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6946118 |
Formulations for treating or preventing mucositis
Mucositis is treated and/or prevented by administrating to a patient a formulation comprising a tetracycline that is poorly absorbed from the gastro-intestinal tract. The tetracycline may be in the...
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6943152 |
DNA vaccine-PCV
The invention relates to immunogenic preparations or vaccines comprising, on the one hand, a plasmid encoding and expressing a gene from PCV, in particular selected from the group consisting of...
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6936729 |
Compound containing a labile disulfide bond
A labile disulfide-containing compound under physiological conditions, comprising: the disulfide-containing compound having a labile disulfide bond that is either a disulfide bond that is cleaved...
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6936273 |
Liposomal analgesic formulation and use
A liposome formulation containing about 1% diclofenac is an effective topical anti-inflammatory topical treatment for lameness in horses. More particularly it has been discovered that a formulation...
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6936263 |
Th1 inducing natural adjuvant for heterologous antigens
The present invention relates to the use of the major OprI lipoprotein of Pseudomonas aeruginosa to elicit a Type-1 immune response towards a heterologous antigen. The invention relates...
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6936594 |
Gene therapy for cerebrovascular disorders
By introducing hepatocyte growth factor (HGF) gene and/or vascular endothelial growth factor (VEGF) gene into the subarachnoid space in humans, cerebrovascular disorders such as cerebrovascular...
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6936272 |
10139483Therapeutic liposome composition and method of preparation
A fusogenic liposome composition for delivering a liposome-entrapped compound into the cytoplasm of a target cell is described. The liposomes have an outer surface coating of chemically releasable...
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6930087 |
Pharmaceutical composition comprising factor VIII and neutral liposomes
A pharmaceutical composition for parenteral administration comprising a therapeutically effective amount of a protein or polypeptide and substantially neutral colloidal particles. The particles...
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6930097 |
Matrix metalloproteinase and tumor necrosis factor inhibitors
A compound of formula 1-[3,4-dihydroxy-5-(2-hydroxyethyl)tetrahydrofuran-2-yl]pryi
midine-2,4(1H,3H)-dione has inhibitory effects of matrix metalloproteinase-2 (gelatinase A) enzyme and binding of...
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6926905 |
Liposomak compositions and methods of preparation
Long-term local anesthesia is provided by administering to a subject in need thereof a liposomal anesthetic formulation prepared by the dehydration-rehydration method. In this method, lyophilized...
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6924273 |
Chondroprotective/restorative compositions and methods of use thereof
The instant invention provides a method of treating or preventing osteoarthritis, joint effusion, joint inflammation and pain, synovitis, lameness, post operative arthroscopic surgery,...
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6921648 |
Neurogenesis inducing genes
The present invention relates to neurogenesis inducing genes. In particular, the present invention provides neurogenesis inducing genes coding for Zic proteins, vectors containing such genes, host...
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6921543 |
Immunomodulatory preparation
A method for modulating the immune response to an immunogen in a human or animal patient comprises administration to the patient of an immunogenically effective amount of the immunogen and an...
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6919091 |
Compositions and methods for drug delivery using pH sensitive molecules
An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative...
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6916488 |
Amphiphilic polymeric vesicles
Vesicles made from amphiphilic copolymers are disclosed. The amphiphilic copolymers can be ABA copolymers, where one of A and B is hydrophilic and the other is hydrophobic. AB copolymers can also...
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6916489 |
Active agent transport systems
Methods for transporting a biologically active agent across a cellular membrane or a lipid bilayer. A first method includes the steps of:
(a) providing a biologically active agent which can...
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6914051 |
Penetrating antibiotic gel for soft tissue diseases
A penetrating antibiotic gel for treating pain, inflammation and other pathological conditions affecting musculoskeletal tissues and other soft tissues of the body. The composition includes an...
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6913761 |
Bioimplant formulation
A pharmaceutical and/or veterinary formulation comprising about 2-30% (w/w) (on an active basis) of at least one active agent, about 0.5-20.0% (w/w) of a pore-foaming agent and the balance stearin....
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6913767 |
Compositions for microencapsulation of antigens for use as vaccines
Methods and compositions are provided for the encapsulation of antigens in PLGA microspheres for use as vaccines. Such microspheres can also contain adjuvants. Mixtures of microspheres are provided...
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6908625 |
Cosmetic material containing triple- encapsulated retinol
The present invention concerns stabilized cosmetic material containing triple-encapsulated retinol. Unstable, fat-soluble retinol is stabilized firstly by addition into vesicles consisting of...
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6899895 |
Lamellar gels and methods for making and regulating
The invention provides novel compositions involving lamellar gels and methods for making them. These compositions and methods of the invention are significant improvements in the field of gels,...
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6897326 |
Asymmetrical bicipital lipid and tubular aggregate formed by using the same
The present invention is a stable, nanometer scale micro-tubular aggregated material of an asymmetric double-headed lipid represented by the general formula
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6897196 |
pH sensitive lipids based on ortho ester linkers, composition and method
The invention comprises lipid derivatives that rapidly degrade in the pH range from 4.0 to 7.0 and lipidic delivery systems that contain them. These lipid derivatives can be used to modify the...
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6890557 |
Emulsion formulations for hydrophilic active agents
This invention discloses emulsion formulations comprising an aqueous carrier and the following components: triglyceride, cholesterol, phospholipid, at least one charged lipid, at least one...
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6890548 |
Rumen bypass supplement
A rumen bypass fat supplement for ruminant animals such as cattle is produced by: (a) blending about 40 to 90 parts by weight fat and about 1 to 10 parts by weight of an emulsifier; (b) adding...
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6890555 |
Liposome compositions of porphyrin photosensitizers
Liposomal pharmaceutical formulations incorporating porphyrin photosensitizers useful for photodynamic therapy or diagnosis of malignant cells. The liposomal formulations comprise a porphyrin...
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6890909 |
Brain-protective agent
A brain-protective agent containing an NF-κB decoy. In brain diseases, the brain can be particularly effectively protected against brain disorders (for example, cerebral vasospasm following a...
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6890901 |
Hyaluronic drug delivery system
Pharmaceutical compositions comprising a mixture of hyaluronic acid and liposomes. Preferably, the pharmaceutical compositions further include a pharmaceutically active substance such as...
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6887493 |
Multi component controlled release system for oral care, food products, nutraceutical, and beverages
The present invention relates to an improved controlled release system that can encapsulate different flavors, sensory markers, and active ingredients, or combinations of flavors, sensory markers...
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6884431 |
Method for treating proliferative diseases with p27 and fusions thereof
The present invention is directed to a method of vascular proliferative disease by administering in vivo a gene encoding p27.
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6884436 |
Method for preparing submicron particle suspensions
The present invention provides a method for preparing a suspension of a pharmaceutically-active compound, the solubility of which is greater in a water-miscible first organic solvent than in a...
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6884842 |
Molecular compounds having complementary surfaces to targets
Synthetic polymer complements (SPCs) are provided, as well as methods for their synthesis and use. The SPCs may have surfaces that include functional groups that are complementary to surface sites...
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6881576 |
Formation of polyampholytes in the presence of a polyion
A polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative...
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6875448 |
Method of intracellular sustained-release of drug and preparations
A substance of interest is contained in nanospheres which are then encapsulated in fusogenic liposomes to prepare transport carriers that allow physiologically active substances, especially those...
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6872406 |
Fusogenic properties of saposin C and related proteins and polypeptides for application to transmembrane drug delivery systems
The present invention comprises a method for delivering pharmaceutical agents within and/or through the dermal and mucosal membranes, utilizing a fusogenic protein. The fusogenic protein is...
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6858227 |
Vitamin E conjugates
Vitamin E conjugates, methods for their preparation, and compositions that include the conjugates. The vitamin E conjugates include a tocopherol moiety covalently coupled through a linker moiety to...
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6858582 |
Composition containing porous microparticle impregnated with biologically-active compound for treatment of infection
Methods and reagents are provided for specifically targeting biologically active compounds such as antiviral and antimicrobial drugs, or prodrugs containing the biologically active compound to...
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6858230 |
Process for producing medicinal composition of basic hydrophobic medicinal compound
The present invention provides a method for preparation of a pharmaceutical composition which comprises suspending a hydrophobic medical compound without generating foams. The present inventors...
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6858226 |
Fusogenic lipids and vesicles
Novel lipid compounds are provided that may be termed “pro-cationic” in that they are neutral or negatively charged until they are either brought into contact with cellular membranes or are...
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6858224 |
Method of preventing aggregation of a lipid:nucleic acid complex
Particle aggregation of lipid:nucleic acid complex particles is prevented by incorporating a non-cationic lipid into lipid:nucleic acid complex particles containing a cationic lipid and a nucleic...
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6855332 |
Absorption promoting agent
The present invention relates to pharmaceutical compositions comprising polyoxyethylene glycol, fatty acid mono- and diglyceride ester as an absorption promoting agent and an absorption controlling...
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6855296 |
Method and apparatus for liposome production
A new method of producing liposomes is described using an in-line mixing system. The liposomes produced by this method find utility in numerous therapeutic applications.
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6852334 |
Cationic peg-lipids and methods of use
The present invention provides cationic-polymer-lipid conjugates (CPLs) such as distal cationic-poly(ethylene glycol)-lipid conjugates which can be incorporated into conventional and stealth...
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6852686 |
Methods for ameliorating icthyosiform skin diseases
The present invention relates to the discovery of a method to provide stabilized transglutaminase 1 enzyme, involucrin, and other molecules necessary for the assembly of the cell envelope to skin...
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6849269 |
Proliposomal drug delivery system
This invention relates to proliposomal drug-delivery systems for medicaments. In particular, it relates to enteric-coated proliposomal formulations for poorly water soluble drugs and methods for...
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6849272 |
Endosomolytic agents and cell delivery systems
The present invention provides improved cell delivery compositions. In particular, the invention provides biocompatible endosomolytic agents. In a preferred embodiment, the endosomolytic agents are...
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6849263 |
Pharmaceutical compositions for buccal delivery of pain relief medications
Pharmaceutical compositions comprising a narcotic analgesic in mixed micellar form are disclosed. The mixed micelles are formed from an alkali metal alkyl sulfate, and other micelle-forming...
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6844009 |
Media in the form of complex dispersions, method for preparing same and uses
The invention concerns novel media in the form of complex dispersions, method for preparing same and their uses. Said media consist of a first medium in the form of droplets wherein is dispersed a...
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6844326 |
Treatment of alopecia
A composition and method for treating and monitoring alopecia by altering hair follicle cells to produce a cell cycle inhibitor is disclosed.
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6838089 |
Antigen delivery system and method of production
The present invention concerns polymer particle vaccine delivery systems in which a water insoluble protein antigen, e.g. a lipidated HpaA protein, is incorporated with particles comprising a...
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