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5744166 |
Drug delivery compositions
Compositions for delivery of pharmacologically active agents and methods for their administration are provided. In one embodiment, the compositions include a complex of a polycationic polymer and a...
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5741479 |
Desensitizing teeth with degradable particles
A method for desensitizing a hypersensitive tooth in a patient includes contacting exposed tubules with particles including a degradable material.
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5727945 |
Impregnated barrier and method of assisting bone or tissue regeneration
A bioresorbable device for use in regeneration of at bone and/or tissue in either a bone void or a tissue deficiency is provided. A primary embodiment is a bioresorbable periodontal barrier for use...
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5725841 |
Aerosol formulation containing an ester-, amide-, or mercaptoester-derived dispersing aid
A medicinal aerosol formulation containing a particulate drug and a dispersing aid derived from a hydroxyacid, a mercapto acid, or an amino acid.
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5723143 |
Solid mucoadhesive therapeutic or hygienic composition for application to the buccal or nasal mucous membrane
Solid mucoadhesive therapeutic or hygienic composition, for human or veterinary use, intended to be administered by application to the buccal or nasal mucous membrane, containing, in a mixture, 15...
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5718885 |
Relief of dentinal hypersensitivity by submicron particles
Phosphate-free oral compositions containing cationically charged colloids are effective to treat tooth hypersensitivity.
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5719197 |
Compositions and methods for topical administration of pharmaceutically active agents
Compositions for topical application comprising a therapeutically effective amount of a pharmaceutical agent(s), a pharmaceutically acceptable bioadhesive carrier, a solvent for the pharmaceutical...
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5716632 |
Compositions and methods for reparation and prevention of fibrotic lesions
In a preferred embodiment, drugs having pharmacological properties which are useful in the medicinal therapy of fibrotic disease for the reparation and prevention of fibrotic lesional tissues, such...
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5711938 |
Oral hygiene composition
Oral hygiene composition containing in combination chitosan and a sulphated, negatively charged polysaccharide in a biologically active amount; a process of improving oral hygiene in a mammal...
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5700478 |
Water-soluble pressure-sensitive mucoadhesive and devices provided therewith for emplacement in a mucosa-lined body cavity
Water-soluble pressure-sensitive adhesives include a water-soluble polymer that is made tacky at room temperature by addition of a water-soluble plasticizer that is miscible with the polymer....
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5700479 |
Surgical element and method for selective tissue regeneration
A surgical element for guided and controlled tissue regeneration and method for selective tissue regeneration. The elements disclosed include embodiments containing protrusions on at least one side...
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5696078 |
Methods of treating fungal infections using histatin-based peptides
Peptides representing defined portions of the amino acid sequences of naturally occurring human and macaque histatins, modified peptides, expression vectors encoding these peptides, and...
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5688521 |
Lactulose pastilles
Object of the invention is a single dose form of application for lactulose in the form of pastilles based on at least partially or completely water soluble natural and/or synthetic polymers...
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5688520 |
Transmucosal delivery of melatonin for prevention of migraine
A method of reducing the frequency of and/or preventing migraine, involving the step of administering melatonin, preferably to and across a mucosal surface, in an amount and for a time sufficient...
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5686095 |
Method of treating canker sores
A method of treating canker sores is disclosed by which a fluoroquinolone is topically applied to the ulcerous area. The fluoroquinolone is shown to be applied in solution form, and also as a...
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5686094 |
Controlled release formulations for the treatment of xerostomia
A polymeric delivery system which is formed by a polycarbophil type composition with an active agent, optionally in the presence of water and/or other cosolvent. The resulting product is especially...
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5672356 |
Bioadhesive pharmaceutical composition for the controlled release of active principles
Bioadhesive pharmaceutical composition for the controlled release of active principles locally across the buccal cavity or systemically across a mucous membrane, wherein it is composed of an active...
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5670138 |
Mouth-care products
The invention is directed to improved mouth care products comprising an amount of at least one copolymer of N-vinylpyrrolidone and acrylic acid, in a weight ratio of 60-95 to 40-5, suitable...
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5667809 |
Continuous fluorochemical microdispersions for the delivery of lipophilic pharmaceutical agents
A method for preparing a pharmaceutical microdispersion exhibiting enhanced bioavailability, including the steps of providing a thermodynamically stable pharmaceutical composition comprising at...
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5665374 |
Ultramulsion containing interdental delivery devices
The present invention relates to unique interdental delivery devices, other than dental floss, which are suitable for cleaning, massaging, and/or treating surfaces of teeth and gums including...
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5662919 |
Sulfated polyvinyl alcohol polymers to stabilize pharmaceutical drug compounds
Stable formulations of positively charged, hydrolytically unstable drug compounds are obtained by adding a sulfated polyvinyl alcohol copolymer to the formulations.
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5662920 |
Nicotine lozenge and therapeutic method for smoking cessation
A method for smoking cessation therapy is described that utilizing an improved nicotine lozenge to satisfy transient craving. The lozenge contains nicotine, a nonnutritive sweetener and an...
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5658586 |
Denture stabilizing compositions
The subject invention encompasses a denture adhesive composition comprising one or more adhesive components suitable for adhering to the oral cavity and a denture base and at least one non-adhesive...
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5656284 |
Oral transmucosal delivery tablet and method of making it
A tablet for delivering a pharmaceutical to a human transmucosally is described. The excipient is a gel which is elastic enough for a comfortable fit in the mouth, has suitable gel strength, holds...
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5656277 |
Nor- and homo- bile acids derivatives as absorption enhancers for medicaments
The use of nor- and homo-bile acids derivatives as absorption enhancers for medicaments is described. Said derivatives show the advantage of improving the absorption of medicaments through mucosae...
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5650192 |
Method for manufacturing buccal delivery device
The invention relates to a muco-adherent, soluble device for administering active ingredients, a method of using said device, and an improved method of manufacturing said device using a continuous,...
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5645827 |
Muco-adhesive polymers
Compositions comprising cationic polysaccharide polymers and anionic therapeutic agents which can have enhanced substantivity to mucosal surfaces are disclosed. These compositions are well suited,...
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5643603 |
Composition of a bioadhesive sustained delivery carrier for drug administration
A composition of a bioadhesive carrier for a prolonged, sustained and controlled delivery of a drug having a local or systemic action contains pregelatinized or thermally modified, food accepted...
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5637314 |
Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
A method for treating atopic dermatitis, hayfever, asthma and pruritis that includes topical or systemic application of an effective amount of buspirone or a buspirone derivative or its...
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5637311 |
Zinc(II) complexes and methods related thereto
Zinc(II) complexes and methods relating thereto are disclosed. The zinc(II) complexes comprise a zinc(II) ion complexed by a multi-dentate ligand. Methods of this invention include the use of the...
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5633003 |
Use of intratracheally administered hyaluronic acid to ameliorate emphysema
The subject invention is directed to the treatment of respiratory disorders by intratracheal administration of an effective amount of hyaluronic acid. Respiratory disorders include emphysema,...
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5620699 |
Method for delivering nonaqueous fluorinated drug delivery vehicle suspensions
Nonaqueous pharmaceutical compositions for use in aqueous physiological systems are disclosed comprising drug delivery vehicles suspended in nonaqueous perfluorocarbon or fluorinated silicone...
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5620701 |
Methods of treatment using di-linoleoyl-mono-gamma-linolenyl glycerol
Atopic eczema, breast pain or premenstrual syndrome are treated by administering to a person in need of same a composition containing at least 20% di-linoleoyl-mono-gamma-linolenyl glycerol by weight.
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5614223 |
Intraoral medicament-releasing device
Disclosed are controlled rate-release devices for releasing a pharmaceutically active agent into the oral cavity by the dissolving action of the saliva, a process of preparing such devices and...
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5607689 |
Latex element designed to achieve guided tissue regeneration in periodontal dental therapy
An element designed to achieve tissue regeneration in periodontal dental therapy, comprising a membrane insertable under the gingiva and made from a non-resorbable, biologically acceptable,...
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5607662 |
Pharmaceutical inhalation compositions
A non-pressurized pharmaceutical inhalation composition includes a therapeutically effective amount of a particulate inhalation medicament. The medicament has a mass median diameter in the range...
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5607686 |
Polymeric composition
A polymeric composition for use in medicine includes a hydrophobic bioabsorbable polymer admixed with a hydrophilic liquid polymer wherein the polymeric composition undergoes macroscopic phase...
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5607685 |
Protracted-release adminstration forms containing clindamycin palmitate
The invention relates to the use of clindamycin palmitate for the production of pharmaceutical administration forms having a protracted release of the antibiotic active compound clindamycin, and...
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5599553 |
Local drug delivery film for periodontal treatment
The present invention provides a local drug delivery film, which is characterized by comprising, as release control component, polymer mixture consistiong of polycaprolactone having molecular...
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5599554 |
Treatment of nicotine craving and/or smoking withdrawal symptoms
The subject invention encompasses a transdermally or transmucosally administrable composition for the treatment or nicotine craving or smoking withdrawal symptoms comprising nicotine and caffeine...
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5591441 |
Composition for nonspecific cellular immune stimulation
A non-specific host immune cell augmentation composition for enhanced microorganism killing utilizes any phagocytosable, biocompatible particle to prime macrophages for enhanced oxidative response...
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5578315 |
Mucosal adhesive device for long-acting delivery of pharmaceutical combinations in oral cavity
Mucosal adhesive devices are provided for use in the oral cavity for therapy against infections. The devices are dosage units which comprise a combination of antimicrobial agents such as antifungal...
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5576014 |
Intrabuccally dissolving compressed moldings and production process thereof
Intrabuccally dissolving compressed moldings comprising a saccharide having low moldability having been granulated with a saccharide having high moldability. The moldings of the present invention...
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5573776 |
Oral osmotic device with hydrogel driving member
An osmotic device (10) for delivering an ergot alkaloid into the mouth of a human patient is disclosed. The device (10) has a size and shape adapting it to be comfortably retained in the mouth for...
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5571524 |
Agent for curing ischemic myocardial disease
An agent for curing ischemic myocardial disease which contains an effective amount of diadenosine 5',5'"-p 1 ,p 4 -tetraphosphate (Ap4A) of formula (I): ##STR1## or a pharmaceutically-acceptable...
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5571526 |
Composite metal hydroxide and its use
A composite metal hydroxide which is a solid solution of the formula (1), Mg 1 -x M 2 + x (OH) 2 (1) wherein M 2 + is at least one divalent metal ion selected from the...
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5562908 |
Treatment of sinus headache
The present invention contemplates nasal compositions effective for relieving mammalian sinus headache associated with inflamed or congested turbinates, or both, accompanied by localized pain...
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5554388 |
Systemic drug delivery compositions comprising a polycationi substance
A composition for administration to the mucosa comprises a pharmacologically active compound and a polycationic substance. The polycationic substance is preferably DEAE-dextran or chitosan and the...
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5552150 |
Compostions containing di-linoleoyl-mono-gamma-linolenyl-glycerol
A natural or synthetic glycerol oil which comprises at least 20% by weight, preferably at least 25% of di-linoleoyl-mono-gamma-linolenyl-glycerol (DLMG), is used to supplement foods, nutritional...
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5540931 |
Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
The present invention provides methods and formulations for site-specific immune suppression of immune/inflammatory responses with localized or topical application of immunosuppressants including...
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