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7618624 |
Weight control using an anti-lipase antibody
A method for regulating the body weight of an animal by feeding it a liposome-encapsulated antibody against lipase.
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7615539 |
Nucleic acid-lipophilic conjugates
The invention relates to a nucleic acid-lipophilic conjugates and methods for modulating an immune response using the conjugates. The lipophilic moiety associated with an immunostimulatory nucleic...
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7612186 |
Compositions and methods for producing recombinant proteins
A class of integral membrane proteins, referred to as Mistic polypeptides, their variants, fusion proteins including a Mistic polypeptide domain, and nucleic acid molecules encoding Mistic...
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7608687 |
Releasable linkage and compositions containing same
A compound comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-containing ligand through a dithiobenzyl linkage is described.
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7605138 |
Nucleic acid compositions for stimulating immune responses
The invention provides an immunostimulatory nucleic acid comprising CpG motifs, and methods of use thereof in stimulating immunity.
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7601872 |
Transfection reagents
Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure:
wherein
Q is selected from the group consisting...
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7601367 |
Compositions and processes using siRNA, amphipathic compounds and polycations
Described is a deliverable composition with low toxicity comprising an amphipathic compound, a polycation, and a siRNA. The composition may be used in the process of delivering a siRNA to an animal...
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7601366 |
Promotion of peroxisomal catalase function in cells
The molecular mechanisms of peroxisome biogenesis have begun to emerge: in contrast, relatively little is known about how the organelle functions as cells age. The present inventors characterized...
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7597906 |
Apoptosis-mimicking synthetic entities and use thereof in medical treatment
Synthetic and semisythetic bodies having a three-dimensional structure, sized and shaped to resemble apoptotic cells and apoptotic bodies, and having phosphatidyl serine (PS) molecules on the...
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7597905 |
Hollow protein nano-particles and method of introducing substances into cells
As a versatile means for specifically and safely transporting and transferring substances (genes, proteins, compounds, etc.) into target cells and tissues, hollow nano particles comprising a...
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7597877 |
Administering a gravity segregation dispersion by continuous infusion
Method and apparatus for continuous infusion to a subject of dispersions in which the dispersed phase is susceptible to flotation or sedimentation. The dispersion is controllably delivered from an...
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7592469 |
Lipid-analogous phosphoric acid triesters
The present invention relates to novel phosphoric triesters which comprise apolar lipid structures.
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7592307 |
Releasable linkage and compositions containing same
A conjugate comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-, hydroxy- or carboxyl-containing ligand is described. The resulting conjugate is capable of releasing the...
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7591949 |
Method for the improvement of transport across adaptable semi-permeable barriers
The invention relates to a method, a kit and a device for controlling the flux of penetrants across an adaptable semi-permeable porous barrier, the method comprising the steps of: preparing a...
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7589072 |
Inositol-based molecular transporters and processes for the preparation thereof
Inositol derivatives in accordance with the present invention are effective in significantly enhancing the transportation of various therapeutic molecules across a biological membrane, which may...
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7588778 |
Delivery carrier for targeting to cells expressed with somatostatin receptors
The present invention relates to a delivery carrier including liposomes or nanoparticles for targeting the cells expressed with somatostatin receptor, consisting of a plurality of liposomes that...
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7585519 |
Esters of L-carnitine or alkanoyl L-carnitines useful as cationic lipids for the intracellular delivery of pharmacologically active compounds
Esters of L-carnitine and alkanoyl L-carnitines are described which can be used as cationic lipids for the intracellular delivery of pharmacologically active compounds. New esters of L-carnitine...
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7582613 |
Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines
The invention provides adjuvants, immunogenic compositions, and methods useful for polynucleotide-based vaccination and immune response. In particular, the invention provides an adjuvant of...
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7576066 |
Nucleic acid compositions for stimulating immune responses
The invention provides an immunostimulatory nucleic acid comprising CpG motifs, and methods of use thereof in stimulating immunity.
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7569850 |
Lipid bilayers on nano-templates
A lipid bilayer on a nano-template comprising a nanotube or nanowire and a lipid bilayer around the nanotube or nanowire. One embodiment provides a method of fabricating a lipid bilayer on a...
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7569553 |
Nucleic acid compositions for stimulating immune responses
The invention provides an immunostimulatory nucleic acid comprising CpG motifs, and methods of use thereof in stimulating immunity.
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7556827 |
Implantable active ingredient depot
The invention relates to an implantable active ingredient depot for therapeutically active substances. The fields of application are in medicine and the pharmaceutical industry. The implantable...
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7556825 |
Method for promoting hair growth
The present invention describes a method for targeted and specific delivery of beneficial compounds, including hair dyes, melanin, proteins, and nucleic acids for gene therapy, to hair follicle...
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7550157 |
Method for the preparation of polymeric micelle via phase separation of block copolymer
A method for preparing a biodegradable polymeric micellar composition using liquid polyethylene glycol as a phase separation medium. The present invention also provides an efficient method to...
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7544670 |
HoxD3, HoxA3 and HoxB3 compositions and methods for improved wound healing
The present invention provides methods and compositions useful in localized transfer of genetic material or proteins. Moreover, the present invention provides methods and compositions for improving...
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7544374 |
Lipidated glycosaminoglycan particles and their use in drug and gene delivery for diagnosis and therapy
Lipidated glycosaminoglycan particles are prepared by reacting a glycosaminoglycan with at least one lipid to cross-link the carboxylic acid groups in the glycosaiminoglycan with a primary amine in...
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7544369 |
Sustained release of antiinfectives
Provided, among other things, is a method of treating or ameliorating pulmonary infection in a cystic fibrosis patient comprising pulmonary administration of an effective amount of a...
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7534915 |
Non-symmetrical gelling agent
The present invention relates to a novel trisubstituted cyclic thickener or gelator. The present invention further relates to a method for thickening or gelating a solution comprising the use of...
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7534438 |
Product and process for liquefaction of mucus or sputum
Disclosed are compositions and methods for decreasing the viscosity and/or cohesiveness of and/or increasing the liquefaction of excessively or abnormally viscous or cohesive mucus or sputum. The...
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7531604 |
Phospholipid derivative
A phospholipid derivative, utilizable for modification of liposomes and the like, which is a copolymer containing, as essential component units, a component unit A represented by the formula (1), a...
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7527802 |
Vaccine for transcutaneous immunization
A vaccine delivered by transcutaneous immunization provides an effective treatment against infections by pathogens such as, for example, enterotoxigenic Escherichia coli (ETEC) and/or for...
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7524981 |
Phospholipid derivatives and process for the production there
A phospholipid derivative represented by the following formula (1):
wherein [PG]k represents a residue of polyglycerin having a polymerization degree of k, wherein k is 2 to 50, R 1 CO and R 2...
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7524828 |
Immunostimulatory nucleic acid molecules
Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity,...
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7514098 |
Use of targeted cross-linked nanoparticles for in vivo gene delivery
The in vivo delivery of nucleic acids is targeted by delivery of the nucleic acid in a complex with cross-linked nanoparticles; where the nanoparticles comprise cross-linked neutral amphipathic...
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7511031 |
Noninvasive vascular therapy
The present invention is drawn to apparatus for transcutaneous photodynamic therapy (“PDT”) of a target tissue or compositions in a mammalian subject, which includes a light source that is...
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7510710 |
Compositions of UCP inhibitors, Fas antibody, a fatty acid metabolism inhibitor and/or a glucose metabolism inhibitor
Systems and methods for treating inflammatory and proliferative diseases, and wounds, using as a pharmacon a UCP and/or Fas antibody or other inhibitor, or combination thereof, and a...
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7501134 |
Microparticles with adsorbed polypeptide-containing molecules
Microparticles with absorbed polypeptide-containing molecules formed without the use of surfactant, methods of making such microparticle compositions, and uses thereof, are disclosed. The...
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7498045 |
Biodegradable polymeric nanocapsules and uses thereof
The present invention relates to a biodegradable polymeric nanocapsule composition, adaptable for encapsulation of an agent of therapeutic interest for enhancing the in vivo circulation time of...
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7498028 |
Preparation of spheres for diagnostic tests
The invention relates to surfactant-free reagent spheres useful for biological tests particularly those involving antigen/antibody reactions.
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7495116 |
Phospholipid derivative
A phospholipid derivative represented by the formula (1) (Z represents a residue of a compound having 3 to 10 hydroxyl groups; AO represents an oxyalkylene group having 2 to 4 carbon atoms; R 1 CO...
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7494666 |
Cationic lipid compositions targeting angiogenic endothelial cells
Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth....
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7491707 |
Synthetic lipid-a-analogs and uses thereof
New synthetic Lipid-A analogs based on monosaccharide (1) and disaccharide (2) derivatives were designed and prepared in the present invention. Both structures (1) and (2) incorporate novel lipid...
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7491409 |
Encapsulation of bioactive complexes in liposomes
This invention provides a method to prepare liposome-encapsulated bioactive agents such as nucleic acids, comprising complexation of the bioactive agents in reverse micelles prior to forming...
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7485321 |
Peyer's patch and/or M-cell targeting ligands
Purified synthetic polypeptide ligands for targeting pharmaceutical agents and carriers comprising such agents to intestinal epithelial tissue, especially Peyer's patch and/or M-Cell tissue. Also...
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7485320 |
Liposome for incorporating large amounts of hydrophobic substances
A liposome formulation for stably incorporating high content of hydrophobic substance is disclosed. The liposome includes two phospholipids with different phase transition temperatures such as...
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7482020 |
Process for making an adjuvanted vaccine comprising host albumin
A process for making an adjuvanted vaccine comprising host albumin. The process comprises mixing host serum or host serum with an antigen, and then mixing the resulting mixture with an adjuvant.
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7479276 |
Antibody fragment-targeted immunoliposomes for systemic gene delivery
Nucleic acid-immunoliposome compositions useful as therapeutic agents are disclosed. These compositions preferably comprise (i) cationic liposomes, (ii) a single chain antibody fragment which binds...
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7476401 |
Protein and peptide delivery to mammalian cells in vitro
Compositions and methods for delivery of proteins and peptides to mammalian cells in vitro are described. Specifically, polypeptide-surfactant complexes formed from noncovalent hydrophobation of...
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7476400 |
High-concentration lidocaine compositions and methods for their preparation
A composition comprising lidocaine-containing liposomes wherein the weight concentration of lidocaine in said composition is greater than 10%. The composition is prepared by mixing water with an...
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7476380 |
Methods for treating illnesses of the tracheo-bronchial tract, especially chronic obstructive pulmonary disease (COPD)
The invention describes a means for the treatment of diseases of the tracheo-bronchial tract, particularly of COPD.
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