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6521211 |
Methods of imaging and treatment with targeted compositions
Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination...
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6518413 |
Utrophin gene expression
Nucleic acid from which a polypeptide with utrophin function can be expressed, especially mini-genes and chimaeric constructs. Expression significantly decreases the severity of the dystrophic...
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6517860 |
Methods and compositions for improved bioavailability of bioactive agents for mucosal delivery
The invention encompasses compositions for increased bioavailability through mucosal delivery comprising, preferably in powder form, an intimate mixture of an effective amount of a bioactive agent...
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6517808 |
Methods for boron delivery to mammalian tissue
Boron neutron capture therapy can be used to destroy tumors. This treatment modality is enhanced by delivering compounds to the tumor site where the compounds have high concentrations of boron, the...
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6514524 |
Orally administerable immediate-release and prolonged-release galenic form comprising an absorption-promoting agent and use of this absorption-promoting agent
The present invention relates to an orally administrable galenic formulation allowing improved absorption by the transmembrane or paracellular route in the gastrointestinal tract of active...
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6515107 |
Human metabotropic glutamate receptor 7 subtypes
The present invention relates to human metabotropic glutamate receptor (hmGluR) proteins, isolated nucleic acids coding therefor, host cells producing the proteins of the invention, methods for the...
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6514523 |
Carrier particles for drug delivery and process for preparation
This invention relates to a carrier particle having a diameter of from 5 to 20 nm which contains an HDL apolipoprotein, an amphipathic lipid such as a phospholipid, and a drug which is either a...
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6511677 |
Polymerizable fatty acids, phospholipids and polymerized liposomes therefrom
The invention relates to an oral drug delivery system which delivers biologically active substances to the mucosal tissue of the intestine utilizing novel polymerized liposomes. Novel polymerizable...
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6511477 |
Method of drug delivery to interstitial regions of the myocardium
A method of treating the heart and other body tissues by injecting a compound comprised of microsphere encapsulated macromolecule therapeutic agents into the myocardium, such that the microsphere...
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6509032 |
Cationic amphiphiles
A cationic lipid useful in transfection of cells with DNA is disclosed.
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6509319 |
EDTA and other chelators with or without antifungal antimicrobial agents for the prevention and treatment of fungal infections
A pharmaceutical composition comprising at least one antifungal agent and at least one chelator, and a method for administering the pharmaceutical composition to a patient having a fungal...
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6509027 |
Injectable pharmaceutical composition comprising coated particles of camptothecin
A pharmaceutical composition is provided which comprises an aqueous suspension of solid particles, the solid particles comprising a camptothecin, the solid particles having mean diameters between...
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6506262 |
Cleanser
The present invention may include a cleanser having a liposome and greater than about 40 weight percent of a solvent. The liposome may be loaded with the solvent more than about 7 days after the...
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6506405 |
Methods and formulations of cremophor-free taxanes
In accordance with the present invention, there are provided composition and methods useful for the in vivo delivery of a pharmaceutically active agent, wherein the agent is associated with a...
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6503533 |
Antisense ogligonucleotides against Hepatitis B viral replication
Antisense oligonucleotides that hybridize to segments of the pres1, S, C, and ε regions of the hepatitis B virus (HBV) RNA pregenome inhibit replication of the virus. Pharmaceutical compositions...
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6500857 |
Subcutaneous muscle treatment using electronic stimulation and topical compositions
Aging and sagging subcutaneous muscles are treated by first applying a composition containing at least one acetylcholine precursor and/or at least one compound exhibiting catecholamine activity to...
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6500646 |
Cell membrane-directed drugs
Drugs in which peptides having affinity specific for phospholipids, preferably those which are contained in the constituents of lipid bilayers forming the surface layers of cells and of which the...
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6500446 |
Compositions which contain at least one cationic polymer and at least one active molecule contained in at least one micro or nonopartculate vector, and their use for treating living or inert surfaces
The present invention relates to compositions which contain at least one cationic polymer and at least one active molecule contained in at least one micro or nanoparticulate vector, and their use...
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RE37947 |
Aromatic polyenic compounds and pharmaceutical/cosmetic compositions comprised thereof
Novel pharmaceutically/cosmetically-active aromatic polyenic compounds have the structural formula (I): and are useful for the treatment of a wide variety of disease states, whether human or...
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6497895 |
Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules
Polymeric micelles for encapsulation of hydrophobic molecules are provided. Methods and formulations for delivering hydrophobic molecules to a host via these micelles are also provided. Methods of...
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6497898 |
Surfactant, and an emulsion-type cosmetic composition and a lipsome containing said surfactant
The invention provides a surfactant comprising at least one trehalose-6-fatty acid ester selected from those represented by the following formula: wherein R represents a saturated or unsaturated...
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6495161 |
Cytoprotective biocompatible containment systems for biologically active materials and methods of making same
In accordance with the invention, there are provided methods, capsules, and delivery systems useful in preparing biological containment systems with properties (e.g., mechanical strength, capsule...
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6495160 |
Biphasic multicomponent pharmaceutical dosage forms containing substances able to modify the partitioning of drugs
The invention provides a biphasic multicomponent pharmaceutical composition consisting of an oil phase and a water phase, comprising one or more lipophilic or oil carrier, one or more hydrophilic...
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6491951 |
Soluble compositions of toremifene
Aqueous compositions of toremifene or a pharmaceutically acceptable salt thereof, comprising lactic acid, acetic acid, formic acid, methanesulfonic acid or the corresponding anion (lactate,...
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6488965 |
Synergistic antimicrobial preparations containing chlorite and hydrogen peroxide
Antimicrobial/pharmaceutical preparations (e.g., solutions, gels, ointments, creams, sustained release preparations, etc.) which comprise chlorite (e.g., a metal salt of a chlorite) in combination...
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6489311 |
Method for the prevention of apoptosis
Heparin reduces ischemia-reperfusion injury to myocardium. This effect has been attributed complement inhibition, but heparin also has other activities that might diminish ischemia-reperfusion. To...
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6479034 |
Method of preparing gas and gaseous precursor-filled microspheres
Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful,...
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6479033 |
Antitumor cystostatic and contrast agent
The invention concerns a composition for the treatment of tumors, of (i) at least one cytostatic drug component which is unencapsulated or is encapsulated in a PEG-, immuno-, or immuno/PEG...
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6475517 |
Method for preparing closed vesicles
A method for preparing a closed vesicle by a rehydration of a closed vesicle using a rehydration solution, wherein the closed vesicle comprises a dehydrated micelle particle or dehydrated...
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6475516 |
Drug delivery via therapeutic hydrogels
The present invention is directed to a vehicle for effecting drug delivery from a solid substrate. Hydrogels loaded with liposomal therapeutic agents such as antibiotics are covalently bonded to...
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6475515 |
Process for increasing the stability of liposome suspensions that contain hydrophilic active ingredients
A process for increasing the stability of liposome suspensions that contain hydrophilic active ingredients is described, which is characterized in that the active ingredient that is to be...
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6476214 |
Inhibition of cytokine production
The invention provides a ds-DNA oligomer which has from 25 to 150 base pairs, preferably 25 to 50 base pairs, and comprises the palindrome-containing sequence (one strand only shown) of formula...
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6471990 |
Gene-containing compositions
The present invention provides a gene-containing composition including a gene and a transporter, the transporter being capable of transporting the gene from a pregnant body to fetal cells. When...
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6468551 |
Cosmetic or dermatological preparations based on emulsifiers which are free from ethylene oxide and propylene oxide, for the preparation of microemulsion gels
Microemulsion gels a) based on oil in water type, comprising an oil phase, substantially consisting of not easily volatile constituents, and an aqueous phase containing one or more O/W emulsifiers...
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6468506 |
Process for producing polymeric microparticles, microparticles produced by said process and the use of such particles in medical diagnostics
The invention relates to a process for the production of gaseous microparticles for ultrasonic diagnosis, whose wall material is built up from polyesters of α-, β- or γ- hydroxycarboxylic acids,...
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6468505 |
Technique to monitor drug delivery noninvasively in vivo
The present invention relates to the field of diagnostic imaging and more specifically to the field of monitoring drug delivery using non-invasive imaging techniques. The present invention provides...
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6468798 |
Expression of cloned genes in the lung by aerosol and liposome-based delivery
Methods and compositions for producing a mammal capable of expressing an exogenously supplied gene in cells of the airway are disclosed. Liposome-nucleic acid complexes are prepared then delivered...
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6468558 |
Liposome-encapsulated poly ICLC
Although poly ICLC possess a broad spectrum of antimicrobial and anticancer activities, it therapeutic potential has yet to be fulfilled due to its toxic side effect. This problem can be overcome...
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6469084 |
Process for preparing an aqueous composition in gel form and compositions obtainable from this process, especially a composition containing vesicles, in particular liposomes
The present invention concerns a process for preparing an aqueous composition in the form of a gel at a given temperature. The process is characterized in that an associative water-soluble polymer...
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6468557 |
Method for treating infectious viral diseases
The present invention provides for the treatment of an individual suffering from infections from herpes virus or human papilloma virus by utilizing a cromolyn compound. The treatment includes the...
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6465007 |
Transgene expression in polarized cells
The well-differentiated airway epithelium is the principal target tissue for gene therapy for the treatment of CF. However, recent studies have shown that gene delivery vehicles, such as cationic...
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6465011 |
Formulations comprising lipid-regulating agents
The present invention is directed to a solid formulation comprising the lipid-regulating agent dispersed in a hydrophilic, amorphous polymer in which said lipid-regulating agent is present as a...
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6465439 |
Pharmaceutical compositions
A pharmaceutical composition is disclosed comprising (A) and oligonucleotide having 5 to 50 nucleotide units, which is specifically hybridizable with DNA or RNA derived from a protein kinase C...
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6464990 |
Nanoemulsion based on ethylene oxide and propylene oxide block copolymers and its uses in the cosmetics, dermatological and/or ophthalmological fields
A nanoemulsion comprising an oily phase dispersed in an aqueous phase and having oil globules with a number-average size of less than 100 mm, which dispersion is facilitated by a surfactant...
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6461625 |
Nanoemulsion based on alkoxylated alkenyl succinates or alkoxylated alkenyl succinates of glucose and its uses in the cosmetics, dermatological, opthalmological and/or pharmaceutical fields
A nanoemulsion, the oil globules of which have an average size of less than 100 nm, comprising a surfactant chosen from the alkoxylated alkenyl succinates, the alkoxylated alkenyl succinates of...
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6462179 |
Phenyldiboronic acid reagents and complexes
Reagents suitable for the modification of a bioactive species for the purpose of incorporating one or more phenyldiboronic acid (PDBA) moieties for subsequent conjugation to a different (or the...
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6458383 |
Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin
A delayed release pharmaceutical dosage form for oral administration of a hydrophilic drug, e.g., a polysaccharide drug such as low molecular weight heparin, are provided. The dosage form comprises...
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6458026 |
Integrin-targeting vectors having transfection activity
A complex that comprises (i) a nucleic acid, (ii) an integrin-binding component, for example, an integrin-binding peptide, (iii) a polycationic nucleic acid-binding component, for example,...
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6458841 |
Topical and oral delivery of arginine to cause beneficial effects
The use of orally administered L-arginine in conjunction with a topical preparation for producing enhanced blood flow in tissue thus causing beneficial effects such as warming cold tissue of the...
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6458381 |
Lipids and their use, for example, in liposomes
The invention concerns novel lipid compounds suitable for the transport of biologically active substances or molecules in cells. A preferred compound according to the invention is...
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