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5955438 |
Collagen-based matrix
A collagen matrix comprise collagen fibrils which are cross-linked to one another by a reducing sugar or a reducing sugar derivative. The collagen matrix may be formed into a membrane useful in...
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5952392 |
Long-chain alcohols, alkanes, fatty acids and amides in the treatment of burns and viral inhibition
Therapeutic compositions including a nonionic surfactant combined with long chain fatty acids, alkanes, amides or mono-unsaturated alcohols, particularly stearyl alcohol, erucyl alcohol, brassidyl...
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5947918 |
Impact energy absorbing composite materials
An impact energy absorbing composite material of expanded polytetrafluoroethylene (ePTFE) and an elastomer is disclosed. The composite is comprised of at least one layer of expanded...
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5945118 |
Indole derivative for the treatment of migraine
This invention relates to (R)-5-(aminosulphonylmethyl)-3-(N-methylpyrrolidin-2-ylmethy
l)-1H-indole and its pharmaceutically acceptable salts. This compound is particularly useful in treating...
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5942244 |
Local oral herbal slow release tablets
A tablet for the local and slow release of herbal medication into the oral cavity of a subject. Also provided is a method of making the tablet and a method of using the tablet. The tablet includes...
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5942243 |
Mucoadhesive compositions for administration of biologically active agents to animal tissue
This invention pertains to mucoadhesive compositions for the delivery of pharmacologically active agents, and to polymeric formulations that allow for a prolonged, sustained release of the active...
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5942252 |
Method for delivering bioactive agents into and through the mucosally-associated lymphoid tissues and controlling their release
A method, and compositions for use therein capable, of delivering a bioactive agent to an animal entailing the steps of encapsulating effective amounts of the agent in a biocompatible excipient to...
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5942242 |
Medicaments for nasal administration
A medicament for nasal administration to be used for disease prevention or treatment comprising a vaccine or a pharmacologically active peptide compounded with an ion exchange resin or adsorbent...
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5916550 |
Aqueous suspension of loteprednol etabonate
The conventional aqueous suspension of loteprednol etabonate is not easily amenable to production pH control and entails a pH depression on long-term storage, thus irritating the eye or the nasal...
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5904928 |
Antitartar composition and its use in food supplements for animals
The invention relates to an anti-tartar composition comprising: (a) 0.5 to 5% by weight of at least one compound selected from among zirconium silicate and hydrated silica; (b) 0.5 to 5% by...
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5900230 |
Dental products to treat and prevent periodontal disease
The dental products of this invention can be used to treat and prevent periodontal disease. They contain a synergistic mixture of poloxamers, and/or poloxamer congeners, plus xylitol. These active...
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5900247 |
Mucoadhesive pharmaceutical composition for the controlled release of active principles
The present invention relates to a new mucoadhesive pharmaceutical composition which makes possible the prolonged release of active pharmaceutical principles in the buccal cavity or via the...
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5891473 |
Granular Compositions
Granular composition comprising 45 to 98% w/w of a water insoluble particulate, whereby 10 to 75% of the water insoluble particulate is made from a water insoluble particulate material, having a...
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5891458 |
Bioerodible device for administering active ingredients
The invention relates to a muco-adherent, soluble device for administering active ingredients, a method of using said device, and an improved method of manufacturing said device using a continuous,...
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5888534 |
Controlled release of drugs delivered by sublingual or buccal administration
A composition providing a relatively slow release of water-soluble drugs, such as apomorphine, for delivery via the sublingual or buccal routes.
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5885829 |
Engineering oral tissues
Disclosed are methods for regenerating dental and oral tissues from viable cells using ex vivo culture on a structural matrix. The regenerated oral tissues and tissue-matrix preparations thus...
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5885551 |
Treatment for dentinal hypersensitivity
A method for treating dentinal hypersensitivity by administering a therapeutic amount of an alginate to a hypersensitive tooth.
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5885552 |
Mouthrinse
A three-component mouthrinse comprises a mouthrinse active material e.g. bactericide, a polymeric material e.g. polysaccharide which can be gelled in the mouth, and means (e.g. a polyacid) for...
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5885611 |
Bandage-forming gel for oral mucosa
A method of administering an oral bandage to lesions in the oral mucosa is disclosed wherein there is prepared a storage stable topical gel formulation adapted to form an oral bandage adherent to...
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5885609 |
Biocompatible articles and method for making same
Articles of manufacture and methods of making the same, comprising a cationic polymer which has been surface-modified by a method comprising the steps of swelling a cationic polymer in a medium...
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5871769 |
Methods and compositions for the prevention and treatment of diabetes mellitus
The present invention relates to methods and compositions for the prevention and/or treatment of diabetes mellitus, using magnesium gluconate alone or in combination with one or more antioxidants...
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5871751 |
Renibacterium salmoninarum vaccine and method for its preparation
A vaccine and method for treating fish susceptible to infection by Renibacterium salmoninarum is described. The vaccine comprises killed microorganisms that lack intact cell-surface-associated...
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5869082 |
Buccal, non-polar spray for nitroglycerin
A buccal aerosol spray using a non-polar solvent has now been developed which provides nitroglycerin for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal...
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5869096 |
Oral osmotic device with hydrogel driving member
An osmotic device (10) for delivering a beneficial drug, such as an anti-fungal, into the mouth of a human patient is disclosed. The device (10) has a size and shape adapting it to be comfortably...
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5863555 |
Buccal delivery of glucagon-like insulinotropic peptides
Drug delivery systems and methods for administering a glucagon-like insulinotropic peptide to the buccal mucosa for transmucosal drug delivery are described. The drug delivery systems comprise a...
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5858402 |
Methods for in vivo reduction of cyanide levels and compositions useful therefor
In accordance with the present invention, there are provided in vivo methods for the reduction of cyanide levels. The present invention employs a scavenging approach whereby cyanide is bound in...
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5858379 |
Adhesive for dental prosthesis
The use of a hydrophobic oleogel of essentially temperature-independent viscosity and consistency as a carrier base substance in an adhesive for dental prostheses is disclosed. The hydrophobic...
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5858333 |
Two-part oral products and methods of using same to remineralize teeth
A two-part oral product capable of remineralizing subsurface lesions and/or mineralizing exposed dentinal tubules in teeth is composed of cationic and anionic discrete parts. The cationic discrete...
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5858389 |
Squalene is an antiviral compound for treating hepatitis C virus carriers
A method and composition for treatment of hepatitis C virus (HCV), administered as two component treatment, involving 1) an orally administered squalene in combination with 2) the inhalation of...
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5855905 |
Compound preparation for the treatment of hypogonadal men and men with hypophyseal diseases
A compound preparation for the treatment of hypogonadal men and men with hypophyseal diseases. This invention relates to compound preparations containing biogenous or synthetic androgens and...
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5849322 |
Compositions and methods for buccal delivery of pharmaceutical agents
A composition for transmucosally administering a drug to the oral cavity comprises an adhesive layer comprising a hydrophilic polymer having one surface adapted to contact a first tissue of the...
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5840279 |
Pharmaceutical powder cartridge with integrated metering device and inhaler for powdered medicaments
Pharmaceutical powder cartridge for powder inhalers for receiving a medicament depot for a large number of pharmaceutical powder doses, having an integrated metering device which comprises at least...
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5837285 |
Fast soluble tablet
The object of the present invention is to provide a tablet that dissolves rapidly in the oral cavity (fast soluble tablets) that can be produced by a simple method without special preparation...
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5830456 |
Treatment of viral disease with oral interferon-α
Viral infections are treated by the administration of alpha-interferon at a dosage of from about 0.01 to about 5 IU/lb./day such that the interferon is held in contact with the patient's oral and...
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5827525 |
Buccal delivery system for therapeutic agents
A unidirectional buccal delivery system for the delivery of therapeutic agents over an extended period of time. The delivery system includes a matrix for releasing the drug into the oral cavity at...
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5824334 |
Tobacco substitute
The present invention relates generally to a cigarette substitute for administering a dose of nicotine. More specifically, the present invention is directed to a nicotine-containing dosage-form...
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5817307 |
Treatment of bacterial infection with oral interferon-α
Bacterial infections are treated by the administration of alpha-interferon at a dosage of from about 0.1 to about 5 IU/lb./day such that the interferon is held in contact with the patient's oral...
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5814331 |
Process for inhibiting pathogenic bacteria in the oral cavity and for binding peptide growth factors on surfaces
A process for inhibiting the growth of pathogenic bacteria and aiding in periodontal tissue healing within the oral cavity by binding therapeutic agents to surfaces is described. The process...
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5814330 |
Mucoadhesive emulsions containing cyclodextrin
The present invention relates to the use of a cyclodextrin or a derivative thereof as a mucoadhesive in an emulsion or aqueous solution, said cyclodextrin or derivative thereof being used in an...
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5800823 |
Elongate PTFE elements and articles made thereof
An elongate PTFE (polytetrafluoroethylene) element is formed, having a PTFE matrix and containing a water soluble additive material in the form of solid particles distributed within the matrix. The...
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5795592 |
Pharmaceutical composition to enhance tissue healing and regeneration and application kit comprising it
Compositions comprising a calcium channel blocker as an active agent and a biocompatible carrier for fixing the agent temporarily at the site of application, or precursor compounds forming such a...
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5783205 |
Injectable drug delivery system and method
The present invention is directed to a material which can be used to deliver a drug, such as an antibiotic, into a diseased tissue pocket, such as a periodontal pocket. The material is preferably a...
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5780045 |
Transmucosal drug delivery device
A transmucosal drug delivery device in the form of a sheet material. The device contains an acid-containing particulate polymeric resin dispersed throughout a polytetrafluoroethylene support matrix.
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5776493 |
Oral osmotic device for delivery of nystatin with hydrogel driving member
An osmotic device (10) for delivering a beneficial drug, such as an anti-fungal, into the mouth of a human patient is disclosed. The device (10) has a size and shape adapting it to be comfortably...
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5770234 |
Particle induced amplification of immune response
A non-specific host defense cell augmentation technique for enhanced microorganism killing utilizes any phagocytosable particle to prime macrophages for enhanced oxidative response and bacterial...
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5762494 |
Applicator device and method
A mucosal applicator for topical anesthetics comprising a delivery member for retaining and delivering the anesthetic to the mucosal tissue, an adhesive which adheres the delivery member to the...
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5759566 |
Microemulsion pharmaceutical compositions for the delivery of pharmaceutically active agents
Bioadhesive microemulsions or liposomic dispersions containing proteinaceous substances, especially calcitonin, that allow the systemic, local or topical administration of drugs by transmucosal...
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5750136 |
Bioadhesive composition and patch
A bioadhesive composition that adheres suitably to a mucosal surface and is capable of delivering drugs in sustained fashion, and a patch comprising the bioadhesive composition. Methods of using...
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5750132 |
Treatment of adverse effects associated with administration of extracellular hemoglobin
The present invention relates to methods of lessening the severity and frequency of adverse effects associated with administration of extracellular hemoglobin comprising administration of a smooth...
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5747058 |
High viscosity liquid controlled delivery system
A composition for the controlled release of substances is provided that includes: (i) a non-polymeric, non-water soluble liquid carrier material (HVLCM) of viscosity of at least 5,000 cP at 37° C....
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