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7375077 |
In vivo synthesis of connective tissues
The in vivo synthesis of connective tissue by fibroblast or fibroblast precursor cells ensconced within a biocompatible scaffold is disclosed. The cells are preferably present in a biocompatible...
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7368126 |
Controlled release depot formulations
Methods and compositions for systemically or locally administering a beneficialagent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired...
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7368125 |
Amphiphilic polymers for medical applications
The present invention is directed to medical devices or pharmaceutical compositions, each containing a synthetic, bioabsorbable, biocompatible polymer that is the reaction product of a polybasic...
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7361369 |
Implant with structure allowing injection of polymer for attaching implant to tissue
Methods and apparatus for bone implants that allow for the directed application of an osteogenic compound. The implant is preferably constructed of a biodegradable polymer formed into a structure...
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7361368 |
Device and method for combining a treatment agent and a gel
A method including introducing a treatment agent at a treatment site within a mammalian host; and introducing a bioerodable gel material at the treatment site. An apparatus including a first...
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7357941 |
Method of delivering a bioactive agent with porous β-tricalcium phosphate granules
A porous β-tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter...
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7358284 |
Particulate acellular tissue matrix
A method of processing an acellular tissue matrix to give a particulate acellular tissue matrix includes: cutting sheets of dry acellular tissue matrix into strips; cryofracturing the dry acellular...
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7354597 |
Microscale lyophilization and drying methods for the stabilization of molecules
Methods and systems are provided for microscale lyophilization or microscale drying of agents of interest, such as pharmaceutical agents or other molecules that are unstable or easily degraded in...
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7351423 |
Musculo-skeletal implant having a bioactive gradient
This invention relates to an implant for a musculoskeletal defect having a bioactive agent having a concentration gradient.
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7351422 |
Hemostatic soluble cellulose fibers containing coagulating protein for treating wound and process for producing the same
Proposed is a novel soluble trauma-healing and hemostatic cellulose fiber capable of absorbing and readily dissolving hemorrhaging trauma loci when applied thereto and of promoting the hemostatic...
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7348020 |
Invasive medical device, especially for guided tissue regeneration
Biodegradable invasive medical device, in particular for guided tissue regeneration, which device comprises a biodegradable polymer, composed of a thermoplastic and/or thermosetting polymer admixed...
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7342048 |
Bioabsorbable pharmaceutical formulation
A bioabsorbable release-sustaining pharmaceutical formulation using a biodegradable release-sustaining base material which can prevent an effective component drug from being released too rapidly...
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7335375 |
Controlling resorption of bioresorbable medical implant material
The resorption of a medical implant can be controlled with the use of particles embedded in a resorbable bulk material forming the implant or portion thereof. The implant can be removed from a body...
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7335383 |
Generation of nitric oxide in vivo from nitrite, nitrate or nitrosothiols endogenous in blood
A material includes a surface and a reactive agent that is located at the surface of the material, covalently attached to a backbone of the material, and/or located within the material. The...
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7332230 |
Multilayer preparation in film form, consisting of hydrophilic polymers, for the rapid release of active ingredients
A multilayer preparation in the form of films of hydrophilic polymers for rapid release of substances present in the film layers into liquid surroundings is characterized in that adjacent layers...
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7332160 |
Medical device and method for tissue removal and repair
The present invention relates to medical devices that are to be implanted or inserted into the body of a patient for the purpose of removing undesired body tissues. In one embodiment of the...
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7329414 |
Biodegradable polymer for marking tissue and sealing tracts
A tissue marker formed of a biodegradable polymer having drug-delivery capabilities is combined with a sealant that encapsulates the tissue marker and which serves to help anchor the tissue marker...
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7326422 |
Dissolvable oxides for biological applications
Controllably dissolvable silica-xerogels prepared via sol-gel process and their use. A delivery device including controllably dissolvable silica-xerogel into which structure a biologically active...
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7326421 |
Device and methods for sequential, regional delivery of multiple cytotoxic agents and directed assembly of wound repair tissues
An implantable delivery system includes a macrostructure formed of bioresorbable material selected from a group of alphahydroxy acids and defined to include an internal architecture of...
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7323190 |
Cell delivery system comprising a fibrous matrix and cells
Cell storage and delivery systems and methods for storing and delivering viable cells to a mammal are disclosed. The cell storage and delivery systems include a biodegradable and/or bioabsorbable...
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7323540 |
Process for preparing microrods using liquid-liquid dispersion
The invention provides a method for forming polymer microrods, the method including the steps of providing a polymer solution comprising a polymer dissolved in a first solvent; providing a...
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7318837 |
Customized alloys for stents
A balloon-expandable stent formed from a customized alloy formulation. The stent alloy has a either a high, variable or no work hardening rate, very high modulus of elasticity (Young's modulus),...
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7316999 |
Glucose dependent release of insulin from glucose sensing insulin derivatives
Insulin derivatives having a built-in glucose sensor, capable of delivering insulin from a depot as a function of the glucose concentration in the surrounding medium (e.g. tissue), such that the...
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7314636 |
Biodegradable injectable implants containing glycolic acid
This invention is directed to the field of medical implants, and more specifically to biodegradable injectable implants and their methods of manufacture and use. The injectable implants disclosed...
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7306812 |
Dissolvable backing layer for use with a transmucosal delivery device
A dissolvable backing layer for use with transmucosal drug delivery devices includes a dissolvable hydrophilic region and a non-hydrophilic region that inhibits or slows migration of water, drugs,...
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7300663 |
Adhesion and sealing of tissue with compositions containing polyfunctional crosslinking agents and protein polymers
Proteinaceous polymers having repetitive units from naturally occurring structural proteins are employed as backbones for functionalities for crosslinking to provide strongly adherent tissue...
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7301001 |
Bioabsorbable, biobeneficial polyester polymers for stent coatings
This disclosure covers polymers, some of which are useful in medical device applications. Some of these medical devices are implantable within a mammalian body, such as in a body lumen. The...
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7300962 |
Hydrogels formed by non-covalent linkages
In one aspect, the present invention provides hydrogels comprising polymer molecules and bridging molecules, wherein substantially all the polymer molecules are cross-linked by hydrogen bonds...
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7297758 |
Method for extending shelf-life of constructs of semi-crystallizable polymers
This invention relates to a method of extending the shelf-life of constructs, in particular bioabsorbable stents, comprising semi-crystalline polymers by increasing the crystallinity of the polymers.
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7294344 |
Sustained-release preparation for AII antagonist, production and use thereof
The present invention is to provide a sustained-release preparation which comprises a compound having angiotensin II antagonistic activity, its pro-drug or their salt, and a biodegradable polymer,...
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7282213 |
Method for applying a drug coating to a medical device
A method for coating a medical device with a drug is provided. Energy, preferably thermal energy, is applied to a crystalline deposit of a drug on the surface of a medical device to increase the...
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7279175 |
Stent coated with a sustained-release drug delivery and method for use thereof
An intraluminal medical device comprises a stent having a coating applied to at least part of an interior surface, an exterior surface, or both. The coating comprises a sustained release...
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7279219 |
Porous calcium phosphate ceramic and method for producing same
A porous calcium phosphate ceramic comprising a support portion having pores, and ring-shaped portions formed in the pores, the ring-shaped portions having pluralities of fine pores so that they...
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7279176 |
Nitric oxide-producing hydrogel materials
Hydrogels releasing or producing NO, most preferably photopolymerizable biodegradable hydrogels capable of releasing physiological amounts of NO for prolonged periods of time, are applied to sites...
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7273896 |
Compositions and methods of using a transient colorant
This invention relates generally to compositions and systems for forming biomaterials containing a transient colorant for visualizing tissue or surgical materials coated with such biomaterials, to...
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7271234 |
Polyarylates for drug delivery and tissue engineering
Biocompatible polyarylates of tyrosine-derived diphenol compounds and poly(alkylene oxide) dicarboxylic acids, articles formed therefrom and therapeutic uses are disclosed.
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7264772 |
Methods for sterilizing cross-linked gelatin compositions
Disclosed are methods for sterilizing cross-linked gelatin as well as to sterilized cross-linked gelatin. In particular, the methods of this invention employ E-beam sterilization techniques.
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7252838 |
Drug releasing elastic band and method
A ligating band according to the present invention comprises an elastomeric layer and an inner drug releasing layer. The inner drug releasing layer includes a therapeutic agent, for example a...
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7252834 |
Elastin stabilization of connective tissue
A method and product are provided for the treatment of connective tissue weakened due to destruction of tissue architecture, and in particular due to elastin degradation. The treatment agents...
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7247314 |
Biocompatible material composition adaptable to diverse therapeutic indications
A biocompatible material genus serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication.
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7247313 |
Polyacrylates coatings for implantable medical devices
A coating for a medical device, particularly for a drug eluting stent, is described. The coating can include a polyacrylate, a blend of polyacrylates, or a blend of the polyacrylate with other...
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7244445 |
Conformable, absorbable, solid composite preforms and their use for bone tissue engineering
The present invention is directed to an absorbable, conformable composite preform for use in making a solid bone filler which is an absorbable mixture of oppositely charged, solid microparticulate...
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7241740 |
Peptides as solubilizing excipients for transforming growth factor beta proteins
The present invention relates to compositions comprising excipients or solubilizing agents for proteins. The invention relates to the discovery that a peptide derived from the N-terminus extension...
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7238364 |
Compliant tissue sealants
An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the...
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RE39713 |
Polymerizable biodegradable polymers including carbonate or dioxanone linkages
Water-soluble macromers including at least one hydrolysable linkage formed from carbonate or dioxanone groups, at least one water-soluble polymeric block, and at least one polymerizable group, and...
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7226617 |
Thermosensitive and biodegradable microgel and a method for the preparation thereof
The present invention provides a thermosensitive and biodegradable microgel and a method of synthesizing such microgels. The thermosensitive and biodegradable microgel is synthesized from a...
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7226622 |
Chemoablation of tissue using biodegradable, solid salt dosage forms
Novel methods for the chemical ablation of tissue (e.g. prostatic tissue) are described. These methods include the steps of: (a) providing one or more solid salt dosage form comprising 50-100% w/w...
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7226612 |
Coating for medical devices
The invention relates to a coating for medical devices. The coating comprises a specific copolymer of which the composition may be adjusted such as to achieve an excellent adhesion to a wide range...
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7223420 |
Powder mixture for resorbable calcium phosphate biocements
The present invention relates to a powder mixture for resorbable calcium phosphate biocements, which mixture consists of 40–99% by volume of powder having a particle size of 0.1–10 μm, 1–20%...
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7217426 |
Coatings containing polycationic peptides for cardiovascular therapy
Coatings for implantable medical devices and methods for fabricating the same are disclosed. The coatings include a region containing a polycationic peptide, such as, for example, the polycationic...
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