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5962013 |
Monolithic matrix transdermal delivery system for administering molsidomine
This invention provides monolithic matrix formulations for transdermal administration of molsidomine. The device includes a copolymer of 2-ethylhexyl acrylate, 2-hydroxyethylmethacrylate, and...
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5952000 |
Fatty acid esters of lactic acid salts as permeation enhancers
A transdermal drug delivery system which enhances the delivery of the drug comprises a composition containing, as an enhancer, one or more C 6 to C 22 fatty acid esters of a lactic acid salt....
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5948433 |
Transdermal patch
Transdermal patches are disclosed, including a backing layer, a liner layer, and a monolithic adhesive and drug-containing layer between the backing layer and the liner layer. The drug-containing...
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5945119 |
Therapeutic preparations containing caesium ions
Various preparations for treating or relieving pain in a patient are disclosed wherein preparations containing caesium ions, preferably in the form of caesium chloride, and preferably also...
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5942233 |
Herbal composition for stimulating blood circulation
This invention relates to an herb composition which comprises an amount of 30 to 45% by weight of one or more herbs for invigorating of blood circulation, an amount of 55 to 70% by weight of one or...
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5939094 |
Transdermal administration of apomorphine
Dosage forms for the transdermal administration of apomorphine are described. The dosage forms are water-soluble gel compositions that contain apomorphine, optionally together with a permeation...
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5939095 |
Transdermal therapeutic system and a process for the combined transdermal application of physostigmine and scopolamine for the prophylaxis and pretreatment of a poisoning caused by highly toxic organophosphorus neurotoxins in particular soman
A transdermal therapeutic system for the prophylaxis and pretreatment of a poisoning caused by highly toxic organophosphorus neurotoxins is characterized in that it has a pharmaceutical formulation...
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5935597 |
Drug delivery devices and methods for treatment of viral and microbial infections and wasting syndromes
Novel drug delivery devices, methods and therapeutic compositions are described for treating viral and microbial infections and wasting syndromes in an animal, including a human patient. According...
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5932240 |
Multidose transdermal drug delivery system
A multidose transdermal drug delivery system comprises a laminate composite with a plurality of compartments. Each compartment is a reservoir for a unit dose of a drug active to be transdermally...
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5932238 |
Galanthamine containing transdermal applicator for the treatment of alcoholism
Galanthamine and the pharmaceutically suitable acid addition salts thereof can be used for the treatment of alcoholism; these compounds are released from adequate pharmaceutic formulations which...
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5932239 |
Transdermal therapeutic system with protection against hydrolysis
A transdermal therapeutic system (TTS) comprising an active substance which is sensitive to hydrolysis, and having a layer-like structure comprising a backing layer impermeable to moisture and...
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5928666 |
Crystalline form of estradiol and pharmaceutical formulations comprising same
The present invention is directed to a stable crystalline form of estradiol suitable for incorporation into pharmaceutical formulations. The invention further provides methods of preparing said...
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5925372 |
Mixed solvent mutually enhanced transdermal therapeutic system
A transdermal drug delivery system comprising (i) an occlusive, impermeable polymeric backing layer; (ii) a drug depot on one side thereof; (iii) a removable, occlusive covering layer over...
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5925373 |
Transdermal delivery device containing an estrogen
A composition for use in a three layer transdermal delivery system is disclosed, the composition comprising an adhesive matrix having sufficient strength to maintain an association on the skin for...
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5919477 |
Transdermal system for simultaneous delivery of a number of active principles
A novel system for percutaneously delivering at least two active principles, consisting of at least two juxtaposed devices. The system includes (i) a first device containing a mixture of all the...
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5919478 |
Incorporating poly-N-vinyl amide in a transdermal system
The present invention comprises a composition comprising a matrix adapted to be placed in drug-and permeation-enhancing mixture-transmitting relation to a selected skin or other body site. The...
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5919479 |
Noninvasive dermal anesthetics
An apparatus, product formulation, and method for improved dermal permeation of pharmaceuticals wherein the apparatus includes a thin drug formulation reservoir and a heat-generating chamber...
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5916587 |
Transdermal delivery matrix for piroxicam
The present invention is directed to a pharmaceutical compositions improving percutaneous absorbability by absorption assistants, which remarkably increase permeation and dissolution of piroxicam,...
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5916968 |
Adhesives resistant to skin-penetration enhancers
A graft copolymer for use as an adhesive for drug delivery patches or dressings that is resistant to dissolution in the presence of skin penetration enhancers comprises copolymerized acrylic and,...
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5912008 |
Transdermal therapeutic system for the release of 17-β-estradiol and process for its production
The invention concerns a transdermal therapeutic system comprising the active substance 17-β-estradiol and optionally further active substances, with a laminated structure comprising a backing...
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5912009 |
Fatty acid esters of glycolic acid and its salts
A transdermal drug delivery system which enhances the delivery of the drug comprises a composition containing, as an enhancer, one or more C 6 to C 22 fatty acid esters of glycolic acid and its...
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5906830 |
Supersaturated transdermal drug delivery systems, and methods for manufacturing the same
Methods are provided for manufacturing transdermal drug delivery systems containing supersaturated drug reservoirs, such that higher drug fluxes are obtained. The methods involve heating the drug...
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5906829 |
Poultice comprising a titanium-based material
The present invention provides a material for promoting health and curing bruises, etc., which is able to widely exert favorable influences on symptoms such as contusions, sprains, stiffness of the...
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5904930 |
Transdermal system in the form of a patch comprising a tamoxifen derivative
A transdermal system in the form of a patch that comprises a tamoxifen derivative and an absorption-promoting additive for systemic administration.
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5904931 |
Transdermal therapeutic systems that contain sex steroids and dimethyl isosorbide
Transdermal therapeutic systems that contain sex steroids and optionally penetration-enhancers and crystallization inhibitors are described, which are characterized in that they contain dimethyl...
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5902433 |
Process and a device for producing a transdermal therapeutic system for the administration of active substances to the skin in the form of a plane multichamber or multichamber-channel system
In a process for the production of a transdermal therapeutic system for the administration of active substances to the skin in the form of a plane multichamber or multichamber-channel system an...
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5902602 |
Estradiol-TTS having water-binding additives
A transdermal therapeutic system comprising the active substance estradiol and having a layered structure of a backing layer which is impermeable to active substances and moisture, and active...
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5902601 |
Volatile active substance containing plaster that may be produced without solvents
An active substance-containing adhesive patch with a pressure sensitive fixing device, containing at least one readily volatile ingredient, consisting of a substantially active...
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5902603 |
Polyurethane hydrogel drug reservoirs for use in transdermal drug delivery systems, and associated methods of manufacture and use
High capacity drug reservoirs are provided for incorporation into transdermal drug delivery systems. The drug reservoirs are hydrogels formulated from polyurethanes crosslinked with diisocyanate...
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5900250 |
Monoglyceride/lactate ester permeation enhancer for oxybutnin
A composition of matter for application to a body surface or membrane to administer oxybutynin by permeation through the body surface or membrane, the composition comprising, in combination, the...
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5895660 |
Deuterated active substances in transdermal application
A drug for the release of active substances to the skin, which has an increased deuterium portion as compared to the natural isotope distribution.
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5891461 |
Transdermal administration of olanzapine
Transdermal administration of olanzapine and pharmaceutically acceptable acid addition salts thereof is described. The method involves treating an individual suffering from or susceptible to...
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5885551 |
Treatment for dentinal hypersensitivity
A method for treating dentinal hypersensitivity by administering a therapeutic amount of an alginate to a hypersensitive tooth.
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5885612 |
Recrystallization-free estradiol-containing patch
An active substance-containing patch for the controlled release of estradiol or its pharmaceutically acceptable derivatives alone or combined with gestagens, comprising a backing layer, an active...
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5882675 |
Percutaneous absorption preparation
The present invention provides a percutaneous absorption preparation which has excellent pressure-sensitive adhesive characteristics and exerts excellent percutaneous absorption property. A...
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5882674 |
Transdermal therapeutic system comprising active substances representing carbon monoxide sources
A transdermal therapeutic system (TTS) comprises compounds releasing carbon monoxide in organisms to increase the CO-concentration in the organism.
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5882676 |
Skin permeation enhancer compositions using acyl lactylates
The present invention is directed to the transdermal administration of a drug together with a suitable amount of an acyl lactylate permeation enhancer. The invention includes a transdermal drug...
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5879701 |
Transdermal delivery of basic drugs using nonpolar adhesive systems and acidic solubilizing agents
Solubilization enhancer compositions are provided which facilitate transdermal administration of basic drugs from transdermal systems composed of nonpolar adhesive materials. Preferred...
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5879702 |
Analgesic anti-inflammatory adhesive preparations
A non-steroidal analgesic anti-inflammatory adhesive preparation rendered by coating one surface of support with an adhesive containing S-(+)-2-(2-fluoro-4-biphenylyl)propionic acid and a...
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RE36138 |
Percutaneous absorption promoter, a tape plaster and a method of promoting percutaneous absorption
A percutaneous absorption promoter comprises a derivative of amino acid in which the amino group has or does not have an acyl substituent or a hydrocarbon substituent, the carboxylic group has a...
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5876745 |
Method for preparing a medical adhesive sheet
A medical adhesive sheet comprising a support having a laminate structure comprising a non-porous sheet and a porous sheet, and a pressure-sensitive layer comprising an acrylic polymer prepared by...
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5869089 |
Manufacturing method of programmable transdermal therapeutic system
A novel manufacturing method for membrane controlled programmable trans-dermal therapeutic systems (PTTS) comprises highly stabilized supersaturated drug solid solution system and easily adjustable...
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5869088 |
Transdermal administration preparation of a 9-aminocyclopenta (b) quinoline
A transdermal administration preparation containing a 9-aminocyclopenta(b)quinoline, preferably 9-amino-2, 3,5,6,7,8-hexahydro-1H-cyclopentane(b)quinoline or its hydrochloride, as an active...
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5869086 |
Systems for the controlled release of pilocarpine
A transdermal therapeutic system for the controlled active substance release to the skin having a backing layer and a pressure sensitive adhesive reservoir layer, wherein the reservoir layer...
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5866157 |
Matrix patch formulation
A matrix type patch formulation which comprises an adhesive layer containing a physiological active substance, an organic acid, a hydrophobic high molecular material, a tackifying resin, a...
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5861170 |
Acetylsalicyclic acid-containing transdermal application system for antithrombotic therapy
A transdermal therapeutic system for antithrombotic therapy is disclosed. The system comprises a hydrophobic polymer matrix, acetic anhydride, and acetylsalicylic acid as the only active ingredient.
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5858393 |
Transdermal formulation
The present invention provides a method for treating a condition associated with muscarinic receptor modulation using a 3- 4-(butylthio)-1,2,5-thiadiazol-3-yl!-1-azabicyclo- 2.2.2!octane...
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5858394 |
Agent for transdermal administration that contains gestodene esters
An agent for transdermal administration is described, which is characterized in that it contains gestodene esters with 1 to 20 carbon atoms in the ester radical optionally in combination with one...
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5851549 |
Patch, with system and apparatus for manufacture
A system of the present invention for applying a substance to an applied area includes a patch (11), as well as apparatus (12, 14, 16, 18 and 21) and methods for making the same. The patch includes...
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5849325 |
Moisture-regulating adhesive dressing
An adhesive dressing includes an adhesive composition in the form of a substantially continuous layer on at least a portion of a conformable backing in which the adhesive composition and the...
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