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5741479 |
Desensitizing teeth with degradable particles
A method for desensitizing a hypersensitive tooth in a patient includes contacting exposed tubules with particles including a degradable material.
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5741600 |
Absorbable coating and blend
Absorbable coating and absorbable blend of polycaprolactone and crystallization modifier especially suitable for use in the coating of surgical sutures and in the controlled release of chemical or...
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5738864 |
Drug delivery agents incorporating mitomycin
A conjugate of a carrier polymer and aziridine ring containing mitomycin (MMC) drug molecules is prepared by coupling the MMC molecules via their aziridine imino groups to spacer groups that...
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5736372 |
Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure
Methods and artificial matrices for the growth and implantation of cartilaginous structures and surfaces and bone are disclosed. In the preferred embodiments, chondrocytes are grown on...
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5733567 |
Biodegradable, controlled-release microspheres and process for preparing them
Method for the preparation of a pharmaceutical composition in the form of microspheres controllably releasing at least one water-soluble active ingredient. The method comprises the steps of...
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5733566 |
Controlled release of antiparasitic agents in animals
A delivery system for providing antiparasitic agents to animals is provided and a method of treating parasitic infections in animals using such delivery systems is described. The delivery system is...
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5728752 |
Injectable microdipersions for soft tissue repair and augmentation
The present invention provides injectable, bioabsorbable microdispersions suitable for use as a soft tissue repair or augmentation material in animals comprising a fluid carrier that is a liquid...
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5725881 |
Semisolid mixtures of amorphous oligomers and crystalline polymers based on lactic acid
The present invention relates to semisolid mixtures of oligomers and/or polymers based on lactic acid, the preparation thereof and the use thereof as absorbable implants.
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5725491 |
Method of forming a biodegradable film dressing on tissue
The invention is directed to a biodegradable film dressing with or without additional therapeutic agents, an apparatus for spray delivery and a method for formation of the film dressing on a human...
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5717030 |
Adjunctive polymer system for use with medical device
A medical device which is a surgically implantable device coated with an adjunctive polymer system. The adjunctive polymer system forms a solid matrix when introduced into a human or animal body....
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5717006 |
Composition for biomaterial; preparation process
Composition for biomaterial for resorption/substitution of support tissues, dental tissues, bone tissues and osteoarticular tissues, which is made up of 40 to 75% by weight of a mineral phase...
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5716411 |
Method of skin regeneration using a collagen-glycosaminoglycan matrix and cultured epithelial autograft
The present invention relates to a method of skin regeneration of a wound or burn in an animal or human. This method comprises the steps of initially covering the wound with a collagen...
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5711960 |
Biocompatible implant material comprising a tri-axial or more three-dimensional fabric
This invention provides an implant material which has high mechanical strength and durability in three-dimensional directions and a function to synchronize with deformation characteristics of...
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5711968 |
Composition and method for the controlled release of metal cation-stabilized interferon
This invention relates to a composition, and method of forming said composition, for the controlled release of interferon. The controlled release composition of this invention comprises a...
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5711957 |
Use of a porous calcium carbonate based material as support of a growth factor in the preparation of a bioabsorbable implant
A method for treating a living organism includes fitting in the living organism a bioabsorbable implant. The bioabsorbable implant includes a support of porous calcium carbonate based material for...
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5709875 |
Implantable biodegradable material and process for its production
The invention relates to a material which can be implanted in living tissue, in particular bony tissue, and having a rate of biodegradation adapted to the rate at which the tissue is regenerated;...
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5709934 |
Bipolymer foams having extracellular matrix particulates
A biopolymer solution is polymerized to form a gel which is freeze-dried and crosslinked with ultraviolet radiation to form a biopolymer foam. The foam is filled with a collagen solution and the...
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5707643 |
Biodegradable scleral plug
The present invention relates to a scleral plug made of lactic acid copolymer; a scleral plug containing a drug that is designed to gradually release the drug into a vitreous body; and a scleral...
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5705181 |
Method of making absorbable polymer blends of polylactides, polycaprolactone and polydioxanone
Absorbable binary and tertiary blends of homopolymers and copolymers of poly(lactide), poly(glycolide), poly(ε-caprolactone), and poly(p-dioxanone) are described. The blends when used to...
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5702717 |
Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
A system and method for the parenteral delivery of a drug in a biodegradable polymeric matrix to a warm blooded animal as a liquid with the resultant formation of a gel depot for the controlled...
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5703200 |
Absorbable copolymers and blends of 6,6-dialkyl-1,4-dioxepan-2-one and its cyclic dimer
This invention provides various copolymers comprising a first repeating unit of the chemical formula: ##STR1## in which R 1 and/or R 2 are alkyl groups and a second repeating units generally...
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5700477 |
Bioabsorbable wound implant materials
Heteromorphic sponges are described which have matrix structures with oriented substructures added to facilitate cellular invasion. A sponge may be used as a wound implant by cutting it to the...
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5700476 |
Heteromorphic sponges containing active agents
The invention provides wound dressing and/or implant materials comprising a matrix structure of sponge, at least one substructure and at least one pharmacologically active agent, wherein both the...
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5700479 |
Surgical element and method for selective tissue regeneration
A surgical element for guided and controlled tissue regeneration and method for selective tissue regeneration. The elements disclosed include embodiments containing protrusions on at least one side...
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5700583 |
Hydrogels of absorbable polyoxaesters containing amines or amido groups
The present invention describes a crosslinked aliphatic polyoxaesters containing amines and/or amido groups and blends thereof with other polymers that may be used to produce surgical devices such...
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5700485 |
Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
Biodegradable controlled release microspheres for the prolonged administration of a local anesthetic agent, and a method for the manufacture thereof are disclosed. The microspheres are formed of a...
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5698213 |
Hydrogels of absorbable polyoxaesters
The present invention describes a new crossslinkable and crosslinked aliphatic polyoxaesters and blends thereof that may be used to produce hydrogels, surgical devices such as sutures, sutures with...
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5698189 |
Method for local application of polymeric material to tissue
This invention relates to devices and techniques for applying therapeutic polymeric material to living tissue.
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5696175 |
Preparation of bonded fiber structures for cell implantation
A novel processing technique is reported to bond non-woven fibers and, thus, prepare structural interconnecting fiber networks with different shapes for organ implants. The fibers are physically...
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5693332 |
Human keratinocytes supported on a hydrophilic membrane and methods of using same to effect wound closure
The present invention provides keratinocytes supported on a hydrophilic membrane, the composition being useful as a skin graft to effect closure of a wound. The invention also provides methods of...
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5691397 |
Isolation of the calcium-phosphate crystals of bone
The present invention is a process for first removing and isolating the calcium-phosphate crystals of bone from a substantial amount of the organic matrix and cellular constituents of bone without...
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5688519 |
Flash-flow fused medicinal implants
A totally-fused pellet and a process and a device for preparing the totally-fused pellet are provided. Conditions are applied to the pelleting material to melt the material uniformly such that the...
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5685879 |
Surgical bone wax applicator
A bone wax applicator having a foot plate and a handle, wherein the bone wax is secured to the lower surface of the foot plate and applied by holding the handle. The handle extends from the upper...
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5686092 |
Growth promoters for animals
A delivery system for providing growth promoters to food animals is provided and a method of promoting growth in food animals using such delivery systems is described.
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5686091 |
Biodegradable foams for cell transplantation
A structurally rigid biodegradable foam scaffold useful for cell transplantation is provided. The foam can be loaded with nutrients and/or drugs that elute from the foam during transplant to...
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5681576 |
Method and composition for post surgical adhesion reduction
A process and compositions for reducing post-surgical adhesion formation/reformation in mammals following injury to organs situated in mammalian body spaces. Aqueous, isotonic gel compositions,...
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5681873 |
Biodegradable polymeric composition
The invention provides moldable, biodegradable composition for use with bone and other tissues. The composition comprises a poly(caprolactone) thermoplastic polymer processed alone or compounded...
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5679658 |
N,O-carbonxymethylchitosan for prevention of surgical adhesions
The invention relates to a method of treating patients to minimize post-surgical adhesions and a kit useful in the method of the invention. The method is based on the timing that...
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5676963 |
Implants, prostheses, and stents comprising polymer-bound nitric oxide/nucleophile adducts capable of releasing nitric oxide
Implants, prostheses, and stents comprising a polymeric composition capable of releasing nitric oxide including a polymer and a nitric oxide-releasing N 2 O 2 - functional group bound to the...
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5670161 |
Biodegradable stent
An expandable, biodegradable stent for use within a body lumen comprises a hollow tube made from a copolymer of L-lactide and ε-caprolactone that is not plastically expandable at normal body...
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5667796 |
Method for producing ceramic implant materials, preferably ceramic implant materials including hydroxyl apatite
The present invention relates to a method for production of ceramic implant material, preferably ceramic implant material including hydroxyl apatite. According to the invention, for the production,...
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5665372 |
Autologous dermal fibroblasts for the repair of skin and soft tissue defects
The application concerns a method of repairing sequelae of acne vulgaris in a subject which comprises the steps of: a) providing a fibroblast-seeded clot having dermal fibroblasts derived from the...
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5665394 |
Matrix for sustained-release preparation
The present invention relates to a matrix for sustained-release preparation comprising an ester formed at a terminal carboxyl group of a straight-chain polyester which essentially consists of an...
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RE35601 |
Delivery device providing beneficial agent stability
The present invention is directed to an improved fluid-imbibing dispensing device for delivering a beneficial agent to a biological environment of use, the dispensing device being of the type...
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5662917 |
Release-controlled implantable somatotropin composition
The present invention relates to a release-controlled implantable composition comprising somatotropin, a bio-compatible wax and a water-soluble polymer. The present composition exhibits superior...
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5662938 |
Bioresorbable-polymer microspheres of hydroxy acid polymer free from surfactant, their preparation and their application as a drug
Bioresorbable microspheres and a process for making microspheres are provided. The microspheres are made of poly(hydroxy acid) having a bimodal distribution; at least one poly(hydroxy acid) having...
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5660857 |
Biopolymer composites
A process for preparing a composite comprising an insoluble protein matrix and an oleaginous material, which is useful as a material for surgical dressings and biomedical implants, and as a...
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5660849 |
Apparatus for forming a biodegradable implant precursor
The invention is directed to a biodegradable implant precursor having a two-part structure made of an outer sac and a liquid content. The implant precursor is composed of a biodegradable,...
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5658593 |
Injectable compositions containing collagen microcapsules
A collagen-based composition including microcapsules of atelocollagen or of a mixture of atelocollagen and a polysaccharide, particularly glycosaminoglycan, suspended in a viscous biocompatible...
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5656605 |
Device to promote drug-induced nerve regeneration
The invention relates generally to a system for promoting regeneration of a damaged nerve. In particular, the invention comprises: (1) a guide tube constructed to be attached to the damaged nerve;...
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