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5846561 |
Method of binding collagen recognizing substances to liposomes
Recognizing substances, including epidermal growth factor, gelatin, collagen and hyaluronic acid, have been covalently bound to liposomal surfaces and utilized to attach liposomes onto a cellular...
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5844017 |
Prepolymers of absorbable polyoxaesters containing amines and/or amido groups
The present invention describes a prepolymer of aliphatic polyoxaesters containing amines and/or amido groups having polymerizable end groups that may be used to produce surgical devices such as...
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5824072 |
Biocompatible ocular implants
Implants comprising active agents are employed for introduction into a suprachoroidal space or an avascular region of an eye for therapeutic purposes. The administration of drugs is controlled and...
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5776482 |
Tetrahydroquinoline analogues for use in glaucoma treatment
Tetrahydroquinoline analogues and compositions containing them for topically treating glaucoma to effectively reduce intraocular eye pressure.
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5744166 |
Drug delivery compositions
Compositions for delivery of pharmacologically active agents and methods for their administration are provided. In one embodiment, the compositions include a complex of a polycationic polymer and a...
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5728405 |
Method for preventing keratocyte loss
Keratocyte loss after trauma or injury to the corneal epithelium is prevented or reduced by applying to the corneal epithelium a keratocyte maintenance solution over a period of time sufficient to...
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5716633 |
Collagen-hydrogel for promoting epithelial cell growth and regeneration of the stroma and artificial lens using the same
A collagen-hydrogel for promoting epithelial cell growth and regeneration of the stroma is shown. Also shown is an optical lens for the eye, fabricated from the collagen-hydrogel, which, when...
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5711957 |
Use of a porous calcium carbonate based material as support of a growth factor in the preparation of a bioabsorbable implant
A method for treating a living organism includes fitting in the living organism a bioabsorbable implant. The bioabsorbable implant includes a support of porous calcium carbonate based material for...
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5707643 |
Biodegradable scleral plug
The present invention relates to a scleral plug made of lactic acid copolymer; a scleral plug containing a drug that is designed to gradually release the drug into a vitreous body; and a scleral...
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5700583 |
Hydrogels of absorbable polyoxaesters containing amines or amido groups
The present invention describes a crosslinked aliphatic polyoxaesters containing amines and/or amido groups and blends thereof with other polymers that may be used to produce surgical devices such...
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5688817 |
Di(aromatic) compounds and their use in human and veterinary medicine and in cosmetics
Di(aromatic) compounds corresponding to the following formula: ##STR1## in which: Ar represents either ##STR2## n=1 or 2 or: ##STR3## X represents a divalent radical, Z represents O, S or a...
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5681576 |
Method and composition for post surgical adhesion reduction
A process and compositions for reducing post-surgical adhesion formation/reformation in mammals following injury to organs situated in mammalian body spaces. Aqueous, isotonic gel compositions,...
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5660851 |
Ocular inserts
Absorbable ocular inserts fabricated of materials that are biologically inert, biodegradable, non-allergenic, and insoluble in tear liquid, and a method for delivering substances to the eye using...
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5660849 |
Apparatus for forming a biodegradable implant precursor
The invention is directed to a biodegradable implant precursor having a two-part structure made of an outer sac and a liquid content. The implant precursor is composed of a biodegradable,...
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5622712 |
N-[ω, (ω-1)-dialkyloxy]- and N-[ω, (ω-1)-dialkenyloxy]-alk-1-yl-N, N, N-tetrasubstituted ammonium lipids and uses therefor
This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R 1 and R 2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R...
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5620699 |
Method for delivering nonaqueous fluorinated drug delivery vehicle suspensions
Nonaqueous pharmaceutical compositions for use in aqueous physiological systems are disclosed comprising drug delivery vehicles suspended in nonaqueous perfluorocarbon or fluorinated silicone...
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5603872 |
Method of binding recognizing substances to liposomes
Recognizing substances, including epidermal growth factor, gelatin, collagen and hyaluronic acid, have been covalently bound to liposomal surfaces and utilized to attach liposomes onto a cellular...
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5599534 |
Reversible gel-forming composition for sustained delivery of bio-affecting substances, and method of use
Reversibly gel-forming compositions for sustained delivery of bio-affecting substances are disclosed. The compositions exhibit significant changes in viscosity in response to changes in pH. The...
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5595751 |
Absorbable polyoxaesters containing amines and/or amido groups
The present invention describes a new aliphatic polyoxaesters that is bioabsorbable and may be used to produce surgical devices such as sutures, sutures with attached needles, molded devices, and...
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5573773 |
Stable highly concentrated formulations of fluorescein derivatives
The present invention relates to stable highly concentrated formulations of specific fluorescein derivatives, to the preparation of said formulations and the use thereof, especially for the...
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5562653 |
Medical devices composed of low ceiling temperature polymers
The present invention provides shaped medical devices adapted for implant and subsequent in-vivo disintegration within a human or animal body. In one embodiment, the medical device is fabricated...
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5559157 |
Ophthalmic compositions containing vitamin E or ester thereof as an active ingredient
This invention relates to novel aqueous ophthalmic compositions containing vitamin E or ester thereof as an active ingredient, sorbic acid or salts thereof as a preservative, and surfactant. The...
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5556633 |
Drug delivery ophthalmic insert and method for preparing same
A drug delivery ophthalmic insert prepared by forming a water soluble solid polymer into a paste by the addition of a small fixed amount of water, drying the paste and then sectioning the paste...
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5554388 |
Systemic drug delivery compositions comprising a polycationi substance
A composition for administration to the mucosa comprises a pharmacologically active compound and a polycationic substance. The polycationic substance is preferably DEAE-dextran or chitosan and the...
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5550289 |
N-(1,(1-1)-dialkyloxy)-and N-(1,(1-1)-dialkenyloxy alk-1-yl-N-N,N-tetrasubstituted ammonium lipids and uses therefor
This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R 1 and R 2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R...
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5547680 |
Method for preparing a topical, aminocaproic acid containing ophthalmic gel
A topical gel formulation containing aminocaproic acid prevents secondary hemorrhage following hyphema without the adverse side effects associated with systemically delivered aminocaproic acid. Of...
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5543156 |
Bioerodible devices and compositions for diffusional release of agents
The present invention is directed to erodible delivery devices and to the compositions comprising the devices. The devices comprise (a) a body formed of a bioerodible polymer or polymers together...
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5534268 |
Liposomes containing bioavailable iron (II) and process for obtaining them
Liposomes comprising an iron (II) source selected from the group consisting of ferrous sulfate, ferrous lactate and ferrous citrate. The iron source is stabilized in aqueous solutions of reducing...
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5518731 |
Nonaqueous fluorinated drug delivery vehicle suspensions
Nonaqueous pharmaceutical compositions for use in aqueous physiological systems are disclosed comprising drug delivery vehicles suspended in nonaqueous perfluorocarbon or fluorinated silicone...
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5514380 |
Biodegradable hydrogel copolymer as drug delivery matrix
This invention concerns the thermoplastic, biodegradable hydrogel copolymer which is easily degraded and excreted in human body by the hydrolysis of intramolecular ester and amide bond. The...
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5505954 |
Topical gel containing aminocaproic acid applied to the eye
A topical gel formulation containing aminocaproic acid prevents secondary hemorrhage following hyphema without the adverse side effects associated with systemically delivered aminocaproic acid. Of...
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5501856 |
Controlled-release pharmaceutical preparation for intra-ocular implant
Presented are a controlled-release pharmaceutical preparation for intra-ocular implant to be applied to the interior of the eye after a surgical operation for disorders in retina/vitreous body or...
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5492937 |
Gel-forming liquid carrier composition
A carrier composition that is a liquid at or below room temperature forms a high viscosity layer or gel at body temperature, which comprises a water-soluble, nonionic cellulose ether having a cloud...
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5474780 |
Monolithic maleic anhydride drug delivery systems
Erodible bioadhesive drug delivery vehicles for use in delivering pharmaceutical compounds to the eye and similar physiological environments are disclosed. The drug delivery vehicles are formed of...
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5422116 |
Liquid ophthalmic sustained release delivery system
Disclosed is a sustained release liquid aqueous ophthalmic delivery system and a method of providing a slow and sustained release of ophthalmic treating agents to the eye of a mammal which...
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5415863 |
Topical containing aminocaproic acid for preventing secondary hemorrhage following hyphema
A topical gel formulation containing aminocaproic acid prevents secondary hemorrhage following hyphema without the adverse side effects associated with systemically delivered aminocaproic acid. Of...
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5399351 |
Biocompatible viscoelastic gel slurries, their preparation and use
Disclosed are biocompatible viscoelastic gel slurries formed from a polymeric gel, preferably a hyaluronan or a derivative thereof such as hylan swollen in an aqueous medium and a fluid phase which...
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5397567 |
Gel, especially for ophthalmology
An ophthalmologic gel is disclosed having a viscosity in the range of about 10,000 to about 50,000 mPa.s and comprising (1) about 0.05 to about 3% by weight of one or more polyacrylates and (2)...
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5342621 |
Antithrombogenic surface
An anticoagulant releasably associated with a cell membrane mimicking substance is incorporated in a biomedical polymer or polymer coating and serves to both prevent the blood from recognizing the...
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5320906 |
Delivery vehicles with amphiphile-associated active ingredient
Delivery vehicles comprising an outer biocompatible encapsulating layer, an inner amphiphilic active ingredient-associated layer and an active ingredient are described. The delivery vehicles are...
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5320839 |
Topical ophthalmic compositions comprising 4-(3-substituted amino-2-hydroxypropoxy)-1,2,5-thiadiazoles and methods for their use
Topical ophthalmic compositions comprising certain thiadiazoles are useful in the treatment of glaucoma and ocular hypertension. The thiadiazoles are slightly less potent than timolol; however,...
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5316774 |
Blocked polymeric particles having internal pore networks for delivering active substances to selected environments
A composition for the controlled release of an active substance comprises a polymeric particle matrix, where each particle defines a network of internal pores. The active substance is entrapped...
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5308624 |
Ophthalmic product
Ophthalmic product comprising nanocapsules, process for preparing it and application of the nanocapsules. The present invention relates to an ophthalmic product comprising nanocapsules,...
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5292517 |
pH sensitive, reversible gelling, copolymeric erodible drug delivery system
pH sensitive, reversible gelling erodible drug delivery compositions and methods for their production are disclosed. The compositions are liquid solutions of poly(methylvinylether/maleic acid)...
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5292514 |
Azlactone-functional substrates, corneal prostheses, and manufacture and use thereof
Azlactone-functional substrates, (especially hydrogels), mammalian body implants, and methods of making and using them are disclosed. The azlactone-functional substrates are the reaction product of...
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5284657 |
Compositions and methods for the sublingual or buccal administration of therapeutic agents
Pharmaceutical compositions for the sublingual or buccal administration of therapeutic agents (particularly polypeptides) which are normally degraded upon oral administration comprise such a...
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5275820 |
Stable suspension formulations of bioerodible polymer matrix microparticles incorporating drug loaded ion exchange resin particles
Sustained release pharmaceutical compound delivery compositions and methods for their production are disclosed wherein ion exchange resin particles are loaded with releasably bound pharmaceutical...
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5273750 |
Uncrosslinked hydrogel, process for its preparation and its uses as an article for medical and/or surgical purposes such as tubes, films, joints, implants and the like, particularly in ophthalmology
The invention relates to an uncrosslinked hydrogel, its process of preparon as well as its uses as an article for medical and/or surgical purposes such as tubes, filaments, films, joints, implants...
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5268178 |
Biodegradable antibiotic implants and methods of their use in treating and preventing infections
Methods are disclosed for preventing or treating infection in a living patient at the site of a void in the patient's body created by surgery. The methods involve the use of biodegradable...
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5263983 |
Medical material and prosthetic skin in which cells can invade
Disclosed is a cell-penetrable medical material in which cells can invade, comprising denatured collagen with helix content of 0 to 80%, and carrier substance having higher resistance to enzyme...
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