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8110218 |
Compositions and methods for less immunogenic protein-lipid complexes
The present invention provides compositions and methods for reducing the immunogenicity and increasing the circulating half-life of therapeutic proteins such as Factor VIII. The compositions...
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8110217 |
Sphingomyelin liposomes for the treatment of hyperactive bladder disorders
The present invention provides pharmaceutical compositions and methods for the instillation of lipid vehicles comprised of liposomes containing sphingomyelin or sphingomyelin metabolites to...
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8097276 |
Method for coating particle with lipid film
A method for coating an object, i.e. a particle, with two sheets of lipid film having a space formed there between. In the method for coating a particle having a positive electrostatic-charging...
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8097277 |
Charge-dynamic polymers and delivery of anionic compounds
The present invention provides dynamic charge state cationic polymers that are useful for delivery of anionic molecules. The dynamic charge state cationic polymers are designed to have cationic...
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8092828 |
Fixed drug ratios for treatment of hematopoietic cancers and proliferative disorders
Provided herein are methods for treating cancer by administering a pharmaceutical composition comprising a fixed, non-antagonistic molar ratio of cytarabine and an anthracycline. Such methods are...
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8088744 |
Cholestanol derivative for combined use
The invention provides a cancer chemotherapeutic agent which has fewer side effects and excellent efficacy. The cancer chemotherapeutic agent of the invention includes a cholestanol derivative...
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8084057 |
Compositions and methods for wound healing
The present invention is related to the field of wound healing or tissue regeneration due to disease (i.e., for example, cardiovascular diseases, osteoarthritic diseases, or diabetes). In...
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8084056 |
Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
The present invention describes processes for the preparation of a lipid blend and a uniform filterable phospholipid suspension containing the lipid blend, such suspension being useful as an...
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8080262 |
Encapsulated peptide amphiphile nanostructures
The present invention provides compositions and methods for creating encapsulated peptide amphiphilic nanostructures useful in treating diseases. In particular, the present invention provides...
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8075913 |
Method of producing a cationic liposomal preparation comprising a lipophilic compound
A method for producing a cationic liposomal preparation comprising a lipophilic active compound with physical and chemical stability during manufacturing, storing and reconstituting, and further a...
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8075896 |
Method to enhance an immune response of nucleic acid vaccination
A composition comprising liposomes associated with a nucleic acid operatively encoding an antigenic protein and with an assistor protein, wherein the assistor protein shares at least one epitope...
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8071127 |
Dual action, inhaled formulations providing both an immediate and sustained release profile
Methods for formulating immediate and sustained release anti-infectives and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations...
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8071582 |
Substituted aniline derivatives
The present invention relates to novel aniline derivatives and their use in therapy, in particular their use in the treatment of fungal infections.
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8071132 |
Unagglomerated core/shell nanocomposite particles
The present invention provides a method for the synthesis of unagglomerated, highly dispersed, stable core/shell nanocomposite particles comprised of preparing a reverse micelle microemulsion that...
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8066971 |
Targeting pulmonary epithelium using ADRP
This invention provides novel compositions and methods for the specific and/or preferential delivery of an effector (e.g. a drug or label) to an epithelial cell (e.g. a pulmonary epithelium). The...
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8067032 |
Method for preparing submicron particles of antineoplastic agents
The present invention is concerned with the formation of submicron particles of an antineoplastic agent, particularly paclitaxel, by precipitating the antineoplastic agent in an aqueous medium to...
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8067017 |
Preservation of bioactive materials by freeze dried foam
This invention provides methods and compositions to preserve bioactive materials in a dried foam matrix. Methods provide non-boiling foam generation and penetration of preservative agents at...
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8062662 |
Liposomes containing an entrapped compound in supersaturated solution
A liposome composition having a compound entrapped in a supersaturated solution and method for preparing such a composition are described.
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8062663 |
Methods and compostions for enhancing transdermal drug delivery
Methods and compositions for enhancing transdermal delivery of a bioactive agent. The method contains the step of applying to a skin tissue an effective amount of a composition comprising: (a) a...
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8058249 |
Immunostimulatory nucleic acid molecules
Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a...
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8057823 |
Lipid nanocapsules, preparation process and use as medicine
The invention concerns nanocapsules, in particular with an average size less than 50 nm, consisting of an essentially lipid core liquid or semiliquid at room temperature, coated with an essentially...
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8057824 |
Compositions for achieving a therapeutic effect in an anatomical structure and methods of using the same
Compositions and methods of using the compositions to achieve a therapeutic effect are provided.
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8058254 |
DNA vaccines encoding heat shock proteins
The present invention is related to a method of treating a T cell-mediated inflammatory autoimmune disease by administering to an individual in need thereof an immunogenic composition comprising a...
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8048448 |
Nanoshells for drug delivery
Nano-constructs comprising nanoshells and methods of using the nano-constructs for treating or ameliorating a medical condition are provided.
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8048444 |
Apparatus and method for preventing adhesions between an implant and surrounding tissues
An anti-adhesion membrane is placed onto an implant introduced into a surgical site of a patient to prevent post-surgical adhesions between the implant and surrounding tissue. The implant may...
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8034375 |
Combinations and modes of administration of therapeutic agents and combination therapy
The present invention provides combination therapy methods of treating proliferative diseases (such as cancer) comprising a first therapy comprising administering to an individual an effective...
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8034385 |
Anti-ageing skin cosmetic
The invention relates to a cosmetic based on various natural raw materials, which can be used to counter ageing processes of the human skin. The inventive cosmetic contains 0.1-5% by weight of an...
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8034378 |
Immunogenic compositions containing phospholipid
Immunogenic compositions containing phospholipid adjuvants, including microparticle and emulsion compositions. According to one aspect of the invention, an immunogenic microparticle composition is...
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8034376 |
Lipid containing formulations
Compositions and methods useful in administering nucleic acid based therapies, for example association complexes such as liposomes and lipoplexes are described.
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8030285 |
Oligodeoxynucleotide and its use to induce an immune response
The present invention provides a substantially pure or isolated oligodeoxynucleotide of at least about 10 nucleotides comprising a sequence represented by either the formula:...
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8029795 |
Targeted iron chelator delivery system
A targeted iron chelator delivery system that comprises an iron chelator, a targeting agent and a lipid carrier, e.g., a liposome, is provided. The iron chelator delivery system may be used to...
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8030075 |
Carrier composition for nucleic acid transport
An object of the present invention is to provide a nucleic acid delivery carrier composition of low toxicity and high safety, the carrier composition, when used to administer a nucleic acid such as...
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8026209 |
Methods and compositions for targeting agents into and across the blood-barrier and other endothelial cell microvascular barriers
The present invention relates to nucleic acids and polypeptides encoded thereby, whose expression is modulated in brain microvascular endothelial cells undergoing early dynamic inflammation-induced...
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8025651 |
Anti-backflow urinary device
A urinary anti-backflow device is provided which prevents urine from flowing back into the patient's bladder from a urine collection bag. The device comprises a flow tube having an upstream section...
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8021666 |
Method and compositions for stimulation of an immune response to CD20 using a xenogeneic CD20 antigen
Tolerance of the immune system for endogenous CD20 can be overcome and an immune response stimulated by administration of xenogeneic or xenoexpressed CD20 antigen. For example, mouse CD20, or...
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8022279 |
Liposomal formulations of anthracycline agents and cytidine analogs
Compositions which comprise an anthracycline agent, and a cytidine analog are encapsulated in liposomal carriers. The preferred anthracycline agent is selected from the group of daunorubicin,...
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8021686 |
Lipid-encapsulated polyanionic nucleic acid
Methods for the preparation of a lipid-nucleic acid composition are provided. According to the methods, a mixture of lipids containing a protonatable or deprotonatable lipid, for example an amino...
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8017147 |
Nutritional supplement for the prevention of cardiovascular disease, alzheimer's disease, diabetes, and regulation and reduction of blood sugar and insulin resistance
A synergistic mixture (which may be utilized as a food or a drink or a supplement or a drug or a cosmetic or a hygienic product) that is formulated and is capable of improving a person's well...
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8017151 |
Amphiphilic polymer-protein conjugates and methods of use thereof
Compositions and methods for transporting biologically active proteins and polypeptides, particularly across the blood-brain barrier, are provided.
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8003610 |
Bradykinin B2 receptor antagonist peptide from amphibian skin
A bradykinin B2-receptor antagonist peptide, kinestatin, isolated from toad (Bombina maxima) defensive skin secretion, and analogs thereof, is disclosed. The structure of kinestatin is...
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8003129 |
Enhanced transport using membrane disruptive agents
Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are...
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7993672 |
Stable lipid-comprising drug delivery complexes and methods for their production
Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes...
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7985417 |
Method of lipid structure preparation
A method of inserting a lipid-linked moiety into a lipid assembly, such as a planar lipid monolayer or bilayer, a spherical lipid vesicle, a micelle, or an emulsion envelope monolayer is described....
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7981442 |
Ultrasound enhancement of drug release across non-ionic surfactant membranes
A method of targeted drug delivery and imaging using nonionic surfactant vesicles (niosomes) in combination with ultrasound. Niosomes have potential applications in targeted drug delivery and...
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7977369 |
Medical compositions for intravesical treatment of bladder cancer
Methods for treating bladder cancer comprising intravesicular administration of a stabilized pharmaceutical formulation comprising...
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7976868 |
Liposomes comprising duramycin and anti-viral agents
Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for...
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7968115 |
Liposomal curcumin for treatment of cancer
The present invention provides a compositions and methods for the treatment of cancer, including pancreatic cancer, breast cancer and melanoma, in a human patient. The methods and compositions of...
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7968116 |
Antitumor agent
A sugar-cholestanol compound which can be readily synthesized and which exhibits a satisfactory antitumor activity. An anticancer agent containing, as an active ingredient, a cholestanol compound...
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7968117 |
Externally triggered microcapsules
Disclosed are microcapsules comprising a polymer shell enclosing one or more immiscible liquid phases in which a drug or drug precursor are contained in a liquid phase. The microparticles also...
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7964214 |
Method and composition for hyperthermally treating cells in the eye with simultaneous imaging
A method and composition for hyperthermally treating cells in the eye with simultaneous imaging. The heat (temperature) production inside the eye (target) tissue is imaged. The desired temperature...
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