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7618643 |
Growth factor delivery system for the healing of wounds and the prevention of inflammation and disease
The present invention features hydrogel drug delivery systems and methods of producing and using such systems for the treatment of wounds. The systems are based on a hydrogel into which a low...
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7592016 |
Methods for preparing and using implantable substance delivery devices
Method for preparing an implantable device for a sustained delivery of a substance within a body of a human or an animal subject, the method including; dissolving a biocompatible polymer in a...
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7584630 |
Photochromic ocular devices
Described are photochromic ocular devices such as contact lenses and intraocular lenses made of an organic polymeric material and at least one photochromic material capable upon exposure to actinic...
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7569212 |
Procedure and composition of treatment and/or care of the eye
A procedure for the manufacture of contact lenses for eye treatment, eye protection and eye-care wherein the lenses are impregnated with a suitable composition, a composition for the impregnation...
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7559949 |
Injectable intraocular lens that minimizes posterior capsule opacification and methods and materials for realizing same
Polymeric materials and methods that realize a gel-type intraocular lens that is formed in situ within the lens capsule of the eye. The polymeric material of the intraocular lens includes reactive...
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7556822 |
Biomedical compositions
A method of preparing intraocular lenses in situ is disclosed. The method involves the injection of an unsaturated macromonomer of Formula I:
The macromonomer is then polymerized to give a...
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7553496 |
VEGF-A as an inhibitor of angiogenesis and methods of using same
The invention relates to methods and compositions for the treatment or prevention of ocular angiogenesis and neovascularization associated with neovascular disease. Administration of vascular...
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7553486 |
Anti-VEGF treatment for radiation-induced vasculopathy
An anti-VEGF method for treating undesirable conditions resulting from radiation-induced vasculopathy. In a specific application, the method is applied to these undesirable conditions found in an eye.
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7547447 |
Bioartificial lacrimal gland
The present invention provides a bioartificial lacrimal gland which contains at least one unit that includes (a) a permeable housing having an interior and an exterior; (b) an outlet connecting the...
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7547445 |
Crosslinkable macromers
A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue...
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7544371 |
Drug delivery systems
Matrix controlled diffusion drug delivery systems based on one or more silicone-containing monomers of the general formula:
wherein x, y, m, m′, R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 ,...
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7544368 |
Structure for modulating intraocular pressure
Embodiments of the present invention are directed to three-dimensional porous structures for modulating intraocular pressure. The structures can include a mixture of copolymers, for example,...
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7476398 |
Corneal implant and uses thereof
A membrane for corneal implant or keratoprosthesis comprising a biological polymer and a polyacrylamide is described. The mixture of both polymers produces a hydrogel that becomes a transparent...
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7455855 |
Delivering substance and drug delivery system using the same
An object of the present invention is to prepare substances which are excellent in delivery and enable drugs to be retained in a body effectively over a long period and to construct a drug delivery...
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7445777 |
Enzymatic treatment of retinitis pigmentosis
A pharmaceutical kit for treatment of retinitis pigmentosis and a method of producing the same, the kit comprising the enzymes glutathione peroxidase, prolidase, glucose-6-phosephate dehydrogenase...
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7384648 |
Implant device with a retinoid for improved biocompatibility
An implant device is provided which incorporates a retinoid for improving the biocompatibility of the device in tissue. The device may be bioerodible for the purpose of systemically or locally...
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7368127 |
Biomedical devices with peptide containing coatings
Biomedical devices with stable peptide coatings are provided. The coatings are formed by incorporating at least one latent reactive component into the reactive mixture, forming a medical device...
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7351430 |
Shape-retentive hydrogel particle aggregates and their uses
The present invention is related to hydrogel particles and aggregates formed therefrom having characteristics including, without limitation, shape-retentiveness, elasticity, controllable pore sizes...
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7351407 |
Agents which regulate, inhibit, or modulate the activity and/or expression of connective tissue growth factor (CTGF) as a unique means to both lower intraocular pressure and treat glaucomatous retinopathies/optic neuropathies
The present invention provides a method for lowering intraocular pressure and providing neuroprotection to a patient in need thereof by administering a therapeutically effective amount of at least...
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7348022 |
Biomedical composition
A method of preparing intraocular lenses in situ is disclosed. The method involves the injection of an unsaturated macromonomer of the formula
The macromonomer is then polymerized to give a...
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7338665 |
Methods compositions and devices utilizing stinging cells/capsules for delivering a therapeutic or a cosmetic agent into a tissue
A delivery device including at least one stinging capsule and methods of use are described.
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7332177 |
Method and formulation for treating resistance to antihypertensives and related conditions
A method for the prevention or treatment of symptoms of hypertension in a patient who is resistant to antihypertensive effects of an antihypertensive compound administered in the absence of...
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7326423 |
Copolymerizable azo compounds and articles containing them
Polymerizable light absorbing azo dyes are disclosed useful as monomers in the formation of devices such as, but not limited to ocular lenses. Specifically, intraocular lenses (IOL) are disclosed...
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7316816 |
Temperature and pH sensitive copolymers
The invention is directed to a copolymer comprising at least three types of monomeric units, said three types of monomeric units comprising:
a temperature-sensitive unit, a hydrophilic unit,...
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7282214 |
Biomedical devices with antimicrobial coatings
Biomedical devices with antimicrobial coatings are provided. One or more surfaces of the device are coated with a cationic peptide, cationic proteins, or mixtures thereof to impart antimicrobial...
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7276050 |
Trans-scleral drug delivery method and apparatus
A method of treating ocular disorders involving angiogenesis includes the steps of providing a trans-scleral drug delivery device comprising an insert stabilizer for attachment to a scleral surface...
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7247702 |
Periocular drug delivery for diabetic retinopathy
This invention provides reagents and methods for delivering insulin, insulinomimetic agents, and the like to a vertebrate eye via subconjunctival routes, sub-Tenon's routes, or intravitreal routes...
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7229634 |
Engineered proteins, and methods of making and using
The present invention provides engineered proteins and biomedical products made from the engineered proteins. The biomedical products include lenses useful for ophthalmic purposes.
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7223744 |
Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof
The present invention provides a method of treating edematous retinal disorders. The method comprises administration of a pharmaceutical formulation comprising a hydrolysis-resistant P2Y receptor...
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7211272 |
Drug delivery device
A drug delivery device for placement in the eye includes a drug core comprising a pharmaceutically active agent, and a holder that holds the drug core. The holder is made of a material impermeable...
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7204995 |
Treatment and control of dry eye by use of biodegradable polymer capsules
A treatment for dry eye and other eye problems using a plug system or a delivery system. The plug system comprises solid, porous or hollow microcapsules composed of a biodegradable biocompatible...
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7195774 |
Implantable and sealable system for unidirectional delivery of therapeutic agents to tissues
A surgically implantable and sealable delivery device that upon contact of its contents via an interface window or port therein with an organ or tissue exposes a therapeutic agent to the organ or...
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7192607 |
Formulations for the prevention or the treatment of diseases affecting mucosae or skin, or for pregnancy prevention, and an applicator for the delivery of topical formulations into mucosal cavities
This invention relates to formulations for the prevention of infection and/or abnormal conditions of mucosae and/or skin caused by any pathogen and/or any disease, and more particularly for the...
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7169767 |
Ophthalmic compositions containing galactomannan polymers and borate
The present invention is directed to ophthalmic compositions containing a gelling amount of a combination of galactomannan polysaccharides and borates. The compositions gel or partially gel upon...
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7169406 |
Growth factor delivery systems for the healing of wounds and the prevention of inflammation and disease
The present invention features hydrogel drug delivery systems and methods of producing and using such systems for the treatment of wounds. The systems are based on a hydrogel into which a low...
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7147865 |
Artificial synapse chip
Devices and methods are provided for administering a fluid to a neuronal site. The device comprises a reservoir, an aperture in fluid connection to the reservoir, and electrical means for moving to...
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7141248 |
Methods of producing intraocular lenses
Methods of producing an intraocular lens include introducing a solution into a lens forming enclosure, wherein the solution comprises discrete crosslinkable units of a size small enough to provide...
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7138135 |
Bioadhesive, closed-cell foam film, sustained release, delivery devices and methods of making and using same
Bioadhesive, closed-cell foam film, sustained release, delivery devices for administering an active agent or combination of active agents to a subject are provided. Methods for making such delivery...
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7135172 |
Bucky paper as a support membrane in retinal cell transplantation
A method for repairing a retinal system of an eye, using bucky paper on which a plurality of retina pigment epithelial cells and/or iris pigment epithelial cells and/or stem cells is deposited,...
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7132410 |
Di(uridine 5′-)tetraphosphate and salts thereof
The present invention are directed to P 1 , P 4 -di(uridine 5′-)tetraphosphate, tetra-alkali metal salts such as tetrasodium, tetralithium, tetrapotassium, and mixed tetra-alkali metal cations...
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7128928 |
Ophthalmic formulation with novel gum composition
There is provided a pharmaceutical composition suitable for topical administration to an eye, the composition comprising (a) a pharmacologically effective concentration of an active agent and (b) a...
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7108718 |
Gold eyelid weight implant
An eyelid implant for implanting in an upper eyelid of a person having a main body with a water-drop shape. The main body has a head end with a center of gravity at substantially a center point...
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7105352 |
Intelligent polymerized crystalline colloidal array carbohydrate sensors
The present invention is related to glucose sensors that are capable of detecting the concentration or level of glucose in a solution or fluid having either low or high ionic strength. The glucose...
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7087237 |
Ocular solutions
Containing at least one macrolide antibiotic and/or mycophenolic acid provide anti-inflammatory, anti-cell proliferation, anti-cell migration, anti-angiogenesis, antimicrobial, and antifungal...
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7087222 |
Method for enhancing integrity of epithelium using retinoic acid
A method for improving the integrity of the corneal epithelium by introducing into the eye an effective amount of a ophthalmically compatible retinoid sufficient to enhance the integrity of the...
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7083803 |
Ocular solutions
Ocular solutions containing at least one macrolide antibiotic and/or mycophenolic acid provide anti-inflammatory, anti-cell proliferation, anti-cell migration, anti-angiogenesis, antimicrobial and...
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7078391 |
Method of treating edematous retinal disorders
The present invention provides a method of treating edematous retinal disorders. The method comprises administration of a pharmaceutical formulation comprising a hydrolysis-resistant P2Y receptor...
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7066955 |
High refractive index compositions useful for intraocular lenses and methods for making same
An intraocular lens suitable for implantation into an eye has an optically clear, deformable lens body composed of a silicone polymer and a silica reinforcer that structurally reinforces the...
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7060288 |
Biomedical devices
The present invention is concerned with biomedical device comprising
(a) a biocompatible organic or inorganic bulk material and (b) a coating comprising polymerizable carbon-carbon double...
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7056893 |
Topical treatment for prevention of ocular infections
Azalide antibiotics such as azithromycin are useful in the treatment and prevention of infections by bacteria and other parasites. Stabilized aqueous compositions containing azithromycin suitable...
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