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6649184 |
Device and method for treating ophthalmic diseases
The invention provides a method for delivering biologically active molecules to the eye by implanting biocompatible capsules containing a cellular source of the biologically active molecule. Also...
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6645978 |
Lipoxin A4 and its analogs for the treatment of dry eye
Ophthalmic compositions containing Lipoxin A 4 and its analogs and methods of their use for treating dry eve are disclosed.
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6641834 |
Compositions containing alpha-2-adrenergic agonist components
Compositions useful for improving effectiveness of alpha-2-adrenergic agonist components include carrier components, alpha-2-adrenergic agonist components, solubility enhancing components which aid...
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6627210 |
Compositions containing α-2-adrenergic agonist components
Compositions useful for improving effectiveness of alpha-2-adrenergic agonist components include carrier components, alpha-2-adrenergic agonist components, solubility enhancing components which aid...
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6623767 |
Mixture containing honey, at least one essential oil and/or at least one essential oil derivative
The invention relates to a formulation comprising honey, at least one essential oil and/or at least on essential oil derivative. It also relates to the different uses of said formulation in the...
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6616941 |
Polymeric composition for solubilizing poorly water soluble drugs and process for the preparation thereof
A composition capable of forming a micelle in body fluids or in an aqueous medium and that can be injected into the body undiluted or as a diluted solution in an aqueous medium and method of...
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6616944 |
Self-assembling colloidal carriers for protein delivery
The invention is directed to self-assembling, polymer-based delivery systems for proteins. The delivery systems comprises an active agent and a polyol ester of the invention, having a linear polyol...
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6613343 |
Injectable intraocular accommodating lens
The present invention relates to compositions comprising polysiloxanes suitable for the preparation of accommodating intraocular lenses, having a specific gravity of greater than about 1.0, a...
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6613358 |
Sustained-release composition including amorphous polymer
Provided is a sustained release composition for sustained release of a pharmaceutical substance. The composition includes a biocompatible polymer that is highly amorphous and a pharmaceutical...
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6610318 |
Sterile ophthalmological gel preparation applicable in drops and process for producing it
The invention relates to a sterile ophthalmic drop preparation, especially a gel preparation, which comprises a two-phase carrier liquid or gel basis comprising a liquid aqueous and a liquid...
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6605295 |
Storage-stable ophthalmic compositions comprising diclofenac and ofloxacin
The invention relates to stable ophthalmic preparations including the penetrant antiphlogistic diclofenac or salts thereof and the penetrant antibiotic ofloxacin present in the form of the...
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6592894 |
Hydrogel-isolated cochleate formulations, process of preparation and their use for the delivery of biologically relevant molecules
A process for producing a small-sized, lipid-based cochleate. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential...
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6589550 |
Methods of producing intraocular lenses and materials suitable for their production
A method for producing an intraocular lens, comprising the steps of injecting a high-refractive index, low viscosity composition of crosslinkable units into an enclosure and initiating...
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6582718 |
Cyclosporin compositions
An ophthalmic composition particularly in the form of eye-drops suitable for the treatment of diseases of the eye and surrounding areas. The composition contains a cyclosporin and a surfactant...
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6582720 |
Medicinal compositions adhering to stomach/duodenum
The present invention provides a gastric and/or duodenal adhesive pharmaceutical composition obtained by coating a composition, which comprises a medicament acting at the stomach and/or duodenum...
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6579276 |
Ocular iontophoretic device and method for inhibiting vascular endothelial growth factor (VEGF) using the same
An ocular iontophoretic device for delivering an aptamer to an affected area of a living being's eye for inhibiting VEGF function therein, the device comprising an active electrode assembly...
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6569443 |
Topical treatment or prevention of ocular infections
The topical application of an azalide antibiotic such as azithromycin to the eye is useful in treating or preventing ocular infections. In one embodiment, the azalide antibiotic is supplied to the...
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6569463 |
Solid carriers for improved delivery of hydrophobic active ingredients in pharmaceutical compositions
The present invention provides solid pharmaceutical compositions for improved delivery of a wide variety of pharmaceutical active ingredients contained therein or separately administered. In one...
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6565889 |
Bilayer structure which encapsulates multiple containment units and uses thereof
The present invention provides compositions and methods of preparing a bilayer structure for encapsulating multiple containment units. These containment units can contain therapeutic, diagnostic...
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6558688 |
Ocular tissue regeneration inducer
The invention relates to an ocular tissue regeneration inducer which comprises, as an active ingredient, a hydrophilic polymer mainly composed of alkylene glycol units or vinyl monomeric units...
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6555582 |
Eye treatments using synthetic thyroid hormone compositions
The present invention involves the discovery that synthetic thyroid hormones can be used as compositions to reduce intraocular pressure in vivo. Methods of screening synthetic thyroid hormones for...
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6548078 |
Method for treating and/or preventing retinal diseases with sustained release corticosteroids
The present invention relates to a method for administering a corticosteroid to a posterior segment of an eye. In the method, a sustained release device is implanted to deliver the corticosteroid...
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6548053 |
Control of intra-ocular pressure
A method of reducing intra-ocular pressure (IOP) in a patient afflicted with elevated IOP is disclosed. The method comprises the step of administering (preferably topically to an afflicted eye) to...
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6546283 |
High current density iontophoretic device and method of use thereof
A high current density iontophoretic device, comprising a reservoir, an applicator, an orientation maintaining member and an iontophoretic medicament administering member. The reservoir is capable...
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6541028 |
Methods for promoting healing of corneal resurfacing wounds
The present invention provides methods for promoting healing of wounds which result from corneal resurfacing procedures, e.g. from laser surgery to alter refractive of the eye. The methods involve...
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6537549 |
Cytokine antagonists for the treatment of localized disorders
Cytokine antagonists for use in localized clinical disorders are provided for the treatment and prevention of damage to the optic nerve, other cranial nerves, spinal cord, nerve roots, peripheral...
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6537545 |
Use of corneal hardening agents in enzymeorthokeratology
An Enzyme Orthokeratology method is provided for correcting refractive errors in the eye of a subject mammal. Accelerating reshaping of the cornea is accomplished by administering a corneal...
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6534082 |
Method of treating disorders of the eye
The present invention relates, in general, to methods of treating disorders of the eye, and, in particular, to methods of preventing or treating elevated eye pressure and glaucoma. The invention...
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6524602 |
Polymer delivery system in treatments for parasitic skin diseases
A formulation for the treatment of a parasitic skin disease includes a parasiticide to kill the parasite. The formulation also includes a polymer effective to increase retention of the formulation...
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6514518 |
Dosage forms exhibiting multi-phasic release kinetics and methods of manufacture thereof
Dosage forms prepared by solid free form fabrication (SFF) provide release of medicament in multiple phases.
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6500461 |
Particulate formulations
This invention provides vehicles capable of delivering high concentrations of poorly hydrophilic/poorly lipophilic compounds to animals, by combining compounds having biocompatible hydrophobic...
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6497887 |
Membrane delivery system
The present invention relates to a delivery system for topical application to the skin comprising a freeze-dried, partially cross-linked polymeric gel membrane which can be reversibly returned to a...
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6488938 |
Polylactic acid scleral plug
A scleral plug which releases a drug accurately in a specified amount. The scleral plug is formed from a blend of a high-molecular weight polylactic acid having a molecular weight of 40,000 or...
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6482428 |
Weighted eyelid implant
A weighted upper eyelid implants for assisting and achieving complete eyelid closure and partial recreation of a natural blinking reflex. The implant is formed of a main plate having suture...
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6475508 |
Methods and pharmaceutical compositions for the closure of retinal breaks
Described are compositions, methods, and articles of manufacture for the closure of retinal breaks with a non-toxic polymer. Transformation to a gel-like coat is achieved by photochemical...
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6458376 |
Nonaqueous fluorinated drug delivery suspensions
Nonaqueous pharmaceutical compositions for use in aqueous physiological systems are disclosed comprising drug delivery suspension of nonaqueous perfluorocarbon or fluorinated silicone liquid...
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6432440 |
Pectin compositions and methods of use for improved delivery of drugs to mucosal surfaces
Liquid pharmaceutical compositions for administration to a mucosal surface, comprising a therapeutic agent and a pectin with a low degree of esterification are described. Such compositions gel, or...
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6432439 |
O/W emulsion composition
An O/W emulsion composition comprising fluorometholone or clobetasone butyrate, a phospholipid, an oil, a nonionic water-soluble cellulose derivative, and water. The O/W composition has advantages...
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6423321 |
Cytokine antagonists for the treatment of sensorineural hearing loss
Specific Cytokine Antagonists, including TNF antagonists and/or Interleukin-1 antagonists, are used as novel therapeutic agents for the treatment of hearing loss, including presbycusis and other...
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6419946 |
Nanoemulsion based on mixed esters of a fatty acid or of a fatty alcohol, of a carboxylic acid and of a glycerol and its uses in the cosmetics, dermatological and/or ophthalmological fields
A nanoemulsion, the oil globules of which have a number-average size of less than 100 nm, comprising a surfactant chosen from mixed esters of a fatty acid or of a fatty alcohol, of a carboxylic...
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6419934 |
TNF modulators for treating neurological disorders associated with viral infection
A method for inhibiting the action of TNF for treating neurological conditions in a human by administering a TNF antagonist for reducing the inflammation of neuronal tissue of said human, or for...
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6413527 |
Nanoemulsion based on alkyl ether citrates and its uses in the cosmetics, dermatological, pharmacological and/or ophthalmological fields
A nanoemulsion, the oil globules of which have an average size of less than 100 nm, comprising an anionic surfactant chosen from alkyl ether citrates and at least one oil having a molecular weight...
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6410046 |
Administering pharmaceuticals to the mammalian central nervous system
A device, methods and pharmaceutical compositions are disclosed for transnasal or transocular drug delivery to the central nervous system using a combination of electrotransport or phonophoresis...
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6410006 |
Composition for prophylaxis and/or treatment of dry eye syndrome comprising vitamin D
An ophthalmic composition for prophylaxis and/or treatment of keratoconjunctivitis sicca, which is locally administered to the eyes and which comprises, as an effective component, at least one...
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6395294 |
Method of visualization of the vitreous during vitrectomy
A composition for rendering a vitreous cavity visible during a surgical procedure to alleviate a structural disorder caused by the vitreous in an eye, and a method of using the composition. The...
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6379692 |
Pharmaceutical composition comprising a suspension for the active ingredient
A pharmaceutical formulation may be prepared by a method comprising providing the active ingredient in solution in a pharmacologically-acceptable base and mixing the resulting solution with a...
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6375972 |
Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained...
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6375973 |
Ophthalmic anti-allergy compositions suitable for use with contact lenses
Topically administrable anti-allergy compositions comprising olopatadine and a polymeric quaternary ammonium preservative are suitable for use by patients wearing contact lenses.
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6372245 |
Plasticized bioerodible controlled delivery system
A controlled release medicament delivery system comprises a plasticized bioerodible polymer, such as a polyorthoester. Medicament desirably is entrapped in the plasticized polymer. The resulting...
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6368614 |
Biological material, method of preparing such materials
A biological material is prepared for use in ophthalmology by steps of providing animal pericardium, subjecting the animal pericardium to multiple steps of freezing and thawing in a salt solution...
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