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9040079 Pegylated compounds for age-related macular degeneration  
A special photosensitizer formulation and Photodynamic Therapy method for treating choroidal neovascularization (CNV) associated with age-related macular degeneration (AMD) is provided. CNV is a...
9040626 Nanofibers and morphology shifting micelles  
The invention discloses novel morphology shifting micelles and amphiphilic coated metal nanofibers. Methods of using and making the same are also disclosed.
9040078 Use of lipid conjugates in the treatment of diseases of the nervous system  
The invention provides a method for treating a subject suffering from a disease of the central nervous system which is associated with an inflammatory response, including, inter alia, multiple...
9034371 Functionalized naonostructures with liquid-like behavior  
Compound containing at least 15% inorganic content demonstrates liquid-like behavior and is distinct in exhibiting liquid-like behavior in the absence of solvent. In one case it is quaternary...
9034329 Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof  
The present invention provides methods of preparing an antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex comprising (a) preparing an antibody or antibody fragment;...
9034330 Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof  
A method of preparing an antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex comprises the steps of (a) preparing an antibody or antibody fragment; (b) mixing said...
9034372 Lipid construct for delivery of insulin to a mammal  
The instant invention is drawn to a hepatocyte targeted composition comprising insulin associated with a lipid construct comprising an amphipathic lipid and an extended amphipathic lipid that...
9028864 Concentrated, inhalable antibiotic formulation  
A concentrated inhalable formulation of an antibiotic drug such as ciprofloxacin is disclosed. The antibiotic is formulated with sodium acetate and liposome which incorporate antibiotic. The...
9028863 Method and system for systemic delivery of growth arresting, lipid-derived bioactive compounds  
A system and method for optimizing the systemic delivery of growth-arresting lipid-derived bioactive drugs or gene therapy agents to an animal or human in need of such agents utilizing nanoscale...
9023384 Liposome and method for injecting substance to cell using this liposome  
It is intended to efficiently inject into a target cell, a substance charged within a liposome. The present inventors have found that connexin synthesized within a liposome is introduced as...
9023385 Pharmaceutical use of 2-(4-morpholinoaniline)-6-cyclohexyl aminopurine and/or salt thereof for improving liver functioning  
A method of treating a patient to improve liver functioning includes providing a drug composed of at least one of pharmaceutical 2-(4-morpholinoaniline)-6-cyclohexyl aminopurine and a...
9017719 Injectable drug carrier comprising layered double hydroxide  
Provided is an injectable drug carrier including a non-toxic Layered Double Hydroxide (LDH) and pharmaceutically acceptable excipients. Provided is also a method of preparing the injectable drug...
9012418 Topical administration of at least one double-stranded RNA oligonucleotide (dsRNA)  
Expression of a messenger RNA which encodes a protein which is expressed by differentiated cells, notably the cells of the skin or appendages thereof, is inhibited by topically administering to...
9012225 Lipophilic polynucleotide conjugates  
Disclosed are lipophilic polynucleotide conjugates including polynucleotide-cholesterol conjugates and methods of delivering therapeutic polynucleotides to a mammalian cell or patient in need of...
9012624 Compositions and methods for inhibiting expression of a gene from the JC virus  
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the JC Virus (JC virus genome), comprising an antisense strand having a nucleotide...
9011903 Cationic lipids for therapeutic agent delivery formulations  
Here described are compounds of formula I: wherein R1 and R2 is independently selected from a group consisting of C10 to C18 alkyl, C12 to C18 alkenyl, and oleyl group; wherein R3 and R4 are...
9011902 Composition for vaginal use  
Compositions for vaginal use comprising lupulus (Humulus lupulus) and an excipient base suitable for application in the vaginal and/or vulvar region, for the treatment of vaginal dryness (atrophic...
9005656 Activated nitric oxide donors and methods of making and using thereof  
Described herein are compositions useful in anticancer treatment and prevention. The compositions are composed of (a) an O2-aryl substituted diazeniumdiolate and (b) an amphiphile, wherein the...
9005654 Systems and methods for manufacturing liposomes  
The present invention provides apparatus and processes for producing liposomes. By providing a buffer solution in a first reservoir, and a lipid solution in a second reservoir, continuously...
9005655 Non-pegylated long-circulating liposomes  
The present invention provides a long circulating non-pegylated liposomal doxorubicin hydrochloride composition for parenteral administration and a process for its preparation. The circulation...
9005695 Composite stent with inner and outer stent elements and method of using the same  
An endoprosthesis comprising a stent, a cover fully covering the stent wherein the cover has variable porosity in the radial direction; and an adhesion layer connecting the stent to the cover....
9006191 Silencing of polo-like kinase expression using interfering RNA  
The present invention provides compositions comprising interfering RNA (e.g., siRNA, aiRNA, miRNA) that target polo-like kinase 1 (PLK-1) expression and methods of using such compositions to...
9005583 Chain-end functionalized poly(ethykene oxide) and process for the preparation of a nano-sized transition metal or metal salt using the same  
There is provided a novel chain-end functionalized PEO of formulas (I) to (IV) prepared via living anionic polymerization and chain-end functionalization, as well as a simple method of preparing...
8999320 Nanoscale bound bilayers, methods of use and production  
Methods for rapidly obtaining a nanoscale apolipoprotein bound phospholipid bilayer (NABB) associated with at least one membrane protein are provided. Also disclosed are methods for rapidly...
8999381 Self-emulsifying pharmaceutical compositions of rhein or diacerein  
The invention relates to self emulsifying drug delivery system based compositions of rhein or diacerein, or salts or esters or prodrugs thereof which are bioequivalent to a 50 mg diacerein...
8999380 Modified polynucleotides for the production of biologics and proteins associated with human disease  
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
8999295 Technique for drug and gene delivery to the cell cytosol  
Provided herein is a composition, a method, and a system for delivering a functional molecule to the cytosol of a cell, comprising a liposome configured to be taken into a cell, including by a...
9000033 Composition for improving skin condition and appearance  
Disclosed is a cosmetic composition comprising prenylated isoflavonoid and a carrier, wherein the prenylated isoflavonoid is from about 0.0000001% to about 10%, preferably from 0.00001% to 1%,...
8992969 Biphasic lipid-vesicle compositions and methods for treating cervical dysplasia by intravaginal delivery  
This invention relates to biphasic lipid-vesicle compositions and methods for treating cervical displasia by intravaginal delivery.
8992970 Liposomes useful for drug delivery  
The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also...
8987338 Active ingredient of a medicinal agent, a medicinal agent, a pharmaceutical composition and method for treating dementia syndrome patients  
The invention relates to an area of the chemical-pharmaceutical industry and medicine, particularly to an agent for treatment of dementias, including Alzheimer's disease (AD), as well as to a...
8986731 Pegylated liposomal formulations of hydrophobic photosensitizers for photodynamic therapy  
Pharmaceutical pegylated liposomal formulations for photodynamic therapy are presented. The pegylated liposomal formulation provides therapeutically effective amounts of the photosensitizer for...
8987224 MicroRNA-198 as a tumor suppressor in pancreatic cancer  
A novel network of tumorigenic prognostic factors is identified that plays a critical role in advanced pancreatic cancer (PC) pathogenesis. This interactome is interconnected through a central...
8986732 Biphasic lipid-vesicle compositions and methods for treating cervical dysplasia by intravaginal delivery  
This invention relates to biphasic lipid-vesicle compositions and methods for treating cervical displasia by intravaginal delivery.
8980311 Liposome-mediated ligation  
Chemoselective ligation of hydrophobic reactants in a lipid phase.
8980310 Non-pegylated long-circulating liposomes  
The present invention provides a long circulating non-pegylated liposomal doxorubicin hydrochloride composition for parenteral administration and a process for its preparation. The circulation...
8974792 Internalizing erbB2 antibodies  
This invention provides novel erbB2-binding internalizing antibodies. The antibodies, designated F5 and C1, specifically bind to c-erbB2 antigen and, upon binding, are readily internalized into...
8974818 Custom-formulated phospholipid microbubbles and methods and uses thereof  
A phospholipid microbubble comprising a shell which comprises a plurality of polyunsaturated fatty acid (“PUFA”)-containing phospholipids, and a core of inert gas surrounded by the shell...
8962015 Orally bioavailable lipid-based constructs  
The present invention is embodied by a composition capable of chaperoning a typically non-orally available therapeutic or diagnostic agent through the environment of the digestive tract such that...
8956627 Method of inducing antibodies to human immunodeficiency virus involving the administration of MPER peptide-liposome conjugates  
The present invention relates to a method of inducing the production in a patient of anti-HIV antibodies. The method comprises administering to a patient in need thereof an amount of at least one...
8956600 Ophthalmic drug delivery system containing phospholipid and cholesterol  
An ophthalmic drug delivery system that contains phospholipid and cholesterol for prolonging drug lifetime in the eyes.
8956646 Zwitterionic lipids  
In various embodiments, the present invention provides zwitterionic lipids, encapsulants incorporating these zwitterionic lipids and such encapsulants encapsulating one or more bioactive agent. An...
8956645 Water-soluble pharmaceutical composition comprising at least one therapeutically active substance having hydrophobic properties and at least one compound selected from among sialoglycosphingolipids, glycosphingolipids or a mixture of sialoglycosphingolipids and glycosphingolipids  
This invention discloses water soluble pharmaceutical compositions including at least one therapeutically active substance and at least one compound selected from the sialoglycosphingolipids, the...
8952074 Medicinal agent for treating patients suffering from diseases caused by the monoaminooxidase excessive activity and a method for treating patients suffering from diseases caused by the monoaminooxidase excessive activity  
The invention relates to the chemical and pharmaceutical industry and to medicine, in particular, to medicinal agents based on a mixture of natural oligomers of isoprenol (Ropren), which inhibits...
8945529 Biphasic lipid-vesicle compositions  
A biphasic lipid vesicle composition for treating cervical displasia by intravaginal delivery. The composition includes a suspension of lipid-bilayer vesicles having entrapped therein, an...
8940312 Composition containing polyunsaturated fatty acid  
An object of the present invention is to provide a composition for external use comprising a polyunsaturated fatty acid having higher stability over time. The present invention provides the...
8940857 Methods and compositions for enhancing delivery of double-stranded RNA or a double-stranded hybrid nucleic acid to regulate gene expression in mammalian cells  
A delivery-enhancing peptide comprising the amino acid sequence of SEQ ID NO:11 or salt thereof. This invention is directed towards methods and compositions to administer a double-stranded...
8940327 Agent for enhancing anti-tumor effect comprising oxaliplatin liposome preparation, and anti-tumor agent comprising the liposome preparation  
An object of the present invention is to further enhance the antitumor effect when oxaliplatin is administered in combination with a combination drug containing tegafur, gimeracil and oteracil...
8936942 Polyethyleneglycol-modified lipid compounds and uses thereof  
The present invention provides compositions comprising polytheylyene-dialkyloxypropyl conjugates (PEG-DAA), liposomes, SNALP, and SPLP comprising such compositions, and methods of using such...
8936807 Use of the cathelicidin LL-37 and derivatives thereof for wound healing  
Use of the antimicrobial cathelicidin peptide II-37, N-terminal fragments of LL-37 or extended sequences of LL-37 having 1-3 amino acids in the C-terminal end, for stimulating proliferation of...