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5945115 |
Polymeric compositions useful as controlled release implants
The invention is directed to an improved system for controlled release of biologically active materials and to a liquid composition for its formation. The liquid composition is composed of a...
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5942252 |
Method for delivering bioactive agents into and through the mucosally-associated lymphoid tissues and controlling their release
A method, and compositions for use therein capable, of delivering a bioactive agent to an animal entailing the steps of encapsulating effective amounts of the agent in a biocompatible excipient to...
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5942242 |
Medicaments for nasal administration
A medicament for nasal administration to be used for disease prevention or treatment comprising a vaccine or a pharmacologically active peptide compounded with an ion exchange resin or adsorbent...
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5935592 |
Method for treating vaginitis and endometriosis
A stable solution, cream, salve, or spray composition containing activated chlorine dioxide and phosphates, such as disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate,...
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5922341 |
Local administration of pharmacologically active agents to treat premature ejaculation
A method is provided for delaying the onset of ejaculation in an individual. The method involves administration of a pharmacologically active agent, particularly an antidepressant, a serotonin...
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5919474 |
Transurethral administration of vasoactive agents to treat peripheral vascular disease, related vascular diseases, and vascular impotence associated therewith
A method for treating peripheral vascular disease (PVD), related vascular diseases, and vascular impotence associated with such diseases, is provided. The method involves transurethral...
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5912006 |
Compositions and methods for alleviating discomforting menstrual pain
There is disclosed a composition and method for reducing or alleviating the discomforting symptoms associate with menstruation, particularly menstrual pain. The composition is administered by...
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5902832 |
Method of synthesizing swollen hydrogel for sphincter augmentation
A synthesis method is set forth for forming a physiologically acceptable composition comprising a plurality of physiologically acceptable hydrogel particles which have been swollen in a water...
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5902575 |
Method for treating the epithelium of bodily orifices with chlorine dioxide and a phosphate compound
A stable solution, cream, salve, or spray composition containing chlorine dioxide and a phosphate, such as disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, and sodium...
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5885601 |
Use of macrolide antibiotics for nonsurgical female sterilization and endometrial ablation
The present invention relates to a method of female sterilization including delivery of a macrolide antibiotic or a pharmacologically acceptable salt of a macrolide antibiotic to the uterine cavity...
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5885608 |
Lipid soluble forms of thiamine for prevention and treatment of age-related cognitive impairment of the nervous system
A method for preventing, ameliorating, and/or treating memory and other cognitive disorders associated with aging, such as Age-Associated Memory Impairment (also known as Age-Related Cognitive...
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5874099 |
Methods for making immunoisolatary implantable vehicles with a biocompatible jacket and a biocompatible matrix core
A method of forming an implantable and retrievable immunoisolatory vehicles is disclosed, the method comprising the steps of first forming a core comprising a volume of at least 1 μl and at least...
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5871767 |
Methods for treatment or prevention of neurodegenerative conditions using immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
A method for treatment of a neurodegenerative condition in a patient comprising implanting in the patient at least one immunoisolatory vehicle comprising a corc comprising a volume of at least 1...
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5869081 |
Progesterone vaginal ring for treatment of infertility
The present invention relates to a method of administering progesterone to a normogonadal or a functionally agonadal human female undergoing an assisted reproduction technique. The invention...
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5863553 |
Bioerodible contraceptive suppository
The invention relates to an intravaginally-dissolvable contraceptive suppository, a method of using said suppository, and an improved method of manufacturing said birth control device. The...
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5861166 |
Delivery device providing beneficial agent stability
This invention relates to fluid-imbibing delivery devices for delivering a beneficial agent to a biological environment of use. In particular, the devices include a rigid housing defining an...
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5855906 |
Intravaginal drug delivery devices for the administration of 17β-oestradiol precursors
The invention relates to an intravaginal drug delivery device for administration to a female mammal of certain 17β-oestradiol precursors at a substantially constant rate for a period of at least...
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5855905 |
Compound preparation for the treatment of hypogonadal men and men with hypophyseal diseases
A compound preparation for the treatment of hypogonadal men and men with hypophyseal diseases. This invention relates to compound preparations containing biogenous or synthetic androgens and...
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5844017 |
Prepolymers of absorbable polyoxaesters containing amines and/or amido groups
The present invention describes a prepolymer of aliphatic polyoxaesters containing amines and/or amido groups having polymerizable end groups that may be used to produce surgical devices such as...
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5837254 |
Method of treating candida and cryptococcus fungal infections by administering gentian
A method and preparations for the treatment of vaginal yeast and other yeast infections is provided for the treatment of infections caused by candida albicans and cryptococcus neoformans. The...
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5834001 |
Methods for making immunoisolatory implantable vehicles with a biocompatiable jacket and a biocompatible matrix core
A method of forming an implantable and retrievable immunoisolatory vehicle is disclosed, the method comprising the steps of first forming a jacket of biocompatible thermoplastic or hydrogel, and...
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5834003 |
Method for oxidatively consuming volatile sulfur compounds at bodily orifices
A method for oxidatively consuming volatile sulfur compounds selected from the group consisting of dimethylsulfide, hydrogen sulfide, and methylmercaptan at the epithelial barrier of the rectal,...
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5814330 |
Mucoadhesive emulsions containing cyclodextrin
The present invention relates to the use of a cyclodextrin or a derivative thereof as a mucoadhesive in an emulsion or aqueous solution, said cyclodextrin or derivative thereof being used in an...
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5814329 |
Hydrophilic polystyrene graft copolymer vehicle for intravaginal administration of pharmacologically active agents
This invention pertains to the vaginal delivery of pharmacologically active agents and to polymeric formulations that allow for a prolonged release of the active agents in the vaginal environment....
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5800829 |
Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
A method of making an immunoisolatory vehicle comprised of a core comprising living cells dispersed in a biocompatible matrix is disclosed, the cells being capable of secreting a biologically...
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5788986 |
Veterinary method for clinically modifying the behavior of dogs exhibiting canine affective aggression using R enantiomers, S enantiomers, and racemic mixtures of selective serotonin reuptake inhibitor compounds or their active metabolites
A veterinary method for clinically modifying the behavior of a household pet dog exhibiting a recognized type of canine affective aggression behavior is provided. The veterinary behavior...
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5788977 |
Method of making controlled release devices
A process is disclosed for making devices which release active material, e.g. a drug, at a controlled rate, which device comprises a closed container and the active material. The device is made by...
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5778886 |
Vaginal compositions combining a spermicidal agent and a peroxygen compound
The invention provides vaginal compositions suitable for preventing conception and transmission of sexually transmitted diseases comprising a spermicidal agent and a peroxygen compound. Preferably,...
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5759566 |
Microemulsion pharmaceutical compositions for the delivery of pharmaceutically active agents
Bioadhesive microemulsions or liposomic dispersions containing proteinaceous substances, especially calcitonin, that allow the systemic, local or topical administration of drugs by transmucosal...
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5756115 |
Contraceptive method using a subdermally implantable device
Disclosed is a subdermally implantable drug-delivery device, which contains: a central core extending in an axial direction and having an outer surface and opposing ends, which core includes a...
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5747058 |
High viscosity liquid controlled delivery system
A composition for the controlled release of substances is provided that includes: (i) a non-polymeric, non-water soluble liquid carrier material (HVLCM) of viscosity of at least 5,000 cP at 37° C....
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5744166 |
Drug delivery compositions
Compositions for delivery of pharmacologically active agents and methods for their administration are provided. In one embodiment, the compositions include a complex of a polycationic polymer and a...
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5744151 |
Silver-based pharmaceutical compositions
The present invention relates to pharmaceutical compositions which are photostable and antimicrobially active comprising one or more medicinal agents and a stabilized ionized silver-based...
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5741525 |
Vaginal pharmaceutical hydrogen peroxide composition
Gelled vaginal pharmaceutical composition containing: a water-soluble bioadhesive polymer, a peroxide source and pH buffer wherein the composition has a pH between about 3.0 and about 6.0; and...
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5725870 |
Methods, composites and articles for contraception
Vaginal application of cysteamine, cystamine, phosphocysteamine, or a pharmaceutically acceptable salt thereof is effective for contraception.
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5703200 |
Absorbable copolymers and blends of 6,6-dialkyl-1,4-dioxepan-2-one and its cyclic dimer
This invention provides various copolymers comprising a first repeating unit of the chemical formula: ##STR1## in which R 1 and/or R 2 are alkyl groups and a second repeating units generally...
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5700478 |
Water-soluble pressure-sensitive mucoadhesive and devices provided therewith for emplacement in a mucosa-lined body cavity
Water-soluble pressure-sensitive adhesives include a water-soluble polymer that is made tacky at room temperature by addition of a water-soluble plasticizer that is miscible with the polymer....
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5700583 |
Hydrogels of absorbable polyoxaesters containing amines or amido groups
The present invention describes a crosslinked aliphatic polyoxaesters containing amines and/or amido groups and blends thereof with other polymers that may be used to produce surgical devices such...
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5700783 |
Method of treating urinary incontinence
A method for treating urinary incontinence consisting of injecting human fibrin glue at or near the bladder neck until the urethral outflow resistance is restored. Human fibrin glue is the reaction...
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5698213 |
Hydrogels of absorbable polyoxaesters
The present invention describes a new crossslinkable and crosslinked aliphatic polyoxaesters and blends thereof that may be used to produce hydrogels, surgical devices such as sutures, sutures with...
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5698214 |
Treatment for Monilial Vulvovaginitis
Monilial Vulvovaginitis is treated by application of a composition containing one or more substances which inhibit glucose transfer into cells and cell metabolism. The composition of the invention...
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5696078 |
Methods of treating fungal infections using histatin-based peptides
Peptides representing defined portions of the amino acid sequences of naturally occurring human and macaque histatins, modified peptides, expression vectors encoding these peptides, and...
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5685872 |
Inhibition of exoprotein using amide compositions in absorbent article
Absorbent articles, such as catamenial tampons, for absorbing body fluids are disclosed which include an effective amount of a nitrogen containing compound to substantially inhibit the production...
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5667492 |
Use and composition of an anti-sexually transmitted diseases formulation
The present invention provides a composition and use of a composition comprising a bioadhesive cross-linked polycarboxylic acid polymer formulation that enables the use of relatively low mounts of...
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5667809 |
Continuous fluorochemical microdispersions for the delivery of lipophilic pharmaceutical agents
A method for preparing a pharmaceutical microdispersion exhibiting enhanced bioavailability, including the steps of providing a thermodynamically stable pharmaceutical composition comprising at...
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5662913 |
Antimicrobial compositions useful for medical applications
Antimicrobial metal-based compositions, which are photostable, non-staining, and which are easily absorbed into lipophilic matrices, contain silver cations, complexed by acyclic polyether polymers...
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5656283 |
In-situ lyophilization of vaginal suppository in unit dose applicator and resultant product
This invention relates to a novel method of manufacturing a lyophilized suppository composition wherein said suppository is made in situ in an applicator cartridge.
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5656628 |
Use of L-acetylcarnitine for the treatment of AIDS
This invention relates to the use of L-acylcarnitine for the preparation of a drug and a technique for relieving the disease symptoms appearing in AIDS by administering an L-acylcarnitine. The...
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5650192 |
Method for manufacturing buccal delivery device
The invention relates to a muco-adherent, soluble device for administering active ingredients, a method of using said device, and an improved method of manufacturing said device using a continuous,...
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5648377 |
Formulations containing carotenoids an procarotenoids combined with polyphenols in the prevention of the damages due to an abnormal production of free radicals
The present invention relates to novel formulations and combinations of lipophilic and hydrophilic antioxidants and the use thereof in the therapeutic, foodstuff, dietetic, and cosmetic fields....
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