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7250403 |
Biodegradable immunomodulatory formulations and methods for use thereof
The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC)...
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7244448 |
Liposomal antineoplastic drugs and uses thereof
This invention relates to liposomal antineoplastic agents (e.g., camptothecin) compositions and methods of using such compositions for treating neoplasia and for inhibiting angiogenesis. The...
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7244450 |
Compositions and methods for treating lymphoma
This invention provides methods for treating neoplasias in a mammal. In particular, the invention provides methods for treating various types of lymphomas, including relapsed forms of non-Hodgkin's...
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7244714 |
Methods of delivering aerosolized polynucleotides to the respiratory tract
Methods and devices for delivering aerosolized formulations containing polynucleotides to specified regions within a subject's respiratory tract are disclosed. The methods find use in the delivery...
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7238369 |
Cationic liposome delivery of taxanes to angiogenic blood vessels
Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth....
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7238367 |
Liposome loading with metal ions
This invention relates to encapsulation of drugs and other agents into liposomes.
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7238361 |
Smart drug delivery system
The present invention provides prodrug and multi-prodrug complexes comprising drugs specifically bound to synthetic receptors in such a manner that active drug becomes available only in the...
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7238366 |
Submicron liposome suspensions obtained from preliposome lyophilizates
This invention provides an aqueous/t-butanol solvent-system, facile reconstitute, submicron-reconsitiute preliposome-lyophilaye and method of its preparation and use. In one embodiment this...
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7235248 |
Pharmaceutical compositions comprising cyclosporins
Pharmaceutical compositions comprising a cyclosporin, e.g. Ciclosporin or [Nva] 2 -Ciclosporin, in “microemulsion pre-concentrate” and microemulsion form. The compositions typically comprise...
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7229973 |
pH-sensitive polymeric micelles for drug delivery
Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug...
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7229611 |
Clear personal care compositions containing visible capsules
Disclosed are clear antiperspirant or deodorant compositions that include visible capsules.
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7226582 |
Sunscreen compositions and methods of use
The invention encompasses additives for addition to a bodywash, where the additives contain one or more sunscreens, and where a bodywash which contains the additive imparts to the skin an SPF of at...
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7226581 |
Bodywashes containing additives
The invention encompasses bodywashes containing an additive. The additive may contain a sunscreen. The additive may contain 2, 3, or more than three sunscreens. Optionally, one or more of the...
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7226932 |
Self-emulsifying drug delivery system
Oral pharmaceutical formulation which improves the bioavailability of pharmaceuticals which are substantially water and oil insoluble is disclosed. In addition to the pharmaceutical, the...
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7223887 |
Multivalent cationic lipids and methods of using same in the production of lipid particles
A multivalent cationic lipid having a positively-charged head group including two quaternary amine groups and a hydrophobic portion including four hydrocarbon chains, which may be the same or...
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7220726 |
Antifungal pimaricin compositions and therapeutic methods employing same
An antifungal composition suitable for parenteral administration to a mammal includes an amount of pimaricin or an antifungal derivative thereof that is effective to inhibit the growth of a fungal...
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7220778 |
Methods and devices for epithelial protection during photodynamic therapy
Methods for preventing damage to epithelial tissue during PDT induced using a photosensitizing agent or pre-photosensitizing agent are provided. The methods of the present invention utilize spatial...
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7217427 |
Polymersomes and related encapsulating membranes
The present invention provides biocompatible vesicles comprising semi-permeable, thin-walled encapsulating membranes which are formed in an aqueous solution, and which comprise one or more...
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7217423 |
Revitalising active complex for the skin
The invention relates to a revitalizing active complex for the skin and cosmetic products produced thereby. Said active complex for the skin consists of between 0.5 and 9 wt. % of creatine or a...
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7214384 |
Lipid-conjugated polyamide compounds
In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present...
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7208173 |
Mixed structures resulting from the incorporation of a biological macromolecule, especially of DNA, in a liquid crystal phase of amphiphiles, and vesicles obtained using these structures
The invention relates to a structured mixed phase formed by the incorporation of a biological macromolecule into a liquid-crystal phase of amphiphiles, preferably a lamellar phase, wherein said...
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7208174 |
Liposome compositions
The present invention provides a non-covalent coupling method for the preparation of sterically stabilized lipsomes which may be used for targeted drug delivery, e.g., pegylated liposomes. The...
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7204996 |
Method of cancer treatment
This invention comprises a method of treating a subject having relapsed or refractory cancer such as leukemia with liposomal annamycin including the steps of
(a) evaluating the subject to...
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7202227 |
Multifunctional molecular complexes for gene transfer to cells
A multifunctional molecular complex for the transfer of a nucleic acid composition to a target cell is provided The complex is comprised of A) said nucleic acid composition and B) a transfer moiety...
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7192597 |
Composition for treatment of skin, hair and nails
A composition, especially for treatment of aged and/or stressed skin, the composition containing, in addition to water, at least one substance that forms lamellar structures with water. The...
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7192605 |
Nucleic acid transfer complexes
The present invention relates to compositions and methods for transferring nucleic acids into cells in vitro and in vivo. The compositions comprise a transfection reagent and one or more...
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7192606 |
Drugs for treating viral infections
A series of imidodisulfamide derivatives encapsulated in liposomes have been prepared and are useful to treat antiviral infections, especially infections caused by orthopox viruses.
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7189705 |
Methods of enhancing SPLP-mediated transfection using endosomal membrane destabilizers
The present invention provides novel and surprisingly effective methods for delivering nucleic acids to cells. These methods are based upon the discovery that the presence of endosomal membrane...
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7189411 |
Peptide/lipid complex formation by co-lyophilization
The invention relates to the formation of peptide/lipid vesicles and complexes through the co-lyophilization of peptides, preferably that are able to adopt an amphipathic alphahelical conformation,...
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7186800 |
Tumor necrosis factor 6α and 6β
The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α & -6β proteins. TNFR-6α &...
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7186796 |
Method for drying water-borne materials
Provided is a method of isolating a bio-molecule from a water-borne mixture, the method comprising: contacting the water-borne mixture with dimethyl ether to form solid particles of the bio-molecule.
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7186418 |
Composition and use of RAR antagonists for promoting chondrogenesis
The invention provides compositions comprising an RAR antagonist for promoting chondrogenesis and methods employing such compositions for treating cartilage and associated bone abnormalities...
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7182933 |
Targeting drug/gene carriers to irradiated tissue
The present invention provides a biomolecular carrier of pharmaceuticals, comprising: a biomolecule carrier bearing molecules that bind to a cellular adhesion molecule expressed on endothelial...
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7182956 |
Stable topical drug delivery compositions
A stable composition of a drug comprising a carrier having a phosphatidylcholine component which entraps the drug is applied to the skin for transdermal delivery of the drug.
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7179449 |
Enhanced ultrasound detection with temperature-dependent contrast agents
Methods and devices for enhanced ultrasound detection based upon changing temperature and ultrasound reflectivity of a temperature-dependent contrast agent bound to an ultrasound target are...
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7179484 |
Protein-stabilized liposomal formulations of pharmaceutical agents
The present invention relates to protein stabilized liposomes. Specifically, the present invention discloses compositions and methods for protein stabilized liposomes, the creation of protein...
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7176191 |
Antimicrobial compounds and methods for their use
The present invention provides protonated compounds having antimicrobial activity. The invention also provides antimicrobial compositions comprising protonated compounds of the invention. The...
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7175850 |
Formulation for topical non-invasive application in vivo
A formulation comprising molecular arrangements capable of penetrating pores in a barrier, owing to penetrant adaptability, despite the fact that the average diameter of said pores is smaller than...
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7169410 |
Targeted liposomal drug delivery system
A metal targeting complex which associates with a charged liposomal structure is provided. The metal targeting complex provides the targetability of the liposomal construct to the desired receptor...
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7169382 |
Reconstructed epidermis/skin equivalent comprising a ceramide 7 and /or 5.5 and lipid lamellar vesicular compositions comprising ceramide 7 and/or 5.5 compounds
A reconstructed epidermis/skin equivalent supplemented with at least one ceramide 7 and/or 5.5 compound, suited for reinforcing the barrier function of normal human epidermis and for improving the...
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7166296 |
Pharmaceutical formulations and ligands for use therein; mimetics for UEA-1
UEA-1 Mimetics, pharmaceutical formulations comprising them, and their uses as targeting agents for therapeutic and diagnostic purposes.
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7166298 |
Genetic immunization with cationic lipids
A method for immunization using genetic material is disclosed. Compositions for genetic immunization comprising cationic lipids and polynucleotides are also disclosed. Methods for using genetic...
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7166295 |
Methods of treatment and diagnostic visualization, particularly in cancer
Methods and reagents for improved treatment and diagnostic imaging, particularly of cancer. The methods and reagents utilize specific targeting of treatment and imaging ligands to the targeted...
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7166605 |
Probucol nitro-derivatives
Probucol derivatives and pharmaceutical compositions containing the same to be employed in treatment or prophylaxis of diseases.
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7166297 |
Lipid-based drug delivery systems against parasitic infections
The present invention is directed to a lipid-based delivery system for administration of an active drug substance selected from lysolipid derivatives which are particularly useful in the treatment...
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7163673 |
Sunscreen reagents from hydroxy-substituted acylglycerides
A class of UVA- and UVB-absorbing esters has been derived by modifying hydroxy triglycerides and other acyltriglycerides with any of a variety of cinnamic acids. The esterification reactions are...
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7163926 |
Adjuvant-containing vaccines
This invention provides a DNA vaccine which comprises a naked DNA incorporating and expressing in vivo a nucleotide sequence encoding an antigenic polypeptide, preferably a gene of a pathogenic...
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7160554 |
Enhanced circulation effector composition and method
A liposome composition comprising small, surface-bound effector molecules is disclosed. The liposomes have a surface layer of hydrophilic polymer chains, for enhanced circulation time in the...
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7157099 |
Sustained release pharmaceutical compositions for the parenteral administration of hydrophilic compounds
Stable, biologically compatible pharmaceutical compositions in the form of water-in-oil microemulsions (w/o), for the sustained release by parenteral administration of active ingredients which are...
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7157098 |
Gene therapy of tumors using non-viral delivery system
The present invention provides a pharmaceutical composition, comprising: (a) cationic lipids, wherein said lipids are a liposomal mixture of a diacyl-ethyl-phosphocholine and...
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