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6656499 |
Composition for transdermal and dermal administration of interferon-α
A composition for transdermal and dermal administration of interferon-α is described. The composition is comprised of lipid vesicles including a fatty acylated amino acid and an oil-in-water ...
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6656497 |
Liposomal vector for active-principle
The invention concerns liposome vectors, in powder form, of active principles, and more particularly active principles sensitive to digestive and/or plasmatic degradation, such as proteins, and...
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6653317 |
Pyrimidine 3-oxide compounds for inducing/stimulating hair growth and/or retarding hair loss
Hair growth-/hair loss-affecting cosmetic/therapeutic compositions contain an effective amount of at least one 2-amino-4-alkylaminopyrimidine 3-oxide having the structural formula (I): in which R1...
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6652865 |
Method and formulation for decreasing statin metabolism
A pharmaceutical composition for oral use is disclosed. It includes, as active principle, a drug liable to undergo a strong first intestinal passage effect and a carrier which is...
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6652866 |
Method for treating diseases of fungal, yeast, and prion protein etiology
A method for treating neurological diseases in mammals comprising the step of administering a mixture comprising selected carboxylic acids in an effective amount for treating the neurological...
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6649193 |
Prophylactic therapeutic and industrial antioxidant compositions enhanced with stabilized atomic hydrogen/free electrons and methods to prepare and use such compositions
The invention is directed to therapeutic antioxidant compositions which are enhanced by the stabilized atomic hydrogen; one of the most potent antioxidants. Such products can be used for...
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6646011 |
Insect repellant compositions
The present invention relates to insect repellant compositions containing, based upon the total weight of the composition, from about 6 to about 30 percent by weight of insect repellant active...
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6645522 |
Erythropoietin liposomal dispersion
The present invention relates to a liposome based formulation of erythropoietin comprising: (a) an effective amount of an erythropoietin;(b) a lipidic phase comprising:(i) lecithin or hydrogenated...
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6638529 |
Amide-based cationic lipids
The present invention provides novel amide-based cationic lipids of the general structure: or a salt, or solvate, or enantiomers thereof wherein; (a) Y is a direct link or an alkylene of 1 to about...
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6632671 |
Nanoparticle encapsulation system and method
The present invention generally relates to nanocapsules and methods of preparing these nanocapsules. The present invention includes a method of forming a surfactant micelle and dispersing the...
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6630161 |
Adjuvant composition and methods for its use
An adjuvant composition which is a stable oil-in-water emulsion comprising a metabolizable oil, one or more surfactants, an antioxidant and a compound to make the emulsion isotonic is described and...
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6630169 |
Particulate delivery systems and methods of use
Compositions and methods are provided for the administration of particulates comprising at least one bioactive agent which, in selected embodiments, may comprise and immunoactive agent. In this...
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6627618 |
Materials and methods for intracellular delivery of biologically active molecules
The subject invention finds utility in the area of gene therapy of diseases. More specifically, the invention concerns the making of a novel non-viral vector which can bind to desired DNA to form a...
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6627218 |
Cationic amphiphiles of cholesterol
A stable aqueous dispersion which comprises a cationic lipid which is a molecule which comprises a cholesterol-derived lipophilic group, a linker bond which is hydrolyzable by cellular enzymes and...
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6627615 |
Methods and compositions for in vivo gene therapy
Novel methods and compositions are provided for introducing a gene capable of modulating the genotype and phenotype into two or more tissues following systemic administration. The gene can be...
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6623753 |
Allylamine-containing liposomes
The invention concerns liposomal preparations comprising as the active agent a compound of formula I in free base form or in acid addition salt form. It also concerns a method of preparation of...
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6624149 |
Method for nucleic acid transfection of cells
The present invention describes methods for introducing nucleic acids into a target cell using a transition metal enhancer. A mixture containing nucleic acid and a transition metal enhancer is...
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6623671 |
Liposome extrusion process
A method of sizing liposomes by passing a suspension of liposomes through an aluminum oxide porous film by entering the film via the smaller pores and extruded via the larger pores, under pressure,...
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6620795 |
Mammalian transformation complex comprising a lipid carrier and DNA encoding CFTR
Methods and compositions for producing a mammal capable of expressing an exogenously supplied gene in cells of the airway are disclosed. Lipid carrier-nucleic acid complexes or nucleic acid abre...
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6616941 |
Polymeric composition for solubilizing poorly water soluble drugs and process for the preparation thereof
A composition capable of forming a micelle in body fluids or in an aqueous medium and that can be injected into the body undiluted or as a diluted solution in an aqueous medium and method of...
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6613799 |
Liposoluble platinum (II) complex and preparation thereof
New derivatives of platinum (II) complex are herein provided, which are liposoluble and applicable as antimicrobial agents and anticancer agents specific to the affected parts of patients and...
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6613352 |
Low-rigidity liposomal formulation
The invention relates to a liposomal formulation that is capable of fusing with cells. The liposomal formulation may contain an agent for delivery to cells. The invention also provides compositions...
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6613735 |
Composition for polypeptide transfer to cells
The present invention is directed to a composition for gene transfer which composition contains a quaternary ammonium salt represented by formula (1): (wherein each of R1, R2, R3, R4, and R5, which...
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6613351 |
Compound capable of introducing at least one molecule into a cell
The invention includes a vector including a complex between at least one compound having an amidine polar head of formula where m is 14 and at least one of nucleic acids molecules, polypeptides,...
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6613353 |
Pharmaceutical formulations
Capsule formulations are provided containing at least two different fill compositions which are prevented from mixing either by providing both of the fill compositions as solids or by providing a...
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6613734 |
Peptides-containing liposomal surfactants
The present invention discloses useful surfactant molecules including polypeptides, proteins, and a variety of other organic molecules, as well as methods of making and using same. Surfactant...
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6610659 |
Use of heat shock protein 70 preparations in vaccination against cancer and infectious disease
The use of cognate heat shock protein 70-peptide complex to elicit an immune response against cancer and viral, bacterial and other infectious agents.
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6610532 |
Intracellular inhibitors of Gq protein signaling
The present invention relates, in general, to myocardial hypertrophy and, in particular, to agents that inhibit cardiac Gq-coupled receptor signaling and to methods of inhibiting myocardial...
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6605298 |
Pharmaceutical compositions and their use
The invention provides a composition for delivering at least one biologically active compound to a living organism, said composition comprising at least one micelle-forming membrane lipid
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6602511 |
Microemulsions for use as vehicles for administration of active compounds
A non-toxic oil-in-water or bicontinous microemulsion used as a pharmaceutically acceptable vehicle for administration of one or more active compounds having a low solubility in water as well as a...
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6602510 |
HLA class I A2 tumor associated antigen peptides and vaccine compositions
A composition or vaccine composition comprising eight isolated epitopes consisting of YLSGANLNV (SEQ. ID. NO: 1), IMIGVLVGV (SEQ. ID. NO: 2), KLBPVQLWV (SEQ. ID. NO: 3), SMPPPGTRV (SEQ. ID. NO: 4),...
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6599533 |
Homogenous water-free formulations containing glycerophospholipids and polar or lipophilic substances, method for the production thereof
This invention relates to homogeneous, anhydrous formulations which contain glycerophospholipids and polar or lipophilic substances (eg, physiologically active ingredients) in a molar ratio of...
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6599517 |
Bone tissue restoring composition
A composition suitable for restoring bone tissue in a human or animal body, which comprises a solid, preferably particulate, calcium phosphate as a biocompatible bone tissue substitute material...
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6599513 |
Products for topical applications comprising oil bodies
The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for...
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6596306 |
Drug delivery system:formulation for fat-soluble drugs
This invention relates to a novel formulation for fat-soluble drugs which self-emulsify in the presence of an aqueous medium with little agitation. More specifically, the invention is concerned...
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6596305 |
Method of controlling the size of liposomes
A process for producing liposomes having a desired mean particle size wherein the desired mean particle size is obtained by varying the initial organic solvent concentration.
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6596543 |
Use of liposomes of defined composition and size for the preparation of prothrombin time reagents
The present invention relates generally to the field of prothrombin time reagents for determining dysfunction in the coagulation system and more specifically to reagents made from native...
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6592894 |
Hydrogel-isolated cochleate formulations, process of preparation and their use for the delivery of biologically relevant molecules
A process for producing a small-sized, lipid-based cochleate. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential...
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6592843 |
Radioactive therapeutic liposomes
The present invention relates to a conjugator system comprising liposomes with ionophores, and with chelator solution and alpha-particle emitting radionuclide(s) located inside of the liposome....
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6586001 |
Neutral lipopolymer and liposomal compositions containing same
Liposomes containing PEG-substituted neutral lipopolymers provide similar circulation times to liposomes incorporating conventional, negatively charged PEG-substituted phospholipids. Use of the...
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6586559 |
Polyamide oligomers
The present invention relates to new polyamide oligomers. These oligomers can be conjugated to lipids, nucleic acids, peptides, proteins, etc. The oligomer-lipid conjugates can be used to form...
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6586003 |
Emulsion and micellar formulations for the delivery of biologically active substances to cells
New emulsion and micelle formulations are described as are complexes of these formulations with biologically active substances. The novel formulations are different from cationic lipid vectors such...
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6582725 |
Human PEA3 is a tumor suppressor for cancer cells
The present invention relates generally to the fields of cancer therapy and gene therapy. More particularly, it demonstrates that PEA3, as exemplified by mPEA3 and hPEA3, is a tumor suppressor and...
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6576679 |
Hydrogel
A hydrogel formed by adding an anion having a molecular weight of 90 or more to an aqueous dispersion of a cationic amphiphile comprising a linear or branched alkyl group having 10 or less carbon...
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6576254 |
Polyamino acid vesicles
There is provided polymeric vesicles formed from polyamino acid derivatives for use in the delivery of therapeutic agents. The polyamino acid is modified so as to bear at least one hydrophilic...
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6576257 |
Targeted drug activation
A method of providing a drug to a specific region of a patient's body is provided. The method includes the steps of: (a) administering to the patient a prodrug being convertible to the drug upon...
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6576611 |
Methods of reducing atrophy or dysfunction of gut-associated lymphoid tissue
The present invention describes methods for reducing the impairment respiratory tract mucosal immunity associated with a lack of enteral feeding or a lack of immunological stimulation of the...
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6576618 |
Methods to enhance wound healing and enhanced wound coverage material
The present invention describes the incorporation of liposomal gene constructs directly into a wound to further improve wound repair, or into wound coverage and/or closure materials to enhance the...
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6573249 |
Topical wound therapeutic compositions
There is provided a composition for healing burns and wounds in mammals, which contains a cromolyn compound or the combination of a cromolyn compound and hyaluronic acid a corticosteroid....
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6572881 |
Lipid-conjugated polyamide compounds and related compositions and methods thereof
In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present...
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