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9040073 Silk polymer-based adenosine release: therapeutic potential for epilepsy  
The invention provides formulations comprising adenosine in a silk fibroin-based, sustained-release delivery system. The formulations provide sustained, focal release of adenosine at therapeutic...
9040074 Material and method for treating internal cavities  
A hydrophilic biocompatible sustained-release material is disclosed. The material comprises amounts of Pluronic F-127, PEG-400, HPMC and water, effective to produce a composition of sufficiently...
9040072 Use of coupling agents to improve the interface in absorbable polymer composites  
A composite having a poly(ethylene-co-acrylic acid) coupling agent, a filler, and a biocompatible, biodegradable polymer matrix is disclosed. The composites are useful for biomedical applications...
9028871 Resorbable ceramics with controlled strength loss rates  
Particular aspects provide bioresorbable and biocompatible compositions for bioengineering, restoring or regenerating tissue or bone, comprising a three-dimensional porous or non-porous scaffold...
9028859 Phase-separated block copolymer coatings for implantable medical devices  
Medical devices and coatings for medical devices are disclosed, including methods for forming the devices and coatings. The devices and coatings comprise a phase-separated block copolymer matrix...
9023379 Biodegradable tissue composition with biodegradable cross-linkers  
Novel implantable tissue fixation methods and compositions are disclosed. Methods and compositions of tissue, fixed using polymeric and/or variable length crosslinks, and di- or polymercapto...
9017713 Magnetic carrier and medical preparation for controllable delivery and release of active substances, methods of their production and methods of treatment using thereof  
The present invention relates to magnetic carriers and medical preparations for controllable delivery and release of active substances. The carrier for active substances comprises material A,...
9017714 Nerve regeneration-inducing tube  
A nerve regeneration-inducing tube is provided which is excellent in cell growth property, resistance to pressure, shape recovery property, and anti-kink property in a nerve regeneration-inducing...
9017715 Prevention of molecular weight reduction of the polymer, impurity formation and gelling in polymer compositions  
Polymer and drug containing compositions and method of preparing such compositions are disclosed. The dispersed phase formulation has a polymer, a pharmaceutically or biologically active agent and...
9017709 Composition comprising polymeric, water-insoluble, anionic particles, processes and uses  
The present invention relates to an injectable composition which comprises polymeric, water-insoluble, non-biodegradable, anionic particles, these particles having an irregular shape and a...
9012594 Catalyst and byproduct-free native chemical ligation using cyclic thioester precursors  
A method of synthesizing a biocompatible hydrogel by covalently cross-linking an effective amount of a first macromonomer including a cyclic thioester group with an effective amount of a second...
9011411 Methods for treatment of bladder cancer  
Apparatus and methods for treatment of an internal cavity are provided. The internal cavity is coated with a treatment solution. The treatment solution can include a solidifiable matrix with or...
8999377 System for forming a biocompatible foam using polymerizable alpha(1-4)glucopyranose polymers and gas-producing component  
Biocompatible foams having excellent physical and chemical properties are described. The biocompatible foams can be formed in situ or applied as a pre-formed foam for the treatment of tissue. The...
8999368 Medical devices and methods including polymers having biologically active agents therein  
The implant design is a drug loaded polymer device, such as a rod, designed to control the release of a biologically active agent, such as clonidine or its derivatives, such as clonidine HCl for a...
8999369 Method of making polymer-bioceramic composite implantable medical devices from a suspension solution of bioceramic particles  
Methods and devices relating to polymer-bioceramic composite implantable medical devices, such as stents are disclosed. A suspension solution is formed including a fluid, a biodegradable polymer,...
8992965 Bone matrix compositions and methods  
An osteoinductive composition, corresponding osteoimplants, and methods for making the osteoinductive composition are disclosed. The osteoinductive composition comprises osteoinductive factors,...
8992968 Composite absorbable/biodegradable rings for controlled drug delivery  
A fiber-reinforced composite ring for the controlled release of at least one bioactive agent includes a biocompatible matrix reinforced with absorbable/biodegradable fibers capable of providing...
8992966 Artificial bone capable of being absorbed and replaced by autogenous bone and its production method  
An artificial bone capable of being absorbed and replaced by an autogenous bone, which comprises a cylindrical body comprising at least an apatite/collagen composite layer and a collagen layer.
8992967 Poly (diol-co-citrate) hydroxyapatite composite for tissue engineering and orthopaedic fixation devices  
The present invention is directed to a novel poly(diol citrates)-based bioceramic composite materials created using completely biodegradable and a bioceramic material polymers that may be used in...
8992512 Medical devices having polymeric regions with copolymers containing hydrocarbon and heteroatom-containing monomeric species  
According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions. These polymeric regions, in turn, contain one...
8986728 Soluble implantable device comprising polyelectrolyte with hydrophobic counterions  
The present invention provides an implantable device having a biosoluble coating or a biosoluble body structure comprising a polyelectrolyte and a counterion and the methods of making and using...
8986724 Nitric oxide generating medical devices  
Medical devices having a catalyst capable of catalyzing the generation of nitric oxide in vivo and methods of treating a vascular condition using the devices are provided.
8980300 Plasticizers for coating compositions  
A biocompatible plasticizer useful for forming a coating composition with a biocompatible polymer is provided. The coating composition may also include a biobeneficial polymer and/or a bioactive...
8980317 Methods and compositions for treating infections comprising a local anesthetic  
The present invention is directed to a drug depot useful for reducing, preventing or treating an infection in a patient in need of such treatment. The drug depot includes a polymer and a...
8980302 Therapeutic implant  
Surgical implants of the present disclosed include a film comprising a first therapeutic agent and a mesh comprising a second therapeutic agent. The surgical implant includes a film in direct...
8980301 Multilayered blood product  
A blood product (10), a method for preparing the blood product, a blood product obtainable by the method and a blood product preparing container means. The blood product comprises components from...
8975231 Bone morphogenic protein binding peptide  
A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a...
8968766 Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods  
Biocompatible intraocular implants include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into an eye for an...
8968782 Combination degradable and non-degradable matrices for active agent delivery  
The present invention relates to relates to combination degradable and non-degradable matrices and related methods. In an embodiment, the invention includes an active agent delivery matrix...
8968761 Particulate tissue graft with components of differing density and methods of making and using the same  
Disclosed are tissue graft compositions made of particles having different densities, methods of making these compositions, and methods of using these compositions for promoting tissue restoration...
8968392 Method of inhibiting vascular intimal hyperplasia using stent  
A method of inhibiting vascular intimal hyperplasia including: placing a stent within a blood vessel, the stent having a stent body of a cylindrical configuration having outer and inner surfaces...
8968767 Drug depots having different release profiles for reducing, preventing or treating pain and inflammation  
Effective treatments of pain and/or inflammation are provided. Through the administration of an effective amount of at least analgesic and/or at least one anti-inflammatory agent at or near a...
8968763 Block biodegradable copolymers for medical devices  
Disclosed herein are implantable medical devices comprising controlled release biodegradable block copolymers or coated with controlled release block copolymers and at least one drug releasable...
8968417 Bioactive implant for myocardial regeneration and ventricular chamber restoration  
Bioactive implant for myocardial regeneration and ventricular chamber support including an elastomeric microporous membrane. The elastomeric microporous membrane being at least one non-degradable...
8968764 Nerve regeneration employing keratin biomaterials  
A keratin hydrogel matrix serves as an effective acellular scaffold for axonal regeneration and facilitates functional nerve recovery.
8968765 Brush polymer and medical use thereof  
The present disclosure provides a brush polymer, including: a linear polymer main chain; and brush structural side chains, including: a hydrophobic molecular branch, and a hydrophilic molecular...
8962037 Dicalcium phosphate ceramics, dicalcium phosphate/hydroxyapatite biphasic ceramics and method of manufacturing the same  
The present invention discloses a method of manufacturing pure dicalcium phosphate ceramics or dicalcium phosphate/hydroxyapaite (HA) biphasic ceramics for medical applications in hard tissue...
8956642 Bupivacaine formulation in a polyorthoester carrier  
Effective treatments of pain, such as chronic pelvic pain, for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the...
8956641 Alpha adrenergic receptor agonists for treatment of inflammatory diseases  
Effective treatments of pain and/or inflammation from tendonitis, carpal tunnel syndrome, tarsal tunnel syndrome, osteoarthritis, bursitis and/or an oral-facial disease are provided. Through the...
8956643 Porous biodegradable polymer scaffolds for in situ tissue regeneration and method for the preparation thereof  
The present invention relates to an intelligent porous biodegradable polymer scaffold for in situ tissue regeneration in which two kinds of physiologically active substances having high...
8951546 Flexible implantable composites and implants comprising same  
Described herein are implantable composites, kits comprising the composites, implant devices comprising the composites, and methods of making and using same, including point of use methods.
8940317 Continuous matrix with osteoconductive particles dispersed therein, method of forming thereof, and method of regenerating bone therewith  
The present disclosure provides compositions useful in regeneration of connective tissue, particularly bone. The compositions comprise a continuous matrix formed of a polypeptide crosslinked with...
8936806 Periostin induces proliferation of cardiomyocytes and promotes cardiac regeneration  
The present invention provides compositions and methods for increasing proliferation, increasing cell cycle activity, and/or proliferation of postmitotic mammalian differentiated cardiomyocytes....
8936805 Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same  
A structure of, and a method of producing, a biocompatible structure for bone and tissue regeneration are disclosed. The method includes dissolving a polyurethane polymer in methanol, adding...
8932622 Tissue coating for preventing undesired tissue-to-tissue adhesions  
Disclosed herein are a kit and a method for forming a tissue coating that prevents undesired tissue-to-tissue adhesions resulting from trauma, surgery, infection, or other stimulus. The tissue...
8932560 Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells  
A hemostatic tissue sealant sponge and a spray for acute wounds are disclosed. The sponge comprises hydrophobically modified polymers that anchor themselves within the membrane of cells in the...
8932638 Polyamine derivatives  
Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules.
8928285 Charging of secondary cells (accumulators) with regulated input current  
Stated is a charging-current regulating device for charging an energy storage device for a field device, and for regulating a charging current for the energy storage device, wherein regulating the...
8920516 Graft prosthesis, material and methods  
A graft prostheses (11), materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis includes a purified, collagen-based matrix structure...
8920828 Implants for treatment of symptomatic or degenerated intervertebral discs  
Devices for the treatment of intervertebral discs are described. The devices, when implanted into the nucleus pulposus of an intervertebral disc, provide for the controlled release of one or more...