical compositions of mycophenolate
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5985322 |
Method for the treatment of CNS disorders
An improved method for the treatment of central nervous system disorders comprises treating patients with an enteric fluoxetine formulation.
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5976577 |
Process for preparing fast dispersing solid oral dosage form
Process is provided for preparing an oral solid rapidly disintegrating freeze-dried dosage form of a pharmaceutically active substance having an unacceptable taste, wherein prior to freeze drying,...
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5968550 |
Liquisolid systems and methods of preparing same
Liquisolid systems are acceptably flowing and compressible powdered forms of liquid medications. According to the concept of liquisolid systems, liquid lipophilic drugs, or water-insoluble solid...
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5958460 |
Preparation process for a multiparticulate pharmaceutical form with plurality of sequences of controlled release
Preparation process for a multiparticulate pharmaceutical form with a plurality of sequences of controlled release of the type which allows the body of the patient to be provided with a sufficient...
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5955104 |
Multiple unit oral pharmaceutical formulations
A multiple unit oral pharmaceutical dosage form having a plurality of pellets in a water soluble capsule or in a tablet compressed from the pellets, wherein each pellet contains (a) a substantially...
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5952005 |
Controlled release preparation for administering morphine
An oral pharmaceutical preparation containing a therapeutically effective amount of a salt of morphine for administration once daily is provided. The preparation contains particles which have a...
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5914134 |
Process for the pulsatile delivery of diltiazem HCL and product produced thereby
A drug delivery system for diltiazem-HCl comprises: a blend of fast, medium and slow release fractions of a multi-layered diltiazem bead substrate, the fast release fraction comprised of a...
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5912014 |
Oral salmon calcitonin pharmaceutical products
Bioavailability of salmon calcitonin to be administered orally is enhanced by a pharmaceutical composition providing targeted release of the peptide to the intestine, together with an absorption...
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5900252 |
Method for targeted and controlled release of drugs in the intestinal tract and more particularly in the colon
The object of the present invention is to obtain a targeted and controlled release of drugs, the pharmacological action and absorption of which takes place in the intestine and in particular in the...
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5837291 |
Enteric preparation coated with a non-solvent enteric coating agent using a liquid plasticizer
An enteric preparation prepared by coating a solid dosage form with a fine powder enteric coating agent while spraying a liquid plasticizer.
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5834023 |
Diltiazem controlled release formulation
A once-a-day controlled release diltiazem formulation is described which includes: (a) from 20 to 50% by weight of enteric polymeric membrane coated pellets comprising a polymer membrane coated...
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5811126 |
Controlled release matrix for pharmaceuticals
A controlled release pharmaceutical composition for oral administration in humans or animals, comprising a controlled release matrix comprising a pharmaceutically acceptable sodium alginate, a...
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RE35903 |
Slow-release preparation of diltiazem, and a medicine provided thereby
The slow release preparation obtained by the method of the invention reduces the number of times the medicine needs to be taken per day, and also provides lower peaks of concentration in the blood...
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5770217 |
Dietary supplement for hematological, immune and appetite enhancement
A dietary supplement comprising herbs and herbal extracts, vitamins, minerals, and amino acids effective in modulating hematological toxicities, enhancing the immune system and maintaining appetite...
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5744164 |
Sustained release microparticulate caffeine formulation
The present invention relates to compositions and methods for increasing the alertness of an individual through the administration of a stimulant such as xanthine or an xanthine derivative and...
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5736161 |
Pharmaceutical preparation for improving the bioavailability of drugs which are difficult to absorb and a procedure for obtaining it
The preparation consists of millispheres, microspheres, nanospheres or array-type particles consisting of a nucleus of a gellable hydrocolloid onto which has been deposited a film of a cationic...
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5723151 |
Cellulose acetate phthalate enteric coating compositions
Provided are enteric coating compositions which utilize a low viscosity cellulose acetate phthalate polymer as a film former. The cellulose acetate phthalates have an inherent viscosity of about...
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5656291 |
Controlled release preparation
A method for manufacturing an oral controlled release pharmaceutical preparation in the form of a capsule containing a plurality of coated particles comprising a therapeutically effective amount of...
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5637320 |
Controlled absorption naproxen formulation for once-daily administration
A once-daily naproxen formulation for oral administration having a first portion of the naproxen as a multi-particulate pellet form, each pellet having a core of naproxen or a pharmaceutically...
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5629017 |
Programmed release oral solid pharmaceutical dosage form
A programmed release pharmaceutical dosage form comprising a core, containing the active ingredient, coated by a hydrophobic layer is described. Such dosage forms release the active ingredient...
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5620883 |
Living cells microencapsulated in a polymeric membrane having two layers
A biocompatible microcapsule containing living cells encapsulated in a membrane is disclosed. The membrane is a complex formed by the cohesion of two polymer layers. An inner layer comprises a...
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5616345 |
Controlled absorption diltiazen formulation for once-daily administration
A diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid, and a multi-layer membrane...
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5593690 |
Sustained release preparations
There is provided a matrix preparation produced by dispersing a pharmaceutically active ingredient into a matrix which is solid at ambient temperature and comprised of a fatty acid ester of a...
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5593691 |
Biotenside solvents for pharmaceuticals and cosmetics
New biotenside esters, processes for their preparation and their use as solvents and hydrotropic agents (coemulgators) in the preparation of spontaneously dispersible concentrates containing...
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5571531 |
Microparticle delivery system with a functionalized silicone bonded to the matrix
A particulate carrier for an agent comprising a solid core of a polysaccharide and a proteinaceous material and an organometallic polymer bonded to the core is provided. The agent has a biological...
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5540945 |
Pharmaceutical preparations for oral administration that are adapted to release the drug at appropriate sites in the intestines
The improved pharmaceutical preparation for oral administration which is adapted to release the drug at appropriate sites in the intestines comprises: a core that comprises an active ingredient and...
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5525354 |
Pharmaceutical preparation and process for its manufacture
In a pharmaceutical preparation for oral use containing a pharmacologically acceptable salt of a bisphosphonic acid, the improvement comprising: a drug delivery form of the preparation which is...
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5508276 |
Duloxetine enteric pellets
A superior enteric formulation of the antidepressant drug, duloxetine, is in the form of enteric pellets of which the enteric layer comprises hydroxypropylmethylcellulose acetate succinate.
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RE35200 |
Coating for pharmaceutical dosage forms
Coated pharmaceutical dosage forms which are resistant to gastric juice and release their active ingredient rapidly at a predetermined pH value in the range from pH 5 to pH 8 are obtained in...
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5484608 |
Sustained-release drug delivery system
A sustained-release pharmaceutical composition comprising a highly soluble pharmaceutical agent, such as selegiline, in a pharmaceutical carrier comprising a hydrophilic polymer dispersed in a...
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5478569 |
Fat-soluble composition of colloidal fish gelatin
Stable, cold water-dispersible, liquid or pulverous compositions of fat-soluble substances which contain fish gelatin as the protective colloid and a method of making same are described.
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5470581 |
Aqueous maltodextrin and cellulosic polymer film coatings
A method of coating substrates such as pharmaceutical tablets, food and confectionery forms, agricultural seeds and the like, with a protective film comprises the steps of mixing a cellulosic...
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5445829 |
Extended release pharmaceutical formulations
An extended release pharmaceutical formulation adapted to approach zero order release of drug over a 12 to at least 24 hour period, comprised of a mixture of 0 to about 50% of an immediate release...
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5430021 |
Hydrophobic drug delivery systems
A pharmaceutical preparation including a drug incorporated into hydrophobic particles comprised of long chain carboxylic acid or ester thereof or long chain alcohol, wherein the particles are...
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5411745 |
Powder-layered morphine sulfate formulations
An oral dosage form of morphine is formulated by powder-layering an homogeneous mixture of morphine sulfate and hydrous lactose impalpable onto inert beads to obtain a multiparticulate product. A...
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5401515 |
Coated active agent-containing article
Aqueous coating compositions for forming elastomeric films around active cores (e.g., drugs) comprising a dispersion of pre-crosslinked polyorganosiloxane latex particles, colloidal silica...
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5364620 |
Controlled absorption diltiazem formulation for once daily administration
A diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid, and a multi-layer membrane...
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5344657 |
Microbeads of diltiazem, a process for their manufacture and a substained-release pharmaceutical composition containing them
The microbeads are composed of a core containing the active ingredient and a microporous membrane, insoluble in aqueous medium, consisting of a film-forming polymer, a plasticizer and a filling...
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5336504 |
Diltiazem formulations and methods of treatment
A diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid, and a multi-layer membrane...
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5296232 |
Pharmaceutical formulation which does not induce tolerance
A controlled-release organic nitrate formulation for once-per-day oral administration is provided by spheres having a core which includes an organic nitrate, and a membrane surrounding the core...
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5283064 |
Large intestinal dissociative hard capsules
A large intestinal dissociative hard capsule comprising a capsule mainly composed of chitosan, the viscosity at 20° C. of a solution obtained by dissolving the chitosan in an aqueous 1% by weight...
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5281711 |
(S)-1-[10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzo[a]quino-lizin-1-yl) carbonyl]-3-ethoxypyrrolidine
The compound (S)-1-[(10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzo[a]quin
o-lizin-1-yl)c arbonyl]-3-ethoxypyrrolidine of the formula ##STR1## which has valuable pharmacological properties, is...
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5219621 |
Methods of treatment with diltiazem formulations
A diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid, and a multi-layer membrane...
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