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6838429 |
Atopic dermatitis treatment method
Compositions are provided for treating atopic dermatitis, other atopic diseases and other inflammatory or allergic skin disorders. The compositions include proteins from Molluscum Contagiosum Virus...
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6835396 |
Preparation of submicron sized nanoparticles via dispersion lyophilization
The present invention relates to a process for preparing submicron sized nanoparticles of a poorly water soluble compound by lyophilizing a dispersion or microdispersion of a multiphase system...
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6835395 |
Composition containing small multilamellar oligodeoxynucleotide-containing lipid vesicles
Lipidic compositions with superior characteristics for in vivo delivery of oligodeoxynucleotides (ODN) can easily and efficiently be made in the form of small multilamellar vesicles. The...
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6833139 |
Composition and method for the treatment of anorectal disorders
A topical preparation for the treatment of anorectal disorders comprises L arginine and a local anesthetic. The L arginine typically comprises 0.1-5% by weight of the composition, and the local...
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6828453 |
Phospholipid-analogous compounds
Phospholipid-analogous compounds of the general formula (I) in which A where R 1 and R 2 are, independently of one another, hydrogen, a saturated or unsaturated acyl or alkyl radical which...
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6828306 |
Charged lipid compositions and methods for their use
The invention provides a pharmaceutical composition comprising a synthetic or naturally occurring charged phospholipid, which is formulated into a dosage form for administration to a subject or...
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6824785 |
Skin treatment composition and methods of use
A composition which when topically applied to the skin of a mammal reduces trans-epidermal water-loss and provides an improved epidermal barrier contains an aqueous dispersion of at least two...
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6821956 |
Therapeutic use of cis-element decoys in vivo
The invention provides for the use of oligodeoxynucleotide decoys for the prophylactic or therapeutic treatment of diseases associated with the binding of endogenous transcription factors to genes...
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6821529 |
Oligo(ethylene glycoll)-terminated 1,2-dithiolanes and their conjugates useful for preparing self-assembled monolayers
The present invention provides biotechnologically useful oligo(ethylene glycol)-terminated 1,2-dithiolane compositions and conjugates of these compositions with biological or non-biological...
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6818657 |
Bioprecursors of a retinoic derivative and pharmaceutical and/or cosmetic compositions
The present invention relates to a ternary glucosyl complex which is a bioprecursor of at least one retinoic active ingredient for percutaneous application, having formula (I), wherein E represents...
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6818227 |
Liposome composition and method for administration of a radiosensitizer
A method for administering a radiosensitizer to a tumor site in a subject is described. The method includes preparing liposomes composed of a vesicle-forming lipid and a lipid-derivatized...
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6815432 |
Methods for encapsulating plasmids in lipid bilayers
Plasmid-lipid particles which are useful for transfection of cells in vitro or in vivo are described. The particles can be formed using either detergent dialysis methods or methods which utilize...
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6814964 |
Supramolecules containing binding and therapeutic molecules bound to hybridized nucleic acids
A supramolecule has a first supramolecular component including a first effector molecule covalently joined to a first nucleic acid, and a second supramolecular component including a second effector...
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6812217 |
Medical device and methods of use
The present invention provides a medical device that includes a carrier and a polynucleotide, where the carrier has a surface that includes a polymer with which the polynucleotide is associated. In...
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6808720 |
Charged lipids and uses for the same
The present invention is directed to charged lipids, compositions comprising charged lipids, and the use of these compositions in drug delivery, targeted drug delivery, therapeutic imaging and...
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6809182 |
VZV ORF29p protein-related compositions and methods
The present invention provides compositions of matter comprising 29p protein having bound thereto an agent whose delivery into a eukaryotic cell is desired. The present invention also provides a...
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6806084 |
Methods for compositions for in vivo gene delivery
Novel methods and compositions are provided for introducing a gene capable of modulating the genotype and phenotype into two or more tissues following systemic administration. The gene can be...
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6805879 |
Stable polymer aqueous/aqueous emulsion system and uses thereof
This invention provides a stable aqueous/aqueous emulsion system which is prepared with a hydrophilic polymer. This invention also provides the method of preparing a stable aqueous/aqueous...
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6803053 |
Lipidic microparticles linked to multiple proteins
The invention provides lipidic microparticles stably associated with at least two different targeting moieties, which targeting moieties are attached to linker molecules comprising a hydrophilic...
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6800298 |
Biological lubricant composition and method of applying lubricant composition
Fluid compositions and methods for lubrication of mammalian joints are disclosed, including both natural and artificial fluids. Synovial fluid acts to lubricate the bearing surfaces of bones and...
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6797281 |
Esters of I-carnitine or alkanoyl I-carnitines
Esters of L-carnitine and alkanoyl L-carnitines are described which can be used as cationic lipids for the intracellular delivery of pharmacologically active compounds. New esters of L-carnitine...
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6793923 |
Vaccines with enhanced immune response and methods for their preparation
The present invention is concerned with vaccines and their preparation. An effective long-term immune response, especially in mammals, can be produced using a vaccine comprising an antigen...
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6793912 |
Treatment of cancers by inhalation of stable platinum-containing formulations
Disclosed are methods of treating cancers by inhalation of stable platinum-containing formulations.
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6790457 |
Compositions and methods for reducing or preventing fertilization in fish and birds
Disclosed is an immunocontraceptive vaccine composition comprising a teleost homolog of zona pellucida (TH-ZP), together with a pharmaceutically acceptable diluent or carrier, for reducing or...
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6790463 |
Uses of targeted oxidative therapeutic formulation in arteriosclerosis
The use of a pharmaceutical formulation in treating coronary arteriosclerosis and a two-component pharmaceutical formulation. The pharmaceutical formulation contains peroxidic species or reaction...
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6787153 |
Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane
A human monoclonal antibody specifically binding to a surface antigen of cancer cell membrane, an isolated DNA encoding the antibody, and a hybridoma producing the antibody. An anti-cancer...
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6787154 |
Artificial antigen presenting cells
The present invention is directed to artificial antigen presenting cells and methods of making artificial antigen presenting cells. Such artificial antigen presenting cells may be used in certain...
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6780428 |
Unimolecular polymeric micelles with an ionizable inner core
The present invention describes the preparation of unimolecular polymeric micelles (UPM) that bear a hydrophilic shell and a potentially ionizable and relatively hydrophobic core at a determined pH...
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6780430 |
Stabilzation method of nano-sized emulsion using tocopheryl derivatives and external application for skin containing the same
Disclosed herein is a stabilization method of nano-sized emulsion by using lecithin and tocopheryl derivatives represented by the following formula (I) and (Wherein, R 1 , R 2 and R 3 are H or...
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6780427 |
Reduction of adhesions using controlled delivery of active oxygen inhibitors
SOD and other active oxygen inhibitors are directly applied in combination with a barrier material at local sites of tissue injury to prevent or decrease formation of adhesions and undesirable...
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6773719 |
Liposomal compositions, and methods of using liposomal compositions to treat dislipidemias
The present invention provides a liposomal composition for treating dislipidemias in human subjects, a method of using a liposomal composition, and devices and modes of operation of the devices and...
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6773720 |
Mesalazine controlled release oral pharmaceutical compositions
Controlled-release oral pharmaceutical compositions containing as active ingredient 5-amino-salicylic acid, comprising: a) an inner lipophilic matrix consisting of substances with a melting point...
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6770292 |
Pharmaceutical compositions for oral administration
A method for oral administration of an active principle includes the steps of incorporating an active principle in multilamellar vesicles having a diameter of between 0.1 and 25 μm, and a lamellar...
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6770290 |
Amphotericin B liposome preparation
A novel composition and method for solubilizing amphiphilic drugs in a small amount of organic solvent for use in improved liposomes is disclosed. A phosphatidylglycerol is acidified in a small...
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6767544 |
Methods for treating cardiovascular diseases with botulinum toxin
The present invention provides for methods of treating cardiovascular diseases in a mammal. The methods include a step of administering an effective amount of a botulinum toxin directly to a blood...
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6767554 |
Use of complexes among cationic liposomes and polydeoxyribonucleotides and medicaments
The invention relates to the use as medicaments, specifically as antiinflammatories, of complexes formed by cationic liposomes and polydeoxyribonucleotides having a molecular weight in the range...
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6764693 |
Free radical quenching composition and a method to increase intracellular and/or extracellular antioxidants
A free radical quenching composition is disclosed comprising a liposome containing at least two antioxidants selected from the following group: beta-carotene, vitamin E, vitamin C, glutathione,...
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6761902 |
Proteoliposomes containing an integral membrane protein having one or more transmembrane domains
A stable proteoliposome containing an integral membrane protein in a lipid membrane around an elliptoid or spherical shape. The shape preferably contains an attractant such as streptavidin or...
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6759057 |
Methods and compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs
Methods and compositions are described for the treatment of inflammatory diseases including the use of liposomes to deliver non-steroidal anti-inflammatory drugs. Drugs may be encapsulated in the...
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6759058 |
Enteric-coated proliposomal formulations for poorly water soluble drugs
This invention relates to enteric-coated proliposomal formulations for oral medicaments. In particular, it relates to an enteric-coated proliposomal oral drug delivery system for poorly water...
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6756054 |
Polycationic sterol derivatives as transfection agents
A compound capable of acting as a cationic lipid is described. The compound comprises a cholesterol group having linked thereto a head group; wherein the head group is more positive than the head...
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6756037 |
Polymer conjugates of biologically active agents and extension moieties for facilitating conjugation of biologically active agents to polymeric terminal groups
The present invention is directed to polymer conjugates of biologically active agents and methods of preparing the same. In preferred aspects of the invention, the conjugates are of the formula ...
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6756354 |
Therapeutic compositions containing oligo (ethylene glycol)-terminated 1,2-dithiolanes and their conjugates
The present invention provides biotechnologically useful oligo(ethylene glycol)-terminated 1,2-dithiolane compositions and conjugates of these compositions with biological or non-biological...
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6752988 |
Method of treating upper resiratory illnesses
A method for the prophylactic and therapeutic treatment of bacterial infections is disclosed which comprises the treatment of an individual with an effective amount of a native or modified version...
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6749863 |
Targeted liposome gene delivery
Targeted ligand-liposome-therapeutic molecule complexes (vectors) for the systemic delivery of the therapeutic molecule to various target cell types including cancer cells such as squamous cell...
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6746690 |
Process for producing composite preparation containing nucleic acid
A method for producing a composition including a nucleic-acid-containing complex is characterized in that two single strand nucleic acid polymers which can at least partly form double strands are...
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6743781 |
Glycerolipid compounds useful for the transfer of an active substance into a target cell
The invention concerns novel compounds of formula (I) in which: R 1 and R 2 , which are identical or different, are C 6 -C 23 alkyl or alkenyl radicals, linear or branched or —C(═O)—(C 6...
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6740643 |
Compositions and methods for drug delivery using amphiphile binding molecules
The present invention relates to the delivery of desired compounds (e.g., nucleic acids) into cells using noncovalent delivery systems which include complexing nucleic acids, amphipathic binding...
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6740335 |
Liposomal camptothecin formulations
Liposomal encapsulated camptothecin formulations are provided. The liposomes have improved pharmacokinetics, enhanced efficacy as anti-tumor agents and provide an increased therapeutic index as...
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6733777 |
Cationic reagents of transfection
Cationic cytofectins and liposomes comprising the same are disclosed which are especially useful for delivering exogenous compounds into cells in vitro and in vivo. The liposomes may comprise (a) a...
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