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8147897 |
Cross-linkable polyionic coatings for medical devices
A method for making an article comprising a core material and a coating thereon, the method comprising the steps of: (a) providing the core material;(b) applying one or more layers of a...
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8097270 |
Use of nanoparticles as carriers for biocides in ophthalmic compositions
The use of nanoparticles of inorganic materials (e.g., synthetic smectite clays) in ophthalmic compositions is described. The nanoparticles are utilized as biologically inert carriers or depots for...
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8083347 |
Drug delivery system and methods of use
Electrospun fibers are utilized to improve the mechanical characteristics of a contact lens reducing the weight and mechanical strength of the polymers from which the lenses are typically formed....
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8075909 |
Contact lens based bioactive agent delivery system
A bioactive agent delivery system comprising an optically transparent contact lens having dispersed therein (1) an ophthalmically bioactive agent capable of diffusion through the contact lens and...
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8071704 |
Prepolymerizable surface active monomers with both fluorine-containing groups and hydrophilic groups
Provided are surface modified contact lenses formed from one or more fumaric- or itaconic-containing prepolymers having reactive functionality that is complimentary to surface modifying polymers.
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8071121 |
Dispersions of microemulsions in hydrogels for drug delivery
An ophthalmically bioactive agent delivery system comprising a contact lens having dispersed therein as an oil-in-water microemulsion, an ophthalmically bioactive agent encapsulated in the oil...
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8062607 |
Lens care methods and kits
The present invention provides a lens care kit for disinfecting and cleaning contact lenses. The lens care kit of the invention allows customers to visually identify when their lenses are...
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8017665 |
Ophthalmic devices containing heterocyclic compounds and methods for their production
This invention relates to ophthalmic devices and methods for their production where the ophthalmic device contain a polymer and at least one heterocyclic compound comprising at least one N—Cl a...
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7985208 |
Ring shaped contoured collagen shield for ophthalmic drug delivery
A collagen corneal shield for placement on the outer surface of the eye for protection of the eye, for delivery of drugs to the eye, or for both protection and drug delivery to the eye, functions...
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7981440 |
Antimicrobial lenses, processes to prepare them and methods of their use
This invention relates to solutions for packaging ophthalmic devices comprising at least one antimicrobial metal salt which prevent the loss of said antimicrobial metal salt during autoclaving and...
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7976863 |
Biomedical devices with antimicrobial coatings
Biomedical devices with antimicrobial coatings are provided. One or more surfaces of the device are coated with a cationic peptide, cationic proteins, or mixtures thereof to impart antimicrobial...
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7963390 |
Contact lens storage case
A contact lens storage case comprising a case body including a pair of chambers for containing contact lenses therein, and a pair of lids for closing and opening the chambers, wherein inner faces...
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7943162 |
Drug delivery device
Drug delivery devices, and methods of delivering pharmaceutically active agents to a target tissue within a body using such devices, are disclosed. One drug delivery device includes a body having...
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7939501 |
Ophthalmic and contact lens solutions containing peptides as preservative
A contact lens solution comprising 0.001 to 10 weight percent or a preservative enhancer chosen from the group consisting of: D4E1, D2A21, and P-113; and at least 0.0001 weight percent of a...
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7901706 |
Materials containing multiple layers of vesicles
The present invention provides a composite material, preferably an ophthalmic device, more preferably a contact lens, which comprises a vesicle-containing coating including at least one layer of a...
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7811601 |
Ophthalmic lenses capable of sustained drug release and preservative solutions therefor
An object of the present invention is to provide a practical ophthalmic lens which has an effect of effectively retaining and sustainedly releasing a drug and has form stability before and after...
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7811605 |
Method of formation of shape-retentive aggregates of gel particles and their uses
The present invention relates to a method of forming shape-retentive aggregates of gel particles in which the aggregates are held together by non-covalent bond physical forces such as, without...
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7771743 |
Infection resistant polymers, their preparation and uses
A family of infection resistant and biocidal polymeric materials incorporates an infection resistant biguanide such as chlorhexidine or polyhexanide pendant to the polymer chain, chemically linked...
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7666914 |
Topical preparation and method for transdermal delivery and localization of therapeutic agents
Disclosed herein is a preparation for topically delivering and localizing therapeutic agents, comprising: a vasoconstrictor for retarding vascular dispersion of a therapeutic agent; and a...
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7638137 |
Ophthalmic drug delivery system
A drug delivery system comprising a contact lens having dispersed therein as nanoparticles having a particle size less than about 50 nm, an ophthalmic drug nanoencapsulated in a material from which...
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7618643 |
Growth factor delivery system for the healing of wounds and the prevention of inflammation and disease
The present invention features hydrogel drug delivery systems and methods of producing and using such systems for the treatment of wounds. The systems are based on a hydrogel into which a low...
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7601361 |
Process for providing antimicrobial surfaces
Processes for providing durable antimicrobial surfaces are disclosed that comprise treating a polymer substrate surface with formaldehyde followed by treatment with an antimicrobial peptide....
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7584630 |
Photochromic ocular devices
Described are photochromic ocular devices such as contact lenses and intraocular lenses made of an organic polymeric material and at least one photochromic material capable upon exposure to actinic...
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7569212 |
Procedure and composition of treatment and/or care of the eye
A procedure for the manufacture of contact lenses for eye treatment, eye protection and eye-care wherein the lenses are impregnated with a suitable composition, a composition for the impregnation...
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7556822 |
Biomedical compositions
A method of preparing intraocular lenses in situ is disclosed. The method involves the injection of an unsaturated macromonomer of Formula I: The macromonomer is then polymerized to give a polymer...
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7416737 |
Antimicrobial lenses, processes to prepare them and methods of their use
This invention relates to solutions for packaging ophthalmic devices comprising at least one antimicrobial metal salt which prevent the loss of said antimicrobial metal salt during autoclaving and...
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7402562 |
Composition for stabilizing corneal tissue during or after orthokeratology lens wear
An orthokeratological procedure is provided that prevents or retards relaxation of corneal tissue back to the original anterior curvature of the cornea. The procedure comprises applying a...
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7368127 |
Biomedical devices with peptide containing coatings
Biomedical devices with stable peptide coatings are provided. The coatings are formed by incorporating at least one latent reactive component into the reactive mixture, forming a medical device...
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7351430 |
Shape-retentive hydrogel particle aggregates and their uses
The present invention is related to hydrogel particles and aggregates formed therefrom having characteristics including, without limitation, shape-retentiveness, elasticity, controllable pore sizes...
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7348022 |
Biomedical composition
A method of preparing intraocular lenses in situ is disclosed. The method involves the injection of an unsaturated macromonomer of the formula The macromonomer is then polymerized to give a polymer...
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7329415 |
Materials containing multiple layers of vesicles
The present invention provides a composite material, preferably an ophthalmic device, more preferably a contact lens, which comprises a vesicle-containing coating including at least one layer of a...
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7326423 |
Copolymerizable azo compounds and articles containing them
Polymerizable light absorbing azo dyes are disclosed useful as monomers in the formation of devices such as, but not limited to ocular lenses. Specifically, intraocular lenses (IOL) are disclosed...
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7303278 |
Multifocal contact lens
A contact lens formed from a transparent material having front and rear surfaces, wherein the rear surface has a base curve which is adapted to fit an eye of a wearer of the lens. The front surface...
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7282214 |
Biomedical devices with antimicrobial coatings
Biomedical devices with antimicrobial coatings are provided. One or more surfaces of the device are coated with a cationic peptide, cationic proteins, or mixtures thereof to impart antimicrobial...
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7249848 |
Wettable hydrogels comprising reactive, hydrophilic, polymeric internal wetting agents
The present invention relates to wettable silicone hydrogels comprising the reaction product of at least one siloxane containing component and at least one reactive, hydrophilic polymeric internal...
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7169406 |
Growth factor delivery systems for the healing of wounds and the prevention of inflammation and disease
The present invention features hydrogel drug delivery systems and methods of producing and using such systems for the treatment of wounds. The systems are based on a hydrogel into which a low...
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7105352 |
Intelligent polymerized crystalline colloidal array carbohydrate sensors
The present invention is related to glucose sensors that are capable of detecting the concentration or level of glucose in a solution or fluid having either low or high ionic strength. The glucose...
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7060288 |
Biomedical devices
The present invention is concerned with biomedical device comprising (a) a biocompatible organic or inorganic bulk material and(b) a coating comprising polymerizable carbon-carbon double bonds...
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6982090 |
More easily visualized punctum plug configurations
An improved punctum plug is more easily visualized when positioned within a punctual canal of a recipient. The body of the plug features an outwardly exposed surface when properly positioned, and a...
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6902548 |
Use of Streptomyces hyalurolyticus enzyme in ophthalmic treatments
A highly specific and easily purified form of hyaluronidase is described for use in ophthalmic treatments. The enzyme, from Streptomyces hyalurolyticus is specific for hyaluronidase and carries out...
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6900188 |
System for treating wounds and method for producing this system
The wound-treatment system is natural and is adapted to change state in a reversible manner by passing from the gel state to the solution state and vice-versa, and has polysaccharide macromolecules...
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6767934 |
Macromolecular compounds
Macromolecular photocrosslinkers have polymeric backbones of substituted siloxane groups carrying photoactive groups. When exposed to light of wavelength above 305 nm, the photocrosslinkers are...
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6726918 |
Methods for treating inflammation-mediated conditions of the eye
Methods for treating inflammation-mediated conditions of the eye are described, comprising: implanting into the vitreous of the eye of an individual a bioerodible implant comprising a steroidal...
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6610318 |
Sterile ophthalmological gel preparation applicable in drops and process for producing it
The invention relates to a sterile ophthalmic drop preparation, especially a gel preparation, which comprises a two-phase carrier liquid or gel basis comprising a liquid aqueous and a liquid...
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6592814 |
Biomedical devices with antimicrobial coatings
Contact lenses with antimicrobial coatings are provided. One or more surfaces of the lenses are coated with lactoferrin to impart antimicrobial properties to the surface.
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6589550 |
Methods of producing intraocular lenses and materials suitable for their production
A method for producing an intraocular lens, comprising the steps of injecting a high-refractive index, low viscosity composition of crosslinkable units into an enclosure and initiating...
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6537545 |
Use of corneal hardening agents in enzymeorthokeratology
An Enzyme Orthokeratology method is provided for correcting refractive errors in the eye of a subject mammal. Accelerating reshaping of the cornea is accomplished by administering a corneal...
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6410045 |
Drug delivery system for antiglaucomatous medication
A drug delivery system for antiglaucomatous medications utilizing a polymeric hydrogel which can absorb an ophthalmic medication which can then be transferred into the ocular fluid of the eye.
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6368615 |
Contact lens having a pharmaceutical agent releasably disposed therein
A contact lens having a pharmaceutical agent releasably disposed therein. The lens itself comprises a polymer of an unsaturated carboxylic acid ester of salicylic acid, the unsaturated carboxylic...
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6346560 |
Method for selecting contact lens materials to minimize corneal staining
The invention provides a method for selecting contact lenses to reduce corneal staining. The method selects contact lens materials based upon the ratio of the water diffusion coefficient to the ion...
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