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5047248 Formulation for preparing sustained release drugs for oral administration  
Pharmaceutical formulations are disclosed, adapted for preparing solid oral dosage forms (tablets, capsules, lozenges, etc.) having a regular and sustained release after administration. Said...
5039524 Vermin-repellent microcapsules with slow-release potentiality  
Disclosed are slow-release vermin-repellent microcapsules composed of a core substance and a wall film formed around the said core substance to encapsulate the same, in which the core substance is...
5021241 Long-term sustained-release preparation  
A solid sustained-release preparation in the form of a needle-like or bar-like shape, which consists essentially of an active ingredient and a pharmaceutically acceptable biodegradable carrier...
5015479 Sustained release capsule or tablet formulation comprising a pharmaceutically acceptable dihydropyridine  
A sustained release capsule or tablet formulation suitable for once-daily administration comprises an adsorbate of a mixture of a pharmaceutically useful dihydropyridine and a polyvinylpyrrolidone...
5002540 Intravaginal device and method for delivering a medicament  
A device for inserting into the vagina of a patient for delivery of a medicament in the vagina. The walls of the tubular member comprising the device are comprised of water-swellable materials...
4976962 Biodegradable polypeptide and the use thereof for the gradual release of drugs  
Biodegradable alkyloxycarbonylmethyl or aryloxycarbonylmethyl polyaspartate and polyglutamate which can be used as a carrier for drugs which are either in the encapsulated state or are incorporated...
4976967 Resin modulated drug delivery device for the delivery of HMG-CoA reductase inhibitor salts  
The instant invention relates to a drug-delivery device for the controlled release of HMG-CoA reductase inhibitor salts, as the therapeutically active ingredient, into an environment of use which...
4970075 Controlled release bases for pharmaceuticals  
The release of therapeutically active agents from controlled release bases is extended by using a combination of a higher aliphatic alcohol and an acrylic resin as the base material.
4956129 Microencapsulation process  
A process is disclosed for the microencapsulation of a substantially water-insoluble liquid material within a porous shell to effect a slow rate of release of said material through said shell which...
4952403 Implants for the promotion of healing of meniscal tissue  
Healing of injured avascular tissue is promoted by applying angiogenic factor in proximity to the injured tissue.
4952404 Promotion of healing of meniscal tissue  
Healing of injured avascular tissue is promoted by applying angiogenic factor in proximity to the injured tissue.
4927636 Association complex comprising pullulan and polyethylene glycol, and preparation and uses of the same  
Pullulan forms an association complex with PEG in a hydrous system. The assocation complex, as well as its pullulan and PEG components, exerts a decreased solubility in water. The association...
4925672 Products containing a calcium antagonist and a lipid-lowering agent  
Combinations of calcium antagonists and lipid-lowering agents are suitable for controlling diseases.
4923645 Sustained release of encapsulated molecules  
A method for sustained release of molecules from gels or microcapsules has been developed. The method is based on controlling the gel state using chelating agents or ion transfer. The method is...
4919929 Mammal immunization  
Mammals are brought to a specific state of immunization by administering an amount of an antigenic substance sufficient to elicit an immunization response to said mammal, said antigenic substance...
4910021 Targeted enternal delivery system  
A capsule for oral administration of a pharmaceutically active ingredient contains a pharmaceutical composition comprising the active ingredient, for example, a peptide, an absorption promoter and...
4900557 Pellet formulation  
The invention relates to pellet formulations which (a) contain at least one active compound, one binder and one weighting agent, (b) are coated with a lacquer which is resistant to gastric juice or...
4895724 Chitosan compositions for controlled and prolonged release of macromolecules  
Compositions for the controlled and prolonged release of macromolecular compounds comprise a porous matrix of chitosan having dispersed therein the macromolecular compound. Examples of...
4892734 Dispensing paste for forming medicinal pellets  
A process for aliquotting precise amounts of an active ingredient and a carrier for forming pellets is provided. The active ingredient and carrier are dispensed separately and then are mixed...
4892778 Juxtaposed laminated arrangement  
A dispenser is enclosed for delivering a beneficial agent to an enviroment of use. The dispenser comprising a wall that surrounds an internal space comprising a first mean in the dispenser for...
4886668 Multiparticulate controlled porosity osmotic pump  
The instant invention is directed to a multiparticulate osmotic pump, for the controlled release of diltiazem L-malate to an environment of use, said pump comprising: (I) a carrier medium which...
4880631 Controlled porosity osmotic pump  
The instant invention is directed to an osmotic pump, for the controlled release of diltiazem L-malate to an environment of use, said pump comprising: (A) a core which comprises a...
4863735 Biodegradable polymeric drug delivery system with adjuvant activity  
An antigen delivery system utilizing a biodegradable polymer with good mechanical properties in combination with a material stimulating the immune system. The material having adjuvant activity may...
4859469 Novel galenic forms of verapamil, their preparation and medicines containing said novel galenic forms  
The invention relates to a novel galenic form of verapamil which show an excellent bioavailability. The novel galenic form comprises microgranules containing a verapamil addition salt with an acid,...
4855313 Method of stimulating cashmere growth on cashmere-producing goats using melatonin  
The invention is a method of stimulating cashmere growth on cashmere-producing goats. The method includes administering melatonin by a sustained release delivery system.
4851229 Composition comprising a therapeutic agent and a modulating agent  
An osmotic delivery system is disclosed for delivering a useful agent at a controlled and constant rate modulated by a pulsed delivery of the useful agent to an environment of use.
4849141 Method for producing sustained release formulation  
A method for preparing a sustained release formulation utilizing collagen and/or gelatin as a carrier, which comprises the steps: (i) preparing a uniform and high concentrated mixture with...
4849228 Polymer, production and use thereof  
The present invention provides a biodegradable high molecular polymer characterized in that the content of water-soluble low molecular compounds, as calculated on the assumption that said compounds...
4834985 Controlled release pharmaceutical composition  
A solid, controlled release, pharmaceutical composition comprising an active ingredient incorporated in a matrix comprising a first substance selected from a water soluble polydextrose and a water...
4834984 Controlled release dihydrocodeine composition  
A solid controlled release, oral dosage form, the dosage form comprising an analgesically effective amount of dihydrocodeine or a salt thereof in a controlled release matrix wherein the dissolution...
4814176 Sustained release preparation  
A sustained release preparation comprising: (a) chitin, chitosan, or a mixture thereof (b) anionic polymer compounds such as those having a carboxyl group, a sulfonic acid group, or a group...
4814175 Nifedipine combination preparation  
The invention relates to nifedipine combination preparations, containing nifedipine with delayed release of active agent and a β-blocker in each case in granulated form, and their pharmaceutical...
4810500 Medication and method for treating heartworms in dogs  
A medication and method for treating heartworms in dogs, which medication includes a time release capsule or tablet dosage structure which is characterized either by discrete elements (capsule) or...
4808707 Chitosan alginate capsules  
The permeability of the walls of chitosan alginate capsules is adjusted by substituting with esterified alginic acid a portion of the metal alginate normally used in the fabrication of such capsules.
4806337 Erodible matrix for sustained release bioactive composition  
A sustained release composition for releasing a biologically active compound into an aqueous liquid environment comprises said biologically active compound dispersed in a bioerodible matrix, the...
4804542 Gelatin capsules and method of preparing same  
Gelatin capsules, consisting of a capsule sheath and a capsule filling, the capsule sheath consisting of gelatin, optionally a plasticizer and further additives, and the capsule filling containing...
4804540 Process for preparing the combination products of triamterene and hydrochlorothiazide  
A combination pharmaceutical composition is described, together with the process for manufacturing said pharmaceutical composition wherein the active ingredients, namely triamterene and...
4801457 Polyacetal hydrogels formed from divinyl ethers and polyols  
A therapeutic composition comprising a therapeutic macromolecular agent incorporated in cross-linked polyacetal.
4800083 Sustained release method and product  
A capsule product and method for gradually releasing a medicament for absorption to a body of a warm blooded animal through the gastrointestinal system. The capsule has a fill material which...
4798725 Sustained release capsule  
The invention involves a sustained release pharmaceutical capsule for oral administration comprising, in a capsule shell, a particulate mixture comprising an active drug ingredient which is a weak...
4795644 Device for pH independent release of drugs through the Donnan-like influence of charged insoluble resins  
A device is disclosed for the controlled delivery of a beneficial agent. The agent is delivered to the environment surrounding the device at a substantially constant rate for a specified period...
4795436 Bioadhesive composition and method of treatment therewith  
A controlled release treatment composition and method of use are disclosed. The composition includes a bioadhesive and an effective amount of a treating agent. The bioadhesive is a water-swellable,...
4795641 Polymer blends having reverse phase morphology for controlled delivery of bioactive agents  
Disclosed are polymer blends containing a minor amount of cellulose acetate and a major amount of cellulose acetate phthalate, cellulose acetate trimellitate or cellulose acetate succinate. The...
4795536 Hydrogen separation and electricity generation using novel three-component membrane  
Apparatus and method for performing an electrochemical process involving hydrogen and gaseous compounds capable of dissociating into or combining with hydrogen ions using a solid electrolyte...
4795643 Medicament with a delayed release of active ingredient  
In addition to the active ingredient, the capsules contain a nonionic surfactant consisting of a polyglycol ester or ether having hydrophilic and lipophilic portions, and an organic polymer which...
4793997 Controlled delivery device  
A device for the controlled release of an active material into an aqueous medium, e.g. body fluids, comprises a water soluble glass container in which the active material is sealed. The container...
4794000 Coacervate-based oral delivery system for medically useful compositions  
The present invention provides for an oral drug delivery system based on a two phase liquid coacervate system prepared from water and one or more surfactants selected from anionic, cationic,...
4793998 Stabilized drug compositions  
The cyclization and hydrolysis of certain ACE inhibitors is minimized when they are formulated with a stabilizer and at least one lubricant and/or excipient.
4777049 Constant release system with pulsed release  
An osmotic delivery system is disclosed for delivering a useful agent at a controlled and constant rate modulated by a pulsed delivery of the useful agent to an environment of use.
4772472 Formed or molded body and method and apparatus for manufacturing such body  
A formed or molded body, a manufacturing method and a manufacturing apparatus therefor, wherein several equal or different active ingredients in suitable, equal or different carrier substances are...