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7166295 |
Methods of treatment and diagnostic visualization, particularly in cancer
Methods and reagents for improved treatment and diagnostic imaging, particularly of cancer. The methods and reagents utilize specific targeting of treatment and imaging ligands to the targeted...
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7166605 |
Probucol nitro-derivatives
Probucol derivatives and pharmaceutical compositions containing the same to be employed in treatment or prophylaxis of diseases.
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7166298 |
Genetic immunization with cationic lipids
A method for immunization using genetic material is disclosed. Compositions for genetic immunization comprising cationic lipids and polynucleotides are also disclosed. Methods for using genetic...
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7163926 |
Adjuvant-containing vaccines
This invention provides a DNA vaccine which comprises a naked DNA incorporating and expressing in vivo a nucleotide sequence encoding an antigenic polypeptide, preferably a gene of a pathogenic...
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7163673 |
Sunscreen reagents from hydroxy-substituted acylglycerides
A class of UVA- and UVB-absorbing esters has been derived by modifying hydroxy triglycerides and other acyltriglycerides with any of a variety of cinnamic acids. The esterification reactions are...
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7160554 |
Enhanced circulation effector composition and method
A liposome composition comprising small, surface-bound effector molecules is disclosed. The liposomes have a surface layer of hydrophilic polymer chains, for enhanced circulation time in the...
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7157099 |
Sustained release pharmaceutical compositions for the parenteral administration of hydrophilic compounds
Stable, biologically compatible pharmaceutical compositions in the form of water-in-oil microemulsions (w/o), for the sustained release by parenteral administration of active ingredients which are...
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7157098 |
Gene therapy of tumors using non-viral delivery system
The present invention provides a pharmaceutical composition, comprising: (a) cationic lipids, wherein said lipids are a liposomal mixture of a diacyl-ethyl-phosphocholine and...
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7153525 |
Microemulsions as precursors to solid nanoparticles
The preparation of novel microemulsions to be used as precursors for solid nanoparticles is described. The microemulsion precursors consist of either alcohol-in-fluorocarbon microemulsions, liquid...
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7153490 |
Liposomes encapsulating anticancer drugs and use thereof in the treatment of malignant tumors
Liposomes encapsulating anticancerous drugs and the use thereof in the treatment of malignant tumors. The liposomes are coated with a lipopeptide composed of three substructures: a lipid fragment,...
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7153838 |
Pharmacologically acceptable solvent vehicles
An antifungal composition suitable for parenteral administration to a mammal includes an amount of pimaricin or an antifungal derivative thereof that is effective to inhibit the growth of a fungal...
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7150883 |
Self forming, thermodynamically stable liposomes and their applications
A lipid composition forms liposomes spontaneously upon mixing with an aqueous solution. The lipid composition includes diacylglycerol-PEG compounds. Such lipid compositions are useful for forming...
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7147841 |
Formulation of UV absorbers by incorporation in solid lipid nanoparticles
Solid lipid nanoparticle compositions containing (a) 1 to 40% by weight of an oil-soluble UV absorber,(b) 20 to 98.9% by weight of a solid lipid,(c) 0.1 to 20% by weight of an emulsifier and(d) 0...
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7147866 |
UV-absorbing lipid vesicles
Highly effective vesicular compositions from UV-absorbing lipids are described in the present invention. Combination of UV-absorbing property and the vesicular delivery system results in higher...
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7148260 |
Water-based emulsifier wax gels including free sphingoid bases and oil in-water emulsion including the same
Water-based emulsifier wax gels are provided that include skin-identical sphingolipids The present invention also provides a process for the preparation of such gels, the use of such gels for the...
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7141236 |
Methods and compositions for delivering macromolecules to or via the respiratory tract
Methods and compositions for delivering macromolecules to or via the respiratory tract, such that the macromolecules exhibit improved local and/or systemic bioavailability are provided. Such...
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7138136 |
Agglomerated particles for aerosol drug delivery
The invention provides a drug delivery vehicle for inhalation by a patient. The drug delivery vehicle comprises biocompatible particles between 0.1 and 1.0 microns in diameter, that are loaded with...
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7135177 |
Immunoliposomes that optimize internalization into target cells
The present invention provides for immunoliposomes that optimizes internalization of a drug into target cells bearing a characteristic cell surface marker. The immunoliposomes comprise an Fab'...
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7135193 |
Liposome compositions of porphyrin photosensitizers
Liposomal pharmaceutical formulations incorporating porphyrin photosensitizers useful for photodynamic therapy or diagnosis of malignant cells. The liposomal formulations comprise a porphyrin...
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7132404 |
Compositions for receptor/liposome mediated transfection and methods of using same
The present invention provides a composition of matter for introducing an exogenous nucleic acid molecule into a target cell, comprising a liposome, a ligand polymeric scaffold, wherein the ligand...
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7128897 |
Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis
Pharmaceutical compositions are described that contain one agent for treatment of sinusitis and a surfactant. The compositions are prepared to have a surface tension that renders the composition...
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7128930 |
Compositions and methods for treating sexual dysfunction
Methods for treating sexual dysfunction are disclosed. The methods generally comprise the administration of an NO donor and an antioxidant; the active ingredients can be administered topically to...
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7128923 |
Preserved and stable compositions containing peptide copper complexes and method related thereto
Compositions comprising at least one peptide copper complex and at least one preservative exhibit chemical stability of the peptide copper complex, as well as resistance and/or toxicity to...
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7129087 |
Oligonucleotide-facilitated coalescence
Coalescence of cells or other membrane-bound entities is facilitated by anchoring an outwardly projecting first oligonucleotide in one member and an outwardly projecting second oligonucleotide,...
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7125718 |
Method for introducing and expressing genes in animal cells, and bacterial blebs for use in same
A method for introducing and expressing genes in animal cells, in which the animal cells are transfected with bacterial blebs containing a eukaryotic expression cassette encoding the gene....
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7122202 |
Therapeutic liposome composition and method of preparation
Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an...
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7122553 |
Liposomal formulation of irinotecan
The present invention is for novel compositions and methods for treating cancer, particularly, for treating cancer in mammals and more particularly in humans. The therapeutic compositions of the...
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7115582 |
HoxD3 and HoxA3 compositions and methods for improved wound healing
The present invention provides methods and compositions useful in localized transfer of genetic material or proteins. Moreover, the present invention provides methods and compositions for improving...
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7112337 |
Liposome composition for delivery of nucleic acid
A liposome composition for delivery of a nucleic acid in vivo or ex vivo is described. The liposomes in the composition are comprised of (i) a lipid that is neutral in charge at physiologic pH and...
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7108863 |
Liposome composition for improved intracellular delivery of a therapeutic agent
A liposomal composition and a method of using the same for achieving intracellular delivery of a liposome-entrapped agent is described. The liposomes are composed of a pH sensitive lipid and...
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7105172 |
Treatment of rosacea
Disclosed herein are methods for the treatment or prevention of rosacea in a patient, including administering a compound that inhibits one or more components of the bradykinin activation pathway in...
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7105161 |
Proteinaceous adjuvants
A modulated immune response to an antigen is achieved by coadministering the antigen and a genetically-detoxified pertussis holotoxin, particularly one retaining its immunogenicity, to a host. The...
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7105151 |
Oxygen delivery agents and uses for the same
The present invention describes, inter alia, oxygen delivery agents or blood substitutes comprising a fluorinated gas and a stabilizing material, uses for the oxygen delivery agents or blood...
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7101570 |
Liposome compositions and methods for the treatment of atherosclerosis
The present invention provides compositions and methods for treating atherosclerosis. The compositions comprise unilamellar liposomes having an average diameter of 100-150 nanometers. Methods for...
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7101532 |
Liposome containing hydrophobic iodine compound
A liposome containing a hydrophobic iodine compound such as a 1,3,5-triiodobenzene derivative having at least one substituent containing 18 or more carbon atoms as a membrane component, and an...
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7098032 |
Compositions and methods for drug delivery using pH sensitive molecules
An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative...
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7097854 |
Amino alcohol derivatives, process for their production and pharmaceutical preparations and reagents containing these compounds
The present invention relates to new amino alcohol derivatives, process for the production thereof and medicaments and reagents containing these compounds.
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7094771 |
Pharmaceutical composition for boron neutron capture therapy containing triphenylboroxin
A pharmaceutical composition for boron neutron capture therapy (BNCT), and in particular for BNCT on hepatoma is disclosed. The pharmaceutical composition contains a therapeutically effective...
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7094810 |
pH-sensitive block copolymers for pharmaceutical compositions
The present invention relates to a pharmaceutical composition of a biologically active agent and a block copolymer composed of a poly(ethylene oxide) forming hydrophilic segment and a poly(butyl...
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7094423 |
Methods for preparation of lipid-encapsulated therapeutic agents
Fully lipid-encapsulated therapeutic agent particles of a charged therapeutic agent are prepared by combining a lipid composition containing preformed lipid vesicles, a charged therapeutic agent,...
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7090868 |
Materials and methods for drug delivery and uptake
The subject invention pertains to novel materials and methods for use in delivering and sequestering substances, such as pharmacological agents, within a patient. One aspect of the invention is...
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7090865 |
Composition and method for treating autoimmune hemolytic anemia
Disclosed are a composition and method to treat or prevent antibody-induced anemia and particularly, autoimmune hemolytic anemia. The composition comprises a bisphosphonate and a pharmaceutically...
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7091028 |
Method for directed packaging of molecular substances in protein shells
The invention relates to a method for packaging molecular substances in protein shells, comprising the following steps: binding a protein shell fragment, via a first region to a matrix; bringing...
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7090864 |
Non-invasive gene targeting to ocular cells
Liposomes containing therapeutic genes are conjugated to multiple targeting agents to provide transport of the encapsulated gene across the blood-retinal barrier and the plasma membrane of ocular...
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7091041 |
Micellar systems
A complex is described that is deliverable to a cell comprising inserting a nucleic acid or other cargo into a reverse micelle. The reverse micelle has the property to compact the nucleic acid for...
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7083572 |
Therapeutic delivery systems
Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled lipid microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic...
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7081253 |
Use of nanodispersions in pharmaceutical end formulations
A description is given of the use of a nanodispersion, which comprises (a) a membrane-forming molecule,(b) a coemulsifier and(c) a lipophilic component,in pharmaceutical end formulations, the...
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7081254 |
Skin preparations for external use
The invention relates to a skin preparation for external use, which contains a lamellar structure containing a fatty acid monoglyceride as a main component, and vitamin A or a derivative thereof....
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7078060 |
Solutions and aerosols of metal-containing compounds
Solutions and aerosols of metal-containing compounds are disclosed. Methods of preparing and using the solutions and aerosols, particularly in the treatment of a subject having a condition, are...
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7078518 |
Forms of 5-Azacytidine
The disclosure includes novel polymorphic and pseudopolymorphic crystalline forms of 5-azacytidine, along with methods for preparing said forms, wherein 5-azacytidine is represented by the formula:...
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