|
Match
|
Document |
Document Title |
|
|
6852331 |
Fabrication of a cartilage implant
A method of fabricating a cartilage implant including embedding and growing chondrocytes or mesenchymal stem cells in a three-dimensional substrate. The substrate contains randomly rewound...
|
|
|
6852330 |
Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
A biocompatible tissue repair stimulating implant or “scaffold” device, and methods for making and using such a device, are provided. The implant includes one or more layers of a bioabsorbable...
|
|
|
6846853 |
Calcium phosphate bone graft material, process for making same and osteoimplant fabricated from same
A calcium phosphate bone graft material comprising an amorphous calcium phosphate glassy phase of from about 30 to about 100 volume % is obtained by plasma spraying calcium phosphate-containing...
|
|
|
6841169 |
Stabilizer for pharmacons
The present invention relates to an auxiliary substance for an active substance, such as a pharmacon. The auxiliary substance has a stabilizing action. The auxiliary substance further has a...
|
|
|
6838089 |
Antigen delivery system and method of production
The present invention concerns polymer particle vaccine delivery systems in which a water insoluble protein antigen, e.g. a lipidated HpaA protein, is incorporated with particles comprising a...
|
|
|
6822000 |
Bioerodible poly (orthoesters) from dioxolane-based diketene acetals
Bioerodible poly(orthoesters) useful as orthopedic implants or vehicles for the sustained delivery of pharmaceutical, cosmetic and agricultural agents contain hydrogen bonding groups and α-hydroxy...
|
|
|
6811767 |
Liquid droplet aerosols of nanoparticulate drugs
There invention discloses aqueous dispersions of nanoparticulate aerosol formulations, dry powder nanoparticulate aerosol formulation, propellant-based aerosol formulations, methods of using the...
|
|
|
6805876 |
Phosphate based biodegradable polymers
Featured are biodegradable polymers comprising repeat units derived from cyclic phosphate monomers and optionally further comprising repeat units derived from lactide or caprolactone monomers. Also...
|
|
|
6793675 |
Polysaccharide sponges for cell culture and transplantation
A polysaccharide sponge characterized by having: (i) an average pore size in the range between about 10 μm to about 300 μm; (ii) an average distance between the pores being the wall thickness of...
|
|
|
6793938 |
Biodegradable compositions for the controlled release of encapsulated substances
Pharmaceutical compositions that enable the release of a physiologically active substance over a prolonged period of time following administration to a patient are described. The pharmaceutical...
|
|
|
6773713 |
Injection molding of living tissues
The invention features methods of making living tissue constructs having a predetermined shape by providing a negative mold having a defined shape; suspending isolated tissue precursor cells in a...
|
|
|
6773714 |
Polymeric delivery formulations of leuprolide with improved efficacy
The present invention is directed to a flowable composition that is suitable for use as a controlled release implant. The flowable composition includes a biodegradable thermoplastic polyester that...
|
|
|
6773699 |
Light energized tissue adhesive conformal patch
Consistent with the present invention, tissue adhesive compositions and an associated laser exposure system are provided for bonding or sealing biological tissues. The compositions are comprised of...
|
|
|
6770695 |
Time release calcium sulfate matrix for bone augmentation
An implant composition having controlled resorption rate in vivo for stimulating bone growth, a method of making the implant composition, and a kit of implant materials are disclosed. The implant...
|
|
|
6767551 |
Coating for use with medical devices and method of making same
The inventive coating may be employed to deliver a pharmaceutical agent to a selected body area that is involved within the insertion or application of a medical device. Such medical devices may...
|
|
|
6767550 |
Hydroxyapatite based drug delivery implant for cancer treatment
A hydroxyapatite based bioresorbable material is incorporated with anti-cancer agents to form an implant used for treatment against cancer. Sustained release of the anti-cancer agents may be...
|
|
|
6764698 |
Controlled drug release system of retinoic acid
The present invention relates to a controlled drug release system in which a certain ratio or retinoic acid is incorporated into a microsphere comprising biodegradable polymer and amphoteric block...
|
|
|
6761887 |
Alginate layer system for chondrogenic differentiation of human mesenchymal stem cells
Disclosed are a composition of chemically defined components which support in vitro and in vivo chondrogenesis of mesenchymal stem cells, a method for in vitro and in vivo chondrogenic induction of...
|
|
|
6761908 |
Collagen preparation for the controlled release of active substances
A collagen preparation for the controlled release of active substances is characterized in that it has mixtures of acid-insoluble collagens with different molecular weight distributions.
|
|
|
6759054 |
Ethylene vinyl alcohol composition and coating
An ethylene vinyl alcohol coating for an implantable device or prosthesis, such as a stent, is provided. Compositions are also provided for coating the implantable device. The compositions can...
|
|
|
6759431 |
Compositions and methods for treating or preventing diseases of body passageways
The present invention provides methods for treating or preventing diseases associated with body passageways, comprising the step of delivering to an external portion of the body passageway a...
|
|
|
6756048 |
Long time drug-sustained release preparation
The present invention relates to a sustained release preparation of a lipophilic drug, comprising a drug dispersion wherein the lipophilic drug and a water-soluble substance are dispersed, in a...
|
|
|
6752938 |
Method of preparing microsphere composite of collagen and bioceramic powder
This invention provides a method of preparing microsphere composite of collagen and bioceramic powder. This method first mixes a collagen solution with bioceramic powder and alginate, and squeezes...
|
|
|
6743783 |
Pharmaceutical compositions comprising poly-β-1→4-N-acetylglucosamine
The present invention relates to a purified, easily produced poly-β-1→4-N-acetylglucosamine (p-GlcNAc) polysaccharide species. The p-GlcNAc of the invention is a polymer of high molecular weight...
|
|
|
6737073 |
Implant for repairing cartilage having outer surface layers of copolymer and ceramic material
A biodegradable, biocompatible porous matrix as a scaffold for tissue engineering cartilage is formed of a copolymer of a polyalkylene glycol and an aromatic polyester such as a polyethylene...
|
|
|
6737074 |
Methods of separating cells, transplanting cells and engineering tissue using fibrin microbeads
The present invention provides fibrin microbeads that are biologically active and comprise extensively cross-linked fibrin(ogen), and a method for preparing the fibrin microbeads. The present...
|
|
|
6737072 |
Matrix for tissue engineering formed of a hyaluronic acid ester and hydrolyzed collagen
A porous composite matrix is formed from a hyaluronic acid derivative and hydrolyzed collagen, which are preferably in a weight ratio range of 30:70 to 99:1. A preferred hyaluronic acid derivative...
|
|
|
6733767 |
Liquid polymeric compositions for controlled release of bioactive substances
Controlled release of hydrophobic bioactive substances in vivo over an extended time period and without “bursts” of drug release is achieved using a liquid polymeric composition including a...
|
|
|
6730298 |
Tissue formation by injecting a cell-polymeric solution that gels in vivo
Slowly polymerizing polysaccharide hydrogels have been demonstrated to be useful as a means of delivering large numbers of isolated cells via injection. The gels promote engraftment and provide...
|
|
|
6726918 |
Methods for treating inflammation-mediated conditions of the eye
Methods for treating inflammation-mediated conditions of the eye are described, comprising: implanting into the vitreous of the eye of an individual a bioerodible implant comprising a steroidal...
|
|
|
6726920 |
Implantable drug delivery patch
The present invention features devices and methods for delivery of drug to an internal organ surface by delivery of drug directly to the surface of the organ such that the drug traverses the organ...
|
|
|
6726923 |
Apparatus and methods for preventing or treating failure of hemodialysis vascular access and other vascular grafts
This invention is a prosthetic device generally placed on the outside surface of the vessel or graft which then elutes antiproliferative drugs or agents from a drug-eluting matrix material. Methods...
|
|
|
6723333 |
Moulded bodies made of thermoplastic polyurethane containing an active substance
The invention provides moulded items made from thermoplastic polyurethanes (TPUs), in particular medical articles such as central venous catheters which contain a homogeneous distribution of...
|
|
|
6719993 |
Calcium phosphate cements prepared from silicate solutions
Methods are provide for producing flowable compositions, e.g. pastes, that set into calcium phosphate products. In the subject methods, dry reactants that include a calcium source and a phosphate...
|
|
|
6719797 |
Nucleus augmentation with in situ formed hydrogels
Artificial disc augmentation for natural intervertebral discs using a solution of polymers. Once inserted into the disc the polymers crosslink to form hydrogels in vivo. Crosslinking of the...
|
|
|
6713081 |
Ocular therapeutic agent delivery devices and methods for making and using such devices
Ocular implant devices for the delivery of a therapeutic agent to an eye in a controlled and sustained manner. Dual mode and single mode drug delivery devices are illustrated and described....
|
|
|
6713079 |
Methods for increasing vascularization and promoting wound healing
The present invention provides a method of stimulating vascularization at a site in a mammal, said method comprising contacting said site with a matrix comprising gelatin and a nitric oxide...
|
|
|
6706274 |
Differential delivery of nitric oxide
This invention relates to devices and methods for the local, differential delivery of nitric oxide within the body. The devices include devices having at least two differing nitric oxide donor...
|
|
|
6706273 |
Composition for implantation into the human and animal body
Compositions for implantation into the human and animal body as bone replacement contain inter alia calcium and phosphorus and consist in particular of mixtures of powders and admixing liquids....
|
|
|
6703037 |
Biodegradable macromers for the controlled release of biologically active substances
A method for delivering a biologically active substance including the steps of: (a) combining said biologically active substance with a macromer; (b) forming a mixture of the combination formed in...
|
|
|
6703038 |
Injectable bone substitute material containing non-ceramic hydroxyapatite cement
A bone substitute material is prepared which comprises a soft matrix, living cells and a setting matrix comprising non-ceramic hydroxyapatite cement. The bone substitute material can be injected...
|
|
|
6703047 |
Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use
Compositions and methods are provided for forming tissue-adherent hydrogels using substantially dry precursors. The dehydrated precursors are premixed prior to in situ therapy and utilize...
|
|
|
6699490 |
Aqueous prolonged release formulation
Prolonged parenteral release into the circulatory system of a cow of a bioactive bovine somatotropin at desirably effective levels can be achieved using novel compositions in which the bovine...
|
|
|
6699484 |
Fibrin sealants or adhesives comprising a hyaluronic acid derivative material
An especially useful fibrin glue composition comprises a biocompatible, bioabsorbable hyaluronic acid derivative material, upon which are applied or chemically bonded fibrinogen and thrombin, along...
|
|
|
6699505 |
Method of increasing the efficacy of antibiotics by compexing with cyclodextrins
The present invention provides methods of increasing the biological activity of a bioactive agent by complexing the bioactive agent with a complexing agent. In one preferred embodiment, the...
|
|
|
6696075 |
Liquid crystalline polymers
Methods for inducing a thermoplastic polymer, which can be non-mesogenic, to exhibit liquid crystalline properties have been developed. The method includes the steps of (a) heating the polymer from...
|
|
|
6692759 |
Methods for preparing and using implantable substance delivery devices
Method for preparing an implantable device for a sustained delivery of a substance within a body of a human or an animal subject, the method including; dissolving a biocompatible polymer in a...
|
|
|
6689375 |
Resorbable bone implant material and method for producing the same
The powdery component of the implant material consists essentially of a mixture of hydroxyl apatite powder and calcium sulfate powder, wherein the hydroxyl apatite powder consists of synthetically...
|
|
|
6685957 |
Preparation of fibrous polymer implant containing bioactive agents using wet spinning technique
A fibrous polymer implant loaded with one or more bioactive agents is prepared using a wet spinning technique. Preferably, an aqueous solution of bioactive agent is added to a solution of...
|
|
|
6682754 |
Ovo delivery of an immunogen containing implant
The disclosure provides a method for administering an agent to an avian species by in ovo delivery of an implant releasably containing the agent. In one embodiment, the method is particularly...
|