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5505961 Gelatin capsules containing a highly concentrated acetaminophen solution  
A method is disclosed for increasing the solubility of acetaminophen alone or in combination with antihistamines, antitussives, decongestants, and expectorants to form a clear solution for...
5498422 Sustained release capsule  
A sustained release capsule excellent in adhesion characteristics in the gastrointestinal tract, stability and so on is provided. The capsule is characterized in that a polymer excellent in initial...
5487894 Composition of dehydrated powdered mung bean sprout and plant fiber for use as dietary supplement in healthcare  
A dietary supplement composition is disclosed which contains dehydrated mung bean sprout and beta-glucan enriched oat groat.
5484608 Sustained-release drug delivery system  
A sustained-release pharmaceutical composition comprising a highly soluble pharmaceutical agent, such as selegiline, in a pharmaceutical carrier comprising a hydrophilic polymer dispersed in a...
5472710 Pharmaceutical preparation to be administered orally with controlled release of active substance and method for its manufacture  
Pharmaceutical preparation to be administered orally with controlled release of active substance and method for its manufacture. Pharmaceutical preparation to be administered orally with controlled...
5468503 Oral pharmaceutical preparation released at infragastrointestinal tract  
An oral pharmaceutical preparation of a type released at infragastrointestinal tract was successfully prepared, wherein a solid organic acid dissolvable, in the form of a solution, of chitosan and...
5461140 Bioerodible polymers for solid controlled release pharmaceutical compositions  
Bioerodible ortho ester polymers useful for preparing solid form bioerodible pharmaceutical compositions such as pellets, capsules, suppositories and the like are provided. A novel synthetic method...
5445829 Extended release pharmaceutical formulations  
An extended release pharmaceutical formulation adapted to approach zero order release of drug over a 12 to at least 24 hour period, comprised of a mixture of 0 to about 50% of an immediate release...
5439687 Dosage forms having zero-order dihydropyridine calcium antagonist release  
Pharmaceutical dosage forms having a linear release rate of the 0 th order for the once-daily oral administration of 20-120 mg of nifedipine or of another calcium antagonist of the dihydropyridine...
5430021 Hydrophobic drug delivery systems  
A pharmaceutical preparation including a drug incorporated into hydrophobic particles comprised of long chain carboxylic acid or ester thereof or long chain alcohol, wherein the particles are...
5427799 Sustained release composition and method utilizing xanthan gum and an active ingredient  
A compacted sustained release composition for delivering a drug as an active ingredient to the gastro-intestinal tract comprises an effective amount of the active ingredient in mixture with xanthan...
5399554 Readily soluble 2',3'-dideoxyinosine compositions  
A readily soluble 2',3'-dideoxyinosine composition is prepared by combining 80 to 1 parts by weight of a basic amino acid and 20 to 99 parts by weight of 2',3'-dideoxyinosine. The greater solution...
5397573 Laxative compositions  
Laxative compositions containing sennoside and menthol, pharmaceutically-acceptable esters of menthol, or mixtures thereof, preferably as peppermint oil; and methods for treating constipation by...
5397574 Controlled release potassium dosage form  
A pharmaceutical composition for oral administration of potassium salt in a form not irritating to the gastrointestinal mucosa comprises tablets or capsules of micropellets of a potassium salt,...
5368861 Gastric preparation with sustained release  
A gastric preparation developed in order to solve the technical problems of conventional preparations, which is prepared by the bilayer packing technique and comprises 5 to 60%, desirably 10 to 40%...
5364634 Controlled-release PH sensitive capsule and adhesive system and method  
A capsule and method for delivery for an active ingredient in the oral cavity that has a pH sensitive encapsulant shell and is associated with an adhesive. The pH sensitive shell dissolves at a pH...
5364620 Controlled absorption diltiazem formulation for once daily administration  
A diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid, and a multi-layer membrane...
5356467 Controlled release coatings derived from aqueous dispersions of zein  
Stable aqueous dispersions of zein which may be used as controlled release coatings of pharmaceutical, animal, health, or food products in an inorganic solvent-free environment are disclosed, as...
5336504 Diltiazem formulations and methods of treatment  
A diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid, and a multi-layer membrane...
5336505 Bioerodible polymers useful for the controlled release of therapeutic agents  
Bioerodible ortho ester polymers useful for preparing bioerodible pharmaceutical compositions such as implants, ointments, creams, gels and the like are provided. The pharmaceutical compositions of...
5332584 Microcapsules  
A process is disclosed for the microencapsulation of a substantially water-insoluble liquid material within a porous shell to effect a slow rate of release of said material through said shell which...
5304377 Prolonged release preparation and polymers thereof  
A polymer for a prolonged release preparation which comprises (A) a polylactic acid and (B) a copolymer of glycolic acid and a hydroxycarboxylic acid of general formula ##STR1## wherein R...
5286492 Method of treatment of Heliobacter pylori infections with triclosan  
A method for the treatment of gastrointestinal disorders associated with Helicobacter pylori infections which comprises administering to a patient an orally effective amount of triclosan is...
5271946 Controlled release azelastine-containing pharmaceutical compositions  
Azelastine-containing pharmaceutical compositions which provide controlled release of the active substance using a sustained release component. The compositions contain azelastine or a...
5262173 Pulsatile once-a-day delivery systems for minocycline  
Pharmaceutical delivery systems containing 7-dimethyl-6-deoxy-6-demethyltetracycline or a non-toxic acid addition salt thereof comprising mixtures of a minor proportion of slow-release blended...
5260073 Use of phenylpropanolamine as a mucus secretogogue in the upper airways  
The present invention encompasses the novel method of using ±phenylpropanolamine to induce mucous secretion in the upper airways of persons afflicted with sinusitis or otitis media characterized...
5258186 Drug release controlling coating material for long acting formulations  
A coating material for controlling drug release, useful for long acting formulations--e.g. for once-a-day administration, and to a long acting granular composition comprising a drug (especially one...
5226902 Pulsatile drug delivery device using stimuli sensitive hydrogel  
A device for the dispensing of a biologically active material into the surrounding environment is disclosed which consists of at least one wall enclosing a compartment which contains a swollen...
5219621 Methods of treatment with diltiazem formulations  
A diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid, and a multi-layer membrane...
5213811 Oral sustained-release drug compositions  
Sugar or sugar/starch beads coated with a first coating of a drug, for example 1,2-dihydro-6-(lower alkyl)-2-oxo-5-(4-pyridinyl)-nicotinonitrile (milrinone), hydroxypropyl methylcellulose or...
5198226 Long acting nicardipine hydrochloride formulation  
A long acting sustained release pharmaceutical composition for dihydropyridine calcium channel blockers wherein the calcium channel blocker and a pH-dependent binder are intimately admixed in...
5187150 Polyester-based composition for the controlled release of polypeptide medicinal substances  
The pharmaceutical composition is intended in particular for the sustained and controlled release of an effective dose of a medicinal substance. It comprises, as a carrier for the medicinal...
5169638 Buoyant controlled release powder formulation  
A buoyant controlled release pharmaceutical powder formulation is provided which may be filled into capsules and releases a pharmaceutical of a basic character at a controlled rate regardless of...
5160529 Microcapsules and microencapsulation process  
Microcapsules containing a substantially water-insoluble liquid material, such as an anilide herbicide, and optionally also a herbicide antidote, within a porous shell to effect a slow rate of...
5156842 Liquid suspension for oral administration  
A non-aqueous pharmaceutical liquid suspension having improved bioavailability for oral administration comprises an active ingredient suspended in an edible, non-aqueous carrier vehicle such as an...
5154925 Treatment of tibial dyschondroplasia  
A method and compositions to treat and prevent tibial dyschondroplasia in animals, particularly fowl, which includes administering to animals an effective amount of the vitamin D 3 derivatives...
5128142 Sustained release drug delivery system  
A controlled release formulation comprising an adsorbate of a mixture of a pharmaceutically useful active ingredient and an inactive substance adsorbed on a cross-linked polymer. The inactive...
5110602 Pharmaceutical compositions comprising esters or amides as active ingredients  
The present invention relates to new pharmaceutical compositions characterizing that esters or amides are suspended or dissolved in a middle chain glyceride or a mixture thereof. These...
5110605 Calcium polycarbophil-alginate controlled release composition and method  
A polymeric complex composition comprising a reaction complex formed by the interaction of a polycarbophil component with alginic acid or a salt thereof, said interaction being performed in the...
5108756 Dispensing devices powered by lyotropic liquid crystals  
This invention relates to devices useful for the controlled delivery of one or more beneficial agents to an environment of use. More specifically, this invention concerns such devices which are...
5102666 Calcium polycarbophil controlled release composition and method  
Controlled release compositions comprising calcium polycarbophil and an active agent selected from the group consisting of medicinal agents, breath fresheners, and flavors, and a method of...
5098425 Method of administering a ruminant dispensing device comprising density member dispersed in hydrogel member  
A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a housing defining an internal space, (2) an expandable composition comprising a dense member in the...
5096717 Double-coated granules of disodium pamidronate  
The invention relates to an advantageous oral administration from the disodium pamidronate in capsules. These capsules are filled with double-coated granules. The inner coating is hydrophilic and...
5091189 Controlled release dosage forms having a defined water content  
A controlled release, solid, oral dosage form containing a 3-alkylxanthine, preferably theophylline, at least one hydrophilic or hydrophobic polymer, at least one wax having a melting point between...
5091191 Pharmaceutical composition with improved dissolution property  
A pharmaceutical composition of the active agent sodium 4-[α-hydroxy-5-(1-imidazolyl)-2-methylbenzyl]-3,5-dimethylb enzoate (a thromboxane synthetase inhibitor for treatment of diseases such as...
5091175 Pharmaceutical composition containing bile acid sequestrant enclosed in a size-exclusion membrane  
A pharmaceutical composition useful for treating hypercholesterolemia comprising a bile acid sequestrant resin such as cholestyramine and cholestipol maintained in a semipermeable water-insoluble...
5082655 Pharmaceutical composition for drugs subject to supercooling  
A sustained release composition for releasing a biologically active compound into an aqueous liquid environment comprises a biologically active compound dispersed in a matrix which progressively...
5079237 Inclusion complex of nicardipine or its hydrochloride with beta-cyclodextrin and a sustained release pharmaceutical preparation containing the same  
There is described a new inclusion complex of nicardipine or its hydrochloride with beta-cyclohdextrin, which is prepared by admixing nicardipine or its hydrochloride with beta-cyclodextrin in a...
5068104 Live vaccine for coccidiosis utilizing coccidial sporozoites  
Methods and compositions are disclosed for vaccinating warm-blooded animals against coccidiosis utilizing suspensions of excysted coccidial sporozoites in physiologically balanced medium containing...
5049380 Anti-allergic extract  
The present invention describes a novel material which is extractable from plants of the order Malvales and which demonstrates anti-allergic activity.