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7618646 |
Matrix, cell implant and method for their production and use
The invention relates to porous matrices based on a biologically compatible polymer or polymer mixture, to a cell implantation that is established on said matrices and to additional cell...
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7615234 |
Drug delivery technology
The invention relates to a novel drug delivery technology. More particularly the invention relates to a method of delivering at least one therapeutic compound or a formulation comprising the at...
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7608281 |
Composition and use of RAR antagonists for promoting chondrogenesis
The invention provides compositions comprising a RAR antagonist for promoting chondrogenesis and to methods employing such compositions for treating cartilage and associated bone abnormalities...
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7604817 |
Method for promoting growth of tissue
A device and method for tissue engineering is disclosed. More particularly this invention relates to a bioabsorbable device and a method of its use which promotes controlled new tissue in-growth...
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7597903 |
Method and composition for producing catheters with antibacterial property
A medical device and a method for imparting antibacterial properties to the device, made from hydrophobic polymer, particularly to urinary latex catheters comprises treatment of the device by...
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7592017 |
Resorbable thin membranes
Resorbable lactide polymer thin membranes are disclosed. The thin membranes are constructed of polylactide resorbable polymers, which are engineered to be absorbed into the body relatively slowly...
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7585929 |
Preparation and uses for polyarylates
The present invention is directed to polyarylates comprising repeating units having the structure:
as well as their preparation and use as cell growth substrates.
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7585516 |
Coatings for drug delivery devices
A polymer coating for medical devices based on a polyolefin derivative. A variety of polymers are described to make coatings for medical devices, particularly, for drug delivery stents. The...
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7585320 |
Energetically-controlled delivery of biologically active material from an implanted medical device
A medical device and system capable of providing on-demand delivery of biologically active material to a body lumen patient, and a method of making such medical device. A first coating layer...
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7582310 |
Biodegradable and bioactive glass-ceramics, and method for fabricating the same
Disclosed herein is a biodegradable and bioactive glass-ceramic fabricated by mixing a slowly biodegradable glass-ceramic and a highly biodegradable glass-ceramic in a predetermined mixing ratio...
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7563824 |
Clathrate complexes formed by hyaluronic acid derivatives and use thereof as pharmaceuticals
A clathrate formed by: a hyaluronic acid derivative (a), a hyaluronic acid derivative (b 1 ) different from (a), and being able to form a clathrate with (a) and/or a component (b 2 ) not containing...
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RE40786 |
Vaccines against intracellular pathogens using antigens encapsulated within biodegradable-biocompatible microspheres
This invention relates to parenteral and mucosal vaccines against diseases caused by intercellular pathogens using antigens encapsulated within a biodegradable-biocompatible microspheres(matrix).
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7547449 |
Method for treating a bone defect with an organic/inorganic composite
The subject invention concerns a composite comprising an organic fluid-swellable, fibrous matrix, such as collagen, and a mineral phase, such as calcium carbonate or phosphate mineral phase, for...
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7547448 |
Bone replacement material comprising crystalline and X-ray amorphous phases
The present invention relates to an X-ray amorphous-crystalline material with high solubility which can be used as a bioactive bone replacement material and as a substrate material in...
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7541049 |
Bioactive and biodegradable composites of polymers and ceramics or glasses and method to manufacture such composites
Surgical osteosynthesis composite material which has three components: biodegradable polymer reinforcement, bioceramic or bioglass filler reinforcement and biodegradable polymer matrix. This...
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7537782 |
Methods for governing bone growth
Resorbable polymer barrier membranes and methods of their applications are disclosed. In a broad embodiment, methods of governing bone growth, or preventing bone growth into a certain spatial area,...
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7531670 |
Methods for treating cognitive/attention deficit disorders using tetrahydroindolone analogues and derivatives
Methods for treating cognitive/attention deficit disorders in general using tetrahydroindolone derivatives and analogues, particularly tetrahydroindolone derivatives or analogues in which the...
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7531035 |
Resorbable ceramic compositions
Ceramic precursor compositions and chemically bonded ceramic (CBC) materials, especially Ca-based, and a composite biomaterial suitable for orthopaedic applications. The CBC-system includes a...
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7521064 |
Non-hormonal vaginal contraceptive
The present invention relates to a non-hormonal, biocompatible, and biodegradable intravaginal device for the delivery of spermiostatic, spermicidal and anti-infectious agents. The present...
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7514095 |
Fabrication of drug loaded biodegradable polymer fibers
The invention provides tissue engineering compositions and methods wherein three-dimensional matrices for growing cells are prepared for in vitro and in vivo use. The matrices comprise...
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7510699 |
In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes
Methods, systems, devices and computer program product include: (i) administering a fluorescent analyte to a subject; (ii) repetitively emitting excitation light from an implanted sensor over a...
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7507421 |
Hydroxycitric acid salt composition and method of making
Disclosed is a hydroxycitric acid salt composition comprising calcium and potassium salts of hydroxycitric acid, preferably in a defined proportion which yields a very pure, stabilized preparation...
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7507394 |
High viscosity embolizing compositions
Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter delivery.
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7504386 |
Biomaterials for preventing post-surgical adhesions comprised of hyaluronic acid derivatives
New biomaterials essentially constituted by esterified derivatives of hyaluronic acid or by cross-linked derivatives of hyaluronic acid for use in the surgical sector, particularly for use in the...
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7498043 |
Silicon substituted oxyapatite
The invention is a silicon substituted oxyapatite compound (Si—OAp) for use as a synthetic bone biomaterial either used alone or in biomaterial compositions. The silicon substituted oxyapatite...
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7498042 |
Stent for blood vessel and material for stent for blood vessel
A luminal stent, implanted and implanted and left in the blood vessel, is disclosed. By permitting a stent ( 1 ), formed of a biodegradable polymer material ( 2 ), to be swollen, and by...
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7494482 |
Methods and apparatus for application of micro-mechanical forces to tissues
Methods and devices for transmitting micromechanical forces locally to induce surface convolutions into tissues on the millimeter to micron scale for promoting wound healing are presented. These...
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7491408 |
Polymer, bioabsorbable material and film for preventing tissue fusion
A novel A 1 -B-A 2 polymer having a number average molecular weight of 10000 to 100000 is provided that has excellent bioabsorbability so as to disappear in a predetermined period of time even...
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7488316 |
Control of drug release by transient modification of local microenvironments
Methods, formulations, and devices are provided for enhancing drug delivery from a medical device. The method is provided for increasing the rate or quantity of a drug formulation released from an...
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7485318 |
Biodegradable carrier and method for preparation thereof
A biodegradable carrier is produced for preservation and/or controlled delivery of biologically active agents where the biodegradable carrier is a silica xerogel which is made from water and silane...
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7473431 |
Injectable methadone, methadone and naltrexone, or buprenorphine and naltrexone microparticle compositions and their use in reducing consumption of abused substances
An injectable slow-release methadone, partial opioid agonist or opioid antagonist formulation is provided comprising methadone, a partial opioid agonist or opioid antagonist in a poly(D,L-lactide)...
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7462471 |
Porous biodegradable polymeric materials for cell transplantation
Polymeric materials are used to make a pliable, non-toxic, injectable porous template for vascular ingrowth. The pore size, usually between approximately 100 and 300 microns, allows vascular and...
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7459170 |
Bone replacement material with orthophosphate
The present invention relates to a material with orthophosphate and having a high solubility which can be used as a bioactive bone replacement material and as a substrate material in biotechnology....
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7449180 |
Macroscopic scaffold containing amphiphilic peptides encapsulating cells
The invention features peptide scaffolds that are useful in the repair and replacement of various tissues. The invention also provides methods for making these scaffolds and methods for using them.
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7445793 |
Support for tissue regeneration and process for producing the same
The present invention provides a scaffold in which cells can be stably retained and grafted in a uniform distribution state in the culture, preferable proliferation ability and viability can be...
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7442385 |
Chemoembolisation
A composition for chemoembolotherapy of solid tumours comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer...
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7442384 |
Bioresorbable hydrogel compositions for implantable prostheses
Crosslinked compositions formed from water-insoluble copolymers are disclosed. These compositions are copolymers having a bioresorbable region, a hydrophilic region and at least two cross-linkable...
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7410947 |
Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with...
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7408018 |
Elastomeric functional biodegradable copolyester amides and copolyester urethanes
The invention provides elastomeric copolyester amides, elastomeric copolyester urethanes, and methods for making the same. The polymers are based on α-amino acids and possess physical, chemical...
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7407668 |
Medical articles having enzymatic surfaces for localized therapy
An enzymatically active medical article is provided, which comprises a medical article and an enzyme disposed at or near a surface of the medical article such that the medical article is provided...
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7393544 |
Dispersion for pulmonary delivery of a bioactive agent
Stabilized dispersions are provided for the delivery of a bioactive agent. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that...
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7393493 |
Crosslinkable polymeric materials and their applications
The present invention relates to a novel composition for dental, orthopedic and drug delivery purpose. Specifically, it relates to composition comprising an admixture of a resorbable bone...
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7390498 |
Method of forming bone with porous βtricalcium phosphate granules
A porous β-tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter...
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7387785 |
Preparation for treating diseases of bone tissues
The present invention refers to an considerably improved medicinal preparation and its synthesizing method, in particular for allowing to affect the osteoreparative process due to stimulation of...
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7375077 |
In vivo synthesis of connective tissues
The in vivo synthesis of connective tissue by fibroblast or fibroblast precursor cells ensconced within a biocompatible scaffold is disclosed. The cells are preferably present in a biocompatible...
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7374776 |
Bone-filling composition for stimulating bone-forming and bone-consolidation comprising calcium sulfate and viscous biopolymers
The present invention relates to a composition for bone-filling, more particularly, to a bone-filling composition for stimulating bone-formation and bone consolidation comprising calcium sulfate...
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7368126 |
Controlled release depot formulations
Methods and compositions for systemically or locally administering a beneficialagent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired...
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7368125 |
Amphiphilic polymers for medical applications
The present invention is directed to medical devices or pharmaceutical compositions, each containing a synthetic, bioabsorbable, biocompatible polymer that is the reaction product of a polybasic...
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7361369 |
Implant with structure allowing injection of polymer for attaching implant to tissue
Methods and apparatus for bone implants that allow for the directed application of an osteogenic compound. The implant is preferably constructed of a biodegradable polymer formed into a structure...
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7361368 |
Device and method for combining a treatment agent and a gel
A method including introducing a treatment agent at a treatment site within a mammalian host; and introducing a bioerodable gel material at the treatment site. An apparatus including a first...
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