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7005135 |
Glass scaffolds with controlled resorption rates and methods for making same
The present invention relates to resorbable glass scaffolds for use in biological applications and methods for making same. Specifically, these scaffolds are composed of phosphate glass fibers,...
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6998137 |
Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix
The present invention relates to compositions and methods for the modulated release of one or more proteins or peptides. The composition is comprised of a biocompatible polymeric matrix, a protein...
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6989195 |
Coated particles, methods of making and using
A particle coated with a nonlamellar material such as a nonlamellar crystalline material, a nonlamellar amorphous material, or a nonlamellar semi-crystalline material includes an internal matrix...
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6987111 |
Aripiprazole, olanzapine and haloperidol pamoate salts
The invention relates to the discovery that pamoate salts of haloperidol and aripiprazole result in a good to superior long acting and/or extended release profile. Thus, in one aspect of the...
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6979465 |
Biocompatible polymer systems carrying triflusal or HTB
New biocompatible polymeric systems carrying triflusal or HTB are described which result from the polymerization of a monomer A of the acrylic or vinylic type and carrying triflusal or HTB, wherein...
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6976981 |
Osmotic delivery system with membrane plug retention mechanism
An osmotic delivery system has a membrane plug retention mechanism which can also be used to control the delivery rate of a beneficial agent from the osmotic delivery system. The osmotic delivery...
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6972130 |
Bioceramic compositions
The present invention provides a synthetic, poorly crystalline apatite (PCA) calcium phosphate containing a biologically active agent and/or cells (preferably tissue-forming or tissue-degrading...
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6969523 |
Collagen/glycosaminoglycan matrix stable to sterilizing by electron beam radiation
Compositions of cross-linked collagen and a glycosaminoglycan are provided which retain characteristics rendering them useful as tissue engineering matrices or scaffolds following terminal...
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6969525 |
Surgically implanted time release medication for post-surgical treatment of a patient
A method of administering a medication to a post operative patient with the medication being administered at the site of a surgery performed on the patient. The medication is formed into a time...
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6967234 |
Alkyd-lactone copolymers for medical applications
The present invention is directed to biodegradable, biocompatible polymers that are the reaction product of a polybasic acid or derivative thereof, a monoglyceride and a lactone monomer, as well as...
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6962574 |
Therapeutic agent delivery device
A biological therapeutic delivery device is provided. In one preferred embodiment, the invention includes a device for effectuating localized tissue injury comprised of a resorbable body having at...
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6960351 |
Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region...
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6960337 |
Methods and compositions for treating benign gynecological disorders
An improvement in a method of treating benign gynecological disorders is described. In the method, treatment of a benign gynecological disorder with a composition comprised of a gonadotropin...
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6958142 |
Nasal spray formulation and method
A nasal spray formulation for use in female contraception or in the treatment of benign gynecological disorders is described. The nasal preparation is comprised of a GnRH compound and an estrogenic...
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6958158 |
Immune modulation device for use in animals
The present invention is directed to an implantable immune modulation device that is useful for modulating an immune response in mammals, comprising a plurality of fibers, within a porous shell....
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6958149 |
Repair of larynx, trachea, and other fibrocartilaginous tissues
Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of...
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6953482 |
Instrument for regenerating living organism tissue or organ
This invention relates to an instrument for regenerating a living organism tissue or organ, characterized in that a support (A) formed from a biodegradable material or a bioabsorbable material...
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6953586 |
Growth promoting pharmaceutical implant
A combination growth promoting pharmaceutical pellet system which delivers doses of both a growth stimulating pharmaceutical agent and a supplemental agent that enhances the growth produced by the...
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6949251 |
Porous β-tricalcium phosphate granules for regeneration of bone tissue
A porous β-tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter...
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6949080 |
Left ventricular conduits to coronary arteries and methods for coronary bypass
A stent suitable for implantation in myocardial tissue to enhance perfusion therein may include a tubular member having first and second ends and a lumen. The first end of the stent may be...
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6949254 |
Bio-decomposable polymer composition showing good thermal decomposition
A biodegradable polymer composition having good resistance to thermal decomposition, wherein it is possible to control the weight-average molecular weight to within 30% of the initial molecular...
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6946117 |
Stabilized preparations for use in nebulizers
Stabilized dispersions are provided for the delivery of a bioactive agent to the respiratory tract of a patient. The dispersions preferably comprise a stabilized colloidal system which may comprise...
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6942873 |
Microfabrication of membranes containing projections and grooves for growing cells
The present invention provides a novel substrate for use in growing cells and for the study of mechanobiology. The membrane of the present invention comprises appropriate microtopography and...
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6939557 |
Slow release protein polymers
The invention features articles for delivery of a biologically active substance, methods for making such articles, and methods for treating an animal using the articles.
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6936271 |
Collagenous tissue compositions
Implant compositions are disclosed consisting of a biocompatible carrier medium such as a saline or dextran solution and particles of collagenous material dispersed therein. The collagenous...
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6933328 |
Composition of crosslinkable prepolymers for biodegradable implants
A composition suitable for preparing a biodegradable implant, comprising a crosslinkable multifunctional prepolymer having at least two polymerizable end groups, the said composition having a...
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6926903 |
Resorbable polymer composition, implant and method of making implant
Novel polymer compositions that are useful in the manufacture of medical implants, implants having osteogenic properties and methods of making said implants are disclosed. Polymer compositions...
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6923990 |
Stabilized silver-ion amine complex compositions and methods
The present invention relates to new silver-ion super-complex compositions. More particularly, the present invention describes silver-ion super-complex compositions comprising a silver-thiosulfate...
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6921541 |
Formulations and methods for providing prolonged local anesthesia
A formulation and methods for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible,...
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6916483 |
Bioabsorbable plugs containing drugs
Bioabsorbable modular drug delivery devices having shapes and sizes adapted to be inserted within a mating receptacle on the surface of an implantable prosthesis are disclosed. The devices may be...
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6913764 |
Antibiotic(s) preparation with retarding active ingredient release
The present invention concerns an antibiotic/antibiotics preparation for resorbable and non-resorbable implants for human and veterinary medicine, for the treatment of local microbial infections in...
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6911212 |
Malleable putty and flowable paste with allograft bone having residual calcium for filling bone defects
The invention is directed toward a malleable bone putty and a flowable pastel composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone...
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6908466 |
Surgical devices having a biodegradable material with a therapeutic agent
Surgical devices such as implants or suture fastenings are assembled from a plurality of discrete components, one of which components includes a heat bondable plastic material for bonding the...
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6905700 |
Hydrogel entrapping therapeutic agent and stent with coating comprising this
A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide containing hydroxy groups which are...
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6902584 |
Bone grafting matrix
A porous three-dimensional bone grafting matrix is provided which is biodegradable. The matrix is preferably formed from mineralized collagen where the mineral comprises particulate calcium...
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6899107 |
Osteoinduction of cortical bone allografts by coating with biopolymers seeded with recipient periosteal bone cells
A method by which immune responses to cortical bone grafts and other substrates (e.g., cement, IPN, etc.) can be minimized and at the same time graft osteoinductive potential can be improved, and...
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6887488 |
Nano-calcium phosphates/collagen based bone substitute materials
The present invention relates to a nano-calcium phosphates/collagen composite that mimics the natural bone, both in composition and microstructure, as well as porous bone substitute and tissue...
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6881227 |
Hydroxylapatite material containing tricalcium phosphate with microporous structure
The invention relates to a hydroxylapatite material containing phosphate wherein the microporous structure of algae hard-tissue raw material is retained in the end product and which can be obtained...
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6881766 |
Sutures and coatings made from therapeutic absorbable glass
Sutures fabricated from and/or coated with compositions including water-soluble glass are described herein. Pledgets containing water-soluble glass within the interstices of the pledget and/or...
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6878369 |
Methods for treating urinary incontinence in mammals
Disclosed are methods for treating urinary incontinence in a mammal wherein a composition comprising a biocompatible polymer, a biocompatible solvent, and a contrast agent is delivered to the...
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6869443 |
Biodegradable drug delivery vascular stent
A stent includes a main body of a generally tubular shape for insertion into a lumen of a vessel of a living being. The tubular main body includes a substantially biodegradable matrix having...
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6869976 |
Inorganic-polymer complexes for the controlled release of compounds including medicinals
This invention relates generally to the production and use of inorganic-polymer complexes for the controlled release of compounds including medicinals. Advantageously, the inorganic used is calcium...
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6866860 |
Cationic alkyd polyesters for medical applications
The present invention is directed to medical devices or pharmaceutical composition, each containing a synthetic, biodegradable, biocompatible polymer that is the reaction product of a polybasic...
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6867240 |
Porous composite materials
Methods and compositions are described that provide three dimensional porous matrices as structural templates for cells. The porous matrices of the present invention have desirable mechanical...
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6863900 |
Regeneration and augmentation of bone using mesenchymal stem cells
Disclosed are compositions and methods for augmenting bone formation by administering isolated human mesenchymal stem cells (hMSCs) with a ceramic material or matrix or by administering hMSCs;...
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6861068 |
Pharmaceutical compositions using semi-solid delivery vehicle
A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical...
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6858221 |
Intravascular delivery of mycophenolic acid
The present invention provides improved devices and methods for minimizing and/or inhibiting restenosis and hyperplasia after intravascular intervention. In particular, the present invention...
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6855329 |
Surface coating spatially controlled patterns
The invention provides a biodegradable and biocompatible polymer article having a surface wherein a biologically active ligand is provided on said surface in a spatially controlled pattern. The...
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6855366 |
Nitric oxide-modified linear poly(ethylenimine) fibers and uses therefor
A novel coating for medical devices provides nitric oxide delivery using nanofibers of linear poly(ethylenimine)diazeniumdiolate. Linear poly(ethylenimine)diazeniumdiolate releases nitric oxide...
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6855331 |
Sustained release hydrophobic bioactive PLGA microspheres
A controlled release microcapsulate pharmaceutical formulation for burst-free, sustained, programmable release of hydrophobic bioactive agent over a duration from 24 hours to 100 days comprising:...
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