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5047248 |
Formulation for preparing sustained release drugs for oral administration
Pharmaceutical formulations are disclosed, adapted for preparing solid oral dosage forms (tablets, capsules, lozenges, etc.) having a regular and sustained release after administration. Said...
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5039524 |
Vermin-repellent microcapsules with slow-release potentiality
Disclosed are slow-release vermin-repellent microcapsules composed of a core substance and a wall film formed around the said core substance to encapsulate the same, in which the core substance is...
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5021241 |
Long-term sustained-release preparation
A solid sustained-release preparation in the form of a needle-like or bar-like shape, which consists essentially of an active ingredient and a pharmaceutically acceptable biodegradable carrier...
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5015479 |
Sustained release capsule or tablet formulation comprising a pharmaceutically acceptable dihydropyridine
A sustained release capsule or tablet formulation suitable for once-daily administration comprises an adsorbate of a mixture of a pharmaceutically useful dihydropyridine and a polyvinylpyrrolidone...
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5002540 |
Intravaginal device and method for delivering a medicament
A device for inserting into the vagina of a patient for delivery of a medicament in the vagina. The walls of the tubular member comprising the device are comprised of water-swellable materials...
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4976962 |
Biodegradable polypeptide and the use thereof for the gradual release of drugs
Biodegradable alkyloxycarbonylmethyl or aryloxycarbonylmethyl polyaspartate and polyglutamate which can be used as a carrier for drugs which are either in the encapsulated state or are incorporated...
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4976967 |
Resin modulated drug delivery device for the delivery of HMG-CoA reductase inhibitor salts
The instant invention relates to a drug-delivery device for the controlled release of HMG-CoA reductase inhibitor salts, as the therapeutically active ingredient, into an environment of use which...
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4970075 |
Controlled release bases for pharmaceuticals
The release of therapeutically active agents from controlled release bases is extended by using a combination of a higher aliphatic alcohol and an acrylic resin as the base material.
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4956129 |
Microencapsulation process
A process is disclosed for the microencapsulation of a substantially water-insoluble liquid material within a porous shell to effect a slow rate of release of said material through said shell which...
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4952403 |
Implants for the promotion of healing of meniscal tissue
Healing of injured avascular tissue is promoted by applying angiogenic factor in proximity to the injured tissue.
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4952404 |
Promotion of healing of meniscal tissue
Healing of injured avascular tissue is promoted by applying angiogenic factor in proximity to the injured tissue.
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4927636 |
Association complex comprising pullulan and polyethylene glycol, and preparation and uses of the same
Pullulan forms an association complex with PEG in a hydrous system. The assocation complex, as well as its pullulan and PEG components, exerts a decreased solubility in water. The association...
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4925672 |
Products containing a calcium antagonist and a lipid-lowering agent
Combinations of calcium antagonists and lipid-lowering agents are suitable for controlling diseases.
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4923645 |
Sustained release of encapsulated molecules
A method for sustained release of molecules from gels or microcapsules has been developed. The method is based on controlling the gel state using chelating agents or ion transfer. The method is...
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4919929 |
Mammal immunization
Mammals are brought to a specific state of immunization by administering an amount of an antigenic substance sufficient to elicit an immunization response to said mammal, said antigenic substance...
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4910021 |
Targeted enternal delivery system
A capsule for oral administration of a pharmaceutically active ingredient contains a pharmaceutical composition comprising the active ingredient, for example, a peptide, an absorption promoter and...
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4900557 |
Pellet formulation
The invention relates to pellet formulations which (a) contain at least one active compound, one binder and one weighting agent, (b) are coated with a lacquer which is resistant to gastric juice or...
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4895724 |
Chitosan compositions for controlled and prolonged release of macromolecules
Compositions for the controlled and prolonged release of macromolecular compounds comprise a porous matrix of chitosan having dispersed therein the macromolecular compound. Examples of...
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4892734 |
Dispensing paste for forming medicinal pellets
A process for aliquotting precise amounts of an active ingredient and a carrier for forming pellets is provided. The active ingredient and carrier are dispensed separately and then are mixed...
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4892778 |
Juxtaposed laminated arrangement
A dispenser is enclosed for delivering a beneficial agent to an enviroment of use. The dispenser comprising a wall that surrounds an internal space comprising a first mean in the dispenser for...
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4886668 |
Multiparticulate controlled porosity osmotic pump
The instant invention is directed to a multiparticulate osmotic pump, for the controlled release of diltiazem L-malate to an environment of use, said pump comprising: (I) a carrier medium which...
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4880631 |
Controlled porosity osmotic pump
The instant invention is directed to an osmotic pump, for the controlled release of diltiazem L-malate to an environment of use, said pump comprising: (A) a core which comprises a...
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4863735 |
Biodegradable polymeric drug delivery system with adjuvant activity
An antigen delivery system utilizing a biodegradable polymer with good mechanical properties in combination with a material stimulating the immune system. The material having adjuvant activity may...
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4859469 |
Novel galenic forms of verapamil, their preparation and medicines containing said novel galenic forms
The invention relates to a novel galenic form of verapamil which show an excellent bioavailability. The novel galenic form comprises microgranules containing a verapamil addition salt with an acid,...
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4855313 |
Method of stimulating cashmere growth on cashmere-producing goats using melatonin
The invention is a method of stimulating cashmere growth on cashmere-producing goats. The method includes administering melatonin by a sustained release delivery system.
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4851229 |
Composition comprising a therapeutic agent and a modulating agent
An osmotic delivery system is disclosed for delivering a useful agent at a controlled and constant rate modulated by a pulsed delivery of the useful agent to an environment of use.
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4849141 |
Method for producing sustained release formulation
A method for preparing a sustained release formulation utilizing collagen and/or gelatin as a carrier, which comprises the steps: (i) preparing a uniform and high concentrated mixture with...
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4849228 |
Polymer, production and use thereof
The present invention provides a biodegradable high molecular polymer characterized in that the content of water-soluble low molecular compounds, as calculated on the assumption that said compounds...
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4834985 |
Controlled release pharmaceutical composition
A solid, controlled release, pharmaceutical composition comprising an active ingredient incorporated in a matrix comprising a first substance selected from a water soluble polydextrose and a water...
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4834984 |
Controlled release dihydrocodeine composition
A solid controlled release, oral dosage form, the dosage form comprising an analgesically effective amount of dihydrocodeine or a salt thereof in a controlled release matrix wherein the dissolution...
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4814176 |
Sustained release preparation
A sustained release preparation comprising: (a) chitin, chitosan, or a mixture thereof (b) anionic polymer compounds such as those having a carboxyl group, a sulfonic acid group, or a group...
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4814175 |
Nifedipine combination preparation
The invention relates to nifedipine combination preparations, containing nifedipine with delayed release of active agent and a β-blocker in each case in granulated form, and their pharmaceutical...
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4810500 |
Medication and method for treating heartworms in dogs
A medication and method for treating heartworms in dogs, which medication includes a time release capsule or tablet dosage structure which is characterized either by discrete elements (capsule) or...
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4808707 |
Chitosan alginate capsules
The permeability of the walls of chitosan alginate capsules is adjusted by substituting with esterified alginic acid a portion of the metal alginate normally used in the fabrication of such capsules.
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4806337 |
Erodible matrix for sustained release bioactive composition
A sustained release composition for releasing a biologically active compound into an aqueous liquid environment comprises said biologically active compound dispersed in a bioerodible matrix, the...
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4804542 |
Gelatin capsules and method of preparing same
Gelatin capsules, consisting of a capsule sheath and a capsule filling, the capsule sheath consisting of gelatin, optionally a plasticizer and further additives, and the capsule filling containing...
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4804540 |
Process for preparing the combination products of triamterene and hydrochlorothiazide
A combination pharmaceutical composition is described, together with the process for manufacturing said pharmaceutical composition wherein the active ingredients, namely triamterene and...
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4801457 |
Polyacetal hydrogels formed from divinyl ethers and polyols
A therapeutic composition comprising a therapeutic macromolecular agent incorporated in cross-linked polyacetal.
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4800083 |
Sustained release method and product
A capsule product and method for gradually releasing a medicament for absorption to a body of a warm blooded animal through the gastrointestinal system. The capsule has a fill material which...
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4798725 |
Sustained release capsule
The invention involves a sustained release pharmaceutical capsule for oral administration comprising, in a capsule shell, a particulate mixture comprising an active drug ingredient which is a weak...
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4795644 |
Device for pH independent release of drugs through the Donnan-like influence of charged insoluble resins
A device is disclosed for the controlled delivery of a beneficial agent. The agent is delivered to the environment surrounding the device at a substantially constant rate for a specified period...
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4795436 |
Bioadhesive composition and method of treatment therewith
A controlled release treatment composition and method of use are disclosed. The composition includes a bioadhesive and an effective amount of a treating agent. The bioadhesive is a water-swellable,...
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4795641 |
Polymer blends having reverse phase morphology for controlled delivery of bioactive agents
Disclosed are polymer blends containing a minor amount of cellulose acetate and a major amount of cellulose acetate phthalate, cellulose acetate trimellitate or cellulose acetate succinate. The...
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4795536 |
Hydrogen separation and electricity generation using novel three-component membrane
Apparatus and method for performing an electrochemical process involving hydrogen and gaseous compounds capable of dissociating into or combining with hydrogen ions using a solid electrolyte...
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4795643 |
Medicament with a delayed release of active ingredient
In addition to the active ingredient, the capsules contain a nonionic surfactant consisting of a polyglycol ester or ether having hydrophilic and lipophilic portions, and an organic polymer which...
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4793997 |
Controlled delivery device
A device for the controlled release of an active material into an aqueous medium, e.g. body fluids, comprises a water soluble glass container in which the active material is sealed. The container...
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4794000 |
Coacervate-based oral delivery system for medically useful compositions
The present invention provides for an oral drug delivery system based on a two phase liquid coacervate system prepared from water and one or more surfactants selected from anionic, cationic,...
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4793998 |
Stabilized drug compositions
The cyclization and hydrolysis of certain ACE inhibitors is minimized when they are formulated with a stabilizer and at least one lubricant and/or excipient.
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4777049 |
Constant release system with pulsed release
An osmotic delivery system is disclosed for delivering a useful agent at a controlled and constant rate modulated by a pulsed delivery of the useful agent to an environment of use.
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4772472 |
Formed or molded body and method and apparatus for manufacturing such body
A formed or molded body, a manufacturing method and a manufacturing apparatus therefor, wherein several equal or different active ingredients in suitable, equal or different carrier substances are...
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