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5631017 |
Topical application of buspirone for treatment of pathological conditions associated with immune responses
A method for the treatment of a cutaneous, ocular, or mucosal pathological condition which is associated with an immune response in a human or other mammal, that includes topical application of an...
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5631243 |
Collagen-based viscoelastic solution for visco-surgery
The present invention relates to a method of treating a patient with visco-surgery, particularly ocular visco-surgery, utilizing a collagen-based viscoelastic solution having a reversibly high...
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5622712 |
N-[ω, (ω-1)-dialkyloxy]- and N-[ω, (ω-1)-dialkenyloxy]-alk-1-yl-N, N, N-tetrasubstituted ammonium lipids and uses therefor
This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R 1 and R 2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R...
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5620699 |
Method for delivering nonaqueous fluorinated drug delivery vehicle suspensions
Nonaqueous pharmaceutical compositions for use in aqueous physiological systems are disclosed comprising drug delivery vehicles suspended in nonaqueous perfluorocarbon or fluorinated silicone...
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5618550 |
Method for treatment of abnormal conditions of the epithelium of bodily orifices
A stable solution, cream, salve, or spray composition containing activated stabilized chlorine dioxide and phosphates, such as disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium...
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5618274 |
Method and device for deep pressurized topical, fornix applied "nerve block" anesthesia
There is provided a method for applying anesthetic to the eye organ during anterior segment or other ophthalmological surgeries. The method comprises the steps of placing a moisture absorbent...
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5601844 |
Sustained release medicinal preparation
A sustained release medicinal preparation is produced by enclosing a macrocyclic compound represented by 17-allyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl
)-1-methylviny...
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5599534 |
Reversible gel-forming composition for sustained delivery of bio-affecting substances, and method of use
Reversibly gel-forming compositions for sustained delivery of bio-affecting substances are disclosed. The compositions exhibit significant changes in viscosity in response to changes in pH. The...
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5593683 |
Method of making thermoreversible polyoxyalkylene gels
Compositions based upon aqueous gels for medical application, comprising polyoxyalkylene copolymers. Such gels which are isotonic, iso-osmotic, pH balanced, thermo-reversible gels are ideal...
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5589185 |
Pharmaceutical compositions and methods of treatment of the cornea following laser irradiation
Methods for treating the cornea following UV laser irradiation and resulting photoablation of corneal tissue are disclosed. The methods include administration of compositions of a non-steroidal...
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5576013 |
Treating vascular and neoplastic tissues
Lesions supplied by abnormal aggregations of vascular tissue or neovascular tissues are treated with photodynamic therapy by application of photosensitizing agent followed by precisely directed and...
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5573773 |
Stable highly concentrated formulations of fluorescein derivatives
The present invention relates to stable highly concentrated formulations of specific fluorescein derivatives, to the preparation of said formulations and the use thereof, especially for the...
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5573774 |
Nicotine metabolites, nicotine dependence and human body weight
A therapeutic method is provided to alleviate the tobacco withdrawal syndrome, the symptoms of nicotine withdrawal or the management of human body weight in nicotine-experienced or nicotine-naive...
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5563496 |
Battery monitoring and charging control unit
A unit that can be a tiny module within a battery pack includes a microprocessor operating through onboard sensors and read circuitry to monitor battery current, voltage and temperature and to...
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5562922 |
Drug incorporating and release polymeric coating for bioprosthesis
In accordance with the present invention, there are provided prosthetic articles having polyurethane coatings with biologically active compounds incorporated within the interstices of the polymer....
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5558876 |
Topical ophthalmic acidic drug formulations
Stable, comfortable, preserved, topical, ophthalmic compositions of acidic drugs are disclosed. Methods for their use are also disclosed.
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5559157 |
Ophthalmic compositions containing vitamin E or ester thereof as an active ingredient
This invention relates to novel aqueous ophthalmic compositions containing vitamin E or ester thereof as an active ingredient, sorbic acid or salts thereof as a preservative, and surfactant. The...
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5556633 |
Drug delivery ophthalmic insert and method for preparing same
A drug delivery ophthalmic insert prepared by forming a water soluble solid polymer into a paste by the addition of a small fixed amount of water, drying the paste and then sectioning the paste...
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5554187 |
Medication dispensing intra-ocular lens system
Medication dispensing intra-ocular lens system for implantation into an eye. An implantable intra-ocular lens includes a carrier medium disposed on a surface of the lens. A biologically active...
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5550289 |
N-(1,(1-1)-dialkyloxy)-and N-(1,(1-1)-dialkenyloxy alk-1-yl-N-N,N-tetrasubstituted ammonium lipids and uses therefor
This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R 1 and R 2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R...
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5547680 |
Method for preparing a topical, aminocaproic acid containing ophthalmic gel
A topical gel formulation containing aminocaproic acid prevents secondary hemorrhage following hyphema without the adverse side effects associated with systemically delivered aminocaproic acid. Of...
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5540930 |
Suspension of loteprednol etabonate for ear, eye, or nose treatment
The invention provides novel compositions of matter containing water-insoluble steroid drugs suitable for therapeutic use. The invention provides stable aqueous suspensions of water-insoluble...
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5529986 |
Conjugate, its preparation and use and a substrate prepared with the conjugate
The present invention relates to a water-soluble conjugate having antithrombin-binding activity comprising a substantially straight-chained organic polymer backbone having at least 30 molecules of...
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5527533 |
Method of retarding and ameliorating central nervous system and eye damage
A method of retarding and ameliorating eye diseases and injuries is disclosed. The method comprises administering astaxanthin in a therapeutically-effective amount to prevent, retard or treat eye...
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5525349 |
Compositions and methods for treating the cornea inconjunction with laser irradiation
Methods for preventing and treating corneal haze resulting from exposure of the eye to laser irradiation are disclosed. The methods include administration of compositions of wound healing...
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5518732 |
Bio-erodible ophthalmic shield
Bio-erodible ophthalmic shields comprising gelatin, a glycosaminoglycan (for example chondroitin sulfate) and carboxymethyl cellulose, and a method of treating a traumatized or "dry" eye by...
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5518731 |
Nonaqueous fluorinated drug delivery vehicle suspensions
Nonaqueous pharmaceutical compositions for use in aqueous physiological systems are disclosed comprising drug delivery vehicles suspended in nonaqueous perfluorocarbon or fluorinated silicone...
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5516522 |
Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same
A biodegradable porous drug delivery device for controllably releasing a pharmacological agent is disclosed which comprises a hollow tube closed at both ends having an interior surface and an...
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5505954 |
Topical gel containing aminocaproic acid applied to the eye
A topical gel formulation containing aminocaproic acid prevents secondary hemorrhage following hyphema without the adverse side effects associated with systemically delivered aminocaproic acid. Of...
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5505964 |
Liquid contact lens
Compositions useful to at least partially correct an effect of ametropia in a mammalian eye are disclosed. Such compositions comprise a plurality of particles sized and adapted to be placed in...
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5501856 |
Controlled-release pharmaceutical preparation for intra-ocular implant
Presented are a controlled-release pharmaceutical preparation for intra-ocular implant to be applied to the interior of the eye after a surgical operation for disorders in retina/vitreous body or...
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5498419 |
Fumarate salt of 4-(diethyl-3-(1-methyloctyl)-7,8,9,10-tetrahydro-6,6,9-trimethyl-6H-dibe nzo[b,d]pyran-1-ol, 4-(diethyl-amino) butyric
The present invention provides the fumarate salt of 4-(diethyl-3-(1-methyloctyl)-7,8,9,10-tetrahydro-6,6,9-trime
thyl-6H-dibenz o[b,d]pyran-1-ol, 4-diethyl-amino)butyric acid ester, i.e. the...
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5496564 |
Suspendible composition and process for preparing the same
A suspendible composition comprising a tricyclic compound such as FK 506 substance which is 17-allyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl
)-1-methylviny...
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5489435 |
Composition for treatment of abnormal conditions of the epithelium of bodily orifices
A stable solution, cream, salve, or spray composition containing activated stabilized chlorine dioxide and phosphates, such as disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium...
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5476515 |
Method of making intraocular lenses with injectable collagen-based compositions
Injectable collagen-based compositions can be used in methods to fill a lens capsular sac, following lens extraction procedures, to form a new intraocular lens. Purified soluble or partially...
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5476511 |
Subconjunctival implants for ocular drug delivery
A system for providing controlled release of an active agent in an eye includes a device with a shape thereof for enabling placement of the device under a conjunctiva of an eye and additionally...
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5472703 |
Ophthalmic lens with anti-toxin agent
An ophthalmic lens for placement on the anterior surface of the eye is disclosed. The lens has impregnated in it or it has coated on its surface an ester of a polyhydric aliphatic alcohol and a...
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5472436 |
Ocular appliance for delivering medication
A device for delivering an anesthetic to the eye, comprising a thin, porous, substantially planar annular body. The inner diameter of the device is slightly greater than the diameter of the limbus...
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5466461 |
Polysaccharide esters
New polysaccharide esters are disclosed, and more precisely esters of acidic polysaccharides chosen from the group formed by carboxymethylcellulose, carboxymethyl starch and carboxymethylchitin....
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5462739 |
Microdelivery device and method for enhanced drug administration to the eye
A device for pinpoint application of micro-quantities of a pharmacologically suitable composition to the outer hard coat of the eye, comprises a micro-container with a fixation element. The...
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5435998 |
Treatment of low-tension glaucoma by topical administration of calcium channel blocking agents
Low-tension glaucoma is treated by topical administration to the eye of an amount of a calcium channel blocking agent effective to increase blood flow to the optic nerve head. Calcium channel...
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5431907 |
Treatment of vascular disorders of the posterior segment of the eye by topical administration of calcium channel blocking agents
Ischemic disorders of the retina and associated tissues of the posterior segment of the eye are treated by topical administration to the eye of an amount of a calcium channel blocking agent...
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5422116 |
Liquid ophthalmic sustained release delivery system
Disclosed is a sustained release liquid aqueous ophthalmic delivery system and a method of providing a slow and sustained release of ophthalmic treating agents to the eye of a mammal which...
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5415863 |
Topical containing aminocaproic acid for preventing secondary hemorrhage following hyphema
A topical gel formulation containing aminocaproic acid prevents secondary hemorrhage following hyphema without the adverse side effects associated with systemically delivered aminocaproic acid. Of...
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5411952 |
Ocular cyclosporine composition
Cyclosporine compositions for topical ophthalmic use for treatment of immune disorders, to enhance or restore tear production, and to enhance or effect normal healing of the surface of the eye,...
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5401508 |
Hydrogel compositions and structures made from same
A hydrogel composition is disclosed which comprises water and a copolymer. In one embodiment, the copolymer is formed by reacting about 85% to about 99% by weight of at least one member selected...
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5399351 |
Biocompatible viscoelastic gel slurries, their preparation and use
Disclosed are biocompatible viscoelastic gel slurries formed from a polymeric gel, preferably a hyaluronan or a derivative thereof such as hylan swollen in an aqueous medium and a fluid phase which...
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5397567 |
Gel, especially for ophthalmology
An ophthalmologic gel is disclosed having a viscosity in the range of about 10,000 to about 50,000 mPa.s and comprising (1) about 0.05 to about 3% by weight of one or more polyacrylates and (2)...
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5380303 |
Method for using an antimicrobial agent for ophthalmic formulations
A disinfectant or preservative composition particularly adapted for use in ophthalmic preparations such as contact lens disinfecting, cleaning, cushioning, wetting, soaking and reconditioning...
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5378475 |
Sustained release drug delivery devices
A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained...
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