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6585997 |
Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds
The present invention relates to a layered pharmaceutical delivery device for the administration of pharmaceuticals or other active compounds to mucosal surfaces. The device may also be used by...
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6582720 |
Medicinal compositions adhering to stomach/duodenum
The present invention provides a gastric and/or duodenal adhesive pharmaceutical composition obtained by coating a composition, which comprises a medicament acting at the stomach and/or duodenum...
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6583160 |
Nicotine therapy method and oral carrier for assuaging tobacco-addiction
A method for assuaging tobacco addiction comprises pulsing doses of nicotine into a user's bloodstream so it reaches the brain before passing through the liver. A nicotine-burst tablet is held in...
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6569463 |
Solid carriers for improved delivery of hydrophobic active ingredients in pharmaceutical compositions
The present invention provides solid pharmaceutical compositions for improved delivery of a wide variety of pharmaceutical active ingredients contained therein or separately administered. In one...
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6565832 |
Spray composition with reduced dripping
An aqueous-based sprayable composition comprises a therapeutic or palliative agent, water and a mixture of microcrystalline cellulose and alkali metal carboxyalkylcellulose. In one embodiment, the...
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6565889 |
Bilayer structure which encapsulates multiple containment units and uses thereof
The present invention provides compositions and methods of preparing a bilayer structure for encapsulating multiple containment units. These containment units can contain therapeutic, diagnostic...
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6562352 |
Vaccine compositions for mucosal delivery
The invention provides the use of an antigen which is a mucosally immunogenically active substance comprising the 50 kD C fragment of tetanus toxin, an immunogenic fragment thereof, or a derivative...
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6562364 |
Desmethylselegiline enantiomers and their use to treat drug withdrawal symptoms
The application is directed to the treatment of one or more symptoms associated with drug withdrawal by administering desmethylselegiline.
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6562365 |
Methods employing R(−)-desmethylselegiline
Methods and pharmaceutical compositions for using desmethylselegiline. In particular, the present invention provides novel compositions and methods for using desmethylselegiline for...
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6562363 |
Bioadhesive compositions and methods for topical administration of active agents
Bioadhesive compositions in a flexible, finite form for topical application to skin or mucous membranes comprising a composition which results from an admixture of at least one PVP polymer, at...
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6558689 |
Proanthocyanidins and ascorbic acid composition for topical application to human respiratory and oral mucosa
A nasal and pharyngeal spray solution for use in spraying into the nose and mouth to protect the mucosa from noxious viruses, bacteria and fungi and excessive drying, in situations of high risk,...
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6555124 |
Use of (meth)acrylic acid copolymers to increase the permeability of mucous membranes
(Meth)acrylic acid copolymers are used to increase mucosal permeability, comonomers present being (meth)acrylic esters and/or other monomers capable of free-radical polymerization, and the...
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6555531 |
Weight promoting composition, method, and product
Pregnanes of formula I, and pharmaceutical compositions and products containing them, are useful in weight promotion by administration to the vomeronasal organ.
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6551611 |
Hormone replacement therapy method
Varying the daily dose of either or both of the estrogen and the progestogen administered for hormone replacement therapy (HRT) is readily and inexpensively accomplished, without the necessity of...
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6548554 |
Ionic aqueous composition containing levomenthol
A composition for relieving a sensation of respiratory discomfort and/or for promoting natural regeneration of mucous membranes of the nasal cavity. The composition contains levomenthol at a...
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6546936 |
Method and apparatus to treat conditions of the naso-pharyngeal area
A patient's upper airway condition such as snoring and sleep apnea is treated by selecting a particulate material selected for limited migration within tissue and for encouraging a fibrotic...
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6544550 |
Medicaments for gastrointestinal disorders
The invention relates to the co-administration in human or veterinary medicine of 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)me
thyl]-4H-carbazol-4-one or a physiologically...
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6544530 |
Stable oil-in-glycerin emulsion
The invention provides a composition of matter comprising a stable oil-in-glycerin emulstion containing at least one oil, at least one emulsifier and glycerin.
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6541040 |
Mixture for use as wound dressing
The invention relates to a mixture for use as wound dressing, which comprises: a) paraffins complying with DAB and/or synthetic waxes selected from the group consisting of montan waxes, petroleum...
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6537566 |
Compositions and methods for the non-invasive treatment of uterine fibroid cells
The proliferation of uterine fibroid leiomyoma cells is inhibited by certain Fibroid Cell Growth Inhibitor (FGI) agents. The pharmacological doses of these FGI agents in the milieu of uterine...
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6537549 |
Cytokine antagonists for the treatment of localized disorders
Cytokine antagonists for use in localized clinical disorders are provided for the treatment and prevention of damage to the optic nerve, other cranial nerves, spinal cord, nerve roots, peripheral...
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6531112 |
Formulations for administering calcitonin and processes for preparing the same
The present invention provides a non-invasive method for administering polypeptides across epithelial membranes. The formulations in the present invention comprise solid polypeptide particles mixed...
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6528082 |
Methods and pharmaceutical compositions employing desmethylselegiline to treat neoplastic diseases or conditions
The application is directed to the treatment of neoplastic diseases or conditions by administering R(−) desmethylselegiline, S(+) desmethylselegiline, or a combination of the two. Neoplastic...
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6528081 |
Nasal spray liquid
The spray liquid of a nasal spray is formed by a hyperosmotically adjusted water saline solution with a common salt content of 1 to 4% by weight. It furthermore contains various essential oils.
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6521257 |
Gelled compositions
A gelled composition was provided by adding a gelling component to a carrier for adsorption. Not only was the taste of the carrier for adsorption significantly reduced in this composition, but the...
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6517860 |
Methods and compositions for improved bioavailability of bioactive agents for mucosal delivery
The invention encompasses compositions for increased bioavailability through mucosal delivery comprising, preferably in powder form, an intimate mixture of an effective amount of a bioactive agent...
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6509028 |
Methods and compositions for treating pain of the mucous membrane
Compositions useful for long-lasting pain relief from mucosal damage, such as mucosal inflamation, abrasions, ulcerations, lesions, trauma and incisions, without significant systemic absorption....
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6509040 |
Fast dispersing dosage forms essentially free of mammalian gelatin
The present invention relates to fast dispersing solid dosage forms that preferably dissolve in the oral cavity within sixty (60), more preferably within thirty (30), most preferably within ten...
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6500461 |
Particulate formulations
This invention provides vehicles capable of delivering high concentrations of poorly hydrophilic/poorly lipophilic compounds to animals, by combining compounds having biocompatible hydrophobic...
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6495154 |
On demand administration of clomipramine and salts thereof to treat premature ejaculation
A method is provided for delaying the onset of ejaculation in an individual. The method involves systemic and on demand administration to an individual of a pharmaceutical formulation containing an...
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6491940 |
Apparatus for administering composition for inhibiting cerebral neurovascular disorders and muscular headaches
Methods, kits, apparatus, and compositions for inhibiting a cerebral neurovascular disorder or a muscular headache in a human patient are provided. The methods comprise intranasally administering...
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6491941 |
Use of at least one lipid extract obtained from the fruit seed of the mirabelle tree
The aim of the invention is to use at least one lipid extract obtained from the fruit seeds of the mirabelle tree as an agent for preparing a cosmetic product for locally active (topical) use for...
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6489358 |
Pharmaceutical compositions containing mupirocin
The invention provides stable pharmaceutical preparations for topical and nasal uses, comprising Mupirocin calcium amorphous as an anti-microbial active agent therein, dissolved in a...
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6488953 |
Oral transmucosal delivery
An autoadhesive oral transmucosal delivery device contains a pharmaceutically active agent which is delivered via mucosal tissues in the mouth. The device comprises a dry hydrogel polymer which...
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6479045 |
Vaginal pH buffering for preventing miscarriage and premature labor, by treating or preventing bacterial vaginosis
The present invention concerns compositions and methods for preventing miscarriage and premature labor, and for treating and preventing Bacterial Vaginosis using a pH-buffering polymer. The present...
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6475509 |
Covalent conjugates of sodium channel blockers and active compounds
Compounds of the general formula P 1 -L-P 2 ; wherein “P 1 ” is a pyrazinoylguanidine sodium channel blocker, “L” is a linking group, and “P 2 ” is either (i) a pyrazinoylguanidine...
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6458383 |
Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin
A delayed release pharmaceutical dosage form for oral administration of a hydrophilic drug, e.g., a polysaccharide drug such as low molecular weight heparin, are provided. The dosage form comprises...
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6458380 |
Dressing and preparation delivery system
A dressing and method of treating wounds is provided. The dressing can comprise water-soluble or swellable polymers which are capable of forming a viscous aqueous or non-aqueous solution and form a...
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6455030 |
Oral adhesive sheet and oral adhesive preparation
An oral adhesive preparation has a substrate and a pressure-sensitive adhesive layer provided on at least one surface of the substrate, in which the pressure-sensitive adhesive layer contains a...
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6455028 |
Ipratropium formulation for pulmonary inhalation
Pharmaceutical aerosol formulations are provided comprising substantially nonacicular particles of a bronchodilator selected from the group consisting of ipratropium and pharmacologically...
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6451848 |
Compositions and methods comprising morphine gluconate
The present invention relates to a pharmaceutical composition which includes morphine gluconate or chemical equivalent thereof. In one embodiment, the present invention includes a method of making...
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6432440 |
Pectin compositions and methods of use for improved delivery of drugs to mucosal surfaces
Liquid pharmaceutical compositions for administration to a mucosal surface, comprising a therapeutic agent and a pectin with a low degree of esterification are described. Such compositions gel, or...
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6432383 |
Method for administering insulin
A mixed micellar pharmaceutical formulation includes a micellar proteinic pharmaceutical agent, an alkali metal lauryl sulphate, alkali metal salicylate, a pharmaceutically acceptable edetate and...
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6428805 |
Powdery nasal compositions
A powdery nasal composition comprising a drug and colloidal cellulose is provided. The composition is a nasal composition providing a superior absorption activity for the drug.
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6428769 |
Acute testosterone administration
The libido of adult human female patients is increased by the intrapulmonary delivery of testosterone. A formulation of testosterone is aerosolized and inhaled into a patient's lungs where...
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6426084 |
Treatment of sexual dysfunction in certain patient groups
Methods for treating specific patient groups for sexual dysfunction are provided. The methods of the present invention comprise the utilization of pharmaceutical compositions in patients who are...
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6423321 |
Cytokine antagonists for the treatment of sensorineural hearing loss
Specific Cytokine Antagonists, including TNF antagonists and/or Interleukin-1 antagonists, are used as novel therapeutic agents for the treatment of hearing loss, including presbycusis and other...
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6419934 |
TNF modulators for treating neurological disorders associated with viral infection
A method for inhibiting the action of TNF for treating neurological conditions in a human by administering a TNF antagonist for reducing the inflammation of neuronal tissue of said human, or for...
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6416779 |
Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections
Devices, methods, and compositions for treating vaginal fungal, bacterial, viral and parasitic infections by intravaginal or transvaginal administration of therapeutic and/or palliative antifungal,...
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6410046 |
Administering pharmaceuticals to the mammalian central nervous system
A device, methods and pharmaceutical compositions are disclosed for transnasal or transocular drug delivery to the central nervous system using a combination of electrotransport or phonophoresis...
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