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5498421 |
Composition useful for in vivo delivery of biologics and methods employing same
In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a...
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5489401 |
Method for entrapment of active materials in chitosan
Encapsulation of active materials in chitosan beads of uniform size and improved mechanical and chemical stability. The active material is suspended in an acidic aqueous solution of a chitosan...
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5484606 |
Process for reducing the precipitation of difficulty soluble pharmaceutical actives
A process for reducing precipitation of difficultly soluble pharmaceutical active in a mixture of polyethylene glycol, polyvinylpyrrolidone and propylene glycol.
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5480645 |
Hydroxyamines N-acyl derivatives having scavenger activity and useful in acute and chronic pathologies associated with peroxidation and inflammation phenomena
Hydroxyamines N-acyl derivatives with benzochroman or 2,3-dihydrobenzofuran carboxy acids and relative pharmaceutical composition for the therapeutic treatment of those CNS, vascular,...
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5478860 |
Stable microemulsions for hydrophobic compound delivery
Microemulsion compositions for the delivery of hydrophobic compounds are provided. Such compositions have a variety of uses. In one embodiment, the hydrophobic compounds are therapeutic agents...
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5478570 |
Process for producing capsule and capsule obtained thereby
The present invention provides a process for producing a capsule containing a substance which is liable to acid, water or heat, comprising: suspending a substance which is liable to acid, water or...
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5456923 |
Method of manufacturing solid dispersion
The object of this invention is to provide a process for producing a solid dispersion, which has overcome the disadvantages of the conventional production technology for solid dispersions. The...
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5455335 |
Pharmaceutical compositions and methods of transporting compounds across biological membrane
Novel glycosylated steroid derivatives for facilitating the transport of compounds across biological membranes are disclosed. A novel process for efficient synthesis of these glycosylated steroid...
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5443842 |
Oral formulations of ubidecarenone in form of capsules
Pharmaceuticals formulations are described, in form of capsules ad oral use, containing as the active ingredient ubidecarenone, characterized in that the active ingredient is dispersed in a mixture...
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5431916 |
Pharmaceutical compositions and process of manufacture thereof
The present invention describes a product comprising least one pharmaceutically acceptable active in a mixture of a tri-ester and polyvinylpyrrolidone, and a process for producing the same. In...
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5427935 |
Hybrid membrane bead and process for encapsulating materials in semi-permeable hybrid membranes
Material such as biological material is encapsulated within a semi-permeable hybrid membrane bead by suspending the material in a medium which comprises an effective amount of a gelling inducer;...
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5424076 |
Method of producing microscopic particles made of hydrolytically decomposable polymers and containing active substances
The invention concerns a method for the production of microscopic particles made of hydrolytically decomposable polymers, in particular copolymers, and containing active substances, using fluid gas...
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5417986 |
Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
This invention is directed to oral parenteral and intestinal vaccines and eir use against diseases caused by enteropathogenic organisms using antigens encapsulated within...
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5397573 |
Laxative compositions
Laxative compositions containing sennoside and menthol, pharmaceutically-acceptable esters of menthol, or mixtures thereof, preferably as peppermint oil; and methods for treating constipation by...
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5395622 |
Calcium chloride containing preparation for the prevention or the treatment of hypocalcemia in ruminants
A preparation for the prevention or treatment of hypocalcemia in ruminants is prepared by forming a homogeneous mixture of CaCl 2 .xH 2 O and CaSO 4 .yH 2 O, x being a number greater than 0 and...
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5395615 |
Free amine benzophenanthridine alkaloid compositions
A pharmaceutical composition of a free amine benzophenanthridine alkaloid and a pharmaceutically acceptable carrier is disclosed. The composition is an antibacterial and antifungal agent.
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5376381 |
Integrity protected gelatin
A pharmaceutical dosage form comprising gelatin encapsulating a pharmaceutical composition wherein said composition is at least about 6% (weight %) ethanol and lipid wherein said lipid comprises at...
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5362564 |
Seamless capsule comprising a lower fatty ester of sucrose
A seamless capsule comprising a content and a film for coating said content is disclosed. The content is an hydrophilic substance. A lower fatty acid ester of sucrose is present between the content...
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5360615 |
Solvent system enhancing the solubility of pharmaceuticals for encapsulation
This invention relates to a solvent system for enhancing the solubility of an acidic, basic, or amphoteric pharmaceutical agent to produce a highly concentrated solution suitable for softgel...
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5330835 |
Seamless capsule and process for producing the same
A seamless capsule comprising a content and a film for coating said content is disclosed. The content is a hydrophilic substance. A viscous liquid having a viscosity of not more than 1000 cp at...
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5318781 |
Absorption enhancement of antibiotics
The oral absorption of antibiotics given of administration is significantly enhanced by use of the antibiotic in conjunction with a two-component absorption enhancing system made up of Laureth-12...
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5281420 |
Solid dispersion compositions of tebufelone
The subject invention relates to compositions in dosage form comprising a solid dispersion which is a solidified melt mixture consisting essentially of the following components: (a) from about...
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5271945 |
Sustained release microcapsule for water soluble drug
Sustained release microcapsules including a water soluble drug and an organic basic substance as a drug retaining substance of this invention not only have a high rate of incorporation (trapping...
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5258184 |
Emulsions
The invention provides a water/oil/water duplex emulsion in which the external continuous phase is gelled. This gelling is obtained by having an osmotic pressure component, e.g. an electrolyte, in...
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5209978 |
Seamless soft capsule and production thereof
A soft capsule composed of a plurality of cells coalesced to each other and filling substances encapsulated in the individual cells, the wall of at least one of the cells being formed of a material...
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5206219 |
Oral compositions of proteinaceous medicaments
Proteinaceous medicaments such as erythropoetin, insulin and calcitonin are formulated in a medium comprising a polyol pharmaceutical solvent combined as co-solvent with a lipid pharmaceutical...
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5200192 |
Instant oral-release capsule containing nifedipine
The invention concerns an instant oral-release capsule containing an aqueous or aqueous alcoholic solution of nifedipine, containing a polyalkylene glycol and a polyoxyethylene ester component, the...
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5190936 |
Process for improving the therapeutic efficacy of fat-soluble corticosteroids and composition for carrying out this process
The process consists in dissolving a corticosteroid in the lipid phase of nonionic amphiphilic lipid vesicles consisting of one or more lipid lamellae. Composition for carrying out the above...
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5178877 |
Encapsulated renin inhibitor composition
A pharmaceutical composition comprising a solution of a tenin inhibitor of the formula: ##STR1## wherein R 1 is 4-piperazinyl, 1-methyl-4-piperazinyl, 1-methyl-1-oxo-4-piperazinyl,...
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5166142 |
Use of type IA antiarrhythmic agents to lower blood lipids
A method is provided to lower serum cholesterol, total triglycerides and/or apoprotein B in a human by administering an effective amount of one or more Type IA antiarrhythmic agents to said human.
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5154930 |
Pharmacological agent-lipid solution preparation
A pharmacological agent-lipid solution preparation comprising a lipophilic pharmacological agent, a desalted charged lipid and an aqueous-miscible lipid solvent such that upon introduction into an...
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5152923 |
Process for the production of a nanoemulsion of oil particles in an aqueous phase
An aqueous phase, an oil of a triglyceride or fatty acid ester, and, per part by weight of oil 0.05 to 0.4 part by weight of an amphoteric emulsifier are mixed together and processed in a...
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5153001 |
Agent for treating heart disease
Vitamin E acts to enhance and improve the effect upon oral administration of coronary active vasodilators and/or blood circulation-promoters. The new use and new agents containing vitamin E are...
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5140021 |
Method and dosage form for treatment of premenstrual syndrome
A pharmaceutical composition suitable for oral administration comprises micronized progesterone in an oil vehicle which is high in glycerides of polyunsaturated fatty acids. Micronized progesterone...
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5139740 |
Polyprenyl compound composition for soft capsules
A pharmacological composition for soft capsules, containing a polyprenyl compound having the formula (1) and a surfactant and/or an unsaturated aliphatic acid, has improved absorbability. ##STR1##...
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5093130 |
Powder coated hydrogel capsules
Methods and materials are provided for coating hydrogel capsules containing botanic tissue with an inert substance that decrease capsule surface adhesiveness and facilitates singulation and...
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5079001 |
Liquid oral formulation of diclofenac
The invention relates to an aqueous oral pharmaceutical preparation of diclofenac which can be used for treating pain and inflammatory processes, and to the preparation of a preparation of this type.
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5071706 |
Oily, free-flowing, microcapsules
This disclosure is directed to the preparation of oily microcapsules which can be easily tray dried to a free flowing product without requiring special drying equipment. These microcapsules have a...
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5057322 |
Method of treating mast cell disease
A method of treating a patient suffering from mast cell disease comprising daily administration to such patient of from about 1 to about 150 mg of a pure narcotic antagonist, e.g., nalmefene or...
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5037698 |
Capsule filling employing hygroscopic components
Capsules containing a hygroscopic or deliquescent component are stabilized by a) forming a mixture of the hydrogscopic or deliquescent compound with a sufficient quantity of water to achieve an...
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5030454 |
Method for delivering drug in tiny pills in liquid carrier
A delivery system is disclosed for delivering a beneficial agent to an environment of use. The delivery system comprises a plurality of tiny dosage forms comprising a beneficial agent. The delivery...
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5011693 |
Haemostatic agents
Basic ferric sulphate or hydrated aluminum chloride solution used as a haemostatic agent, is made easier to handle and apply by gelling with colloidal silicon dioxide.
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5002768 |
Rodent-repellent microcapsules and preparations thereof
There are herein disclosed rodent-repellent microcapsules in which a core material is coated with a wall material of the microcapsules, the core material being a solution containing cycloheximide;...
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4983402 |
Orally administerable ANF
Atrial naturiuretic factor (ANF) is encapsulated within hollow acidic proteinoid microspheres which are stable and protective in the acidic stomach of a mammal but which dissolve at the near...
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4978533 |
Liquid nifidipine composition
A gelatin capsule form of nifedipine dosage unit containing from 12-20 parts by wt of glycerin per part by wt of nifedipine.
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4976968 |
Anhydrous delivery systems for pharmacological agents
Substantially anhydrous pharmacological agents microencapsulated within protective hollow proteinoid microspheres are produced by contacting an aqueous mixture of such agent with an insoluble...
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4970031 |
Process for preparing microcapsules with controlled-release
Microcapsules with controlled-release are prepared by subjecting microcapsules encasing an aqueous solution of a substance to be released from the microcapsules under control to a heat treatment in...
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4963367 |
Drug delivery compositions and methods
Drug delivery compositions yeild new and unexpected degrees of stabilization, solubilization and delivery of incorporated medicaments, drugs, or other physiologically-active compounds. The...
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4963364 |
Microencapsulated antitumor agent
Thermally polymerized copolyamino acids are used to microencapsulate a chemotherapeutic compound for more efficient drug delivery.
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4961932 |
Plurality of tiny pills in liquid dosage form
A delivery system is disclosed for delivering a beneficial agent to an environment of use. The delivery system comprises a plurality of tiny dosage forms comprising a beneficial agent. The delivery...
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